SEQUENCE LISTING

<110> Diversa Corporation
      Trefzer, Axel 
      Green, Brian 
      Bibb, Mervyn 
      Mason, Dylan 

<120> GLYCOSYLATION ENZYMES AND SYSTEMS AND METHODS OF MAKING AND USING THEM 

<130> 564462012740

<140> Not Yet Assigned 
<141> 2004-08-04

<150> 60/492,781
<151> 2003-08-04

<150> 60/515,950
<151> 2003-10-29

<160>  149   

<170>  PatentIn version 3.1

<210>  1
<211>  870
<212>  DNA
<213>  Streptomyces diversa

<220>
<221>  CDS
<222>  (1)..(870)
<223>  

<400>  1
gtg aaa ggc atc gtc ctg gcc gga ggc cac ggc acc cgg ctg cac ccg       48
Val Lys Gly Ile Val Leu Ala Gly Gly His Gly Thr Arg Leu His Pro         
1               5                   10                  15              

atc acc ctc ggc acg tcc aag cag atg ctg ccg gtc tac gac aag ccg       96
Ile Thr Leu Gly Thr Ser Lys Gln Met Leu Pro Val Tyr Asp Lys Pro         
            20                  25                  30                  

atg atc tac tac ccg ctc tcg gtg ctg atg ctc gcc ggg atc cgg gac      144
Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp         
        35                  40                  45                      

atc cag atc atc tcg tcc ccc gac gac atc gag aac ttc cgc cgg ctg      192
Ile Gln Ile Ile Ser Ser Pro Asp Asp Ile Glu Asn Phe Arg Arg Leu         
    50                  55                  60                          

ctc ggc gac ggc tcc ccg ctc ggc atc tcg ctc agc tac gcc gtc cag      240
Leu Gly Asp Gly Ser Pro Leu Gly Ile Ser Leu Ser Tyr Ala Val Gln         
65                  70                  75                  80          

gag cag ccc cgc ggc ctc gcc gag gcc ttc ctc atc tcc gcc gac cac      288
Glu Gln Pro Arg Gly Leu Ala Glu Ala Phe Leu Ile Ser Ala Asp His         
                85                  90                  95              

atc ggg gac gac tcc gtc gcc ctc gtc ctc ggc gac aac atc ttc cac      336
Ile Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe His         
            100                 105                 110                 

ggc ccc ggc ttc gcc gga atc ctc cag gac aag gcc gtg gac gtg gac      384
Gly Pro Gly Phe Ala Gly Ile Leu Gln Asp Lys Ala Val Asp Val Asp         
        115                 120                 125                     

ggc tgc gtg ctc ttc ggc tac ccg gtc cgc gac ccc gag cgc tac ggc      432
Gly Cys Val Leu Phe Gly Tyr Pro Val Arg Asp Pro Glu Arg Tyr Gly         
    130                 135                 140                         

gtc ggc gag gtc gac gcg gac ggc cgg ctg gtc tcc ctg gag gag aag      480
Val Gly Glu Val Asp Ala Asp Gly Arg Leu Val Ser Leu Glu Glu Lys         
145                 150                 155                 160         

ccg gag cac ccg cgc tcc gac ctc gcc atc acc ggc ctc tac ttc tac      528
Pro Glu His Pro Arg Ser Asp Leu Ala Ile Thr Gly Leu Tyr Phe Tyr         
                165                 170                 175             

gac aac gac gtc atc gac atc gcc aag aac ctc acg ccc tcg gcg cgc      576
Asp Asn Asp Val Ile Asp Ile Ala Lys Asn Leu Thr Pro Ser Ala Arg         
            180                 185                 190                 

ggc gaa ctg gag atc acc gac gtc aac cgg atc tac ctg gag cgc ggc      624
Gly Glu Leu Glu Ile Thr Asp Val Asn Arg Ile Tyr Leu Glu Arg Gly         
        195                 200                 205                     

aag gcc gaa ctg gtg tcc ctg gga cgc ggg ttc gtc tgg ctc gac gcc      672
Lys Ala Glu Leu Val Ser Leu Gly Arg Gly Phe Val Trp Leu Asp Ala         
    210                 215                 220                         

gga acg cac gac gcg ctg acc gag gcc ggc cag tac gtg cag atc ctg      720
Gly Thr His Asp Ala Leu Thr Glu Ala Gly Gln Tyr Val Gln Ile Leu         
225                 230                 235                 240         

gag cac cgc cag ggc gtc cgg ctc gcc tgc ctc gag gag atc gcc tgg      768
Glu His Arg Gln Gly Val Arg Leu Ala Cys Leu Glu Glu Ile Ala Trp         
                245                 250                 255             

cgc atg ggg ttc atc gac cgg gag gcc tgc ctg cgg ctc ggc gag gag      816
Arg Met Gly Phe Ile Asp Arg Glu Ala Cys Leu Arg Leu Gly Glu Glu         
            260                 265                 270                 

ctc tcg aag tcc ccg tac ggc cag tac gtc atg gag ata gcc cgg gcc      864
Leu Ser Lys Ser Pro Tyr Gly Gln Tyr Val Met Glu Ile Ala Arg Ala         
        275                 280                 285                     

ggc tga                                                              870
Gly                                                                     
                                                                        


<210>  2
<211>  289
<212>  PRT
<213>  Streptomyces diversa

<400>  2

Val Lys Gly Ile Val Leu Ala Gly Gly His Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Ile Thr Leu Gly Thr Ser Lys Gln Met Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Ile Gln Ile Ile Ser Ser Pro Asp Asp Ile Glu Asn Phe Arg Arg Leu 
    50                  55                  60                  


Leu Gly Asp Gly Ser Pro Leu Gly Ile Ser Leu Ser Tyr Ala Val Gln 
65                  70                  75                  80  


Glu Gln Pro Arg Gly Leu Ala Glu Ala Phe Leu Ile Ser Ala Asp His 
                85                  90                  95      


Ile Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe His 
            100                 105                 110         


Gly Pro Gly Phe Ala Gly Ile Leu Gln Asp Lys Ala Val Asp Val Asp 
        115                 120                 125             


Gly Cys Val Leu Phe Gly Tyr Pro Val Arg Asp Pro Glu Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Ala Asp Gly Arg Leu Val Ser Leu Glu Glu Lys 
145                 150                 155                 160 


Pro Glu His Pro Arg Ser Asp Leu Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Ile Asp Ile Ala Lys Asn Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Arg Ile Tyr Leu Glu Arg Gly 
        195                 200                 205             


Lys Ala Glu Leu Val Ser Leu Gly Arg Gly Phe Val Trp Leu Asp Ala 
    210                 215                 220                 


Gly Thr His Asp Ala Leu Thr Glu Ala Gly Gln Tyr Val Gln Ile Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Leu Ala Cys Leu Glu Glu Ile Ala Trp 
                245                 250                 255     


Arg Met Gly Phe Ile Asp Arg Glu Ala Cys Leu Arg Leu Gly Glu Glu 
            260                 265                 270         


Leu Ser Lys Ser Pro Tyr Gly Gln Tyr Val Met Glu Ile Ala Arg Ala 
        275                 280                 285             


Gly 
    


<210>  3
<211>  882
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (1)..(882)
<223>  

<400>  3
gtg aag ggg atc gtg ctg gcg ggt ggc aac ggg acc cgg ctg cat ccg       48
Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro         
1               5                   10                  15              

ctg acg cag gcc gtg tcc aaa cag cta ctt ccg gtg tac gac aag ccg       96
Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro         
            20                  25                  30                  

atg atc tac tac ccg ctg tcg gtg ctg atg ctg gcc ggc atc cgg gac      144
Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp         
        35                  40                  45                      

gtg ctg ctg atc tcg acc ccg gcc gac atg ccg ttg ttc cag cgg ctg      192
Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu         
    50                  55                  60                          

ctc ggg aac ggg tcg cag ttc ggc att cgg atc gag tac gcc gag cag      240
Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln         
65                  70                  75                  80          

tcc cag ccc aac ggg cta gcc gag gcg ttc gtg atc ggt gcc gac ttc      288
Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe         
                85                  90                  95              

gtc ggc gac gac tcg gtg gcg ttg gtg ctc ggc gac aac atc ttt tac      336
Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr         
            100                 105                 110                 

ggg cag ggc ttt tcc ggg atc ctc cag cag tgc gtc cgg gag ctc gac      384
Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp         
        115                 120                 125                     

ggc tgc acg ctg ttc ggc tac ccg gtc cgc gac ccg cag cgc tac ggc      432
Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly         
    130                 135                 140                         

gtc ggt gag gtg gac gac gac ggt cgg ctg ttg tcc atc gtg gag aag      480
Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys         
145                 150                 155                 160         

ccg gag cgg ccg aag tcc aac atg gcc atc acc ggc ctg tac ttc tac      528
Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr         
                165                 170                 175             

gac aac gac gtg gtg cgc atc gcc aag ggg ctc acg ccg tcg gcc cgc      576
Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg         
            180                 185                 190                 

ggc gag ctg gag atc acc gac gtc aac ctg gcc tac ctg cag gag ggc      624
Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly         
        195                 200                 205                     

cgg gcg cac ctg acc aag ctc ggc cgc ggg ttc gcc tgg ctg gac acc      672
Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr         
    210                 215                 220                         

ggg acc cac gac tcg cta gtg gag gcc tcg cag ttc gtg cag gtg ctg      720
Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu         
225                 230                 235                 240         

gag cac cgg cag ggc gtg cgg atc gcc tgc ctg gag gag atc gcc ctg      768
Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu         
                245                 250                 255             

cgc atg ggc tac atc tcg gcc gac gac tgt ttc gcg ctg ggc gtg aag      816
Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys         
            260                 265                 270                 

ctg gcc aag tcg ggc tac ggc gag tac gtc atg gac gtc gcc cgc aac      864
Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn         
        275                 280                 285                     

tcc ggc gcg cgg ggc tga                                              882
Ser Gly Ala Arg Gly                                                     
    290                                                                 


<210>  4
<211>  293
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  4

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  5
<211>  969
<212>  DNA
<213>  Streptomyces diversa

<220>
<221>  CDS
<222>  (1)..(969)
<223>  

<400>  5
atg agg atc ctc gtc acc ggc ggt gcc ggc ttc atc ggc tcc cac tac       48
Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr         
1               5                   10                  15              

gtc cgc tcc ctc ctc gac ggg gcg tac ggc ggc gac ggc acc gac acc       96
Val Arg Ser Leu Leu Asp Gly Ala Tyr Gly Gly Asp Gly Thr Asp Thr         
            20                  25                  30                  

gtc acc gtc ctc gac aag ctg acc tac gcg ggc aac cgg gac aac ctg      144
Val Thr Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Arg Asp Asn Leu         
        35                  40                  45                      

ccc gcc tcc cac gag cgg ctc acc ttc gtc cgc ggc gac atc tgc gac      192
Pro Ala Ser His Glu Arg Leu Thr Phe Val Arg Gly Asp Ile Cys Asp         
    50                  55                  60                          

ctg ccg ctg ctg ctc gac ctc ctc ccc ggg cac gac gcg gtc gtc cac      240
Leu Pro Leu Leu Leu Asp Leu Leu Pro Gly His Asp Ala Val Val His         
65                  70                  75                  80          

ttc gcc gcc gag tcg cac gtc gac cgg tcc ctg gag tcg gcc gcc gag      288
Phe Ala Ala Glu Ser His Val Asp Arg Ser Leu Glu Ser Ala Ala Glu         
                85                  90                  95              

ttc gtc cgc acc aac gtc ctc ggc acc cag acc gtc ctg gag gcc gcg      336
Phe Val Arg Thr Asn Val Leu Gly Thr Gln Thr Val Leu Glu Ala Ala         
            100                 105                 110                 

ctg cgc acc ggc gtc cag cgg ctc gtg cac gtc tcc acc gac gag gtg      384
Leu Arg Thr Gly Val Gln Arg Leu Val His Val Ser Thr Asp Glu Val         
        115                 120                 125                     

tac ggc acg atc gac gag ggc tcg tgg acc gag gac ttc ccg ctc ctg      432
Tyr Gly Thr Ile Asp Glu Gly Ser Trp Thr Glu Asp Phe Pro Leu Leu         
    130                 135                 140                         

ccc aac tcc ccg tac gcc gcc tcc aag gcg agc tcg gac ctg gtg gcc      480
Pro Asn Ser Pro Tyr Ala Ala Ser Lys Ala Ser Ser Asp Leu Val Ala         
145                 150                 155                 160         

cgc tcc tac tgg cgc acc cac ggg ctc gac ctg tcg atc acc cgc tgc      528
Arg Ser Tyr Trp Arg Thr His Gly Leu Asp Leu Ser Ile Thr Arg Cys         
                165                 170                 175             

tcc aac aac tac ggg ccg tac cag cac ccc gag aag ctc atc ccg cgc      576
Ser Asn Asn Tyr Gly Pro Tyr Gln His Pro Glu Lys Leu Ile Pro Arg         
            180                 185                 190                 

ttc gtc acc aac ctc ctg gag ggc cac ccg gtg ccg gtc tac ggc gac      624
Phe Val Thr Asn Leu Leu Glu Gly His Pro Val Pro Val Tyr Gly Asp         
        195                 200                 205                     

ggg cgg aac gtc cgc gag tgg ctg cac gtc gac gac cac tgc cgg gcg      672
Gly Arg Asn Val Arg Glu Trp Leu His Val Asp Asp His Cys Arg Ala         
    210                 215                 220                         

atc cac ctg gtg ctc acc acc ggc cgg gcg ggc gag acg tac aac atc      720
Ile His Leu Val Leu Thr Thr Gly Arg Ala Gly Glu Thr Tyr Asn Ile         
225                 230                 235                 240         

ggc agc ggg aac gag ctc acc aac ctc gac ctg acc gaa cgc atc ctg      768
Gly Ser Gly Asn Glu Leu Thr Asn Leu Asp Leu Thr Glu Arg Ile Leu         
                245                 250                 255             

gac ctc tgc ggc gcc gac cgc tcg atg atc cgg tac gtc gag gac cgc      816
Asp Leu Cys Gly Ala Asp Arg Ser Met Ile Arg Tyr Val Glu Asp Arg         
            260                 265                 270                 

aag gga cac gac ctg cgg tac tcg ctc tcc gac gcc aag atc cgc gaa      864
Lys Gly His Asp Leu Arg Tyr Ser Leu Ser Asp Ala Lys Ile Arg Glu         
        275                 280                 285                     

gag ctg ggc tac acg ccc cgg acc tcc ttc gag gac ggc ctg cgc cgg      912
Glu Leu Gly Tyr Thr Pro Arg Thr Ser Phe Glu Asp Gly Leu Arg Arg         
    290                 295                 300                         

acc gtc gac tgg tac cgc gac aac ccc cag tgg tgg aag gcc ggc aag      960
Thr Val Asp Trp Tyr Arg Asp Asn Pro Gln Trp Trp Lys Ala Gly Lys         
305                 310                 315                 320         

gag aag tga                                                          969
Glu Lys                                                                 
                                                                        


<210>  6
<211>  322
<212>  PRT
<213>  Streptomyces diversa

<400>  6

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Ser Leu Leu Asp Gly Ala Tyr Gly Gly Asp Gly Thr Asp Thr 
            20                  25                  30          


Val Thr Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Arg Asp Asn Leu 
        35                  40                  45              


Pro Ala Ser His Glu Arg Leu Thr Phe Val Arg Gly Asp Ile Cys Asp 
    50                  55                  60                  


Leu Pro Leu Leu Leu Asp Leu Leu Pro Gly His Asp Ala Val Val His 
65                  70                  75                  80  


Phe Ala Ala Glu Ser His Val Asp Arg Ser Leu Glu Ser Ala Ala Glu 
                85                  90                  95      


Phe Val Arg Thr Asn Val Leu Gly Thr Gln Thr Val Leu Glu Ala Ala 
            100                 105                 110         


Leu Arg Thr Gly Val Gln Arg Leu Val His Val Ser Thr Asp Glu Val 
        115                 120                 125             


Tyr Gly Thr Ile Asp Glu Gly Ser Trp Thr Glu Asp Phe Pro Leu Leu 
    130                 135                 140                 


Pro Asn Ser Pro Tyr Ala Ala Ser Lys Ala Ser Ser Asp Leu Val Ala 
145                 150                 155                 160 


Arg Ser Tyr Trp Arg Thr His Gly Leu Asp Leu Ser Ile Thr Arg Cys 
                165                 170                 175     


Ser Asn Asn Tyr Gly Pro Tyr Gln His Pro Glu Lys Leu Ile Pro Arg 
            180                 185                 190         


Phe Val Thr Asn Leu Leu Glu Gly His Pro Val Pro Val Tyr Gly Asp 
        195                 200                 205             


Gly Arg Asn Val Arg Glu Trp Leu His Val Asp Asp His Cys Arg Ala 
    210                 215                 220                 


Ile His Leu Val Leu Thr Thr Gly Arg Ala Gly Glu Thr Tyr Asn Ile 
225                 230                 235                 240 


Gly Ser Gly Asn Glu Leu Thr Asn Leu Asp Leu Thr Glu Arg Ile Leu 
                245                 250                 255     


Asp Leu Cys Gly Ala Asp Arg Ser Met Ile Arg Tyr Val Glu Asp Arg 
            260                 265                 270         


Lys Gly His Asp Leu Arg Tyr Ser Leu Ser Asp Ala Lys Ile Arg Glu 
        275                 280                 285             


Glu Leu Gly Tyr Thr Pro Arg Thr Ser Phe Glu Asp Gly Leu Arg Arg 
    290                 295                 300                 


Thr Val Asp Trp Tyr Arg Asp Asn Pro Gln Trp Trp Lys Ala Gly Lys 
305                 310                 315                 320 


Glu Lys 
        


<210>  7
<211>  990
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (1)..(990)
<223>  

<400>  7
atg cgg att ctg gtc acc ggc gga gcc ggt ttc atc ggc tcg cac tac       48
Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr         
1               5                   10                  15              

gtt cgg cag ttg ctc ggt ggt gcg tac ccc gca ttc gcc gac gcc gac       96
Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp         
            20                  25                  30                  

gtg gtc gtg ctc gac aag ctc acc tac gcc ggc aac gag gcg aac ctg      144
Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu         
        35                  40                  45                      

gcg ccg gtc gcg gac aac ccc cgg ctg aag ttc gtc tgc ggc gac atc      192
Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile         
    50                  55                  60                          

tgc gac cgc gaa ctg gtt ggc ggc ctg atg tcc ggc gtg gac gtg gtg      240
Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val         
65                  70                  75                  80          

gtg cac ttc gcc gcc gaa acc cac gtc gac cgc tcg atc acc ggc tcg      288
Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser         
                85                  90                  95              

gac gcc ttc gtg atc acc aac gtg gtc ggc acc aac gtg ctg ctg cag      336
Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln         
            100                 105                 110                 

gcc gcg ctc gac gcc gag atc ggc aag ttc gtg cac gtt tcc acc gac      384
Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp         
        115                 120                 125                     

gag gtc tac ggc tcc atc gag gac ggc tcg tgg ccc gaa gac cac gcg      432
Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala         
    130                 135                 140                         

ctg gag ccg aat tcc ccg tac tcg gcg gcg aaa gcg ggc tcg gac ctg      480
Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu         
145                 150                 155                 160         

ctg gcc cgc gcc tac cac cgc acc cac gga ctg ccg gtg tgc atc acc      528
Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr         
                165                 170                 175             

cgc tgc tcc aac aac tac ggg ccc tac cag ttc ccg gag aag gtg ctg      576
Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu         
            180                 185                 190                 

ccg ctg ttc atc acg aac ctg atg gac ggc agc cag gtg ccg ctc tac      624
Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr         
        195                 200                 205                     

ggc gac ggg ctc aac gtg cgg gac tgg ctg cac gtc agc gac cac tgc      672
Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys         
    210                 215                 220                         

cgg ggc atc cag ctg gtg gcc gac tcc ggg cgc gcg ggc gag atc tac      720
Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr         
225                 230                 235                 240         

aac atc ggc ggc ggc acc gag ctg acc aac aac gag ctg acc gag cgg      768
Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg         
                245                 250                 255             

ctg ctg gca gag ctg ggc ctc gac tgg tcg gtg gtg cgg ccg gtc acc      816
Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr         
            260                 265                 270                 

gac cgc aag ggc cac gac cgc cgc tac tcg gtg gac cac agc aag atc      864
Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile         
        275                 280                 285                     

gtc gag gaa ctg ggg tac gcg ccg cag gtc gac ttc gag acc ggg ctg      912
Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu         
    290                 295                 300                         

cgc gag aca atc cgc tgg tac cag gac aac cgg gac tgg tgg gag ccg      960
Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro         
305                 310                 315                 320         

ctg aag gcc cga tcg gcg gtg gct cga tga                              990
Leu Lys Ala Arg Ser Ala Val Ala Arg                                     
                325                                                     


<210>  8
<211>  329
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  8

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  9
<211>  597
<212>  DNA
<213>  Streptomyces diversa

<220>
<221>  CDS
<222>  (1)..(597)
<223>  

<400>  9
atg cag gtg acc ccc ctg gcc atc gag ggc gcc ttc gcc ttc acg ccc       48
Met Gln Val Thr Pro Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro         
1               5                   10                  15              

ccc gtc ttc aag gac agc cgc ggc ctg ttc gcc tcc ccc tac cag ggg       96
Pro Val Phe Lys Asp Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly         
            20                  25                  30                  

gac gtg ttc gcc ggg cag ctc ggc cgc ccg ctc ttc cag gtc gaa cag      144
Asp Val Phe Ala Gly Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln         
        35                  40                  45                      

gtc agc cac aac ctg tcc gcc agg ggc acc ctc cgc ggc gtc cac ttc      192
Val Ser His Asn Leu Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe         
    50                  55                  60                          

acc gcg acc ccg ccg ggc atg gcg aag tac gtc tac tgc ccg tac ggc      240
Thr Ala Thr Pro Pro Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly         
65                  70                  75                  80          

agg ctc cgg gac ttc ctc atc gac ctc cgg gtc ggc tca ccg acc ttc      288
Arg Leu Arg Asp Phe Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe         
                85                  90                  95              

ggg cag tgg gtg atg aac gaa ctc gac gcg gag acc agc cgc gcc ctc      336
Gly Gln Trp Val Met Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu         
            100                 105                 110                 

tac gtc ccg gtc ggc gtc ggc cac gcg ttc gtc tcg ctc cag gac gac      384
Tyr Val Pro Val Gly Val Gly His Ala Phe Val Ser Leu Gln Asp Asp         
        115                 120                 125                     

tcc atg tgc gtc tac gtg atg tcg cag ggg tac gtc ccc gcc aac gaa      432
Ser Met Cys Val Tyr Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu         
    130                 135                 140                         

ctg gcc ctg aac ccg ctc gac ccg gcg ctc gga ctc gac ctg ccg gac      480
Leu Ala Leu Asn Pro Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp         
145                 150                 155                 160         

gac gtc gag ctg atc ctg tcc gac cgg gac aag atc gcc ccc acc ctc      528
Asp Val Glu Leu Ile Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu         
                165                 170                 175             

gcc gag gcc cgc gac cgc ggc ctc ctg ccc gac ttc gac acc tgc cgc      576
Ala Glu Ala Arg Asp Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg         
            180                 185                 190                 

aag ctg gag gaa ctg ctg tga                                          597
Lys Leu Glu Glu Leu Leu                                                 
        195                                                             


<210>  10
<211>  198
<212>  PRT
<213>  Streptomyces diversa

<400>  10

Met Gln Val Thr Pro Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro 
1               5                   10                  15      


Pro Val Phe Lys Asp Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly 
            20                  25                  30          


Asp Val Phe Ala Gly Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln 
        35                  40                  45              


Val Ser His Asn Leu Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe 
    50                  55                  60                  


Thr Ala Thr Pro Pro Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly 
65                  70                  75                  80  


Arg Leu Arg Asp Phe Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Trp Val Met Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu 
            100                 105                 110         


Tyr Val Pro Val Gly Val Gly His Ala Phe Val Ser Leu Gln Asp Asp 
        115                 120                 125             


Ser Met Cys Val Tyr Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu 
    130                 135                 140                 


Leu Ala Leu Asn Pro Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp 
145                 150                 155                 160 


Asp Val Glu Leu Ile Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu 
                165                 170                 175     


Ala Glu Ala Arg Asp Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg 
            180                 185                 190         


Lys Leu Glu Glu Leu Leu 
        195             


<210>  11
<211>  609
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (1)..(609)
<223>  

<400>  11
gtg cag gta cgt cga ctt gac atc acg ggt gca tac gag ttc acc ccg       48
Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro         
1               5                   10                  15              

aag gcc ttc ccc gac cac cgg ggc ctg ttc gtg gcc ccg ttc cag gag       96
Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu         
            20                  25                  30                  

gcg gcg ttc atc gac gcc acg ggg cac ccg ctg cga gtc gcg cag acc      144
Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr         
        35                  40                  45                      

aac cac agc gtc tcg gcg cgc aac gtc atc cgc ggc gtg cac ttc tcg      192
Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser         
    50                  55                  60                          

gac gtg ccg ccg ggc caa gcg aag tac gtg tac tgc ccg cag ggc gcg      240
Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala         
65                  70                  75                  80          

ctg ctc gac gtg gtc atc gac atc cgg gtc ggt tcc ccg acc ttc ggc      288
Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly         
                85                  90                  95              

cgc tgg gag gcg gtc cgg ctc gac gac acc gag tac cgg gcc gtc tac      336
Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr         
            100                 105                 110                 

cta gcc gaa gga ctc ggg cac gcg ttc gcc gcg ctg acc gac gac acc      384
Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr         
        115                 120                 125                     

gtg atg acc tac ctc tgc tcg acg ccc tac acc ccg ggc gcc gag cac      432
Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His         
    130                 135                 140                         

ggc atc gac ccg ttc gac ccg gaa ctc gcg ttg ccg tgg tcc gac ctc      480
Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu         
145                 150                 155                 160         

gac ggt gaa ccg gtc ctg tcc gaa aag gac cgg acc gcc ccg agc ctc      528
Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu         
                165                 170                 175             

gcg gaa gcc gcc gac aac ggc ctg ctt ccg gac tac gaa aca tgc ctc      576
Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu         
            180                 185                 190                 

gcc cac tac gaa ggc ctg cgc agc ccc ggc tga                          609
Ala His Tyr Glu Gly Leu Arg Ser Pro Gly                                 
        195                 200                                         


<210>  12
<211>  202
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  12

Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro 
1               5                   10                  15      


Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu 
            20                  25                  30          


Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr 
        35                  40                  45              


Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser 
    50                  55                  60                  


Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala 
65                  70                  75                  80  


Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly 
                85                  90                  95      


Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 
            100                 105                 110         


Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 
        115                 120                 125             


Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 
    130                 135                 140                 


Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 
145                 150                 155                 160 


Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 
                165                 170                 175     


Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 
            180                 185                 190         


Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 
        195                 200         


<210>  13
<211>  1020
<212>  DNA
<213>  Streptomyces diversa

<220>
<221>  CDS
<222>  (1)..(1020)
<223>  

<400>  13
gtg acc gcc acc acc gga cag acc ggg gac acc cga ccc ctg gtg gtc       48
Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val         
1               5                   10                  15              

gtc ctc ggc gcc gcc ggc ttc gtc ggc tcc gcc gtc ctg cgc gaa ctc       96
Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu         
            20                  25                  30                  

gcc cgc cac gac ctg cgg gtg cgg gcc gtc tcc cgg cgc ccg gtg acc      144
Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr         
        35                  40                  45                      

gtc ccg gcc ggc gcc cgc gcc gag gtg gag acc cgc agc gtc gac ctc      192
Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu         
    50                  55                  60                          

acc gtc ccc ggc gcg atg gcc ggg gcg atc gag ggc gcc gac gtg gtc      240
Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val         
65                  70                  75                  80          

gtc cac tcg atc gcc tac atc gcg ggc tcc tcg acc tgg cgc atc acg      288
Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr         
                85                  90                  95              

gac ggc gac acc ggc gcc gag cgg gtc aac gtg gga ctc gta cgg gac      336
Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp         
            100                 105                 110                 

ctg gtc gag gcc gtg cgg gcg agc ggc cgc ccc gac acc gcc gtc ctg      384
Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu         
        115                 120                 125                     

ttc acc ggc tcc gtc tcc gcc gcc gga ccc tcg gag cgg ggc gtc tac      432
Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr         
    130                 135                 140                         

gac ggt acg gag ccg gac gag ccg cag ggc gag tac gac cgg cag aag      480
Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys         
145                 150                 155                 160         

ctg gcg gcc gag cgg gtg ctg ctc gcg gcg agc gcc gag ggc gtg ctg      528
Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu         
                165                 170                 175             

cgc ggg atc tcg ctc cgg ctc ccc acg gtc ttc ggc tac ggc ccc gac      576
Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp         
            180                 185                 190                 

tcg acc gcg cgg gac aag ggc atc gtc tcc tcg atg gtc cgc cgg gcg      624
Ser Thr Ala Arg Asp Lys Gly Ile Val Ser Ser Met Val Arg Arg Ala         
        195                 200                 205                     

gtg gcg ggc gag ccg atc acc atg tgg cac gac ggc acg gtc cgc cgc      672
Val Ala Gly Glu Pro Ile Thr Met Trp His Asp Gly Thr Val Arg Arg         
    210                 215                 220                         

gac ctg ctg tac gtg gag gac gtg gcg cgc gcc ttc gcg gcg gcc ctc      720
Asp Leu Leu Tyr Val Glu Asp Val Ala Arg Ala Phe Ala Ala Ala Leu         
225                 230                 235                 240         

ggc cac ctc gac gcg ctc gcg gga cgg cac tgg gtg ctc ggc agc ggg      768
Gly His Leu Asp Ala Leu Ala Gly Arg His Trp Val Leu Gly Ser Gly         
                245                 250                 255             

cac ggc gcc gag ctc ggc ccg gtc ttc acc acg gtc gcc cgg atg gtg      816
His Gly Ala Glu Leu Gly Pro Val Phe Thr Thr Val Ala Arg Met Val         
            260                 265                 270                 

gcg gag cgg acc ggc aag ccg ccg gtg gcc gtg cgc tcg gtg gag ccg      864
Ala Glu Arg Thr Gly Lys Pro Pro Val Ala Val Arg Ser Val Glu Pro         
        275                 280                 285                     

ccc gcg cac gcc gag gcc cgg gac ttc gcc agc gtc acc gtc gac ccg      912
Pro Ala His Ala Glu Ala Arg Asp Phe Ala Ser Val Thr Val Asp Pro         
    290                 295                 300                         

cgc gcc ttc cac gag gtc acc ggc tgg cgg gcc gag gtc ccg ctg gac      960
Arg Ala Phe His Glu Val Thr Gly Trp Arg Ala Glu Val Pro Leu Asp         
305                 310                 315                 320         

gag gcc ctg gac cgg acg acg gcc ttc agc gcg agc ggc gcg gag gag     1008
Glu Ala Leu Asp Arg Thr Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu         
                325                 330                 335             

cac ttc ggc tga                                                     1020
His Phe Gly                                                             
                                                                        


<210>  14
<211>  339
<212>  PRT
<213>  Streptomyces diversa

<400>  14

Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val 
1               5                   10                  15      


Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu 
            20                  25                  30          


Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr 
        35                  40                  45              


Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu 
    50                  55                  60                  


Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val 
65                  70                  75                  80  


Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr 
                85                  90                  95      


Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp 
            100                 105                 110         


Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu 
        115                 120                 125             


Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr 
    130                 135                 140                 


Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys 
145                 150                 155                 160 


Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu 
                165                 170                 175     


Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp 
            180                 185                 190         


Ser Thr Ala Arg Asp Lys Gly Ile Val Ser Ser Met Val Arg Arg Ala 
        195                 200                 205             


Val Ala Gly Glu Pro Ile Thr Met Trp His Asp Gly Thr Val Arg Arg 
    210                 215                 220                 


Asp Leu Leu Tyr Val Glu Asp Val Ala Arg Ala Phe Ala Ala Ala Leu 
225                 230                 235                 240 


Gly His Leu Asp Ala Leu Ala Gly Arg His Trp Val Leu Gly Ser Gly 
                245                 250                 255     


His Gly Ala Glu Leu Gly Pro Val Phe Thr Thr Val Ala Arg Met Val 
            260                 265                 270         


Ala Glu Arg Thr Gly Lys Pro Pro Val Ala Val Arg Ser Val Glu Pro 
        275                 280                 285             


Pro Ala His Ala Glu Ala Arg Asp Phe Ala Ser Val Thr Val Asp Pro 
    290                 295                 300                 


Arg Ala Phe His Glu Val Thr Gly Trp Arg Ala Glu Val Pro Leu Asp 
305                 310                 315                 320 


Glu Ala Leu Asp Arg Thr Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu 
                325                 330                 335     


His Phe Gly 
            


<210>  15
<211>  918
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (1)..(918)
<223>  

<400>  15
atg agt cgc ctc gcc gtg ctg gtg ccc ggc ggc cgc ggc cag ctg ggc       48
Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly         
1               5                   10                  15              

tcg gag ctg gcc cgg atc ctc gcc gcg cgg acg ggg gcg ctg gtg cac       96
Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His         
            20                  25                  30                  

cgg ccg ggt tcc ggg gaa ctg gac gtc acc gac gcc gag gag gtc gcc      144
Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala         
        35                  40                  45                      

gac gcg ttg ggt tcc ttc gcg gag acg gcg aag gac gcg gag ctg cga      192
Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg         
    50                  55                  60                          

ccg gtg gtg atc aac gcc gcg gcg tac acg gcg gtg gac gcg gcc gag      240
Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu         
65                  70                  75                  80          

tcc gac ccg gac cgc gcg gcc cgg atc aac gcc gaa ggc gcg gcc tcg      288
Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser         
                85                  90                  95              

ctg gcg aaa gcg tgc cgg agc agc ggt ctg ccc ctg gtg cac gtg tcg      336
Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser         
            100                 105                 110                 

acg gat tac gtg ttc ccc ggt gat ggg gcc cgg ccg tac gag ccg acg      384
Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr         
        115                 120                 125                     

gac ccg acc ggg ccg cga tcg gtc tac ggg cgc acc aag ctc gaa ggc      432
Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly         
    130                 135                 140                         

gaa cgg gcc gtg ctg gag tcc ggc gcg cgg gcc tgg gtg gtg cgc acg      480
Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr         
145                 150                 155                 160         

gca tgg gtg tac ggc gcg agc ggc aag aac ttc ctg aaa acg atg atc      528
Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile         
                165                 170                 175             

cgc ctc tcg ggg gag cgc gac acg ctg tcc gtt gtg gac gat cag atc      576
Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asp Gln Ile         
            180                 185                 190                 

ggc tcg ccg act tgg gcg gcg gac ctg gcg agc ggc ctg ctg gag ctg      624
Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu         
        195                 200                 205                     

gcc gaa cgg gtc gcc gaa cgc cgt gga ccg gag cag aag gtg ctg cac      672
Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gln Lys Val Leu His         
    210                 215                 220                         

tgc acc aat tcc ggc cag gtg acc tgg tac gag ttc gcg cgg gcg atc      720
Cys Thr Asn Ser Gly Gln Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile         
225                 230                 235                 240         

ttc gcg gaa ttc ggc ctg gac gag aac cgc gtc cac ccg tgc acg acg      768
Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr         
                245                 250                 255             

gcg gac ttc ccc ctc ccg gcg cac cgc ccg gcc tac tcg gtc ctg tcc      816
Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser         
            260                 265                 270                 

gac gtg gcg tgg cga gag gcg ggc ctg acc ccg atg cgc acc tgg cgg      864
Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg         
        275                 280                 285                     

gaa gcc ctg gcg gcg gcc ttc gag aaa gac ggc gaa acc ctc cga acc      912
Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr         
    290                 295                 300                         

cgc tga                                                              918
Arg                                                                     
305                                                                     


<210>  16
<211>  305
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  16

Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly 
1               5                   10                  15      


Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His 
            20                  25                  30          


Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala 
        35                  40                  45              


Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg 
    50                  55                  60                  


Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu 
65                  70                  75                  80  


Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser 
                85                  90                  95      


Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser 
            100                 105                 110         


Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr 
        115                 120                 125             


Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly 
    130                 135                 140                 


Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr 
145                 150                 155                 160 


Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile 
                165                 170                 175     


Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asp Gln Ile 
            180                 185                 190         


Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu 
        195                 200                 205             


Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gln Lys Val Leu His 
    210                 215                 220                 


Cys Thr Asn Ser Gly Gln Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile 
225                 230                 235                 240 


Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr 
                245                 250                 255     


Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser 
            260                 265                 270         


Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg 
        275                 280                 285             


Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr 
    290                 295                 300                 


Arg 
305 


<210>  17
<211>  1416
<212>  DNA
<213>  Streptomyces diversa

<220>
<221>  CDS
<222>  (1)..(1416)
<223>  

<400>  17
atg agc acc gcc acc acc acg ccc gcc ccc gcc ctc acc gcc cgc cgg       48
Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg         
1               5                   10                  15              

ccc gcc ggg ctc gcc gag cgg atc gcc cgc tcg gcc gcc acc ggc cgc       96
Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg         
            20                  25                  30                  

ggc gcc cac ctg gcc acc gag gac ttc cac gac tgg ctc gac ggc cgc      144
Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg         
        35                  40                  45                      

cgc cgc gcc aac acc ttc cgc gtc gac aag atc ccc ttc gac gcg ctc      192
Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu         
    50                  55                  60                          

gac ggc tgg tcc ttc gac gag gag gac ggc aac ctc gtc cac cgc agc      240
Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser         
65                  70                  75                  80          

ggc cgc ttc ttc acc gtc gag ggc ctg cac gtc gtc gag gag gac gga      288
Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly         
                85                  90                  95              

ccc tac ggc gac ggc ccg tac cgc tcc tgg tac cag ccc gtc atc aag      336
Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys         
            100                 105                 110                 

cag ccc gag gtc ggc atc ctc ggc atc ctc gcc aag gag ttc gac ggc      384
Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly         
        115                 120                 125                     

gtc ctg cac ttc ctc atg cag gcc aag atg gag ccc ggc aac ccg aac      432
Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn         
    130                 135                 140                         

ctg ctc cag ctg tcg ccg acc gtc cag gcc acc cgc agc aac tac acc      480
Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr         
145                 150                 155                 160         

aag gcg cac cgc ggc ggc gac gtg aag tac atc gag tac ttc acc ggc      528
Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly         
                165                 170                 175             

gcc gaa cac ggc acc gtc atc gcc gac tcc ctc cag tcc gag cac ggc      576
Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly         
            180                 185                 190                 

gcc tgg ttc ttc cac aag tcc aac cgc aac atg atc gtc gag gcc acc      624
Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr         
        195                 200                 205                     

ggc gag gtc ccg ctc ctc gac gac ttc tgc tgg ctc acc ctc ggc cag      672
Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln         
    210                 215                 220                         

ctc ggc gag ctc ctc cac cag gac aac gtc atc aac atg gac gcc agg      720
Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg         
225                 230                 235                 240         

acc gtc ctg tcc tgc gtg ccg tac gag gac gcc gac gcc ggg cgg gcg      768
Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala         
                245                 250                 255             

ctg ctc tcc gac gtc cag ctg ctc tcc tgg ttc acc ggc gag cgc tcc      816
Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser         
            260                 265                 270                 

cgc cac gac gta cgg gcc cgg cgc gtc ccg ctg cgc gag ctg ccc ggc      864
Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly         
        275                 280                 285                     

tgg aag cag ggc gag gag acc atc gag cac gag gag ggc cgg cac ttc      912
Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe         
    290                 295                 300                         

aag gtc gtc gcc gtc tcc gtg cag gcc ggg aac cgc gaa gtg acc agc      960
Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser         
305                 310                 315                 320         

tgg acc cag ccg ctg atc gaa ccg gtc gga ctc ggc gtc gcc gcc ttc     1008
Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe         
                325                 330                 335             

ctg acc cgc gac ttc gac ggc gtc ccg cac tac ctg gtg cac gcc cgc     1056
Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg         
            340                 345                 350                 

gtc gag ggc ggc ttc ctc gac acc gtg gaa ctg gcc ccc acc gtc cag     1104
Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln         
        355                 360                 365                     

tac acc ccg ggc aac tac gcc cac ctg ccg acc gac gag cgc ccg ccc     1152
Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro         
    370                 375                 380                         

ttc ctc gac ctc gtc ctc gac acc gac ccc gcc cgc gtc cgc tac gag     1200
Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu         
385                 390                 395                 400         

gcc gtg cac tcc gag gaa ggc ggc cgc ttc ctc aac gcc gag agc cgc     1248
Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg         
                405                 410                 415             

tac ctc ctg gtg gag gcc gac gag acg cag gcc ccg gcc gac ccg ccg     1296
Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro         
            420                 425                 430                 

ccc ggc tac gcc tgg gcg acc gcc gca cag ctc acc tcc ctc acc cgg     1344
Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg         
        435                 440                 445                     

cac ggc cac tac ctc aac gtc cag gcc cgc acc ctg ctg gcc tgc gtc     1392
His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val         
    450                 455                 460                         

cac gcc ggg gcg gtg cgg cct tga                                     1416
His Ala Gly Ala Val Arg Pro                                             
465                 470                                                 


<210>  18
<211>  471
<212>  PRT
<213>  Streptomyces diversa

<400>  18

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  19
<211>  1002
<212>  DNA
<213>  Streptomyces diversa

<220>
<221>  CDS
<222>  (1)..(1002)
<223>  

<400>  19
ttg acg agc acc ccg gcg ccc ctg cgg atc ggt gtg ctc ggc tgc gcc       48
Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala         
1               5                   10                  15              

gac atc gcc gtc cgg cgc atg atg ccc gcg atg gcc gcg ctc ccc ggg       96
Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly         
            20                  25                  30                  

acc gag gtc acc gcc gtc gcc agc cgc gac gcg gcg aag gcc gcc gtg      144
Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val         
        35                  40                  45                      

gcc gcc gcc ccg tac ggc gcg gcg gcc gtc gag ggc tac cag gag ctg      192
Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu         
    50                  55                  60                          

ctg cgc cgc ccg gac gtc gac gcc gtc tac gta ccg ctg ccc gcc gcc      240
Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala         
65                  70                  75                  80          

ctg cac gcc gag tgg acc gag gcc gcc ctg cgg gcc ggc aag cac gtc      288
Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val         
                85                  90                  95              

ctg gcc gag aag ccg ctc acc acg gac ccg gag agc acc gcc gcg ctg      336
Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu         
            100                 105                 110                 

ctc ggc ctg gcc gcc gcg tcc ggg ctc gcg ctg atg gag aac gtc atg      384
Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met         
        115                 120                 125                     

ttc gtc cac cac cgc ctc cac acc gac gtc cgc aag ctc gtc gcg gac      432
Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp         
    130                 135                 140                         

gga gcc atc ggc gaa ctc cgc gcc ctg cac gcc tcg ttc ggc atc ccc      480
Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro         
145                 150                 155                 160         

cgg ctg ccc gac acc gac atc cgg cac gac ccc ggg ctc ggc ggc ggc      528
Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly         
                165                 170                 175             

gcc ctc ggc gac gtc ggc gtc tac ccg ctg cga gcc gcc cag cac ctg      576
Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu         
            180                 185                 190                 

ctc ggc gac gaa ctc gac gtc ctc ggc gcg cac ctc gtc cgg ggg ccc      624
Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro         
        195                 200                 205                     

ggc agc cgg gtc gag acc gcc ggc ggg gcg ctg ctc gcc acc ccg gcg      672
Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala         
    210                 215                 220                         

ggc gtc acc gcg cac atc gcc ttc ggc atg gac cac ggc tac cgc tcg      720
Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser         
225                 230                 235                 240         

gcg tac gag ctg tgg ggc agc cag ggc cgg ctc gtc gtc gag cgg gcc      768
Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala         
                245                 250                 255             

tac acc ccg ccc gcc gac cac cgc ccg gtg gtg cgc ctg gag acc cgc      816
Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg         
            260                 265                 270                 

acc ggc gtc gag gag ctc gtc ctc gac gcc gac gac cag gtc cgc aac      864
Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn         
        275                 280                 285                     

acg gtg gcc gcc ttc gcc gcc ctc gtg gcg cgc acc gga gcc ggc cac      912
Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His         
    290                 295                 300                         

ccc ggg gac ggc ggc gcg ccc gac ccg gag gcc ccg ctg cgc cag gcg      960
Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala         
305                 310                 315                 320         

cgg ctg ctc gac gcc gtg cgg cgc cgg gcc gcc ctc gtc tga             1002
Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val                     
                325                 330                                 


<210>  20
<211>  333
<212>  PRT
<213>  Streptomyces diversa

<400>  20

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  21
<211>  1173
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (1)..(1173)
<223>  

<400>  21
atg cgc gta ctc gtc gtt ccc ttg ccc tat ccg acg cat ctc atg gca       48
Met Arg Val Leu Val Val Pro Leu Pro Tyr Pro Thr His Leu Met Ala         
1               5                   10                  15              

atg gtg ccg ctg tgc tgg gcg ctg caa gca tcc ggg cac gag gtc ctg       96
Met Val Pro Leu Cys Trp Ala Leu Gln Ala Ser Gly His Glu Val Leu         
            20                  25                  30                  

atc gcc gca cca cca gag ctg cag gcg acc gcg cat ggt gca ggt ctc      144
Ile Ala Ala Pro Pro Glu Leu Gln Ala Thr Ala His Gly Ala Gly Leu         
        35                  40                  45                      

acc acg gcc ggg atc cgc ggg aac gac agg acc ggc gat acg ggt gga      192
Thr Thr Ala Gly Ile Arg Gly Asn Asp Arg Thr Gly Asp Thr Gly Gly         
    50                  55                  60                          

acc acg cag ctg cgc ttt ccc aat ccg gcg ttc ggt cag cgc gac acc      240
Thr Thr Gln Leu Arg Phe Pro Asn Pro Ala Phe Gly Gln Arg Asp Thr         
65                  70                  75                  80          

gag gca ggc cgg caa ctg tgg gag cag acc gcg tcc aat gtc gcg caa      288
Glu Ala Gly Arg Gln Leu Trp Glu Gln Thr Ala Ser Asn Val Ala Gln         
                85                  90                  95              

agc tcg ctc gat cag ctc ccc gaa tac ctt cga ctg gcc gag gcc tgg      336
Ser Ser Leu Asp Gln Leu Pro Glu Tyr Leu Arg Leu Ala Glu Ala Trp         
            100                 105                 110                 

cga ccg tca gtg ctg ttg gtc gac gtc tgc gcg ctg atc ggc cgg gtg      384
Arg Pro Ser Val Leu Leu Val Asp Val Cys Ala Leu Ile Gly Arg Val         
        115                 120                 125                     

ctc ggc gga ttg ctc gac ctg ccg gtc gtg ctg cac cgc tgg gga gtc      432
Leu Gly Gly Leu Leu Asp Leu Pro Val Val Leu His Arg Trp Gly Val         
    130                 135                 140                         

gac ccc acc gca ggc ccc ttc agc gat cga gcc cac gag ttg ctt gac      480
Asp Pro Thr Ala Gly Pro Phe Ser Asp Arg Ala His Glu Leu Leu Asp         
145                 150                 155                 160         

ccg gtg tgc cgg cac cac gga ctg acc ggc ctg ccc act ccc gag ctc      528
Pro Val Cys Arg His His Gly Leu Thr Gly Leu Pro Thr Pro Glu Leu         
                165                 170                 175             

atc ctc gat ccc tgt ccg ccg agc ctg caa gca agc gac gcg ccg caa      576
Ile Leu Asp Pro Cys Pro Pro Ser Leu Gln Ala Ser Asp Ala Pro Gln         
            180                 185                 190                 

ggc gca ccg gtc cag tac gtg ccg tac aac gga agc ggc gca ttc ccg      624
Gly Ala Pro Val Gln Tyr Val Pro Tyr Asn Gly Ser Gly Ala Phe Pro         
        195                 200                 205                     

gca tgg ggc gcg gcg cgc acc tca gca cgg cgg gtc tgc atc tgc atg      672
Ala Trp Gly Ala Ala Arg Thr Ser Ala Arg Arg Val Cys Ile Cys Met         
    210                 215                 220                         

ggc cgc atg gtg ctg aac gcc acc ggg ccg gct ccg ctg ctg cgc gca      720
Gly Arg Met Val Leu Asn Ala Thr Gly Pro Ala Pro Leu Leu Arg Ala         
225                 230                 235                 240         

gta gcg gct gcc acc gag ttg ccc ggc gtc gag gcc gtg atc gcc gtt      768
Val Ala Ala Ala Thr Glu Leu Pro Gly Val Glu Ala Val Ile Ala Val         
                245                 250                 255             

ccc ccc gag cac cgg gca ctt ctc acc gac cta ccc gac aac gcc cgg      816
Pro Pro Glu His Arg Ala Leu Leu Thr Asp Leu Pro Asp Asn Ala Arg         
            260                 265                 270                 

atc gcc gaa tcg gtc ccg ctc aac ctg ttc ctg cgt acc tgc gag ctg      864
Ile Ala Glu Ser Val Pro Leu Asn Leu Phe Leu Arg Thr Cys Glu Leu         
        275                 280                 285                     

gtc atc tgc gcg ggc ggc tcg gga acg gca ttc acc gcg acc cga ctc      912
Val Ile Cys Ala Gly Gly Ser Gly Thr Ala Phe Thr Ala Thr Arg Leu         
    290                 295                 300                         

ggc atc ccg caa ctc gtg ctt ccc cag tac ttc gac cag ttc gac tac      960
Gly Ile Pro Gln Leu Val Leu Pro Gln Tyr Phe Asp Gln Phe Asp Tyr         
305                 310                 315                 320         

gcg cgc aac ctc gcc gct gcc ggg gcg ggc atc tgc ttg ccg gat gag     1008
Ala Arg Asn Leu Ala Ala Ala Gly Ala Gly Ile Cys Leu Pro Asp Glu         
                325                 330                 335             

cag gcc cag tcc gac cac gaa cag ttc acc gac tca atc gca acg gtg     1056
Gln Ala Gln Ser Asp His Glu Gln Phe Thr Asp Ser Ile Ala Thr Val         
            340                 345                 350                 

ctc ggc gac acc ggc ttc gct tct gcg gca atc aaa ctc agc gac gag     1104
Leu Gly Asp Thr Gly Phe Ala Ser Ala Ala Ile Lys Leu Ser Asp Glu         
        355                 360                 365                     

atc acg gcc atg ccc cat ccc gcc gcg ctg gtg cgg aca ctg gag aac     1152
Ile Thr Ala Met Pro His Pro Ala Ala Leu Val Arg Thr Leu Glu Asn         
    370                 375                 380                         

act gcg gcc atc cgt gcc tga                                         1173
Thr Ala Ala Ile Arg Ala                                                 
385                 390                                                 


<210>  22
<211>  390
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  22

Met Arg Val Leu Val Val Pro Leu Pro Tyr Pro Thr His Leu Met Ala 
1               5                   10                  15      


Met Val Pro Leu Cys Trp Ala Leu Gln Ala Ser Gly His Glu Val Leu 
            20                  25                  30          


Ile Ala Ala Pro Pro Glu Leu Gln Ala Thr Ala His Gly Ala Gly Leu 
        35                  40                  45              


Thr Thr Ala Gly Ile Arg Gly Asn Asp Arg Thr Gly Asp Thr Gly Gly 
    50                  55                  60                  


Thr Thr Gln Leu Arg Phe Pro Asn Pro Ala Phe Gly Gln Arg Asp Thr 
65                  70                  75                  80  


Glu Ala Gly Arg Gln Leu Trp Glu Gln Thr Ala Ser Asn Val Ala Gln 
                85                  90                  95      


Ser Ser Leu Asp Gln Leu Pro Glu Tyr Leu Arg Leu Ala Glu Ala Trp 
            100                 105                 110         


Arg Pro Ser Val Leu Leu Val Asp Val Cys Ala Leu Ile Gly Arg Val 
        115                 120                 125             


Leu Gly Gly Leu Leu Asp Leu Pro Val Val Leu His Arg Trp Gly Val 
    130                 135                 140                 


Asp Pro Thr Ala Gly Pro Phe Ser Asp Arg Ala His Glu Leu Leu Asp 
145                 150                 155                 160 


Pro Val Cys Arg His His Gly Leu Thr Gly Leu Pro Thr Pro Glu Leu 
                165                 170                 175     


Ile Leu Asp Pro Cys Pro Pro Ser Leu Gln Ala Ser Asp Ala Pro Gln 
            180                 185                 190         


Gly Ala Pro Val Gln Tyr Val Pro Tyr Asn Gly Ser Gly Ala Phe Pro 
        195                 200                 205             


Ala Trp Gly Ala Ala Arg Thr Ser Ala Arg Arg Val Cys Ile Cys Met 
    210                 215                 220                 


Gly Arg Met Val Leu Asn Ala Thr Gly Pro Ala Pro Leu Leu Arg Ala 
225                 230                 235                 240 


Val Ala Ala Ala Thr Glu Leu Pro Gly Val Glu Ala Val Ile Ala Val 
                245                 250                 255     


Pro Pro Glu His Arg Ala Leu Leu Thr Asp Leu Pro Asp Asn Ala Arg 
            260                 265                 270         


Ile Ala Glu Ser Val Pro Leu Asn Leu Phe Leu Arg Thr Cys Glu Leu 
        275                 280                 285             


Val Ile Cys Ala Gly Gly Ser Gly Thr Ala Phe Thr Ala Thr Arg Leu 
    290                 295                 300                 


Gly Ile Pro Gln Leu Val Leu Pro Gln Tyr Phe Asp Gln Phe Asp Tyr 
305                 310                 315                 320 


Ala Arg Asn Leu Ala Ala Ala Gly Ala Gly Ile Cys Leu Pro Asp Glu 
                325                 330                 335     


Gln Ala Gln Ser Asp His Glu Gln Phe Thr Asp Ser Ile Ala Thr Val 
            340                 345                 350         


Leu Gly Asp Thr Gly Phe Ala Ser Ala Ala Ile Lys Leu Ser Asp Glu 
        355                 360                 365             


Ile Thr Ala Met Pro His Pro Ala Ala Leu Val Arg Thr Leu Glu Asn 
    370                 375                 380                 


Thr Ala Ala Ile Arg Ala 
385                 390 


<210>  23
<211>  1320
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (1)..(1320)
<223>  

<400>  23
atg cgt gtc ctg ttc acc ccg ctg ccg gcg agt tcg cac ttc ttc aac       48
Met Arg Val Leu Phe Thr Pro Leu Pro Ala Ser Ser His Phe Phe Asn         
1               5                   10                  15              

ctg gtg ccg ttg gcg tgg gcg ttg cgt gcc gcg ggg cac gag gtc cgt       96
Leu Val Pro Leu Ala Trp Ala Leu Arg Ala Ala Gly His Glu Val Arg         
            20                  25                  30                  

gtc gcc atc tgc ccg aat atg gtg tcg atg gtc acc gga gca gga ctc      144
Val Ala Ile Cys Pro Asn Met Val Ser Met Val Thr Gly Ala Gly Leu         
        35                  40                  45                      

acc gcg gtt ccc gtc ggc gac gag ctc gac ctc atc tcc ttg gcg gcc      192
Thr Ala Val Pro Val Gly Asp Glu Leu Asp Leu Ile Ser Leu Ala Ala         
    50                  55                  60                          

aag aac gaa ctc gtt ctc ggc agc ggg gtc tcg ttc gac gag aag ggg      240
Lys Asn Glu Leu Val Leu Gly Ser Gly Val Ser Phe Asp Glu Lys Gly         
65                  70                  75                  80          

cgg cat ccg gaa ctc ttc gac gag ctg ctg tca atc aac tcc ggc aga      288
Arg His Pro Glu Leu Phe Asp Glu Leu Leu Ser Ile Asn Ser Gly Arg         
                85                  90                  95              

gac acg gac gcc gtg gag caa ctc cac ctt gtg gat gac cga tcg ctg      336
Asp Thr Asp Ala Val Glu Gln Leu His Leu Val Asp Asp Arg Ser Leu         
            100                 105                 110                 

gac gat ctc atg ggg ttc gcc gag aaa tgg cag cct gat ctc gtt gtg      384
Asp Asp Leu Met Gly Phe Ala Glu Lys Trp Gln Pro Asp Leu Val Val         
        115                 120                 125                     

tgg gac gct atg gtg tgt tcg ggg cca gtt gtg gcg cga gcg ctc ggc      432
Trp Asp Ala Met Val Cys Ser Gly Pro Val Val Ala Arg Ala Leu Gly         
    130                 135                 140                         

gca cga cac gtg cgg atg ctc gtc gcc ctc gat gtg tcg ggg tgg ctg      480
Ala Arg His Val Arg Met Leu Val Ala Leu Asp Val Ser Gly Trp Leu         
145                 150                 155                 160         

cgg tcc ggt ttc ctc gaa tac cag gaa tcg aag ccg cct gag cag cgc      528
Arg Ser Gly Phe Leu Glu Tyr Gln Glu Ser Lys Pro Pro Glu Gln Arg         
                165                 170                 175             

gtc gac ccg ctc ggg acg tgg ctg gga gcg aag ctc gcc aag ttc gga      576
Val Asp Pro Leu Gly Thr Trp Leu Gly Ala Lys Leu Ala Lys Phe Gly         
            180                 185                 190                 

gcc acg ttc gat gaa gag atc gtg acg ggc caa gcg acc ata gat ccg      624
Ala Thr Phe Asp Glu Glu Ile Val Thr Gly Gln Ala Thr Ile Asp Pro         
        195                 200                 205                     

att cca tcc tgg atg cgc ctg cct gtg gac ttg gac tac atc tcg atg      672
Ile Pro Ser Trp Met Arg Leu Pro Val Asp Leu Asp Tyr Ile Ser Met         
    210                 215                 220                         

cgt ttc gtg ccg tac aac ggt ccg gcg gtg ttg ccg gag tgg ttg cgc      720
Arg Phe Val Pro Tyr Asn Gly Pro Ala Val Leu Pro Glu Trp Leu Arg         
225                 230                 235                 240         

gaa cga ccg acg aag ccg cgc gtc tgc atc acg cgc ggg ctg acc aag      768
Glu Arg Pro Thr Lys Pro Arg Val Cys Ile Thr Arg Gly Leu Thr Lys         
                245                 250                 255             

cgg cgg ctg agc agg gtg acc gaa cag tac ggg gag caa agt gac cag      816
Arg Arg Leu Ser Arg Val Thr Glu Gln Tyr Gly Glu Gln Ser Asp Gln         
            260                 265                 270                 

gaa caa gca atg gtg gaa agg ttg ttg cgc ggc gcg gcc agg ctc gac      864
Glu Gln Ala Met Val Glu Arg Leu Leu Arg Gly Ala Ala Arg Leu Asp         
        275                 280                 285                     

gtc gag gtg atc gcc acc ttg tct gac gac gaa gta cgg gag atg ggg      912
Val Glu Val Ile Ala Thr Leu Ser Asp Asp Glu Val Arg Glu Met Gly         
    290                 295                 300                         

gag ttg ccc tcg aac gtc cgg gtc cac gaa tac gta ccg ctc aac gaa      960
Glu Leu Pro Ser Asn Val Arg Val His Glu Tyr Val Pro Leu Asn Glu         
305                 310                 315                 320         

ctg ctg gag tcg tgt tca gtg atc atc cat cat ggc tcg acg acg acg     1008
Leu Leu Glu Ser Cys Ser Val Ile Ile His His Gly Ser Thr Thr Thr         
                325                 330                 335             

cag gaa acc gcc acg gtc aac ggc gta ccg cag ttg att ctc cct ggg     1056
Gln Glu Thr Ala Thr Val Asn Gly Val Pro Gln Leu Ile Leu Pro Gly         
            340                 345                 350                 

acc ttc tgg gac gaa tct cgt agg gcg gag ctc cta gcc gat cgg gga     1104
Thr Phe Trp Asp Glu Ser Arg Arg Ala Glu Leu Leu Ala Asp Arg Gly         
        355                 360                 365                     

gcc ggt ctg gtc ctc gac ccc gcg acg ttt acc gaa gac gac gtg cga     1152
Ala Gly Leu Val Leu Asp Pro Ala Thr Phe Thr Glu Asp Asp Val Arg         
    370                 375                 380                         

ggt cag ctg gcc cgc ctg ctc gac gag ccg tcg ttc gct gcc aac gcg     1200
Gly Gln Leu Ala Arg Leu Leu Asp Glu Pro Ser Phe Ala Ala Asn Ala         
385                 390                 395                 400         

gcg ctg atc cgc cgt gaa atc gag gaa agt ccc agc ccg cac gac atc     1248
Ala Leu Ile Arg Arg Glu Ile Glu Glu Ser Pro Ser Pro His Asp Ile         
                405                 410                 415             

gtt cca cgt ctg gaa aag cta gtt gcc gaa cgt gag aac cgc cgc act     1296
Val Pro Arg Leu Glu Lys Leu Val Ala Glu Arg Glu Asn Arg Arg Thr         
            420                 425                 430                 

ggg cag tct gat ggc cat ccg tga                                     1320
Gly Gln Ser Asp Gly His Pro                                             
        435                                                             


<210>  24
<211>  439
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  24

Met Arg Val Leu Phe Thr Pro Leu Pro Ala Ser Ser His Phe Phe Asn 
1               5                   10                  15      


Leu Val Pro Leu Ala Trp Ala Leu Arg Ala Ala Gly His Glu Val Arg 
            20                  25                  30          


Val Ala Ile Cys Pro Asn Met Val Ser Met Val Thr Gly Ala Gly Leu 
        35                  40                  45              


Thr Ala Val Pro Val Gly Asp Glu Leu Asp Leu Ile Ser Leu Ala Ala 
    50                  55                  60                  


Lys Asn Glu Leu Val Leu Gly Ser Gly Val Ser Phe Asp Glu Lys Gly 
65                  70                  75                  80  


Arg His Pro Glu Leu Phe Asp Glu Leu Leu Ser Ile Asn Ser Gly Arg 
                85                  90                  95      


Asp Thr Asp Ala Val Glu Gln Leu His Leu Val Asp Asp Arg Ser Leu 
            100                 105                 110         


Asp Asp Leu Met Gly Phe Ala Glu Lys Trp Gln Pro Asp Leu Val Val 
        115                 120                 125             


Trp Asp Ala Met Val Cys Ser Gly Pro Val Val Ala Arg Ala Leu Gly 
    130                 135                 140                 


Ala Arg His Val Arg Met Leu Val Ala Leu Asp Val Ser Gly Trp Leu 
145                 150                 155                 160 


Arg Ser Gly Phe Leu Glu Tyr Gln Glu Ser Lys Pro Pro Glu Gln Arg 
                165                 170                 175     


Val Asp Pro Leu Gly Thr Trp Leu Gly Ala Lys Leu Ala Lys Phe Gly 
            180                 185                 190         


Ala Thr Phe Asp Glu Glu Ile Val Thr Gly Gln Ala Thr Ile Asp Pro 
        195                 200                 205             


Ile Pro Ser Trp Met Arg Leu Pro Val Asp Leu Asp Tyr Ile Ser Met 
    210                 215                 220                 


Arg Phe Val Pro Tyr Asn Gly Pro Ala Val Leu Pro Glu Trp Leu Arg 
225                 230                 235                 240 


Glu Arg Pro Thr Lys Pro Arg Val Cys Ile Thr Arg Gly Leu Thr Lys 
                245                 250                 255     


Arg Arg Leu Ser Arg Val Thr Glu Gln Tyr Gly Glu Gln Ser Asp Gln 
            260                 265                 270         


Glu Gln Ala Met Val Glu Arg Leu Leu Arg Gly Ala Ala Arg Leu Asp 
        275                 280                 285             


Val Glu Val Ile Ala Thr Leu Ser Asp Asp Glu Val Arg Glu Met Gly 
    290                 295                 300                 


Glu Leu Pro Ser Asn Val Arg Val His Glu Tyr Val Pro Leu Asn Glu 
305                 310                 315                 320 


Leu Leu Glu Ser Cys Ser Val Ile Ile His His Gly Ser Thr Thr Thr 
                325                 330                 335     


Gln Glu Thr Ala Thr Val Asn Gly Val Pro Gln Leu Ile Leu Pro Gly 
            340                 345                 350         


Thr Phe Trp Asp Glu Ser Arg Arg Ala Glu Leu Leu Ala Asp Arg Gly 
        355                 360                 365             


Ala Gly Leu Val Leu Asp Pro Ala Thr Phe Thr Glu Asp Asp Val Arg 
    370                 375                 380                 


Gly Gln Leu Ala Arg Leu Leu Asp Glu Pro Ser Phe Ala Ala Asn Ala 
385                 390                 395                 400 


Ala Leu Ile Arg Arg Glu Ile Glu Glu Ser Pro Ser Pro His Asp Ile 
                405                 410                 415     


Val Pro Arg Leu Glu Lys Leu Val Ala Glu Arg Glu Asn Arg Arg Thr 
            420                 425                 430         


Gly Gln Ser Asp Gly His Pro 
        435                 


<210>  25
<211>  750
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (1)..(750)
<223>  

<400>  25
atg tcg cgc gtg agc gac aca ttc gca gaa acc tcc tcg gta tac agc       48
Met Ser Arg Val Ser Asp Thr Phe Ala Glu Thr Ser Ser Val Tyr Ser         
1               5                   10                  15              

cca gat cat gcc gac atc tac gac gcg atc cac tcc gcg cgt ggc cgg       96
Pro Asp His Ala Asp Ile Tyr Asp Ala Ile His Ser Ala Arg Gly Arg         
            20                  25                  30                  

gac tgg gca gcc gag gcc ggg gaa gta gtc cag ctc gta cgc acc agg      144
Asp Trp Ala Ala Glu Ala Gly Glu Val Val Gln Leu Val Arg Thr Arg         
        35                  40                  45                      

ctg ccc gaa gca cag tcc cta ctc gac gtc gcc tgt ggg acc ggg gcg      192
Leu Pro Glu Ala Gln Ser Leu Leu Asp Val Ala Cys Gly Thr Gly Ala         
    50                  55                  60                          

cac cta gag cga ttc cgt gcc gaa tac gcg aag gtc gcg ggg ctt gaa      240
His Leu Glu Arg Phe Arg Ala Glu Tyr Ala Lys Val Ala Gly Leu Glu         
65                  70                  75                  80          

ctg tcc gat gcg atg cgg gag atc gcg atc aga cga gtc cct gag gta      288
Leu Ser Asp Ala Met Arg Glu Ile Ala Ile Arg Arg Val Pro Glu Val         
                85                  90                  95              

ccg att cac atc ggt gac atc cgc gat ttc gac ctc ggc gag cca ttc      336
Pro Ile His Ile Gly Asp Ile Arg Asp Phe Asp Leu Gly Glu Pro Phe         
            100                 105                 110                 

gac gtc atc acc tgc ctg tgc ttt acc gcg gct tac atg cgg acc gtt      384
Asp Val Ile Thr Cys Leu Cys Phe Thr Ala Ala Tyr Met Arg Thr Val         
        115                 120                 125                     

gac gac ctg cga cgc gtg acg cgg aac atg gcc cgg cac ctg gcc cct      432
Asp Asp Leu Arg Arg Val Thr Arg Asn Met Ala Arg His Leu Ala Pro         
    130                 135                 140                         

ggt gga gtc gcg gtc atc gaa ccc tgg tgg ttt ccc gac aag ttc atc      480
Gly Gly Val Ala Val Ile Glu Pro Trp Trp Phe Pro Asp Lys Phe Ile         
145                 150                 155                 160         

gac ggg ttc gtc acc gga gcc gtc gcg cac cac ggc gag cgg gtg atc      528
Asp Gly Phe Val Thr Gly Ala Val Ala His His Gly Glu Arg Val Ile         
                165                 170                 175             

agc cgg cta tcg cac tcg gtc ctg gag ggc cgt acg agc cgg atg acc      576
Ser Arg Leu Ser His Ser Val Leu Glu Gly Arg Thr Ser Arg Met Thr         
            180                 185                 190                 

gtc cgc tac aca gtc gcc gaa ccc acc ggg atc cgg gac ttc aca gag      624
Val Arg Tyr Thr Val Ala Glu Pro Thr Gly Ile Arg Asp Phe Thr Glu         
        195                 200                 205                     

ttc gaa atc ctc tcg ctg ttc act gag gac gag tac acc gcc gcg ctc      672
Phe Glu Ile Leu Ser Leu Phe Thr Glu Asp Glu Tyr Thr Ala Ala Leu         
    210                 215                 220                         

gaa gac gca ggg atc cgc gcg gaa tac ctt cct gga gca ccg aac ggc      720
Glu Asp Ala Gly Ile Arg Ala Glu Tyr Leu Pro Gly Ala Pro Asn Gly         
225                 230                 235                 240         

cga ggc ctg ttc gtc gga atc cgc aac tga                              750
Arg Gly Leu Phe Val Gly Ile Arg Asn                                     
                245                                                     


<210>  26
<211>  249
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  26

Met Ser Arg Val Ser Asp Thr Phe Ala Glu Thr Ser Ser Val Tyr Ser 
1               5                   10                  15      


Pro Asp His Ala Asp Ile Tyr Asp Ala Ile His Ser Ala Arg Gly Arg 
            20                  25                  30          


Asp Trp Ala Ala Glu Ala Gly Glu Val Val Gln Leu Val Arg Thr Arg 
        35                  40                  45              


Leu Pro Glu Ala Gln Ser Leu Leu Asp Val Ala Cys Gly Thr Gly Ala 
    50                  55                  60                  


His Leu Glu Arg Phe Arg Ala Glu Tyr Ala Lys Val Ala Gly Leu Glu 
65                  70                  75                  80  


Leu Ser Asp Ala Met Arg Glu Ile Ala Ile Arg Arg Val Pro Glu Val 
                85                  90                  95      


Pro Ile His Ile Gly Asp Ile Arg Asp Phe Asp Leu Gly Glu Pro Phe 
            100                 105                 110         


Asp Val Ile Thr Cys Leu Cys Phe Thr Ala Ala Tyr Met Arg Thr Val 
        115                 120                 125             


Asp Asp Leu Arg Arg Val Thr Arg Asn Met Ala Arg His Leu Ala Pro 
    130                 135                 140                 


Gly Gly Val Ala Val Ile Glu Pro Trp Trp Phe Pro Asp Lys Phe Ile 
145                 150                 155                 160 


Asp Gly Phe Val Thr Gly Ala Val Ala His His Gly Glu Arg Val Ile 
                165                 170                 175     


Ser Arg Leu Ser His Ser Val Leu Glu Gly Arg Thr Ser Arg Met Thr 
            180                 185                 190         


Val Arg Tyr Thr Val Ala Glu Pro Thr Gly Ile Arg Asp Phe Thr Glu 
        195                 200                 205             


Phe Glu Ile Leu Ser Leu Phe Thr Glu Asp Glu Tyr Thr Ala Ala Leu 
    210                 215                 220                 


Glu Asp Ala Gly Ile Arg Ala Glu Tyr Leu Pro Gly Ala Pro Asn Gly 
225                 230                 235                 240 


Arg Gly Leu Phe Val Gly Ile Arg Asn 
                245                 


<210>  27
<211>  1158
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (1)..(1158)
<223>  

<400>  27
gtg atc aac ctg cac cag ccg atc ctc ggc acc gaa gaa ctc gac gcg       48
Val Ile Asn Leu His Gln Pro Ile Leu Gly Thr Glu Glu Leu Asp Ala         
1               5                   10                  15              

atc gcg gag gtg ttc gcc tcc aac tgg atc ggg ctc ggg ccg cgc acc       96
Ile Ala Glu Val Phe Ala Ser Asn Trp Ile Gly Leu Gly Pro Arg Thr         
            20                  25                  30                  

cgg acg ttc gag gcc gaa ttc gcc cac cac ctg gga gtg gat ccc gaa      144
Arg Thr Phe Glu Ala Glu Phe Ala His His Leu Gly Val Asp Pro Glu         
        35                  40                  45                      

cag gtc gtg ttc ctc aac tcg ggg act gcc gcg ctg ttc ctt acc gtg      192
Gln Val Val Phe Leu Asn Ser Gly Thr Ala Ala Leu Phe Leu Thr Val         
    50                  55                  60                          

cag gtg ctc gac ctc ggc cca ggc gac gac gtg gta ctt cct tcg ata      240
Gln Val Leu Asp Leu Gly Pro Gly Asp Asp Val Val Leu Pro Ser Ile         
65                  70                  75                  80          

agc ttc gtg gcg gcg gcc aac gcc atc gca tcc tcc ggt gcc cgc ccg      288
Ser Phe Val Ala Ala Ala Asn Ala Ile Ala Ser Ser Gly Ala Arg Pro         
                85                  90                  95              

gtg ttc tgc gac gtc gac ccc cgg acg ttg aac ccc acg ctg gat gat      336
Val Phe Cys Asp Val Asp Pro Arg Thr Leu Asn Pro Thr Leu Asp Asp         
            100                 105                 110                 

gtg gcg agg gcc atc acg ccg gcg acc aag gcc gta ttg ctg ctc cac      384
Val Ala Arg Ala Ile Thr Pro Ala Thr Lys Ala Val Leu Leu Leu His         
        115                 120                 125                     

tat gga gga tcg ccg gga gaa gtc acc gcg atc gcc gat ttc tgc cgt      432
Tyr Gly Gly Ser Pro Gly Glu Val Thr Ala Ile Ala Asp Phe Cys Arg         
    130                 135                 140                         

gaa aag ggc ctc atg ctc atc gag gac tcc gcc tgc gcg gtg gca tcg      480
Glu Lys Gly Leu Met Leu Ile Glu Asp Ser Ala Cys Ala Val Ala Ser         
145                 150                 155                 160         

tcc gtg cac ggc acc gct tgc gga acc ttt ggt gac ctg gcc acg tgg      528
Ser Val His Gly Thr Ala Cys Gly Thr Phe Gly Asp Leu Ala Thr Trp         
                165                 170                 175             

agt ttc gat gcg atg aag atc ctg gtc acc ggg gat ggg ggc atg ttc      576
Ser Phe Asp Ala Met Lys Ile Leu Val Thr Gly Asp Gly Gly Met Phe         
            180                 185                 190                 

tac gcg gcg gat ccg gag ctg gcg cac cgc gca aga cga ctc gcc tac      624
Tyr Ala Ala Asp Pro Glu Leu Ala His Arg Ala Arg Arg Leu Ala Tyr         
        195                 200                 205                     

cac ggt ctt gag cag atg agc gga ttc gat tcg gcc aag tct tcc aac      672
His Gly Leu Glu Gln Met Ser Gly Phe Asp Ser Ala Lys Ser Ser Asn         
    210                 215                 220                         

cgc tgg tgg gat att cgc gtc gaa gac atc ggc cag cgg ctg atc ggg      720
Arg Trp Trp Asp Ile Arg Val Glu Asp Ile Gly Gln Arg Leu Ile Gly         
225                 230                 235                 240         

aac gac atg acg gca gcg ctt ggc agc gtg cag ctg cgc aaa ctg cca      768
Asn Asp Met Thr Ala Ala Leu Gly Ser Val Gln Leu Arg Lys Leu Pro         
                245                 250                 255             

gaa ttc atc aac agg cgt aga gaa atc gct acg cag tac gac cgg ttg      816
Glu Phe Ile Asn Arg Arg Arg Glu Ile Ala Thr Gln Tyr Asp Arg Leu         
            260                 265                 270                 

ctt tcc gat gtg ccg ggt gtc ctc cta ccg ccg acg cta ccg gat ggg      864
Leu Ser Asp Val Pro Gly Val Leu Leu Pro Pro Thr Leu Pro Asp Gly         
        275                 280                 285                     

cac gtc tcg tca cac tac ttc tac tgg gtc cag ctg gct ccg gag atc      912
His Val Ser Ser His Tyr Phe Tyr Trp Val Gln Leu Ala Pro Glu Ile         
    290                 295                 300                         

cgc gac cag gtg gcg cag caa atg ctg gaa cgc ggc atc tac acg agc      960
Arg Asp Gln Val Ala Gln Gln Met Leu Glu Arg Gly Ile Tyr Thr Ser         
305                 310                 315                 320         

tac cgc tac ccg ccc ctg cac aag gtc ccc atc tac cgc gcg gac tgc     1008
Tyr Arg Tyr Pro Pro Leu His Lys Val Pro Ile Tyr Arg Ala Asp Cys         
                325                 330                 335             

aag ctg cct tct gcg gag gac gcc tgc cgc aga aca ctc ctg cta cca     1056
Lys Leu Pro Ser Ala Glu Asp Ala Cys Arg Arg Thr Leu Leu Leu Pro         
            340                 345                 350                 

ctg cac cca agc ctt gac gac gcc gag gtg cgc acg gtg gct gac gag     1104
Leu His Pro Ser Leu Asp Asp Ala Glu Val Arg Thr Val Ala Asp Glu         
        355                 360                 365                     

ttc cag aag gcc gtc gaa cac cac atc agc caa aga tca cca ctc cga     1152
Phe Gln Lys Ala Val Glu His His Ile Ser Gln Arg Ser Pro Leu Arg         
    370                 375                 380                         

aag tga                                                             1158
Lys                                                                     
385                                                                     


<210>  28
<211>  385
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  28

Val Ile Asn Leu His Gln Pro Ile Leu Gly Thr Glu Glu Leu Asp Ala 
1               5                   10                  15      


Ile Ala Glu Val Phe Ala Ser Asn Trp Ile Gly Leu Gly Pro Arg Thr 
            20                  25                  30          


Arg Thr Phe Glu Ala Glu Phe Ala His His Leu Gly Val Asp Pro Glu 
        35                  40                  45              


Gln Val Val Phe Leu Asn Ser Gly Thr Ala Ala Leu Phe Leu Thr Val 
    50                  55                  60                  


Gln Val Leu Asp Leu Gly Pro Gly Asp Asp Val Val Leu Pro Ser Ile 
65                  70                  75                  80  


Ser Phe Val Ala Ala Ala Asn Ala Ile Ala Ser Ser Gly Ala Arg Pro 
                85                  90                  95      


Val Phe Cys Asp Val Asp Pro Arg Thr Leu Asn Pro Thr Leu Asp Asp 
            100                 105                 110         


Val Ala Arg Ala Ile Thr Pro Ala Thr Lys Ala Val Leu Leu Leu His 
        115                 120                 125             


Tyr Gly Gly Ser Pro Gly Glu Val Thr Ala Ile Ala Asp Phe Cys Arg 
    130                 135                 140                 


Glu Lys Gly Leu Met Leu Ile Glu Asp Ser Ala Cys Ala Val Ala Ser 
145                 150                 155                 160 


Ser Val His Gly Thr Ala Cys Gly Thr Phe Gly Asp Leu Ala Thr Trp 
                165                 170                 175     


Ser Phe Asp Ala Met Lys Ile Leu Val Thr Gly Asp Gly Gly Met Phe 
            180                 185                 190         


Tyr Ala Ala Asp Pro Glu Leu Ala His Arg Ala Arg Arg Leu Ala Tyr 
        195                 200                 205             


His Gly Leu Glu Gln Met Ser Gly Phe Asp Ser Ala Lys Ser Ser Asn 
    210                 215                 220                 


Arg Trp Trp Asp Ile Arg Val Glu Asp Ile Gly Gln Arg Leu Ile Gly 
225                 230                 235                 240 


Asn Asp Met Thr Ala Ala Leu Gly Ser Val Gln Leu Arg Lys Leu Pro 
                245                 250                 255     


Glu Phe Ile Asn Arg Arg Arg Glu Ile Ala Thr Gln Tyr Asp Arg Leu 
            260                 265                 270         


Leu Ser Asp Val Pro Gly Val Leu Leu Pro Pro Thr Leu Pro Asp Gly 
        275                 280                 285             


His Val Ser Ser His Tyr Phe Tyr Trp Val Gln Leu Ala Pro Glu Ile 
    290                 295                 300                 


Arg Asp Gln Val Ala Gln Gln Met Leu Glu Arg Gly Ile Tyr Thr Ser 
305                 310                 315                 320 


Tyr Arg Tyr Pro Pro Leu His Lys Val Pro Ile Tyr Arg Ala Asp Cys 
                325                 330                 335     


Lys Leu Pro Ser Ala Glu Asp Ala Cys Arg Arg Thr Leu Leu Leu Pro 
            340                 345                 350         


Leu His Pro Ser Leu Asp Asp Ala Glu Val Arg Thr Val Ala Asp Glu 
        355                 360                 365             


Phe Gln Lys Ala Val Glu His His Ile Ser Gln Arg Ser Pro Leu Arg 
    370                 375                 380                 


Lys 
385 


<210>  29
<211>  1389
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (1)..(1389)
<223>  

<400>  29
atg cag agc cgg aaa acc aga gcg ctg ggg aaa ggg cgc gcc aga gtg       48
Met Gln Ser Arg Lys Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val         
1               5                   10                  15              

act tcg tgt gac gac act tgc gct acc gct act gag atg gtg ccg gat       96
Thr Ser Cys Asp Asp Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp         
            20                  25                  30                  

gcc aag gac cgg ata ttg gca tcc gta cgc gat tac cac cgc gaa cag      144
Ala Lys Asp Arg Ile Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln         
        35                  40                  45                      

gaa tcc ccg acc ttc gtg gct gga tcg acg ccg atc cgg cca tcg ggc      192
Glu Ser Pro Thr Phe Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly         
    50                  55                  60                          

gcc gtg ctc gac gag gac gac cgg gtg gca ctg gtg gaa gcc gcg ctg      240
Ala Val Leu Asp Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu         
65                  70                  75                  80          

gag ctc cgg atc gcc gcg ggc ggg aat gca cgg cga ttc gag agc gag      288
Glu Leu Arg Ile Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu         
                85                  90                  95              

ttc gcc cgc ttc ttc ggc ctc cgc aag gct cat ctc gtc aac tcc ggt      336
Phe Ala Arg Phe Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly         
            100                 105                 110                 

tcg tcg gcc aat ctc ctg gca ctg agt tcg ctt acc tcc ccc aaa ctc      384
Ser Ser Ala Asn Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu         
        115                 120                 125                     

ggc gag gca cga ctg cgg ccc ggc gac gaa gtg atc act gcg gcg gtc      432
Gly Glu Ala Arg Leu Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val         
    130                 135                 140                         

ggc ttc ccc acg acg atc aat ccg gcg gtc caa aac gga ctc gtc ccg      480
Gly Phe Pro Thr Thr Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro         
145                 150                 155                 160         

gta ttc gtc gac gtg gaa ctg ggc acc tac aac gca acg cca gac cgc      528
Val Phe Val Asp Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg         
                165                 170                 175             

atc aag gcc gcc gtc acg gaa cgg acg cga gcc atc atg ctg gcg cac      576
Ile Lys Ala Ala Val Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His         
            180                 185                 190                 

acc ctg ggc aac ccc ttc gcc gct gac gaa atc gcg gag atc gca aaa      624
Thr Leu Gly Asn Pro Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys         
        195                 200                 205                     

gaa cac gag ctg ttc ctc gtc gaa gac aac tgt gat gcg gtg gga tcc      672
Glu His Glu Leu Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser         
    210                 215                 220                         

acc tac cgg gga cgg ctg acc gga acc ttc ggc gac ctg aca acg gtc      720
Thr Tyr Arg Gly Arg Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val         
225                 230                 235                 240         

agc ttc tat cct gcc cat cac atc acc agc ggc gag ggt ggc tgc gtg      768
Ser Phe Tyr Pro Ala His His Ile Thr Ser Gly Glu Gly Gly Cys Val         
                245                 250                 255             

ttg acc ggc agc ctg gaa ttg gct cgc atc atc gag tcg ctg cgt gac      816
Leu Thr Gly Ser Leu Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp         
            260                 265                 270                 

tgg gga cgg gat tgc tgg tgc gag ccc ggc gtg gac aac acc tgc cgc      864
Trp Gly Arg Asp Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg         
        275                 280                 285                     

aag agg ttc gac tac cac ctc ggt acc ctt cca ccg ggc tac gac cac      912
Lys Arg Phe Asp Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His         
    290                 295                 300                         

aag tac acg ttc tcc cac gtc ggt tac aac ctc aag acc acc gac ctg      960
Lys Tyr Thr Phe Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu         
305                 310                 315                 320         

cag gcc gca ctt gcg ctg agc cag ttg agc aag att tcc gca ttc ggg     1008
Gln Ala Ala Leu Ala Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly         
                325                 330                 335             

tcg gca cgc cgc cgt aac tgg cga cgg ttg cgc gaa ggg ctg tcc ggg     1056
Ser Ala Arg Arg Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly         
            340                 345                 350                 

ttg ccg ggc ctg ctg ctg ccg gta gcc aca ccg cac agc gac ccg agc     1104
Leu Pro Gly Leu Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser         
        355                 360                 365                     

tgg ttc ggg ttt gcg atc acc atc agt gcg gac gcc ggg ttc acc cgt     1152
Trp Phe Gly Phe Ala Ile Thr Ile Ser Ala Asp Ala Gly Phe Thr Arg         
    370                 375                 380                         

gcc gcc ctg gtg aac ttc ctg gaa tcc cgc aac atc ggc acc cga ctg     1200
Ala Ala Leu Val Asn Phe Leu Glu Ser Arg Asn Ile Gly Thr Arg Leu         
385                 390                 395                 400         

ctg ttc ggc ggt aac atc acc cgg cac ccg gcc ttc gag cag gtg cgg     1248
Leu Phe Gly Gly Asn Ile Thr Arg His Pro Ala Phe Glu Gln Val Arg         
                405                 410                 415             

tac cgg atc gcc gac gcg ctc acc aac agc gac atc gtc acc gac cga     1296
Tyr Arg Ile Ala Asp Ala Leu Thr Asn Ser Asp Ile Val Thr Asp Arg         
            420                 425                 430                 

acc ttc tgg gtc ggc gtc tac cca ggc ata acg gac caa atg atc gac     1344
Thr Phe Trp Val Gly Val Tyr Pro Gly Ile Thr Asp Gln Met Ile Asp         
        435                 440                 445                     

tac gtc gtc gaa tca atc gct gaa ttc gtg gcc aag agt tcc tag         1389
Tyr Val Val Glu Ser Ile Ala Glu Phe Val Ala Lys Ser Ser                 
    450                 455                 460                         


<210>  30
<211>  462
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  30

Met Gln Ser Arg Lys Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val 
1               5                   10                  15      


Thr Ser Cys Asp Asp Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp 
            20                  25                  30          


Ala Lys Asp Arg Ile Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln 
        35                  40                  45              


Glu Ser Pro Thr Phe Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly 
    50                  55                  60                  


Ala Val Leu Asp Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu 
65                  70                  75                  80  


Glu Leu Arg Ile Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu 
                85                  90                  95      


Phe Ala Arg Phe Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly 
            100                 105                 110         


Ser Ser Ala Asn Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu 
        115                 120                 125             


Gly Glu Ala Arg Leu Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val 
    130                 135                 140                 


Gly Phe Pro Thr Thr Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro 
145                 150                 155                 160 


Val Phe Val Asp Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg 
                165                 170                 175     


Ile Lys Ala Ala Val Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His 
            180                 185                 190         


Thr Leu Gly Asn Pro Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys 
        195                 200                 205             


Glu His Glu Leu Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser 
    210                 215                 220                 


Thr Tyr Arg Gly Arg Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val 
225                 230                 235                 240 


Ser Phe Tyr Pro Ala His His Ile Thr Ser Gly Glu Gly Gly Cys Val 
                245                 250                 255     


Leu Thr Gly Ser Leu Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp 
            260                 265                 270         


Trp Gly Arg Asp Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg 
        275                 280                 285             


Lys Arg Phe Asp Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His 
    290                 295                 300                 


Lys Tyr Thr Phe Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu 
305                 310                 315                 320 


Gln Ala Ala Leu Ala Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly 
                325                 330                 335     


Ser Ala Arg Arg Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly 
            340                 345                 350         


Leu Pro Gly Leu Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser 
        355                 360                 365             


Trp Phe Gly Phe Ala Ile Thr Ile Ser Ala Asp Ala Gly Phe Thr Arg 
    370                 375                 380                 


Ala Ala Leu Val Asn Phe Leu Glu Ser Arg Asn Ile Gly Thr Arg Leu 
385                 390                 395                 400 


Leu Phe Gly Gly Asn Ile Thr Arg His Pro Ala Phe Glu Gln Val Arg 
                405                 410                 415     


Tyr Arg Ile Ala Asp Ala Leu Thr Asn Ser Asp Ile Val Thr Asp Arg 
            420                 425                 430         


Thr Phe Trp Val Gly Val Tyr Pro Gly Ile Thr Asp Gln Met Ile Asp 
        435                 440                 445             


Tyr Val Val Glu Ser Ile Ala Glu Phe Val Ala Lys Ser Ser 
    450                 455                 460         


<210>  31
<211>  1952
<212>  DNA
<213>  Saccharopolyspora spinosa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<400>  31
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attctagttc taga                                      1952


<210>  32
<211>  293
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  32

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  33
<211>  329
<212>  PRT
<213>  Saccharopolyspora spinosa

<400>  33

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  34
<211>  3536
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1962)..(2570)
<223>  epi gene from S. spinosa


<220>
<221>  CDS
<222>  (2600)..(3517)
<223>  kre gene from S. spinosa


<400>  34
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgacgtca taggctttcg gcc gtg cag gta cgt cga ctt    1979
                                         Val Gln Val Arg Arg Leu        
                                                 625                    

gac atc acg ggt gca tac gag ttc acc ccg aag gcc ttc ccc gac cac     2027
Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro Lys Ala Phe Pro Asp His         
    630                 635                 640                         

cgg ggc ctg ttc gtg gcc ccg ttc cag gag gcg gcg ttc atc gac gcc     2075
Arg Gly Leu Phe Val Ala Pro Phe Gln Glu Ala Ala Phe Ile Asp Ala         
645                 650                 655                 660         

acg ggg cac ccg ctg cga gtc gcg cag acc aac cac agc gtc tcg gcg     2123
Thr Gly His Pro Leu Arg Val Ala Gln Thr Asn His Ser Val Ser Ala         
                665                 670                 675             

cgc aac gtc atc cgc ggc gtg cac ttc tcg gac gtg ccg ccg ggc caa     2171
Arg Asn Val Ile Arg Gly Val His Phe Ser Asp Val Pro Pro Gly Gln         
            680                 685                 690                 

gcg aag tac gtg tac tgc ccg cag ggc gcg ctg ctc gac gtg gtc atc     2219
Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala Leu Leu Asp Val Val Ile         
        695                 700                 705                     

gac atc cgg gtc ggt tcc ccg acc ttc ggc cgc tgg gag gcg gtc cgg     2267
Asp Ile Arg Val Gly Ser Pro Thr Phe Gly Arg Trp Glu Ala Val Arg         
    710                 715                 720                         

ctc gac gac acc gag tac cgg gcc gtc tac cta gcc gaa gga ctc ggg     2315
Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr Leu Ala Glu Gly Leu Gly         
725                 730                 735                 740         

cac gcg ttc gcc gcg ctg acc gac gac acc gtg atg acc tac ctc tgc     2363
His Ala Phe Ala Ala Leu Thr Asp Asp Thr Val Met Thr Tyr Leu Cys         
                745                 750                 755             

tcg acg ccc tac acc ccg ggc gcc gag cac ggc atc gac ccg ttc gac     2411
Ser Thr Pro Tyr Thr Pro Gly Ala Glu His Gly Ile Asp Pro Phe Asp         
            760                 765                 770                 

ccg gaa ctc gcg ttg ccg tgg tcc gac ctc gac ggt gaa ccg gtc ctg     2459
Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu Asp Gly Glu Pro Val Leu         
        775                 780                 785                     

tcc gaa aag gac cgg acc gcc ccg agc ctc gcg gaa gcc gcc gac aac     2507
Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu Ala Glu Ala Ala Asp Asn         
    790                 795                 800                         

ggc ctg ctt ccg gac tac gaa aca tgc ctc gcc cac tac gaa ggc ctg     2555
Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu Ala His Tyr Glu Gly Leu         
805                 810                 815                 820         

cgc agc ccc ggc tga acggtcaatg catgatcggc ggtggctcg atg agt cgc     2608
Arg Ser Pro Gly                                     Met Ser Arg         
                                                    825                 

ctc gcc gtg ctg gtg ccc ggc ggc cgc ggc cag ctg ggc tcg gag ctg     2656
Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly Ser Glu Leu         
        830                 835                 840                     

gcc cgg atc ctc gcc gcg cgg acg ggg gcg ctg gtg cac cgg ccg ggt     2704
Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His Arg Pro Gly         
    845                 850                 855                         

tcc ggg gaa ctg gac gtc acc gac gcc gag gag gtc gcc gac gcg ttg     2752
Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala Asp Ala Leu         
860                 865                 870                 875         

ggt tcc ttc gcg gag acg gcg aag gac gcg gag ctg cga ccg gtg gtg     2800
Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg Pro Val Val         
                880                 885                 890             

atc aac gcc gcg gcg tac acg gcg gtg gac gcg gcc gag tcc gac ccg     2848
Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu Ser Asp Pro         
            895                 900                 905                 

gac cgc gcg gcc cgg atc aac gcc gaa ggc gcg gcc tcg ctg gcg aaa     2896
Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser Leu Ala Lys         
        910                 915                 920                     

gcg tgc cgg agc agc ggt ctg ccc ctg gtg cac gtg tcg acg gat tac     2944
Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser Thr Asp Tyr         
    925                 930                 935                         

gtg ttc ccc ggt gat ggg gcc cgg ccg tac gag ccg acg gac ccg acc     2992
Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr Asp Pro Thr         
940                 945                 950                 955         

ggg ccg cga tcg gtc tac ggg cgc acc aag ctc gaa ggc gaa cgg gcc     3040
Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly Glu Arg Ala         
                960                 965                 970             

gtg ctg gag tcc ggc gcg cgg gcc tgg gtg gtg cgc acg gca tgg gtg     3088
Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr Ala Trp Val         
            975                 980                 985                 

tac ggc gcg agc ggc aag aac ttc ctg aaa acg atg atc  cgc ctc tcg    3136
Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile  Arg Leu Ser        
        990                 995                 1000                    

ggg gag  cgc gac acg ctg tcc  gtt gtg gac gat cag  atc ggc tcg      3181
Gly Glu  Arg Asp Thr Leu Ser  Val Val Asp Asp Gln  Ile Gly Ser          
    1005                 1010                 1015                      

ccg act  tgg gcg gcg gac ctg  gcg agc ggc ctg ctg  gag ctg gcc      3226
Pro Thr  Trp Ala Ala Asp Leu  Ala Ser Gly Leu Leu  Glu Leu Ala          
    1020                 1025                 1030                      

gaa cgg  gtc gcc gaa cgc cgt  gga ccg gag cag aag  gtg ctg cac      3271
Glu Arg  Val Ala Glu Arg Arg  Gly Pro Glu Gln Lys  Val Leu His          
    1035                 1040                 1045                      

tgc acc  aat tcc ggc cag gtg  acc tgg tac gag ttc  gcg cgg gcg      3316
Cys Thr  Asn Ser Gly Gln Val  Thr Trp Tyr Glu Phe  Ala Arg Ala          
    1050                 1055                 1060                      

atc ttc  gcg gaa ttc ggc ctg  gac gag aac cgc gtc  cac ccg tgc      3361
Ile Phe  Ala Glu Phe Gly Leu  Asp Glu Asn Arg Val  His Pro Cys          
    1065                 1070                 1075                      

acg acg  gcg gac ttc ccc ctc  ccg gcg cac cgc ccg  gcc tac tcg      3406
Thr Thr  Ala Asp Phe Pro Leu  Pro Ala His Arg Pro  Ala Tyr Ser          
    1080                 1085                 1090                      

gtc ctg  tcc gac gtg gcg tgg  cga gag gcg ggc ctg  acc ccg atg      3451
Val Leu  Ser Asp Val Ala Trp  Arg Glu Ala Gly Leu  Thr Pro Met          
    1095                 1100                 1105                      

cgc acc  tgg cgg gaa gcc ctg  gcg gcg gcc ttc gag  aaa gac ggc      3496
Arg Thr  Trp Arg Glu Ala Leu  Ala Ala Ala Phe Glu  Lys Asp Gly          
    1110                 1115                 1120                      

gaa acc  ctc cga acc cgc tga ccagtcacta gttctagat                   3536
Glu Thr  Leu Arg Thr Arg                                                
    1125                                                                


<210>  35
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  35

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  36
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  36

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  37
<211>  202
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  37

Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro 
1               5                   10                  15      


Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu 
            20                  25                  30          


Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr 
        35                  40                  45              


Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser 
    50                  55                  60                  


Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala 
65                  70                  75                  80  


Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly 
                85                  90                  95      


Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 
            100                 105                 110         


Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 
        115                 120                 125             


Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 
    130                 135                 140                 


Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 
145                 150                 155                 160 


Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 
                165                 170                 175     


Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 
            180                 185                 190         


Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 
        195                 200         


<210>  38
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  38

Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly 
1               5                   10                  15      


Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His 
            20                  25                  30          


Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala 
        35                  40                  45              


Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg 
    50                  55                  60                  


Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu 
65                  70                  75                  80  


Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser 
                85                  90                  95      


Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser 
            100                 105                 110         


Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr 
        115                 120                 125             


Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly 
    130                 135                 140                 


Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr 
145                 150                 155                 160 


Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile 
                165                 170                 175     


Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asp Gln Ile 
            180                 185                 190         


Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu 
        195                 200                 205             


Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gln Lys Val Leu His 
    210                 215                 220                 


Cys Thr Asn Ser Gly Gln Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile 
225                 230                 235                 240 


Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr 
                245                 250                 255     


Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser 
            260                 265                 270         


Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg 
        275                 280                 285             


Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr 
    290                 295                 300                 


Arg 
305 


<210>  39
<211>  3633
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1962)..(2570)
<223>  epi gene from S. spinosa


<220>
<221>  CDS
<222>  (2599)..(3618)
<223>  kre gene from S. diversa


<400>  39
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgacgtca taggctttcg gcc gtg cag gta cgt cga ctt    1979
                                         Val Gln Val Arg Arg Leu        
                                                 625                    

gac atc acg ggt gca tac gag ttc acc ccg aag gcc ttc ccc gac cac     2027
Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro Lys Ala Phe Pro Asp His         
    630                 635                 640                         

cgg ggc ctg ttc gtg gcc ccg ttc cag gag gcg gcg ttc atc gac gcc     2075
Arg Gly Leu Phe Val Ala Pro Phe Gln Glu Ala Ala Phe Ile Asp Ala         
645                 650                 655                 660         

acg ggg cac ccg ctg cga gtc gcg cag acc aac cac agc gtc tcg gcg     2123
Thr Gly His Pro Leu Arg Val Ala Gln Thr Asn His Ser Val Ser Ala         
                665                 670                 675             

cgc aac gtc atc cgc ggc gtg cac ttc tcg gac gtg ccg ccg ggc caa     2171
Arg Asn Val Ile Arg Gly Val His Phe Ser Asp Val Pro Pro Gly Gln         
            680                 685                 690                 

gcg aag tac gtg tac tgc ccg cag ggc gcg ctg ctc gac gtg gtc atc     2219
Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala Leu Leu Asp Val Val Ile         
        695                 700                 705                     

gac atc cgg gtc ggt tcc ccg acc ttc ggc cgc tgg gag gcg gtc cgg     2267
Asp Ile Arg Val Gly Ser Pro Thr Phe Gly Arg Trp Glu Ala Val Arg         
    710                 715                 720                         

ctc gac gac acc gag tac cgg gcc gtc tac cta gcc gaa gga ctc ggg     2315
Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr Leu Ala Glu Gly Leu Gly         
725                 730                 735                 740         

cac gcg ttc gcc gcg ctg acc gac gac acc gtg atg acc tac ctc tgc     2363
His Ala Phe Ala Ala Leu Thr Asp Asp Thr Val Met Thr Tyr Leu Cys         
                745                 750                 755             

tcg acg ccc tac acc ccg ggc gcc gag cac ggc atc gac ccg ttc gac     2411
Ser Thr Pro Tyr Thr Pro Gly Ala Glu His Gly Ile Asp Pro Phe Asp         
            760                 765                 770                 

ccg gaa ctc gcg ttg ccg tgg tcc gac ctc gac ggt gaa ccg gtc ctg     2459
Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu Asp Gly Glu Pro Val Leu         
        775                 780                 785                     

tcc gaa aag gac cgg acc gcc ccg agc ctc gcg gaa gcc gcc gac aac     2507
Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu Ala Glu Ala Ala Asp Asn         
    790                 795                 800                         

ggc ctg ctt ccg gac tac gaa aca tgc ctc gcc cac tac gaa ggc ctg     2555
Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu Ala His Tyr Glu Gly Leu         
805                 810                 815                 820         

cgc agc ccc ggc tga acggtcaatg catgctggag gaatcgct gtg acc gcc      2607
Arg Ser Pro Gly                                    Val Thr Ala          
                                                   825                  

acc acc gga cag acc ggg gac acc cga ccc ctg gtg gtc gtc ctc ggc     2655
Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val Val Leu Gly         
        830                 835                 840                     

gcc gcc ggc ttc gtc ggc tcc gcc gtc ctg cgc gaa ctc gcc cgc cac     2703
Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu Ala Arg His         
    845                 850                 855                         

gac ctg cgg gtg cgg gcc gtc tcc cgg cgc ccg gtg acc gtc ccg gcc     2751
Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr Val Pro Ala         
860                 865                 870                 875         

ggc gcc cgc gcc gag gtg gag acc cgc agc gtc gac ctc acc gtc ccc     2799
Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu Thr Val Pro         
                880                 885                 890             

ggc gcg atg gcc ggg gcg atc gag ggc gcc gac gtg gtc gtc cac tcg     2847
Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val Val His Ser         
            895                 900                 905                 

atc gcc tac atc gcg ggc tcc tcg acc tgg cgc atc acg gac ggc gac     2895
Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr Asp Gly Asp         
        910                 915                 920                     

acc ggc gcc gag cgg gtc aac gtg gga ctc gta cgg gac ctg gtc gag     2943
Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp Leu Val Glu         
    925                 930                 935                         

gcc gtg cgg gcg agc ggc cgc ccc gac acc gcc gtc ctg ttc acc ggc     2991
Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu Phe Thr Gly         
940                 945                 950                 955         

tcc gtc tcc gcc gcc gga ccc tcg gag cgg ggc gtc tac gac ggt acg     3039
Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr Asp Gly Thr         
                960                 965                 970             

gag ccg gac gag ccg cag ggc gag tac gac cgg cag aag ctg gcg gcc     3087
Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys Leu Ala Ala         
            975                 980                 985                 

gag cgg gtg ctg ctc gcg gcg agc gcc gag ggc gtg ctg  cgc ggg atc    3135
Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu  Arg Gly Ile        
        990                 995                 1000                    

tcg ctc  cgg ctc ccc acg gtc  ttc ggc tac ggc ccc  gac tcg acc      3180
Ser Leu  Arg Leu Pro Thr Val  Phe Gly Tyr Gly Pro  Asp Ser Thr          
    1005                 1010                 1015                      

gcg cgg  gac aag ggc atc gtc  tcc tcg atg gtc cgc  cgg gcg gtg      3225
Ala Arg  Asp Lys Gly Ile Val  Ser Ser Met Val Arg  Arg Ala Val          
    1020                 1025                 1030                      

gcg ggc  gag ccg atc acc atg  tgg cac gac ggc acg  gtc cgc cgc      3270
Ala Gly  Glu Pro Ile Thr Met  Trp His Asp Gly Thr  Val Arg Arg          
    1035                 1040                 1045                      

gac ctg  ctg tac gtg gag gac  gtg gcg cgc gcc ttc  gcg gcg gcc      3315
Asp Leu  Leu Tyr Val Glu Asp  Val Ala Arg Ala Phe  Ala Ala Ala          
    1050                 1055                 1060                      

ctc ggc  cac ctc gac gcg ctc  gcg gga cgg cac tgg  gtg ctc ggc      3360
Leu Gly  His Leu Asp Ala Leu  Ala Gly Arg His Trp  Val Leu Gly          
    1065                 1070                 1075                      

agc ggg  cac ggc gcc gag ctc  ggc ccg gtc ttc acc  acg gtc gcc      3405
Ser Gly  His Gly Ala Glu Leu  Gly Pro Val Phe Thr  Thr Val Ala          
    1080                 1085                 1090                      

cgg atg  gtg gcg gag cgg acc  ggc aag ccg ccg gtg  gcc gtg cgc      3450
Arg Met  Val Ala Glu Arg Thr  Gly Lys Pro Pro Val  Ala Val Arg          
    1095                 1100                 1105                      

tcg gtg  gag ccg ccc gcg cac  gcc gag gcc cgg gac  ttc gcc agc      3495
Ser Val  Glu Pro Pro Ala His  Ala Glu Ala Arg Asp  Phe Ala Ser          
    1110                 1115                 1120                      

gtc acc  gtc gac ccg cgc gcc  ttc cac gag gtc acc  ggc tgg cgg      3540
Val Thr  Val Asp Pro Arg Ala  Phe His Glu Val Thr  Gly Trp Arg          
    1125                 1130                 1135                      

gcc gag  gtc ccg ctg gac gag  gcc ctg gac cgg acg  acg gcc ttc      3585
Ala Glu  Val Pro Leu Asp Glu  Ala Leu Asp Arg Thr  Thr Ala Phe          
    1140                 1145                 1150                      

agc gcg  agc ggc gcg gag gag  cac ttc ggc tga cccactagtt ctaga      3633
Ser Ala  Ser Gly Ala Glu Glu  His Phe Gly                               
    1155                 1160                                           


<210>  40
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  40

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  41
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  41

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  42
<211>  202
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  42

Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro 
1               5                   10                  15      


Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu 
            20                  25                  30          


Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr 
        35                  40                  45              


Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser 
    50                  55                  60                  


Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala 
65                  70                  75                  80  


Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly 
                85                  90                  95      


Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 
            100                 105                 110         


Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 
        115                 120                 125             


Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 
    130                 135                 140                 


Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 
145                 150                 155                 160 


Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 
                165                 170                 175     


Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 
            180                 185                 190         


Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 
        195                 200         


<210>  43
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  43

Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val 
1               5                   10                  15      


Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu 
            20                  25                  30          


Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr 
        35                  40                  45              


Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu 
    50                  55                  60                  


Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val 
65                  70                  75                  80  


Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr 
                85                  90                  95      


Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp 
            100                 105                 110         


Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu 
        115                 120                 125             


Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr 
    130                 135                 140                 


Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys 
145                 150                 155                 160 


Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu 
                165                 170                 175     


Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp 
            180                 185                 190         


Ser Thr Ala Arg Asp Lys Gly Ile Val Ser Ser Met Val Arg Arg Ala 
        195                 200                 205             


Val Ala Gly Glu Pro Ile Thr Met Trp His Asp Gly Thr Val Arg Arg 
    210                 215                 220                 


Asp Leu Leu Tyr Val Glu Asp Val Ala Arg Ala Phe Ala Ala Ala Leu 
225                 230                 235                 240 


Gly His Leu Asp Ala Leu Ala Gly Arg His Trp Val Leu Gly Ser Gly 
                245                 250                 255     


His Gly Ala Glu Leu Gly Pro Val Phe Thr Thr Val Ala Arg Met Val 
            260                 265                 270         


Ala Glu Arg Thr Gly Lys Pro Pro Val Ala Val Arg Ser Val Glu Pro 
        275                 280                 285             


Pro Ala His Ala Glu Ala Arg Asp Phe Ala Ser Val Thr Val Asp Pro 
    290                 295                 300                 


Arg Ala Phe His Glu Val Thr Gly Trp Arg Ala Glu Val Pro Leu Asp 
305                 310                 315                 320 


Glu Ala Leu Asp Arg Thr Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu 
                325                 330                 335     


His Phe Gly 
            


<210>  44
<211>  2996
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1962)..(2981)
<223>  kre gene from S. diversa


<400>  44
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca atttgcatgc tggaggaatc gct gtg acc gcc acc acc gga    1979
                                         Val Thr Ala Thr Thr Gly        
                                                 625                    

cag acc ggg gac acc cga ccc ctg gtg gtc gtc ctc ggc gcc gcc ggc     2027
Gln Thr Gly Asp Thr Arg Pro Leu Val Val Val Leu Gly Ala Ala Gly         
    630                 635                 640                         

ttc gtc ggc tcc gcc gtc ctg cgc gaa ctc gcc cgc cac gac ctg cgg     2075
Phe Val Gly Ser Ala Val Leu Arg Glu Leu Ala Arg His Asp Leu Arg         
645                 650                 655                 660         

gtg cgg gcc gtc tcc cgg cgc ccg gtg acc gtc ccg gcc ggc gcc cgc     2123
Val Arg Ala Val Ser Arg Arg Pro Val Thr Val Pro Ala Gly Ala Arg         
                665                 670                 675             

gcc gag gtg gag acc cgc agc gtc gac ctc acc gtc ccc ggc gcg atg     2171
Ala Glu Val Glu Thr Arg Ser Val Asp Leu Thr Val Pro Gly Ala Met         
            680                 685                 690                 

gcc ggg gcg atc gag ggc gcc gac gtg gtc gtc cac tcg atc gcc tac     2219
Ala Gly Ala Ile Glu Gly Ala Asp Val Val Val His Ser Ile Ala Tyr         
        695                 700                 705                     

atc gcg ggc tcc tcg acc tgg cgc atc acg gac ggc gac acc ggc gcc     2267
Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr Asp Gly Asp Thr Gly Ala         
    710                 715                 720                         

gag cgg gtc aac gtg gga ctc gta cgg gac ctg gtc gag gcc gtg cgg     2315
Glu Arg Val Asn Val Gly Leu Val Arg Asp Leu Val Glu Ala Val Arg         
725                 730                 735                 740         

gcg agc ggc cgc ccc gac acc gcc gtc ctg ttc acc ggc tcc gtc tcc     2363
Ala Ser Gly Arg Pro Asp Thr Ala Val Leu Phe Thr Gly Ser Val Ser         
                745                 750                 755             

gcc gcc gga ccc tcg gag cgg ggc gtc tac gac ggt acg gag ccg gac     2411
Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr Asp Gly Thr Glu Pro Asp         
            760                 765                 770                 

gag ccg cag ggc gag tac gac cgg cag aag ctg gcg gcc gag cgg gtg     2459
Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys Leu Ala Ala Glu Arg Val         
        775                 780                 785                     

ctg ctc gcg gcg agc gcc gag ggc gtg ctg cgc ggg atc tcg ctc cgg     2507
Leu Leu Ala Ala Ser Ala Glu Gly Val Leu Arg Gly Ile Ser Leu Arg         
    790                 795                 800                         

ctc ccc acg gtc ttc ggc tac ggc ccc gac tcg acc gcg cgg gac aag     2555
Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp Ser Thr Ala Arg Asp Lys         
805                 810                 815                 820         

ggc atc gtc tcc tcg atg gtc cgc cgg gcg gtg gcg ggc gag ccg atc     2603
Gly Ile Val Ser Ser Met Val Arg Arg Ala Val Ala Gly Glu Pro Ile         
                825                 830                 835             

acc atg tgg cac gac ggc acg gtc cgc cgc gac ctg ctg tac gtg gag     2651
Thr Met Trp His Asp Gly Thr Val Arg Arg Asp Leu Leu Tyr Val Glu         
            840                 845                 850                 

gac gtg gcg cgc gcc ttc gcg gcg gcc ctc ggc cac ctc gac gcg ctc     2699
Asp Val Ala Arg Ala Phe Ala Ala Ala Leu Gly His Leu Asp Ala Leu         
        855                 860                 865                     

gcg gga cgg cac tgg gtg ctc ggc agc ggg cac ggc gcc gag ctc ggc     2747
Ala Gly Arg His Trp Val Leu Gly Ser Gly His Gly Ala Glu Leu Gly         
    870                 875                 880                         

ccg gtc ttc acc acg gtc gcc cgg atg gtg gcg gag cgg acc ggc aag     2795
Pro Val Phe Thr Thr Val Ala Arg Met Val Ala Glu Arg Thr Gly Lys         
885                 890                 895                 900         

ccg ccg gtg gcc gtg cgc tcg gtg gag ccg ccc gcg cac gcc gag gcc     2843
Pro Pro Val Ala Val Arg Ser Val Glu Pro Pro Ala His Ala Glu Ala         
                905                 910                 915             

cgg gac ttc gcc agc gtc acc gtc gac ccg cgc gcc ttc cac gag gtc     2891
Arg Asp Phe Ala Ser Val Thr Val Asp Pro Arg Ala Phe His Glu Val         
            920                 925                 930                 

acc ggc tgg cgg gcc gag gtc ccg ctg gac gag gcc ctg gac cgg acg     2939
Thr Gly Trp Arg Ala Glu Val Pro Leu Asp Glu Ala Leu Asp Arg Thr         
        935                 940                 945                     

acg gcc ttc agc gcg agc ggc gcg gag gag cac ttc ggc tga             2981
Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu His Phe Gly                     
    950                 955                 960                         

cccactagtt ctaga                                                    2996


<210>  45
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  45

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  46
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  46

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  47
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  47

Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val 
1               5                   10                  15      


Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu 
            20                  25                  30          


Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr 
        35                  40                  45              


Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu 
    50                  55                  60                  


Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val 
65                  70                  75                  80  


Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr 
                85                  90                  95      


Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp 
            100                 105                 110         


Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu 
        115                 120                 125             


Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr 
    130                 135                 140                 


Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys 
145                 150                 155                 160 


Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu 
                165                 170                 175     


Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp 
            180                 185                 190         


Ser Thr Ala Arg Asp Lys Gly Ile Val Ser Ser Met Val Arg Arg Ala 
        195                 200                 205             


Val Ala Gly Glu Pro Ile Thr Met Trp His Asp Gly Thr Val Arg Arg 
    210                 215                 220                 


Asp Leu Leu Tyr Val Glu Asp Val Ala Arg Ala Phe Ala Ala Ala Leu 
225                 230                 235                 240 


Gly His Leu Asp Ala Leu Ala Gly Arg His Trp Val Leu Gly Ser Gly 
                245                 250                 255     


His Gly Ala Glu Leu Gly Pro Val Phe Thr Thr Val Ala Arg Met Val 
            260                 265                 270         


Ala Glu Arg Thr Gly Lys Pro Pro Val Ala Val Arg Ser Val Glu Pro 
        275                 280                 285             


Pro Ala His Ala Glu Ala Arg Asp Phe Ala Ser Val Thr Val Asp Pro 
    290                 295                 300                 


Arg Ala Phe His Glu Val Thr Gly Trp Arg Ala Glu Val Pro Leu Asp 
305                 310                 315                 320 


Glu Ala Leu Asp Arg Thr Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu 
                325                 330                 335     


His Phe Gly 
            


<210>  48
<211>  2593
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1962)..(2570)
<223>  epi gene from S. spinosa


<400>  48
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgacgtca taggctttcg gcc gtg cag gta cgt cga ctt    1979
                                         Val Gln Val Arg Arg Leu        
                                                 625                    

gac atc acg ggt gca tac gag ttc acc ccg aag gcc ttc ccc gac cac     2027
Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro Lys Ala Phe Pro Asp His         
    630                 635                 640                         

cgg ggc ctg ttc gtg gcc ccg ttc cag gag gcg gcg ttc atc gac gcc     2075
Arg Gly Leu Phe Val Ala Pro Phe Gln Glu Ala Ala Phe Ile Asp Ala         
645                 650                 655                 660         

acg ggg cac ccg ctg cga gtc gcg cag acc aac cac agc gtc tcg gcg     2123
Thr Gly His Pro Leu Arg Val Ala Gln Thr Asn His Ser Val Ser Ala         
                665                 670                 675             

cgc aac gtc atc cgc ggc gtg cac ttc tcg gac gtg ccg ccg ggc caa     2171
Arg Asn Val Ile Arg Gly Val His Phe Ser Asp Val Pro Pro Gly Gln         
            680                 685                 690                 

gcg aag tac gtg tac tgc ccg cag ggc gcg ctg ctc gac gtg gtc atc     2219
Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala Leu Leu Asp Val Val Ile         
        695                 700                 705                     

gac atc cgg gtc ggt tcc ccg acc ttc ggc cgc tgg gag gcg gtc cgg     2267
Asp Ile Arg Val Gly Ser Pro Thr Phe Gly Arg Trp Glu Ala Val Arg         
    710                 715                 720                         

ctc gac gac acc gag tac cgg gcc gtc tac cta gcc gaa gga ctc ggg     2315
Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr Leu Ala Glu Gly Leu Gly         
725                 730                 735                 740         

cac gcg ttc gcc gcg ctg acc gac gac acc gtg atg acc tac ctc tgc     2363
His Ala Phe Ala Ala Leu Thr Asp Asp Thr Val Met Thr Tyr Leu Cys         
                745                 750                 755             

tcg acg ccc tac acc ccg ggc gcc gag cac ggc atc gac ccg ttc gac     2411
Ser Thr Pro Tyr Thr Pro Gly Ala Glu His Gly Ile Asp Pro Phe Asp         
            760                 765                 770                 

ccg gaa ctc gcg ttg ccg tgg tcc gac ctc gac ggt gaa ccg gtc ctg     2459
Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu Asp Gly Glu Pro Val Leu         
        775                 780                 785                     

tcc gaa aag gac cgg acc gcc ccg agc ctc gcg gaa gcc gcc gac aac     2507
Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu Ala Glu Ala Ala Asp Asn         
    790                 795                 800                         

ggc ctg ctt ccg gac tac gaa aca tgc ctc gcc cac tac gaa ggc ctg     2555
Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu Ala His Tyr Glu Gly Leu         
805                 810                 815                 820         

cgc agc ccc ggc tga acggtcaatg cactagttct aga                       2593
Arg Ser Pro Gly                                                         
                                                                        


<210>  49
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  49

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  50
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  50

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  51
<211>  202
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  51

Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro 
1               5                   10                  15      


Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu 
            20                  25                  30          


Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr 
        35                  40                  45              


Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser 
    50                  55                  60                  


Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala 
65                  70                  75                  80  


Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly 
                85                  90                  95      


Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 
            100                 105                 110         


Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 
        115                 120                 125             


Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 
    130                 135                 140                 


Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 
145                 150                 155                 160 


Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 
                165                 170                 175     


Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 
            180                 185                 190         


Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 
        195                 200         


<210>  52
<211>  3528
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1967)..(2563)
<223>  epi gene from S. diversa


<220>
<221>  CDS
<222>  (2592)..(3509)
<223>  kre gene from S. spinosa


<400>  52
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgcggcaa ggagaagtga cgacgacc atg cag gtg acc ccc   1981
                                              Met Gln Val Thr Pro       
                                                      625               

ctg gcc atc gag ggc gcc ttc gcc ttc acg ccc ccc gtc ttc aag gac     2029
Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro Pro Val Phe Lys Asp         
        630                 635                 640                     

agc cgc ggc ctg ttc gcc tcc ccc tac cag ggg gac gtg ttc gcc ggg     2077
Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly Asp Val Phe Ala Gly         
    645                 650                 655                         

cag ctc ggc cgc ccg ctc ttc cag gtc gaa cag gtc agc cac aac ctg     2125
Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln Val Ser His Asn Leu         
660                 665                 670                 675         

tcc gcc agg ggc acc ctc cgc ggc gtc cac ttc acc gcg acc ccg ccg     2173
Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe Thr Ala Thr Pro Pro         
                680                 685                 690             

ggc atg gcg aag tac gtc tac tgc ccg tac ggc agg ctc cgg gac ttc     2221
Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly Arg Leu Arg Asp Phe         
            695                 700                 705                 

ctc atc gac ctc cgg gtc ggc tca ccg acc ttc ggg cag tgg gtg atg     2269
Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe Gly Gln Trp Val Met         
        710                 715                 720                     

aac gaa ctc gac gcg gag acc agc cgc gcc ctc tac gtc ccg gtc ggc     2317
Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu Tyr Val Pro Val Gly         
    725                 730                 735                         

gtc ggc cac gcg ttc gtc tcg ctc cag gac gac tcc atg tgc gtc tac     2365
Val Gly His Ala Phe Val Ser Leu Gln Asp Asp Ser Met Cys Val Tyr         
740                 745                 750                 755         

gtg atg tcg cag ggg tac gtc ccc gcc aac gaa ctg gcc ctg aac ccg     2413
Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu Leu Ala Leu Asn Pro         
                760                 765                 770             

ctc gac ccg gcg ctc gga ctc gac ctg ccg gac gac gtc gag ctg atc     2461
Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp Asp Val Glu Leu Ile         
            775                 780                 785                 

ctg tcc gac cgg gac aag atc gcc ccc acc ctc gcc gag gcc cgc gac     2509
Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu Ala Glu Ala Arg Asp         
        790                 795                 800                     

cgc ggc ctc ctg ccc gac ttc gac acc tgc cgc aag ctg gag gaa ctg     2557
Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg Lys Leu Glu Glu Leu         
    805                 810                 815                         

ctg tga ccgccaatgc atgatcggcg gtggctcg atg agt cgc ctc gcc gtg      2609
Leu                                    Met Ser Arg Leu Ala Val          
820                                                    825              

ctg gtg ccc ggc ggc cgc ggc cag ctg ggc tcg gag ctg gcc cgg atc     2657
Leu Val Pro Gly Gly Arg Gly Gln Leu Gly Ser Glu Leu Ala Arg Ile         
            830                 835                 840                 

ctc gcc gcg cgg acg ggg gcg ctg gtg cac cgg ccg ggt tcc ggg gaa     2705
Leu Ala Ala Arg Thr Gly Ala Leu Val His Arg Pro Gly Ser Gly Glu         
        845                 850                 855                     

ctg gac gtc acc gac gcc gag gag gtc gcc gac gcg ttg ggt tcc ttc     2753
Leu Asp Val Thr Asp Ala Glu Glu Val Ala Asp Ala Leu Gly Ser Phe         
    860                 865                 870                         

gcg gag acg gcg aag gac gcg gag ctg cga ccg gtg gtg atc aac gcc     2801
Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg Pro Val Val Ile Asn Ala         
875                 880                 885                 890         

gcg gcg tac acg gcg gtg gac gcg gcc gag tcc gac ccg gac cgc gcg     2849
Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu Ser Asp Pro Asp Arg Ala         
                895                 900                 905             

gcc cgg atc aac gcc gaa ggc gcg gcc tcg ctg gcg aaa gcg tgc cgg     2897
Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser Leu Ala Lys Ala Cys Arg         
            910                 915                 920                 

agc agc ggt ctg ccc ctg gtg cac gtg tcg acg gat tac gtg ttc ccc     2945
Ser Ser Gly Leu Pro Leu Val His Val Ser Thr Asp Tyr Val Phe Pro         
        925                 930                 935                     

ggt gat ggg gcc cgg ccg tac gag ccg acg gac ccg acc ggg ccg cga     2993
Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr Asp Pro Thr Gly Pro Arg         
    940                 945                 950                         

tcg gtc tac ggg cgc acc aag ctc gaa ggc gaa cgg gcc gtg ctg gag     3041
Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly Glu Arg Ala Val Leu Glu         
955                 960                 965                 970         

tcc ggc gcg cgg gcc tgg gtg gtg cgc acg gca tgg gtg tac ggc gcg     3089
Ser Gly Ala Arg Ala Trp Val Val Arg Thr Ala Trp Val Tyr Gly Ala         
                975                 980                 985             

agc ggc aag aac ttc ctg aaa acg atg atc cgc ctc tcg ggg  gag cgc    3137
Ser Gly Lys Asn Phe Leu Lys Thr Met Ile Arg Leu Ser Gly  Glu Arg        
            990                 995                 1000                

gac acg ctg  tcc gtt gtg gac gat  cag atc ggc tcg ccg  act tgg      3182
Asp Thr Leu  Ser Val Val Asp Asp  Gln Ile Gly Ser Pro  Thr Trp          
        1005                 1010                 1015                  

gcg gcg gac  ctg gcg agc ggc ctg  ctg gag ctg gcc gaa  cgg gtc      3227
Ala Ala Asp  Leu Ala Ser Gly Leu  Leu Glu Leu Ala Glu  Arg Val          
        1020                 1025                 1030                  

gcc gaa cgc  cgt gga ccg gag cag  aag gtg ctg cac tgc  acc aat      3272
Ala Glu Arg  Arg Gly Pro Glu Gln  Lys Val Leu His Cys  Thr Asn          
        1035                 1040                 1045                  

tcc ggc cag  gtg acc tgg tac gag  ttc gcg cgg gcg atc  ttc gcg      3317
Ser Gly Gln  Val Thr Trp Tyr Glu  Phe Ala Arg Ala Ile  Phe Ala          
        1050                 1055                 1060                  

gaa ttc ggc  ctg gac gag aac cgc  gtc cac ccg tgc acg  acg gcg      3362
Glu Phe Gly  Leu Asp Glu Asn Arg  Val His Pro Cys Thr  Thr Ala          
        1065                 1070                 1075                  

gac ttc ccc  ctc ccg gcg cac cgc  ccg gcc tac tcg gtc  ctg tcc      3407
Asp Phe Pro  Leu Pro Ala His Arg  Pro Ala Tyr Ser Val  Leu Ser          
        1080                 1085                 1090                  

gac gtg gcg  tgg cga gag gcg ggc  ctg acc ccg atg cgc  acc tgg      3452
Asp Val Ala  Trp Arg Glu Ala Gly  Leu Thr Pro Met Arg  Thr Trp          
        1095                 1100                 1105                  

cgg gaa gcc  ctg gcg gcg gcc ttc  gag aaa gac ggc gaa  acc ctc      3497
Arg Glu Ala  Leu Ala Ala Ala Phe  Glu Lys Asp Gly Glu  Thr Leu          
        1110                 1115                 1120                  

cga acc cgc  tga ccagtcacta gttctagat                               3528
Arg Thr Arg                                                             
        1125                                                            


<210>  53
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  53

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  54
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  54

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  55
<211>  198
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  55

Met Gln Val Thr Pro Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro 
1               5                   10                  15      


Pro Val Phe Lys Asp Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly 
            20                  25                  30          


Asp Val Phe Ala Gly Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln 
        35                  40                  45              


Val Ser His Asn Leu Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe 
    50                  55                  60                  


Thr Ala Thr Pro Pro Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly 
65                  70                  75                  80  


Arg Leu Arg Asp Phe Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Trp Val Met Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu 
            100                 105                 110         


Tyr Val Pro Val Gly Val Gly His Ala Phe Val Ser Leu Gln Asp Asp 
        115                 120                 125             


Ser Met Cys Val Tyr Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu 
    130                 135                 140                 


Leu Ala Leu Asn Pro Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp 
145                 150                 155                 160 


Asp Val Glu Leu Ile Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu 
                165                 170                 175     


Ala Glu Ala Arg Asp Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg 
            180                 185                 190         


Lys Leu Glu Glu Leu Leu 
        195             


<210>  56
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  56

Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly 
1               5                   10                  15      


Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His 
            20                  25                  30          


Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala 
        35                  40                  45              


Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg 
    50                  55                  60                  


Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu 
65                  70                  75                  80  


Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser 
                85                  90                  95      


Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser 
            100                 105                 110         


Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr 
        115                 120                 125             


Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly 
    130                 135                 140                 


Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr 
145                 150                 155                 160 


Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile 
                165                 170                 175     


Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asp Gln Ile 
            180                 185                 190         


Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu 
        195                 200                 205             


Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gln Lys Val Leu His 
    210                 215                 220                 


Cys Thr Asn Ser Gly Gln Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile 
225                 230                 235                 240 


Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr 
                245                 250                 255     


Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser 
            260                 265                 270         


Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg 
        275                 280                 285             


Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr 
    290                 295                 300                 


Arg 
305 


<210>  57
<211>  2898
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1963)..(2880)
<223>  kre gene from S. spinosa


<400>  57
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca atttgcatga tcggcggtgg ctcg atg agt cgc ctc gcc gtg   1980
                                          Met Ser Arg Leu Ala Val       
                                                  625                   

ctg gtg ccc ggc ggc cgc ggc cag ctg ggc tcg gag ctg gcc cgg atc     2028
Leu Val Pro Gly Gly Arg Gly Gln Leu Gly Ser Glu Leu Ala Arg Ile         
    630                 635                 640                         

ctc gcc gcg cgg acg ggg gcg ctg gtg cac cgg ccg ggt tcc ggg gaa     2076
Leu Ala Ala Arg Thr Gly Ala Leu Val His Arg Pro Gly Ser Gly Glu         
645                 650                 655                 660         

ctg gac gtc acc gac gcc gag gag gtc gcc gac gcg ttg ggt tcc ttc     2124
Leu Asp Val Thr Asp Ala Glu Glu Val Ala Asp Ala Leu Gly Ser Phe         
                665                 670                 675             

gcg gag acg gcg aag gac gcg gag ctg cga ccg gtg gtg atc aac gcc     2172
Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg Pro Val Val Ile Asn Ala         
            680                 685                 690                 

gcg gcg tac acg gcg gtg gac gcg gcc gag tcc gac ccg gac cgc gcg     2220
Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu Ser Asp Pro Asp Arg Ala         
        695                 700                 705                     

gcc cgg atc aac gcc gaa ggc gcg gcc tcg ctg gcg aaa gcg tgc cgg     2268
Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser Leu Ala Lys Ala Cys Arg         
    710                 715                 720                         

agc agc ggt ctg ccc ctg gtg cac gtg tcg acg gat tac gtg ttc ccc     2316
Ser Ser Gly Leu Pro Leu Val His Val Ser Thr Asp Tyr Val Phe Pro         
725                 730                 735                 740         

ggt gat ggg gcc cgg ccg tac gag ccg acg gac ccg acc ggg ccg cga     2364
Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr Asp Pro Thr Gly Pro Arg         
                745                 750                 755             

tcg gtc tac ggg cgc acc aag ctc gaa ggc gaa cgg gcc gtg ctg gag     2412
Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly Glu Arg Ala Val Leu Glu         
            760                 765                 770                 

tcc ggc gcg cgg gcc tgg gtg gtg cgc acg gca tgg gtg tac ggc gcg     2460
Ser Gly Ala Arg Ala Trp Val Val Arg Thr Ala Trp Val Tyr Gly Ala         
        775                 780                 785                     

agc ggc aag aac ttc ctg aaa acg atg atc cgc ctc tcg ggg gag cgc     2508
Ser Gly Lys Asn Phe Leu Lys Thr Met Ile Arg Leu Ser Gly Glu Arg         
    790                 795                 800                         

gac acg ctg tcc gtt gtg gac gat cag atc ggc tcg ccg act tgg gcg     2556
Asp Thr Leu Ser Val Val Asp Asp Gln Ile Gly Ser Pro Thr Trp Ala         
805                 810                 815                 820         

gcg gac ctg gcg agc ggc ctg ctg gag ctg gcc gaa cgg gtc gcc gaa     2604
Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu Ala Glu Arg Val Ala Glu         
                825                 830                 835             

cgc cgt gga ccg gag cag aag gtg ctg cac tgc acc aat tcc ggc cag     2652
Arg Arg Gly Pro Glu Gln Lys Val Leu His Cys Thr Asn Ser Gly Gln         
            840                 845                 850                 

gtg acc tgg tac gag ttc gcg cgg gcg atc ttc gcg gaa ttc ggc ctg     2700
Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile Phe Ala Glu Phe Gly Leu         
        855                 860                 865                     

gac gag aac cgc gtc cac ccg tgc acg acg gcg gac ttc ccc ctc ccg     2748
Asp Glu Asn Arg Val His Pro Cys Thr Thr Ala Asp Phe Pro Leu Pro         
    870                 875                 880                         

gcg cac cgc ccg gcc tac tcg gtc ctg tcc gac gtg gcg tgg cga gag     2796
Ala His Arg Pro Ala Tyr Ser Val Leu Ser Asp Val Ala Trp Arg Glu         
885                 890                 895                 900         

gcg ggc ctg acc ccg atg cgc acc tgg cgg gaa gcc ctg gcg gcg gcc     2844
Ala Gly Leu Thr Pro Met Arg Thr Trp Arg Glu Ala Leu Ala Ala Ala         
                905                 910                 915             

ttc gag aaa gac ggc gaa acc ctc cga acc cgc tga ccagtcacta          2890
Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr Arg                             
            920                 925                                     

gttctaga                                                            2898


<210>  58
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  58

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  59
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  59

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  60
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa

<400>  60

Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly 
1               5                   10                  15      


Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His 
            20                  25                  30          


Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala 
        35                  40                  45              


Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg 
    50                  55                  60                  


Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu 
65                  70                  75                  80  


Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser 
                85                  90                  95      


Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser 
            100                 105                 110         


Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr 
        115                 120                 125             


Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly 
    130                 135                 140                 


Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr 
145                 150                 155                 160 


Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile 
                165                 170                 175     


Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asp Gln Ile 
            180                 185                 190         


Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu 
        195                 200                 205             


Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gln Lys Val Leu His 
    210                 215                 220                 


Cys Thr Asn Ser Gly Gln Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile 
225                 230                 235                 240 


Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr 
                245                 250                 255     


Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser 
            260                 265                 270         


Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg 
        275                 280                 285             


Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr 
    290                 295                 300                 


Arg 
305 


<210>  61
<211>  3625
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1967)..(2563)
<223>  epi gene from S. diversa


<220>
<221>  CDS
<222>  (2591)..(3610)
<223>  kre gene from S. diversa


<400>  61
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgcggcaa ggagaagtga cgacgacc atg cag gtg acc ccc   1981
                                              Met Gln Val Thr Pro       
                                                      625               

ctg gcc atc gag ggc gcc ttc gcc ttc acg ccc ccc gtc ttc aag gac     2029
Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro Pro Val Phe Lys Asp         
        630                 635                 640                     

agc cgc ggc ctg ttc gcc tcc ccc tac cag ggg gac gtg ttc gcc ggg     2077
Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly Asp Val Phe Ala Gly         
    645                 650                 655                         

cag ctc ggc cgc ccg ctc ttc cag gtc gaa cag gtc agc cac aac ctg     2125
Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln Val Ser His Asn Leu         
660                 665                 670                 675         

tcc gcc agg ggc acc ctc cgc ggc gtc cac ttc acc gcg acc ccg ccg     2173
Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe Thr Ala Thr Pro Pro         
                680                 685                 690             

ggc atg gcg aag tac gtc tac tgc ccg tac ggc agg ctc cgg gac ttc     2221
Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly Arg Leu Arg Asp Phe         
            695                 700                 705                 

ctc atc gac ctc cgg gtc ggc tca ccg acc ttc ggg cag tgg gtg atg     2269
Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe Gly Gln Trp Val Met         
        710                 715                 720                     

aac gaa ctc gac gcg gag acc agc cgc gcc ctc tac gtc ccg gtc ggc     2317
Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu Tyr Val Pro Val Gly         
    725                 730                 735                         

gtc ggc cac gcg ttc gtc tcg ctc cag gac gac tcc atg tgc gtc tac     2365
Val Gly His Ala Phe Val Ser Leu Gln Asp Asp Ser Met Cys Val Tyr         
740                 745                 750                 755         

gtg atg tcg cag ggg tac gtc ccc gcc aac gaa ctg gcc ctg aac ccg     2413
Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu Leu Ala Leu Asn Pro         
                760                 765                 770             

ctc gac ccg gcg ctc gga ctc gac ctg ccg gac gac gtc gag ctg atc     2461
Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp Asp Val Glu Leu Ile         
            775                 780                 785                 

ctg tcc gac cgg gac aag atc gcc ccc acc ctc gcc gag gcc cgc gac     2509
Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu Ala Glu Ala Arg Asp         
        790                 795                 800                     

cgc ggc ctc ctg ccc gac ttc gac acc tgc cgc aag ctg gag gaa ctg     2557
Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg Lys Leu Glu Glu Leu         
    805                 810                 815                         

ctg tga ccgccaatgc atgctggagg aatcgct gtg acc gcc acc acc gga cag   2611
Leu                                   Val Thr Ala Thr Thr Gly Gln       
820                                                   825               

acc ggg gac acc cga ccc ctg gtg gtc gtc ctc ggc gcc gcc ggc ttc     2659
Thr Gly Asp Thr Arg Pro Leu Val Val Val Leu Gly Ala Ala Gly Phe         
        830                 835                 840                     

gtc ggc tcc gcc gtc ctg cgc gaa ctc gcc cgc cac gac ctg cgg gtg     2707
Val Gly Ser Ala Val Leu Arg Glu Leu Ala Arg His Asp Leu Arg Val         
    845                 850                 855                         

cgg gcc gtc tcc cgg cgc ccg gtg acc gtc ccg gcc ggc gcc cgc gcc     2755
Arg Ala Val Ser Arg Arg Pro Val Thr Val Pro Ala Gly Ala Arg Ala         
860                 865                 870                 875         

gag gtg gag acc cgc agc gtc gac ctc acc gtc ccc ggc gcg atg gcc     2803
Glu Val Glu Thr Arg Ser Val Asp Leu Thr Val Pro Gly Ala Met Ala         
                880                 885                 890             

ggg gcg atc gag ggc gcc gac gtg gtc gtc cac tcg atc gcc tac atc     2851
Gly Ala Ile Glu Gly Ala Asp Val Val Val His Ser Ile Ala Tyr Ile         
            895                 900                 905                 

gcg ggc tcc tcg acc tgg cgc atc acg gac ggc gac acc ggc gcc gag     2899
Ala Gly Ser Ser Thr Trp Arg Ile Thr Asp Gly Asp Thr Gly Ala Glu         
        910                 915                 920                     

cgg gtc aac gtg gga ctc gta cgg gac ctg gtc gag gcc gtg cgg gcg     2947
Arg Val Asn Val Gly Leu Val Arg Asp Leu Val Glu Ala Val Arg Ala         
    925                 930                 935                         

agc ggc cgc ccc gac acc gcc gtc ctg ttc acc ggc tcc gtc tcc gcc     2995
Ser Gly Arg Pro Asp Thr Ala Val Leu Phe Thr Gly Ser Val Ser Ala         
940                 945                 950                 955         

gcc gga ccc tcg gag cgg ggc gtc tac gac ggt acg gag ccg gac gag     3043
Ala Gly Pro Ser Glu Arg Gly Val Tyr Asp Gly Thr Glu Pro Asp Glu         
                960                 965                 970             

ccg cag ggc gag tac gac cgg cag aag ctg gcg gcc gag cgg gtg ctg     3091
Pro Gln Gly Glu Tyr Asp Arg Gln Lys Leu Ala Ala Glu Arg Val Leu         
            975                 980                 985                 

ctc gcg gcg agc gcc gag ggc gtg ctg cgc ggg atc tcg  ctc cgg ctc    3139
Leu Ala Ala Ser Ala Glu Gly Val Leu Arg Gly Ile Ser  Leu Arg Leu        
        990                 995                 1000                    

ccc acg  gtc ttc ggc tac ggc  ccc gac tcg acc gcg  cgg gac aag      3184
Pro Thr  Val Phe Gly Tyr Gly  Pro Asp Ser Thr Ala  Arg Asp Lys          
    1005                 1010                 1015                      

ggc atc  gtc tcc tcg atg gtc  cgc cgg gcg gtg gcg  ggc gag ccg      3229
Gly Ile  Val Ser Ser Met Val  Arg Arg Ala Val Ala  Gly Glu Pro          
    1020                 1025                 1030                      

atc acc  atg tgg cac gac ggc  acg gtc cgc cgc gac  ctg ctg tac      3274
Ile Thr  Met Trp His Asp Gly  Thr Val Arg Arg Asp  Leu Leu Tyr          
    1035                 1040                 1045                      

gtg gag  gac gtg gcg cgc gcc  ttc gcg gcg gcc ctc  ggc cac ctc      3319
Val Glu  Asp Val Ala Arg Ala  Phe Ala Ala Ala Leu  Gly His Leu          
    1050                 1055                 1060                      

gac gcg  ctc gcg gga cgg cac  tgg gtg ctc ggc agc  ggg cac ggc      3364
Asp Ala  Leu Ala Gly Arg His  Trp Val Leu Gly Ser  Gly His Gly          
    1065                 1070                 1075                      

gcc gag  ctc ggc ccg gtc ttc  acc acg gtc gcc cgg  atg gtg gcg      3409
Ala Glu  Leu Gly Pro Val Phe  Thr Thr Val Ala Arg  Met Val Ala          
    1080                 1085                 1090                      

gag cgg  acc ggc aag ccg ccg  gtg gcc gtg cgc tcg  gtg gag ccg      3454
Glu Arg  Thr Gly Lys Pro Pro  Val Ala Val Arg Ser  Val Glu Pro          
    1095                 1100                 1105                      

ccc gcg  cac gcc gag gcc cgg  gac ttc gcc agc gtc  acc gtc gac      3499
Pro Ala  His Ala Glu Ala Arg  Asp Phe Ala Ser Val  Thr Val Asp          
    1110                 1115                 1120                      

ccg cgc  gcc ttc cac gag gtc  acc ggc tgg cgg gcc  gag gtc ccg      3544
Pro Arg  Ala Phe His Glu Val  Thr Gly Trp Arg Ala  Glu Val Pro          
    1125                 1130                 1135                      

ctg gac  gag gcc ctg gac cgg  acg acg gcc ttc agc  gcg agc ggc      3589
Leu Asp  Glu Ala Leu Asp Arg  Thr Thr Ala Phe Ser  Ala Ser Gly          
    1140                 1145                 1150                      

gcg gag  gag cac ttc ggc tga cccactagtt ctaga                       3625
Ala Glu  Glu His Phe Gly                                                
    1155                                                                


<210>  62
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  62

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  63
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  63

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  64
<211>  198
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  64

Met Gln Val Thr Pro Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro 
1               5                   10                  15      


Pro Val Phe Lys Asp Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly 
            20                  25                  30          


Asp Val Phe Ala Gly Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln 
        35                  40                  45              


Val Ser His Asn Leu Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe 
    50                  55                  60                  


Thr Ala Thr Pro Pro Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly 
65                  70                  75                  80  


Arg Leu Arg Asp Phe Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Trp Val Met Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu 
            100                 105                 110         


Tyr Val Pro Val Gly Val Gly His Ala Phe Val Ser Leu Gln Asp Asp 
        115                 120                 125             


Ser Met Cys Val Tyr Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu 
    130                 135                 140                 


Leu Ala Leu Asn Pro Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp 
145                 150                 155                 160 


Asp Val Glu Leu Ile Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu 
                165                 170                 175     


Ala Glu Ala Arg Asp Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg 
            180                 185                 190         


Lys Leu Glu Glu Leu Leu 
        195             


<210>  65
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  65

Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val 
1               5                   10                  15      


Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu 
            20                  25                  30          


Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr 
        35                  40                  45              


Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu 
    50                  55                  60                  


Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val 
65                  70                  75                  80  


Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr 
                85                  90                  95      


Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp 
            100                 105                 110         


Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu 
        115                 120                 125             


Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr 
    130                 135                 140                 


Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys 
145                 150                 155                 160 


Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu 
                165                 170                 175     


Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp 
            180                 185                 190         


Ser Thr Ala Arg Asp Lys Gly Ile Val Ser Ser Met Val Arg Arg Ala 
        195                 200                 205             


Val Ala Gly Glu Pro Ile Thr Met Trp His Asp Gly Thr Val Arg Arg 
    210                 215                 220                 


Asp Leu Leu Tyr Val Glu Asp Val Ala Arg Ala Phe Ala Ala Ala Leu 
225                 230                 235                 240 


Gly His Leu Asp Ala Leu Ala Gly Arg His Trp Val Leu Gly Ser Gly 
                245                 250                 255     


His Gly Ala Glu Leu Gly Pro Val Phe Thr Thr Val Ala Arg Met Val 
            260                 265                 270         


Ala Glu Arg Thr Gly Lys Pro Pro Val Ala Val Arg Ser Val Glu Pro 
        275                 280                 285             


Pro Ala His Ala Glu Ala Arg Asp Phe Ala Ser Val Thr Val Asp Pro 
    290                 295                 300                 


Arg Ala Phe His Glu Val Thr Gly Trp Arg Ala Glu Val Pro Leu Asp 
305                 310                 315                 320 


Glu Ala Leu Asp Arg Thr Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu 
                325                 330                 335     


His Phe Gly 
            


<210>  66
<211>  2583
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1967)..(2563)
<223>  epi gene from S. diversa


<400>  66
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgcggcaa ggagaagtga cgacgacc atg cag gtg acc ccc   1981
                                              Met Gln Val Thr Pro       
                                                      625               

ctg gcc atc gag ggc gcc ttc gcc ttc acg ccc ccc gtc ttc aag gac     2029
Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro Pro Val Phe Lys Asp         
        630                 635                 640                     

agc cgc ggc ctg ttc gcc tcc ccc tac cag ggg gac gtg ttc gcc ggg     2077
Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly Asp Val Phe Ala Gly         
    645                 650                 655                         

cag ctc ggc cgc ccg ctc ttc cag gtc gaa cag gtc agc cac aac ctg     2125
Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln Val Ser His Asn Leu         
660                 665                 670                 675         

tcc gcc agg ggc acc ctc cgc ggc gtc cac ttc acc gcg acc ccg ccg     2173
Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe Thr Ala Thr Pro Pro         
                680                 685                 690             

ggc atg gcg aag tac gtc tac tgc ccg tac ggc agg ctc cgg gac ttc     2221
Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly Arg Leu Arg Asp Phe         
            695                 700                 705                 

ctc atc gac ctc cgg gtc ggc tca ccg acc ttc ggg cag tgg gtg atg     2269
Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe Gly Gln Trp Val Met         
        710                 715                 720                     

aac gaa ctc gac gcg gag acc agc cgc gcc ctc tac gtc ccg gtc ggc     2317
Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu Tyr Val Pro Val Gly         
    725                 730                 735                         

gtc ggc cac gcg ttc gtc tcg ctc cag gac gac tcc atg tgc gtc tac     2365
Val Gly His Ala Phe Val Ser Leu Gln Asp Asp Ser Met Cys Val Tyr         
740                 745                 750                 755         

gtg atg tcg cag ggg tac gtc ccc gcc aac gaa ctg gcc ctg aac ccg     2413
Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu Leu Ala Leu Asn Pro         
                760                 765                 770             

ctc gac ccg gcg ctc gga ctc gac ctg ccg gac gac gtc gag ctg atc     2461
Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp Asp Val Glu Leu Ile         
            775                 780                 785                 

ctg tcc gac cgg gac aag atc gcc ccc acc ctc gcc gag gcc cgc gac     2509
Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu Ala Glu Ala Arg Asp         
        790                 795                 800                     

cgc ggc ctc ctg ccc gac ttc gac acc tgc cgc aag ctg gag gaa ctg     2557
Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg Lys Leu Glu Glu Leu         
    805                 810                 815                         

ctg tga ccgccaatgc tagttctaga                                       2583
Leu                                                                     
820                                                                     


<210>  67
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  67

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  68
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  68

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  69
<211>  198
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  69

Met Gln Val Thr Pro Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro 
1               5                   10                  15      


Pro Val Phe Lys Asp Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly 
            20                  25                  30          


Asp Val Phe Ala Gly Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln 
        35                  40                  45              


Val Ser His Asn Leu Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe 
    50                  55                  60                  


Thr Ala Thr Pro Pro Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly 
65                  70                  75                  80  


Arg Leu Arg Asp Phe Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Trp Val Met Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu 
            100                 105                 110         


Tyr Val Pro Val Gly Val Gly His Ala Phe Val Ser Leu Gln Asp Asp 
        115                 120                 125             


Ser Met Cys Val Tyr Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu 
    130                 135                 140                 


Leu Ala Leu Asn Pro Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp 
145                 150                 155                 160 


Asp Val Glu Leu Ile Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu 
                165                 170                 175     


Ala Glu Ala Arg Asp Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg 
            180                 185                 190         


Lys Leu Glu Glu Leu Leu 
        195             


<210>  70
<211>  3727
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (79)..(948)
<223>  gtt gene from S. diversa


<220>
<221>  CDS
<222>  (1049)..(2017)
<223>  gdh gene from S. diversa


<220>
<221>  CDS
<222>  (2056)..(2664)
<223>  epi gene from S. spinosa


<220>
<221>  CDS
<222>  (2693)..(3712)
<223>  kre gene from S. diversa


<400>  70
ggtctcaagc tttgaaccga ggctccttga acgccgcgcc gcacccggtg aggctgggaa     60

ccccaggagg agagaact gtg aaa ggc atc gtc ctg gcc gga ggc cac ggc      111
                    Val Lys Gly Ile Val Leu Ala Gly Gly His Gly         
                    1               5                   10              

acc cgg ctg cac ccg atc acc ctc ggc acg tcc aag cag atg ctg ccg      159
Thr Arg Leu His Pro Ile Thr Leu Gly Thr Ser Lys Gln Met Leu Pro         
            15                  20                  25                  

gtc tac gac aag ccg atg atc tac tac ccg ctc tcg gtg ctg atg ctc      207
Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu         
        30                  35                  40                      

gcc ggg atc cgg gac atc cag atc atc tcg tcc ccc gac gac atc gag      255
Ala Gly Ile Arg Asp Ile Gln Ile Ile Ser Ser Pro Asp Asp Ile Glu         
    45                  50                  55                          

aac ttc cgc cgg ctg ctc ggc gac ggc tcc ccg ctc ggc atc tcg ctc      303
Asn Phe Arg Arg Leu Leu Gly Asp Gly Ser Pro Leu Gly Ile Ser Leu         
60                  65                  70                  75          

agc tac gcc gtc cag gag cag ccc cgc ggc ctc gcc gag gcc ttc ctc      351
Ser Tyr Ala Val Gln Glu Gln Pro Arg Gly Leu Ala Glu Ala Phe Leu         
                80                  85                  90              

atc tcc gcc gac cac atc ggg gac gac tcc gtc gcc ctc gtc ctc ggc      399
Ile Ser Ala Asp His Ile Gly Asp Asp Ser Val Ala Leu Val Leu Gly         
            95                  100                 105                 

gac aac atc ttc cac ggc ccc ggc ttc gcc gga atc ctc cag gac aag      447
Asp Asn Ile Phe His Gly Pro Gly Phe Ala Gly Ile Leu Gln Asp Lys         
        110                 115                 120                     

gcc gtg gac gtg gac ggc tgc gtg ctc ttc ggc tac ccg gtc cgc gac      495
Ala Val Asp Val Asp Gly Cys Val Leu Phe Gly Tyr Pro Val Arg Asp         
    125                 130                 135                         

ccc gag cgc tac ggc gtc ggc gag gtc gac gcg gac ggc cgg ctg gtc      543
Pro Glu Arg Tyr Gly Val Gly Glu Val Asp Ala Asp Gly Arg Leu Val         
140                 145                 150                 155         

tcc ctg gag gag aag ccg gag cac ccg cgc tcc gac ctc gcc atc acc      591
Ser Leu Glu Glu Lys Pro Glu His Pro Arg Ser Asp Leu Ala Ile Thr         
                160                 165                 170             

ggc ctc tac ttc tac gac aac gac gtc atc gac atc gcc aag aac ctc      639
Gly Leu Tyr Phe Tyr Asp Asn Asp Val Ile Asp Ile Ala Lys Asn Leu         
            175                 180                 185                 

acg ccc tcg gcg cgc ggc gaa ctg gag atc acc gac gtc aac cgg atc      687
Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val Asn Arg Ile         
        190                 195                 200                     

tac ctg gag cgc ggc aag gcc gaa ctg gtg tcc ctg gga cgc ggg ttc      735
Tyr Leu Glu Arg Gly Lys Ala Glu Leu Val Ser Leu Gly Arg Gly Phe         
    205                 210                 215                         

gtc tgg ctc gac gcc gga acg cac gac gcg ctg acc gag gcc ggc cag      783
Val Trp Leu Asp Ala Gly Thr His Asp Ala Leu Thr Glu Ala Gly Gln         
220                 225                 230                 235         

tac gtg cag atc ctg gag cac cgc cag ggc gtc cgg ctc gcc tgc ctc      831
Tyr Val Gln Ile Leu Glu His Arg Gln Gly Val Arg Leu Ala Cys Leu         
                240                 245                 250             

gag gag atc gcc tgg cgc atg ggg ttc atc gac cgg gag gcc tgc ctg      879
Glu Glu Ile Ala Trp Arg Met Gly Phe Ile Asp Arg Glu Ala Cys Leu         
            255                 260                 265                 

cgg ctc ggc gag gag ctc tcg aag tcc ccg tac ggc cag tac gtc atg      927
Arg Leu Gly Glu Glu Leu Ser Lys Ser Pro Tyr Gly Gln Tyr Val Met         
        270                 275                 280                     

gag ata gcc cgg gcc ggc tga cccggccgcc cccaccgccc cgccacgccc         978
Glu Ile Ala Arg Ala Gly                                                 
    285                                                                 

ccgccccgcg gagagagaac catgcgataa gatctctggt ccagctcaac gcgctcctcg   1038

gagggacggc atg agg atc ctc gtc acc ggc ggt gcc ggc ttc atc ggc      1087
           Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly          
           290                 295                 300                  

tcc cac tac gtc cgc tcc ctc ctc gac ggg gcg tac ggc ggc gac ggc     1135
Ser His Tyr Val Arg Ser Leu Leu Asp Gly Ala Tyr Gly Gly Asp Gly         
        305                 310                 315                     

acc gac acc gtc acc gtc ctc gac aag ctg acc tac gcg ggc aac cgg     1183
Thr Asp Thr Val Thr Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Arg         
    320                 325                 330                         

gac aac ctg ccc gcc tcc cac gag cgg ctc acc ttc gtc cgc ggc gac     1231
Asp Asn Leu Pro Ala Ser His Glu Arg Leu Thr Phe Val Arg Gly Asp         
335                 340                 345                 350         

atc tgc gac ctg ccg ctg ctg ctc gac ctc ctc ccc ggg cac gac gcg     1279
Ile Cys Asp Leu Pro Leu Leu Leu Asp Leu Leu Pro Gly His Asp Ala         
                355                 360                 365             

gtc gtc cac ttc gcc gcc gag tcg cac gtc gac cgg tcc ctg gag tcg     1327
Val Val His Phe Ala Ala Glu Ser His Val Asp Arg Ser Leu Glu Ser         
            370                 375                 380                 

gcc gcc gag ttc gtc cgc acc aac gtc ctc ggc acc cag acc gtc ctg     1375
Ala Ala Glu Phe Val Arg Thr Asn Val Leu Gly Thr Gln Thr Val Leu         
        385                 390                 395                     

gag gcc gcg ctg cgc acc ggc gtc cag cgg ctc gtg cac gtc tcc acc     1423
Glu Ala Ala Leu Arg Thr Gly Val Gln Arg Leu Val His Val Ser Thr         
    400                 405                 410                         

gac gag gtg tac ggc acg atc gac gag ggc tcg tgg acc gag gac ttc     1471
Asp Glu Val Tyr Gly Thr Ile Asp Glu Gly Ser Trp Thr Glu Asp Phe         
415                 420                 425                 430         

ccg ctc ctg ccc aac tcc ccg tac gcc gcc tcc aag gcg agc tcg gac     1519
Pro Leu Leu Pro Asn Ser Pro Tyr Ala Ala Ser Lys Ala Ser Ser Asp         
                435                 440                 445             

ctg gtg gcc cgc tcc tac tgg cgc acc cac ggg ctc gac ctg tcg atc     1567
Leu Val Ala Arg Ser Tyr Trp Arg Thr His Gly Leu Asp Leu Ser Ile         
            450                 455                 460                 

acc cgc tgc tcc aac aac tac ggg ccg tac cag cac ccc gag aag ctc     1615
Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln His Pro Glu Lys Leu         
        465                 470                 475                     

atc ccg cgc ttc gtc acc aac ctc ctg gag ggc cac ccg gtg ccg gtc     1663
Ile Pro Arg Phe Val Thr Asn Leu Leu Glu Gly His Pro Val Pro Val         
    480                 485                 490                         

tac ggc gac ggg cgg aac gtc cgc gag tgg ctg cac gtc gac gac cac     1711
Tyr Gly Asp Gly Arg Asn Val Arg Glu Trp Leu His Val Asp Asp His         
495                 500                 505                 510         

tgc cgg gcg atc cac ctg gtg ctc acc acc ggc cgg gcg ggc gag acg     1759
Cys Arg Ala Ile His Leu Val Leu Thr Thr Gly Arg Ala Gly Glu Thr         
                515                 520                 525             

tac aac atc ggc agc ggg aac gag ctc acc aac ctc gac ctg acc gaa     1807
Tyr Asn Ile Gly Ser Gly Asn Glu Leu Thr Asn Leu Asp Leu Thr Glu         
            530                 535                 540                 

cgc atc ctg gac ctc tgc ggc gcc gac cgc tcg atg atc cgg tac gtc     1855
Arg Ile Leu Asp Leu Cys Gly Ala Asp Arg Ser Met Ile Arg Tyr Val         
        545                 550                 555                     

gag gac cgc aag gga cac gac ctg cgg tac tcg ctc tcc gac gcc aag     1903
Glu Asp Arg Lys Gly His Asp Leu Arg Tyr Ser Leu Ser Asp Ala Lys         
    560                 565                 570                         

atc cgc gaa gag ctg ggc tac acg ccc cgg acc tcc ttc gag gac ggc     1951
Ile Arg Glu Glu Leu Gly Tyr Thr Pro Arg Thr Ser Phe Glu Asp Gly         
575                 580                 585                 590         

ctg cgc cgg acc gtc gac tgg tac cgc gac aac ccc cag tgg tgg aag     1999
Leu Arg Arg Thr Val Asp Trp Tyr Arg Asp Asn Pro Gln Trp Trp Lys         
                595                 600                 605             

gcc ggc aag gag aag tga cgacgaccat gcacaattga cgtcataggc tttcggcc   2055
Ala Gly Lys Glu Lys                                                     
            610                                                         

gtg cag gta cgt cga ctt gac atc acg ggt gca tac gag ttc acc ccg     2103
Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro         
            615                 620                 625                 

aag gcc ttc ccc gac cac cgg ggc ctg ttc gtg gcc ccg ttc cag gag     2151
Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu         
        630                 635                 640                     

gcg gcg ttc atc gac gcc acg ggg cac ccg ctg cga gtc gcg cag acc     2199
Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr         
    645                 650                 655                         

aac cac agc gtc tcg gcg cgc aac gtc atc cgc ggc gtg cac ttc tcg     2247
Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser         
660                 665                 670                 675         

gac gtg ccg ccg ggc caa gcg aag tac gtg tac tgc ccg cag ggc gcg     2295
Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala         
                680                 685                 690             

ctg ctc gac gtg gtc atc gac atc cgg gtc ggt tcc ccg acc ttc ggc     2343
Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly         
            695                 700                 705                 

cgc tgg gag gcg gtc cgg ctc gac gac acc gag tac cgg gcc gtc tac     2391
Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr         
        710                 715                 720                     

cta gcc gaa gga ctc ggg cac gcg ttc gcc gcg ctg acc gac gac acc     2439
Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr         
    725                 730                 735                         

gtg atg acc tac ctc tgc tcg acg ccc tac acc ccg ggc gcc gag cac     2487
Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His         
740                 745                 750                 755         

ggc atc gac ccg ttc gac ccg gaa ctc gcg ttg ccg tgg tcc gac ctc     2535
Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu         
                760                 765                 770             

gac ggt gaa ccg gtc ctg tcc gaa aag gac cgg acc gcc ccg agc ctc     2583
Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu         
            775                 780                 785                 

gcg gaa gcc gcc gac aac ggc ctg ctt ccg gac tac gaa aca tgc ctc     2631
Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu         
        790                 795                 800                     

gcc cac tac gaa ggc ctg cgc agc ccc ggc tga acggtcaatg catgctggag   2684
Ala His Tyr Glu Gly Leu Arg Ser Pro Gly                                 
    805                 810                                             

gaatcgct gtg acc gcc acc acc gga cag acc ggg gac acc cga ccc ctg    2734
         Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu        
             815                 820                 825                

gtg gtc gtc ctc ggc gcc gcc ggc ttc gtc ggc tcc gcc gtc ctg cgc     2782
Val Val Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg         
        830                 835                 840                     

gaa ctc gcc cgc cac gac ctg cgg gtg cgg gcc gtc tcc cgg cgc ccg     2830
Glu Leu Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro         
    845                 850                 855                         

gtg acc gtc ccg gcc ggc gcc cgc gcc gag gtg gag acc cgc agc gtc     2878
Val Thr Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val         
860                 865                 870                 875         

gac ctc acc gtc ccc ggc gcg atg gcc ggg gcg atc gag ggc gcc gac     2926
Asp Leu Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp         
                880                 885                 890             

gtg gtc gtc cac tcg atc gcc tac atc gcg ggc tcc tcg acc tgg cgc     2974
Val Val Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg         
            895                 900                 905                 

atc acg gac ggc gac acc ggc gcc gag cgg gtc aac gtg gga ctc gta     3022
Ile Thr Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val         
        910                 915                 920                     

cgg gac ctg gtc gag gcc gtg cgg gcg agc ggc cgc ccc gac acc gcc     3070
Arg Asp Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala         
    925                 930                 935                         

gtc ctg ttc acc ggc tcc gtc tcc gcc gcc gga ccc tcg gag cgg ggc     3118
Val Leu Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly         
940                 945                 950                 955         

gtc tac gac ggt acg gag ccg gac gag ccg cag ggc gag tac gac cgg     3166
Val Tyr Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg         
                960                 965                 970             

cag aag ctg gcg gcc gag cgg gtg ctg ctc gcg gcg agc gcc gag ggc     3214
Gln Lys Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly         
            975                 980                 985                 

gtg ctg cgc ggg atc tcg ctc cgg ctc ccc acg gtc ttc  ggc tac ggc    3262
Val Leu Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe  Gly Tyr Gly        
        990                 995                 1000                    

ccc gac  tcg acc gcg cgg gac  aag ggc atc gtc tcc  tcg atg gtc      3307
Pro Asp  Ser Thr Ala Arg Asp  Lys Gly Ile Val Ser  Ser Met Val          
    1005                 1010                 1015                      

cgc cgg  gcg gtg gcg ggc gag  ccg atc acc atg tgg  cac gac ggc      3352
Arg Arg  Ala Val Ala Gly Glu  Pro Ile Thr Met Trp  His Asp Gly          
    1020                 1025                 1030                      

acg gtc  cgc cgc gac ctg ctg  tac gtg gag gac gtg  gcg cgc gcc      3397
Thr Val  Arg Arg Asp Leu Leu  Tyr Val Glu Asp Val  Ala Arg Ala          
    1035                 1040                 1045                      

ttc gcg  gcg gcc ctc ggc cac  ctc gac gcg ctc gcg  gga cgg cac      3442
Phe Ala  Ala Ala Leu Gly His  Leu Asp Ala Leu Ala  Gly Arg His          
    1050                 1055                 1060                      

tgg gtg  ctc ggc agc ggg cac  ggc gcc gag ctc ggc  ccg gtc ttc      3487
Trp Val  Leu Gly Ser Gly His  Gly Ala Glu Leu Gly  Pro Val Phe          
    1065                 1070                 1075                      

acc acg  gtc gcc cgg atg gtg  gcg gag cgg acc ggc  aag ccg ccg      3532
Thr Thr  Val Ala Arg Met Val  Ala Glu Arg Thr Gly  Lys Pro Pro          
    1080                 1085                 1090                      

gtg gcc  gtg cgc tcg gtg gag  ccg ccc gcg cac gcc  gag gcc cgg      3577
Val Ala  Val Arg Ser Val Glu  Pro Pro Ala His Ala  Glu Ala Arg          
    1095                 1100                 1105                      

gac ttc  gcc agc gtc acc gtc  gac ccg cgc gcc ttc  cac gag gtc      3622
Asp Phe  Ala Ser Val Thr Val  Asp Pro Arg Ala Phe  His Glu Val          
    1110                 1115                 1120                      

acc ggc  tgg cgg gcc gag gtc  ccg ctg gac gag gcc  ctg gac cgg      3667
Thr Gly  Trp Arg Ala Glu Val  Pro Leu Asp Glu Ala  Leu Asp Arg          
    1125                 1130                 1135                      

acg acg  gcc ttc agc gcg agc  ggc gcg gag gag cac  ttc ggc tga      3712
Thr Thr  Ala Phe Ser Ala Ser  Gly Ala Glu Glu His  Phe Gly              
    1140                 1145                 1150                      

cccactagtt ctaga                                                    3727


<210>  71
<211>  289
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  71

Val Lys Gly Ile Val Leu Ala Gly Gly His Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Ile Thr Leu Gly Thr Ser Lys Gln Met Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Ile Gln Ile Ile Ser Ser Pro Asp Asp Ile Glu Asn Phe Arg Arg Leu 
    50                  55                  60                  


Leu Gly Asp Gly Ser Pro Leu Gly Ile Ser Leu Ser Tyr Ala Val Gln 
65                  70                  75                  80  


Glu Gln Pro Arg Gly Leu Ala Glu Ala Phe Leu Ile Ser Ala Asp His 
                85                  90                  95      


Ile Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe His 
            100                 105                 110         


Gly Pro Gly Phe Ala Gly Ile Leu Gln Asp Lys Ala Val Asp Val Asp 
        115                 120                 125             


Gly Cys Val Leu Phe Gly Tyr Pro Val Arg Asp Pro Glu Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Ala Asp Gly Arg Leu Val Ser Leu Glu Glu Lys 
145                 150                 155                 160 


Pro Glu His Pro Arg Ser Asp Leu Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Ile Asp Ile Ala Lys Asn Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Arg Ile Tyr Leu Glu Arg Gly 
        195                 200                 205             


Lys Ala Glu Leu Val Ser Leu Gly Arg Gly Phe Val Trp Leu Asp Ala 
    210                 215                 220                 


Gly Thr His Asp Ala Leu Thr Glu Ala Gly Gln Tyr Val Gln Ile Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Leu Ala Cys Leu Glu Glu Ile Ala Trp 
                245                 250                 255     


Arg Met Gly Phe Ile Asp Arg Glu Ala Cys Leu Arg Leu Gly Glu Glu 
            260                 265                 270         


Leu Ser Lys Ser Pro Tyr Gly Gln Tyr Val Met Glu Ile Ala Arg Ala 
        275                 280                 285             


Gly 
    


<210>  72
<211>  322
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  72

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Ser Leu Leu Asp Gly Ala Tyr Gly Gly Asp Gly Thr Asp Thr 
            20                  25                  30          


Val Thr Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Arg Asp Asn Leu 
        35                  40                  45              


Pro Ala Ser His Glu Arg Leu Thr Phe Val Arg Gly Asp Ile Cys Asp 
    50                  55                  60                  


Leu Pro Leu Leu Leu Asp Leu Leu Pro Gly His Asp Ala Val Val His 
65                  70                  75                  80  


Phe Ala Ala Glu Ser His Val Asp Arg Ser Leu Glu Ser Ala Ala Glu 
                85                  90                  95      


Phe Val Arg Thr Asn Val Leu Gly Thr Gln Thr Val Leu Glu Ala Ala 
            100                 105                 110         


Leu Arg Thr Gly Val Gln Arg Leu Val His Val Ser Thr Asp Glu Val 
        115                 120                 125             


Tyr Gly Thr Ile Asp Glu Gly Ser Trp Thr Glu Asp Phe Pro Leu Leu 
    130                 135                 140                 


Pro Asn Ser Pro Tyr Ala Ala Ser Lys Ala Ser Ser Asp Leu Val Ala 
145                 150                 155                 160 


Arg Ser Tyr Trp Arg Thr His Gly Leu Asp Leu Ser Ile Thr Arg Cys 
                165                 170                 175     


Ser Asn Asn Tyr Gly Pro Tyr Gln His Pro Glu Lys Leu Ile Pro Arg 
            180                 185                 190         


Phe Val Thr Asn Leu Leu Glu Gly His Pro Val Pro Val Tyr Gly Asp 
        195                 200                 205             


Gly Arg Asn Val Arg Glu Trp Leu His Val Asp Asp His Cys Arg Ala 
    210                 215                 220                 


Ile His Leu Val Leu Thr Thr Gly Arg Ala Gly Glu Thr Tyr Asn Ile 
225                 230                 235                 240 


Gly Ser Gly Asn Glu Leu Thr Asn Leu Asp Leu Thr Glu Arg Ile Leu 
                245                 250                 255     


Asp Leu Cys Gly Ala Asp Arg Ser Met Ile Arg Tyr Val Glu Asp Arg 
            260                 265                 270         


Lys Gly His Asp Leu Arg Tyr Ser Leu Ser Asp Ala Lys Ile Arg Glu 
        275                 280                 285             


Glu Leu Gly Tyr Thr Pro Arg Thr Ser Phe Glu Asp Gly Leu Arg Arg 
    290                 295                 300                 


Thr Val Asp Trp Tyr Arg Asp Asn Pro Gln Trp Trp Lys Ala Gly Lys 
305                 310                 315                 320 


Glu Lys 
        


<210>  73
<211>  202
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  73

Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro 
1               5                   10                  15      


Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu 
            20                  25                  30          


Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr 
        35                  40                  45              


Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser 
    50                  55                  60                  


Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala 
65                  70                  75                  80  


Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly 
                85                  90                  95      


Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 
            100                 105                 110         


Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 
        115                 120                 125             


Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 
    130                 135                 140                 


Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 
145                 150                 155                 160 


Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 
                165                 170                 175     


Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 
            180                 185                 190         


Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 
        195                 200         


<210>  74
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  74

Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val 
1               5                   10                  15      


Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu 
            20                  25                  30          


Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr 
        35                  40                  45              


Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu 
    50                  55                  60                  


Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val 
65                  70                  75                  80  


Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr 
                85                  90                  95      


Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp 
            100                 105                 110         


Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu 
        115                 120                 125             


Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr 
    130                 135                 140                 


Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys 
145                 150                 155                 160 


Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu 
                165                 170                 175     


Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp 
            180                 185                 190         


Ser Thr Ala Arg Asp Lys Gly Ile Val Ser Ser Met Val Arg Arg Ala 
        195                 200                 205             


Val Ala Gly Glu Pro Ile Thr Met Trp His Asp Gly Thr Val Arg Arg 
    210                 215                 220                 


Asp Leu Leu Tyr Val Glu Asp Val Ala Arg Ala Phe Ala Ala Ala Leu 
225                 230                 235                 240 


Gly His Leu Asp Ala Leu Ala Gly Arg His Trp Val Leu Gly Ser Gly 
                245                 250                 255     


His Gly Ala Glu Leu Gly Pro Val Phe Thr Thr Val Ala Arg Met Val 
            260                 265                 270         


Ala Glu Arg Thr Gly Lys Pro Pro Val Ala Val Arg Ser Val Glu Pro 
        275                 280                 285             


Pro Ala His Ala Glu Ala Arg Asp Phe Ala Ser Val Thr Val Asp Pro 
    290                 295                 300                 


Arg Ala Phe His Glu Val Thr Gly Trp Arg Ala Glu Val Pro Leu Asp 
305                 310                 315                 320 


Glu Ala Leu Asp Arg Thr Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu 
                325                 330                 335     


His Phe Gly 
            


<210>  75
<211>  6010
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1962)..(2570)
<223>  epi gene from S. spinosa


<220>
<221>  CDS
<222>  (2600)..(3517)
<223>  kre gene from S. spinosa


<220>
<221>  CDS
<222>  (3545)..(4960)
<223>  tdh gene from S. diversa


<220>
<221>  CDS
<222>  (4995)..(5996)
<223>  tkr gene from S. diversa


<400>  75
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgacgtca taggctttcg gcc gtg cag gta cgt cga ctt    1979
                                         Val Gln Val Arg Arg Leu        
                                                 625                    

gac atc acg ggt gca tac gag ttc acc ccg aag gcc ttc ccc gac cac     2027
Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro Lys Ala Phe Pro Asp His         
    630                 635                 640                         

cgg ggc ctg ttc gtg gcc ccg ttc cag gag gcg gcg ttc atc gac gcc     2075
Arg Gly Leu Phe Val Ala Pro Phe Gln Glu Ala Ala Phe Ile Asp Ala         
645                 650                 655                 660         

acg ggg cac ccg ctg cga gtc gcg cag acc aac cac agc gtc tcg gcg     2123
Thr Gly His Pro Leu Arg Val Ala Gln Thr Asn His Ser Val Ser Ala         
                665                 670                 675             

cgc aac gtc atc cgc ggc gtg cac ttc tcg gac gtg ccg ccg ggc caa     2171
Arg Asn Val Ile Arg Gly Val His Phe Ser Asp Val Pro Pro Gly Gln         
            680                 685                 690                 

gcg aag tac gtg tac tgc ccg cag ggc gcg ctg ctc gac gtg gtc atc     2219
Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala Leu Leu Asp Val Val Ile         
        695                 700                 705                     

gac atc cgg gtc ggt tcc ccg acc ttc ggc cgc tgg gag gcg gtc cgg     2267
Asp Ile Arg Val Gly Ser Pro Thr Phe Gly Arg Trp Glu Ala Val Arg         
    710                 715                 720                         

ctc gac gac acc gag tac cgg gcc gtc tac cta gcc gaa gga ctc ggg     2315
Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr Leu Ala Glu Gly Leu Gly         
725                 730                 735                 740         

cac gcg ttc gcc gcg ctg acc gac gac acc gtg atg acc tac ctc tgc     2363
His Ala Phe Ala Ala Leu Thr Asp Asp Thr Val Met Thr Tyr Leu Cys         
                745                 750                 755             

tcg acg ccc tac acc ccg ggc gcc gag cac ggc atc gac ccg ttc gac     2411
Ser Thr Pro Tyr Thr Pro Gly Ala Glu His Gly Ile Asp Pro Phe Asp         
            760                 765                 770                 

ccg gaa ctc gcg ttg ccg tgg tcc gac ctc gac ggt gaa ccg gtc ctg     2459
Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu Asp Gly Glu Pro Val Leu         
        775                 780                 785                     

tcc gaa aag gac cgg acc gcc ccg agc ctc gcg gaa gcc gcc gac aac     2507
Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu Ala Glu Ala Ala Asp Asn         
    790                 795                 800                         

ggc ctg ctt ccg gac tac gaa aca tgc ctc gcc cac tac gaa ggc ctg     2555
Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu Ala His Tyr Glu Gly Leu         
805                 810                 815                 820         

cgc agc ccc ggc tga acggtcaatg catgatcggc ggtggctcg atg agt cgc     2608
Arg Ser Pro Gly                                     Met Ser Arg         
                                                    825                 

ctc gcc gtg ctg gtg ccc ggc ggc cgc ggc cag ctg ggc tcg gag ctg     2656
Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly Ser Glu Leu         
        830                 835                 840                     

gcc cgg atc ctc gcc gcg cgg acg ggg gcg ctg gtg cac cgg ccg ggt     2704
Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His Arg Pro Gly         
    845                 850                 855                         

tcc ggg gaa ctg gac gtc acc gac gcc gag gag gtc gcc gac gcg ttg     2752
Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala Asp Ala Leu         
860                 865                 870                 875         

ggt tcc ttc gcg gag acg gcg aag gac gcg gag ctg cga ccg gtg gtg     2800
Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg Pro Val Val         
                880                 885                 890             

atc aac gcc gcg gcg tac acg gcg gtg gac gcg gcc gag tcc gac ccg     2848
Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu Ser Asp Pro         
            895                 900                 905                 

gac cgc gcg gcc cgg atc aac gcc gaa ggc gcg gcc tcg ctg gcg aaa     2896
Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser Leu Ala Lys         
        910                 915                 920                     

gcg tgc cgg agc agc ggt ctg ccc ctg gtg cac gtg tcg acg gat tac     2944
Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser Thr Asp Tyr         
    925                 930                 935                         

gtg ttc ccc ggt gat ggg gcc cgg ccg tac gag ccg acg gac ccg acc     2992
Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr Asp Pro Thr         
940                 945                 950                 955         

ggg ccg cga tcg gtc tac ggg cgc acc aag ctc gaa ggc gaa cgg gcc     3040
Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly Glu Arg Ala         
                960                 965                 970             

gtg ctg gag tcc ggc gcg cgg gcc tgg gtg gtg cgc acg gca tgg gtg     3088
Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr Ala Trp Val         
            975                 980                 985                 

tac ggc gcg agc ggc aag aac ttc ctg aaa acg atg atc  cgc ctc tcg    3136
Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile  Arg Leu Ser        
        990                 995                 1000                    

ggg gag  cgc gac acg ctg tcc  gtt gtg gac gat cag  atc ggc tcg      3181
Gly Glu  Arg Asp Thr Leu Ser  Val Val Asp Asp Gln  Ile Gly Ser          
    1005                 1010                 1015                      

ccg act  tgg gcg gcg gac ctg  gcg agc ggc ctg ctg  gag ctg gcc      3226
Pro Thr  Trp Ala Ala Asp Leu  Ala Ser Gly Leu Leu  Glu Leu Ala          
    1020                 1025                 1030                      

gaa cgg  gtc gcc gaa cgc cgt  gga ccg gag cag aag  gtg ctg cac      3271
Glu Arg  Val Ala Glu Arg Arg  Gly Pro Glu Gln Lys  Val Leu His          
    1035                 1040                 1045                      

tgc acc  aat tcc ggc cag gtg  acc tgg tac gag ttc  gcg cgg gcg      3316
Cys Thr  Asn Ser Gly Gln Val  Thr Trp Tyr Glu Phe  Ala Arg Ala          
    1050                 1055                 1060                      

atc ttc  gcg gaa ttc ggc ctg  gac gag aac cgc gtc  cac ccg tgc      3361
Ile Phe  Ala Glu Phe Gly Leu  Asp Glu Asn Arg Val  His Pro Cys          
    1065                 1070                 1075                      

acg acg  gcg gac ttc ccc ctc  ccg gcg cac cgc ccg  gcc tac tcg      3406
Thr Thr  Ala Asp Phe Pro Leu  Pro Ala His Arg Pro  Ala Tyr Ser          
    1080                 1085                 1090                      

gtc ctg  tcc gac gtg gcg tgg  cga gag gcg ggc ctg  acc ccg atg      3451
Val Leu  Ser Asp Val Ala Trp  Arg Glu Ala Gly Leu  Thr Pro Met          
    1095                 1100                 1105                      

cgc acc  tgg cgg gaa gcc ctg  gcg gcg gcc ttc gag  aaa gac ggc      3496
Arg Thr  Trp Arg Glu Ala Leu  Ala Ala Ala Phe Glu  Lys Asp Gly          
    1110                 1115                 1120                      

gaa acc  ctc cga acc cgc tga ccagtcacta gtggagggcc actcctg atg      3547
Glu Thr  Leu Arg Thr Arg                                   Met          
    1125                                                   1130         

agc acc gcc acc acc  acg ccc gcc ccc gcc  ctc acc gcc cgc cgg       3592
Ser Thr Ala Thr Thr  Thr Pro Ala Pro Ala  Leu Thr Ala Arg Arg           
                1135                 1140                 1145          

ccc gcc ggg ctc gcc  gag cgg atc gcc cgc  tcg gcc gcc acc ggc       3637
Pro Ala Gly Leu Ala  Glu Arg Ile Ala Arg  Ser Ala Ala Thr Gly           
                1150                 1155                 1160          

cgc ggc gcc cac ctg  gcc acc gag gac ttc  cac gac tgg ctc gac       3682
Arg Gly Ala His Leu  Ala Thr Glu Asp Phe  His Asp Trp Leu Asp           
                1165                 1170                 1175          

ggc cgc cgc cgc gcc  aac acc ttc cgc gtc  gac aag atc ccc ttc       3727
Gly Arg Arg Arg Ala  Asn Thr Phe Arg Val  Asp Lys Ile Pro Phe           
                1180                 1185                 1190          

gac gcg ctc gac ggc  tgg tcc ttc gac gag  gag gac ggc aac ctc       3772
Asp Ala Leu Asp Gly  Trp Ser Phe Asp Glu  Glu Asp Gly Asn Leu           
                1195                 1200                 1205          

gtc cac cgc agc ggc  cgc ttc ttc acc gtc  gag ggc ctg cac gtc       3817
Val His Arg Ser Gly  Arg Phe Phe Thr Val  Glu Gly Leu His Val           
                1210                 1215                 1220          

gtc gag gag gac gga  ccc tac ggc gac ggc  ccg tac cgc tcc tgg       3862
Val Glu Glu Asp Gly  Pro Tyr Gly Asp Gly  Pro Tyr Arg Ser Trp           
                1225                 1230                 1235          

tac cag ccc gtc atc  aag cag ccc gag gtc  ggc atc ctc ggc atc       3907
Tyr Gln Pro Val Ile  Lys Gln Pro Glu Val  Gly Ile Leu Gly Ile           
                1240                 1245                 1250          

ctc gcc aag gag ttc  gac ggc gtc ctg cac  ttc ctc atg cag gcc       3952
Leu Ala Lys Glu Phe  Asp Gly Val Leu His  Phe Leu Met Gln Ala           
                1255                 1260                 1265          

aag atg gag ccc ggc  aac ccg aac ctg ctc  cag ctg tcg ccg acc       3997
Lys Met Glu Pro Gly  Asn Pro Asn Leu Leu  Gln Leu Ser Pro Thr           
                1270                 1275                 1280          

gtc cag gcc acc cgc  agc aac tac acc aag  gcg cac cgc ggc ggc       4042
Val Gln Ala Thr Arg  Ser Asn Tyr Thr Lys  Ala His Arg Gly Gly           
                1285                 1290                 1295          

gac gtg aag tac atc  gag tac ttc acc ggc  gcc gaa cac ggc acc       4087
Asp Val Lys Tyr Ile  Glu Tyr Phe Thr Gly  Ala Glu His Gly Thr           
                1300                 1305                 1310          

gtc atc gcc gac tcc  ctc cag tcc gag cac  ggc gcc tgg ttc ttc       4132
Val Ile Ala Asp Ser  Leu Gln Ser Glu His  Gly Ala Trp Phe Phe           
                1315                 1320                 1325          

cac aag tcc aac cgc  aac atg atc gtc gag  gcc acc ggc gag gtc       4177
His Lys Ser Asn Arg  Asn Met Ile Val Glu  Ala Thr Gly Glu Val           
                1330                 1335                 1340          

ccg ctc ctc gac gac  ttc tgc tgg ctc acc  ctc ggc cag ctc ggc       4222
Pro Leu Leu Asp Asp  Phe Cys Trp Leu Thr  Leu Gly Gln Leu Gly           
                1345                 1350                 1355          

gag ctc ctc cac cag  gac aac gtc atc aac  atg gac gcc agg acc       4267
Glu Leu Leu His Gln  Asp Asn Val Ile Asn  Met Asp Ala Arg Thr           
                1360                 1365                 1370          

gtc ctg tcc tgc gtg  ccg tac gag gac gcc  gac gcc ggg cgg gcg       4312
Val Leu Ser Cys Val  Pro Tyr Glu Asp Ala  Asp Ala Gly Arg Ala           
                1375                 1380                 1385          

ctg ctc tcc gac gtc  cag ctg ctc tcc tgg  ttc acc ggc gag cgc       4357
Leu Leu Ser Asp Val  Gln Leu Leu Ser Trp  Phe Thr Gly Glu Arg           
                1390                 1395                 1400          

tcc cgc cac gac gta  cgg gcc cgg cgc gtc  ccg ctg cgc gag ctg       4402
Ser Arg His Asp Val  Arg Ala Arg Arg Val  Pro Leu Arg Glu Leu           
                1405                 1410                 1415          

ccc ggc tgg aag cag  ggc gag gag acc atc  gag cac gag gag ggc       4447
Pro Gly Trp Lys Gln  Gly Glu Glu Thr Ile  Glu His Glu Glu Gly           
                1420                 1425                 1430          

cgg cac ttc aag gtc  gtc gcc gtc tcc gtg  cag gcc ggg aac cgc       4492
Arg His Phe Lys Val  Val Ala Val Ser Val  Gln Ala Gly Asn Arg           
                1435                 1440                 1445          

gaa gtg acc agc tgg  acc cag ccg ctg atc  gaa ccg gtc gga ctc       4537
Glu Val Thr Ser Trp  Thr Gln Pro Leu Ile  Glu Pro Val Gly Leu           
                1450                 1455                 1460          

ggc gtc gcc gcc ttc  ctg acc cgc gac ttc  gac ggc gtc ccg cac       4582
Gly Val Ala Ala Phe  Leu Thr Arg Asp Phe  Asp Gly Val Pro His           
                1465                 1470                 1475          

tac ctg gtg cac gcc  cgc gtc gag ggc ggc  ttc ctc gac acc gtg       4627
Tyr Leu Val His Ala  Arg Val Glu Gly Gly  Phe Leu Asp Thr Val           
                1480                 1485                 1490          

gaa ctg gcc ccc acc  gtc cag tac acc ccg  ggc aac tac gcc cac       4672
Glu Leu Ala Pro Thr  Val Gln Tyr Thr Pro  Gly Asn Tyr Ala His           
                1495                 1500                 1505          

ctg ccg acc gac gag  cgc ccg ccc ttc ctc  gac ctc gtc ctc gac       4717
Leu Pro Thr Asp Glu  Arg Pro Pro Phe Leu  Asp Leu Val Leu Asp           
                1510                 1515                 1520          

acc gac ccc gcc cgc  gtc cgc tac gag gcc  gtg cac tcc gag gaa       4762
Thr Asp Pro Ala Arg  Val Arg Tyr Glu Ala  Val His Ser Glu Glu           
                1525                 1530                 1535          

ggc ggc cgc ttc ctc  aac gcc gag agc cgc  tac ctc ctg gtg gag       4807
Gly Gly Arg Phe Leu  Asn Ala Glu Ser Arg  Tyr Leu Leu Val Glu           
                1540                 1545                 1550          

gcc gac gag acg cag  gcc ccg gcc gac ccg  ccg ccc ggc tac gcc       4852
Ala Asp Glu Thr Gln  Ala Pro Ala Asp Pro  Pro Pro Gly Tyr Ala           
                1555                 1560                 1565          

tgg gcg acc gcc gca  cag ctc acc tcc ctc  acc cgg cac ggc cac       4897
Trp Ala Thr Ala Ala  Gln Leu Thr Ser Leu  Thr Arg His Gly His           
                1570                 1575                 1580          

tac ctc aac gtc cag  gcc cgc acc ctg ctg  gcc tgc gtc cac gcc       4942
Tyr Leu Asn Val Gln  Ala Arg Thr Leu Leu  Ala Cys Val His Ala           
                1585                 1590                 1595          

ggg gcg gtg cgg cct  tga cgagcacccc ggcgcatatg ggggaggtgc ggcc      4994
Gly Ala Val Arg Pro                                                     
                1600                                                    

ttg acg agc acc ccg  gcg ccc ctg cgg atc  ggt gtg ctc ggc tgc       5039
Leu Thr Ser Thr Pro  Ala Pro Leu Arg Ile  Gly Val Leu Gly Cys           
                1605                 1610                 1615          

gcc gac atc gcc gtc  cgg cgc atg atg ccc  gcg atg gcc gcg ctc       5084
Ala Asp Ile Ala Val  Arg Arg Met Met Pro  Ala Met Ala Ala Leu           
                1620                 1625                 1630          

ccc ggg acc gag gtc  acc gcc gtc gcc agc  cgc gac gcg gcg aag       5129
Pro Gly Thr Glu Val  Thr Ala Val Ala Ser  Arg Asp Ala Ala Lys           
                1635                 1640                 1645          

gcc gcc gtg gcc gcc  gcc ccg tac ggc gcg  gcg gcc gtc gag ggc       5174
Ala Ala Val Ala Ala  Ala Pro Tyr Gly Ala  Ala Ala Val Glu Gly           
                1650                 1655                 1660          

tac cag gag ctg ctg  cgc cgc ccg gac gtc  gac gcc gtc tac gta       5219
Tyr Gln Glu Leu Leu  Arg Arg Pro Asp Val  Asp Ala Val Tyr Val           
                1665                 1670                 1675          

ccg ctg ccc gcc gcc  ctg cac gcc gag tgg  acc gag gcc gcc ctg       5264
Pro Leu Pro Ala Ala  Leu His Ala Glu Trp  Thr Glu Ala Ala Leu           
                1680                 1685                 1690          

cgg gcc ggc aag cac  gtc ctg gcc gag aag  ccg ctc acc acg gac       5309
Arg Ala Gly Lys His  Val Leu Ala Glu Lys  Pro Leu Thr Thr Asp           
                1695                 1700                 1705          

ccg gag agc acc gcc  gcg ctg ctc ggc ctg  gcc gcc gcg tcc ggg       5354
Pro Glu Ser Thr Ala  Ala Leu Leu Gly Leu  Ala Ala Ala Ser Gly           
                1710                 1715                 1720          

ctc gcg ctg atg gag  aac gtc atg ttc gtc  cac cac cgc ctc cac       5399
Leu Ala Leu Met Glu  Asn Val Met Phe Val  His His Arg Leu His           
                1725                 1730                 1735          

acc gac gtc cgc aag  ctc gtc gcg gac gga  gcc atc ggc gaa ctc       5444
Thr Asp Val Arg Lys  Leu Val Ala Asp Gly  Ala Ile Gly Glu Leu           
                1740                 1745                 1750          

cgc gcc ctg cac gcc  tcg ttc ggc atc ccc  cgg ctg ccc gac acc       5489
Arg Ala Leu His Ala  Ser Phe Gly Ile Pro  Arg Leu Pro Asp Thr           
                1755                 1760                 1765          

gac atc cgg cac gac  ccc ggg ctc ggc ggc  ggc gcc ctc ggc gac       5534
Asp Ile Arg His Asp  Pro Gly Leu Gly Gly  Gly Ala Leu Gly Asp           
                1770                 1775                 1780          

gtc ggc gtc tac ccg  ctg cga gcc gcc cag  cac ctg ctc ggc gac       5579
Val Gly Val Tyr Pro  Leu Arg Ala Ala Gln  His Leu Leu Gly Asp           
                1785                 1790                 1795          

gaa ctc gac gtc ctc  ggc gcg cac ctc gtc  cgg ggg ccc ggc agc       5624
Glu Leu Asp Val Leu  Gly Ala His Leu Val  Arg Gly Pro Gly Ser           
                1800                 1805                 1810          

cgg gtc gag acc gcc  ggc ggg gcg ctg ctc  gcc acc ccg gcg ggc       5669
Arg Val Glu Thr Ala  Gly Gly Ala Leu Leu  Ala Thr Pro Ala Gly           
                1815                 1820                 1825          

gtc acc gcg cac atc  gcc ttc ggc atg gac  cac ggc tac cgc tcg       5714
Val Thr Ala His Ile  Ala Phe Gly Met Asp  His Gly Tyr Arg Ser           
                1830                 1835                 1840          

gcg tac gag ctg tgg  ggc agc cag ggc cgg  ctc gtc gtc gag cgg       5759
Ala Tyr Glu Leu Trp  Gly Ser Gln Gly Arg  Leu Val Val Glu Arg           
                1845                 1850                 1855          

gcc tac acc ccg ccc  gcc gac cac cgc ccg  gtg gtg cgc ctg gag       5804
Ala Tyr Thr Pro Pro  Ala Asp His Arg Pro  Val Val Arg Leu Glu           
                1860                 1865                 1870          

acc cgc acc ggc gtc  gag gag ctc gtc ctc  gac gcc gac gac cag       5849
Thr Arg Thr Gly Val  Glu Glu Leu Val Leu  Asp Ala Asp Asp Gln           
                1875                 1880                 1885          

gtc cgc aac acg gtg  gcc gcc ttc gcc gcc  ctc gtg gcg cgc acc       5894
Val Arg Asn Thr Val  Ala Ala Phe Ala Ala  Leu Val Ala Arg Thr           
                1890                 1895                 1900          

gga gcc ggc cac ccc  ggg gac ggc ggc gcg  ccc gac ccg gag gcc       5939
Gly Ala Gly His Pro  Gly Asp Gly Gly Ala  Pro Asp Pro Glu Ala           
                1905                 1910                 1915          

ccg ctg cgc cag gcg  cgg ctg ctc gac gcc  gtg cgg cgc cgg gcc       5984
Pro Leu Arg Gln Ala  Arg Leu Leu Asp Ala  Val Arg Arg Arg Ala           
                1920                 1925                 1930          

gcc ctc gtc tga cccgcgcctc taga                                     6010
Ala Leu Val                                                             
                                                                        


<210>  76
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  76

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  77
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  77

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  78
<211>  202
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  78

Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro 
1               5                   10                  15      


Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu 
            20                  25                  30          


Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr 
        35                  40                  45              


Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser 
    50                  55                  60                  


Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala 
65                  70                  75                  80  


Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly 
                85                  90                  95      


Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 
            100                 105                 110         


Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 
        115                 120                 125             


Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 
    130                 135                 140                 


Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 
145                 150                 155                 160 


Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 
                165                 170                 175     


Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 
            180                 185                 190         


Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 
        195                 200         


<210>  79
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  79

Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly 
1               5                   10                  15      


Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His 
            20                  25                  30          


Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala 
        35                  40                  45              


Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg 
    50                  55                  60                  


Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu 
65                  70                  75                  80  


Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser 
                85                  90                  95      


Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser 
            100                 105                 110         


Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr 
        115                 120                 125             


Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly 
    130                 135                 140                 


Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr 
145                 150                 155                 160 


Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile 
                165                 170                 175     


Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asp Gln Ile 
            180                 185                 190         


Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu 
        195                 200                 205             


Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gln Lys Val Leu His 
    210                 215                 220                 


Cys Thr Asn Ser Gly Gln Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile 
225                 230                 235                 240 


Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr 
                245                 250                 255     


Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser 
            260                 265                 270         


Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg 
        275                 280                 285             


Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr 
    290                 295                 300                 


Arg 
305 


<210>  80
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  80

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  81
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  81

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  82
<211>  6108
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1962)..(2570)
<223>  epi gene from S. spinosa


<220>
<221>  CDS
<222>  (2599)..(3618)
<223>  kre gene from S. diversa


<220>
<221>  CDS
<222>  (3643)..(5058)
<223>  tdh gene from S. diversa


<220>
<221>  CDS
<222>  (5093)..(6094)
<223>  tkr gene from S. diversa


<400>  82
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgacgtca taggctttcg gcc gtg cag gta cgt cga ctt    1979
                                         Val Gln Val Arg Arg Leu        
                                                 625                    

gac atc acg ggt gca tac gag ttc acc ccg aag gcc ttc ccc gac cac     2027
Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro Lys Ala Phe Pro Asp His         
    630                 635                 640                         

cgg ggc ctg ttc gtg gcc ccg ttc cag gag gcg gcg ttc atc gac gcc     2075
Arg Gly Leu Phe Val Ala Pro Phe Gln Glu Ala Ala Phe Ile Asp Ala         
645                 650                 655                 660         

acg ggg cac ccg ctg cga gtc gcg cag acc aac cac agc gtc tcg gcg     2123
Thr Gly His Pro Leu Arg Val Ala Gln Thr Asn His Ser Val Ser Ala         
                665                 670                 675             

cgc aac gtc atc cgc ggc gtg cac ttc tcg gac gtg ccg ccg ggc caa     2171
Arg Asn Val Ile Arg Gly Val His Phe Ser Asp Val Pro Pro Gly Gln         
            680                 685                 690                 

gcg aag tac gtg tac tgc ccg cag ggc gcg ctg ctc gac gtg gtc atc     2219
Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala Leu Leu Asp Val Val Ile         
        695                 700                 705                     

gac atc cgg gtc ggt tcc ccg acc ttc ggc cgc tgg gag gcg gtc cgg     2267
Asp Ile Arg Val Gly Ser Pro Thr Phe Gly Arg Trp Glu Ala Val Arg         
    710                 715                 720                         

ctc gac gac acc gag tac cgg gcc gtc tac cta gcc gaa gga ctc ggg     2315
Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr Leu Ala Glu Gly Leu Gly         
725                 730                 735                 740         

cac gcg ttc gcc gcg ctg acc gac gac acc gtg atg acc tac ctc tgc     2363
His Ala Phe Ala Ala Leu Thr Asp Asp Thr Val Met Thr Tyr Leu Cys         
                745                 750                 755             

tcg acg ccc tac acc ccg ggc gcc gag cac ggc atc gac ccg ttc gac     2411
Ser Thr Pro Tyr Thr Pro Gly Ala Glu His Gly Ile Asp Pro Phe Asp         
            760                 765                 770                 

ccg gaa ctc gcg ttg ccg tgg tcc gac ctc gac ggt gaa ccg gtc ctg     2459
Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu Asp Gly Glu Pro Val Leu         
        775                 780                 785                     

tcc gaa aag gac cgg acc gcc ccg agc ctc gcg gaa gcc gcc gac aac     2507
Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu Ala Glu Ala Ala Asp Asn         
    790                 795                 800                         

ggc ctg ctt ccg gac tac gaa aca tgc ctc gcc cac tac gaa ggc ctg     2555
Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu Ala His Tyr Glu Gly Leu         
805                 810                 815                 820         

cgc agc ccc ggc tga acggtcaatg catgctggag gaatcgct gtg acc gcc      2607
Arg Ser Pro Gly                                    Val Thr Ala          
                                                   825                  

acc acc gga cag acc ggg gac acc cga ccc ctg gtg gtc gtc ctc ggc     2655
Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val Val Leu Gly         
        830                 835                 840                     

gcc gcc ggc ttc gtc ggc tcc gcc gtc ctg cgc gaa ctc gcc cgc cac     2703
Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu Ala Arg His         
    845                 850                 855                         

gac ctg cgg gtg cgg gcc gtc tcc cgg cgc ccg gtg acc gtc ccg gcc     2751
Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr Val Pro Ala         
860                 865                 870                 875         

ggc gcc cgc gcc gag gtg gag acc cgc agc gtc gac ctc acc gtc ccc     2799
Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu Thr Val Pro         
                880                 885                 890             

ggc gcg atg gcc ggg gcg atc gag ggc gcc gac gtg gtc gtc cac tcg     2847
Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val Val His Ser         
            895                 900                 905                 

atc gcc tac atc gcg ggc tcc tcg acc tgg cgc atc acg gac ggc gac     2895
Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr Asp Gly Asp         
        910                 915                 920                     

acc ggc gcc gag cgg gtc aac gtg gga ctc gta cgg gac ctg gtc gag     2943
Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp Leu Val Glu         
    925                 930                 935                         

gcc gtg cgg gcg agc ggc cgc ccc gac acc gcc gtc ctg ttc acc ggc     2991
Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu Phe Thr Gly         
940                 945                 950                 955         

tcc gtc tcc gcc gcc gga ccc tcg gag cgg ggc gtc tac gac ggt acg     3039
Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr Asp Gly Thr         
                960                 965                 970             

gag ccg gac gag ccg cag ggc gag tac gac cgg cag aag ctg gcg gcc     3087
Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys Leu Ala Ala         
            975                 980                 985                 

gag cgg gtg ctg ctc gcg gcg agc gcc gag ggc gtg ctg  cgc ggg atc    3135
Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu  Arg Gly Ile        
        990                 995                 1000                    

tcg ctc  cgg ctc ccc acg gtc  ttc ggc tac ggc ccc  gac tcg acc      3180
Ser Leu  Arg Leu Pro Thr Val  Phe Gly Tyr Gly Pro  Asp Ser Thr          
    1005                 1010                 1015                      

gcg cgg  gac aag ggc atc gtc  tcc tcg atg gtc cgc  cgg gcg gtg      3225
Ala Arg  Asp Lys Gly Ile Val  Ser Ser Met Val Arg  Arg Ala Val          
    1020                 1025                 1030                      

gcg ggc  gag ccg atc acc atg  tgg cac gac ggc acg  gtc cgc cgc      3270
Ala Gly  Glu Pro Ile Thr Met  Trp His Asp Gly Thr  Val Arg Arg          
    1035                 1040                 1045                      

gac ctg  ctg tac gtg gag gac  gtg gcg cgc gcc ttc  gcg gcg gcc      3315
Asp Leu  Leu Tyr Val Glu Asp  Val Ala Arg Ala Phe  Ala Ala Ala          
    1050                 1055                 1060                      

ctc ggc  cac ctc gac gcg ctc  gcg gga cgg cac tgg  gtg ctc ggc      3360
Leu Gly  His Leu Asp Ala Leu  Ala Gly Arg His Trp  Val Leu Gly          
    1065                 1070                 1075                      

agc ggg  cac ggc gcc gag ctc  ggc ccg gtc ttc acc  acg gtc gcc      3405
Ser Gly  His Gly Ala Glu Leu  Gly Pro Val Phe Thr  Thr Val Ala          
    1080                 1085                 1090                      

cgg atg  gtg gcg gag cgg acc  ggc aag ccg ccg gtg  gcc gtg cgc      3450
Arg Met  Val Ala Glu Arg Thr  Gly Lys Pro Pro Val  Ala Val Arg          
    1095                 1100                 1105                      

tcg gtg  gag ccg ccc gcg cac  gcc gag gcc cgg gac  ttc gcc agc      3495
Ser Val  Glu Pro Pro Ala His  Ala Glu Ala Arg Asp  Phe Ala Ser          
    1110                 1115                 1120                      

gtc acc  gtc gac ccg cgc gcc  ttc cac gag gtc acc  ggc tgg cgg      3540
Val Thr  Val Asp Pro Arg Ala  Phe His Glu Val Thr  Gly Trp Arg          
    1125                 1130                 1135                      

gcc gag  gtc ccg ctg gac gag  gcc ctg gac cgg acg  acg gcc ttc      3585
Ala Glu  Val Pro Leu Asp Glu  Ala Leu Asp Arg Thr  Thr Ala Phe          
    1140                 1145                 1150                      

agc gcg  agc ggc gcg gag gag  cac ttc ggc tga cccactagtg            3628
Ser Ala  Ser Gly Ala Glu Glu  His Phe Gly                               
    1155                 1160                                           

gagggccact cctg atg agc  acc gcc acc acc acg  ccc gcc ccc gcc       3675
                Met Ser  Thr Ala Thr Thr Thr  Pro Ala Pro Ala           
                    1165                 1170                           

ctc  acc gcc cgc cgg ccc  gcc ggg ctc gcc gag  cgg atc gcc cgc      3720
Leu  Thr Ala Arg Arg Pro  Ala Gly Leu Ala Glu  Arg Ile Ala Arg          
1175                 1180                 1185                          

tcg  gcc gcc acc ggc cgc  ggc gcc cac ctg gcc  acc gag gac ttc      3765
Ser  Ala Ala Thr Gly Arg  Gly Ala His Leu Ala  Thr Glu Asp Phe          
1190                 1195                 1200                          

cac  gac tgg ctc gac ggc  cgc cgc cgc gcc aac  acc ttc cgc gtc      3810
His  Asp Trp Leu Asp Gly  Arg Arg Arg Ala Asn  Thr Phe Arg Val          
1205                 1210                 1215                          

gac  aag atc ccc ttc gac  gcg ctc gac ggc tgg  tcc ttc gac gag      3855
Asp  Lys Ile Pro Phe Asp  Ala Leu Asp Gly Trp  Ser Phe Asp Glu          
1220                 1225                 1230                          

gag  gac ggc aac ctc gtc  cac cgc agc ggc cgc  ttc ttc acc gtc      3900
Glu  Asp Gly Asn Leu Val  His Arg Ser Gly Arg  Phe Phe Thr Val          
1235                 1240                 1245                          

gag  ggc ctg cac gtc gtc  gag gag gac gga ccc  tac ggc gac ggc      3945
Glu  Gly Leu His Val Val  Glu Glu Asp Gly Pro  Tyr Gly Asp Gly          
1250                 1255                 1260                          

ccg  tac cgc tcc tgg tac  cag ccc gtc atc aag  cag ccc gag gtc      3990
Pro  Tyr Arg Ser Trp Tyr  Gln Pro Val Ile Lys  Gln Pro Glu Val          
1265                 1270                 1275                          

ggc  atc ctc ggc atc ctc  gcc aag gag ttc gac  ggc gtc ctg cac      4035
Gly  Ile Leu Gly Ile Leu  Ala Lys Glu Phe Asp  Gly Val Leu His          
1280                 1285                 1290                          

ttc  ctc atg cag gcc aag  atg gag ccc ggc aac  ccg aac ctg ctc      4080
Phe  Leu Met Gln Ala Lys  Met Glu Pro Gly Asn  Pro Asn Leu Leu          
1295                 1300                 1305                          

cag  ctg tcg ccg acc gtc  cag gcc acc cgc agc  aac tac acc aag      4125
Gln  Leu Ser Pro Thr Val  Gln Ala Thr Arg Ser  Asn Tyr Thr Lys          
1310                 1315                 1320                          

gcg  cac cgc ggc ggc gac  gtg aag tac atc gag  tac ttc acc ggc      4170
Ala  His Arg Gly Gly Asp  Val Lys Tyr Ile Glu  Tyr Phe Thr Gly          
1325                 1330                 1335                          

gcc  gaa cac ggc acc gtc  atc gcc gac tcc ctc  cag tcc gag cac      4215
Ala  Glu His Gly Thr Val  Ile Ala Asp Ser Leu  Gln Ser Glu His          
1340                 1345                 1350                          

ggc  gcc tgg ttc ttc cac  aag tcc aac cgc aac  atg atc gtc gag      4260
Gly  Ala Trp Phe Phe His  Lys Ser Asn Arg Asn  Met Ile Val Glu          
1355                 1360                 1365                          

gcc  acc ggc gag gtc ccg  ctc ctc gac gac ttc  tgc tgg ctc acc      4305
Ala  Thr Gly Glu Val Pro  Leu Leu Asp Asp Phe  Cys Trp Leu Thr          
1370                 1375                 1380                          

ctc  ggc cag ctc ggc gag  ctc ctc cac cag gac  aac gtc atc aac      4350
Leu  Gly Gln Leu Gly Glu  Leu Leu His Gln Asp  Asn Val Ile Asn          
1385                 1390                 1395                          

atg  gac gcc agg acc gtc  ctg tcc tgc gtg ccg  tac gag gac gcc      4395
Met  Asp Ala Arg Thr Val  Leu Ser Cys Val Pro  Tyr Glu Asp Ala          
1400                 1405                 1410                          

gac  gcc ggg cgg gcg ctg  ctc tcc gac gtc cag  ctg ctc tcc tgg      4440
Asp  Ala Gly Arg Ala Leu  Leu Ser Asp Val Gln  Leu Leu Ser Trp          
1415                 1420                 1425                          

ttc  acc ggc gag cgc tcc  cgc cac gac gta cgg  gcc cgg cgc gtc      4485
Phe  Thr Gly Glu Arg Ser  Arg His Asp Val Arg  Ala Arg Arg Val          
1430                 1435                 1440                          

ccg  ctg cgc gag ctg ccc  ggc tgg aag cag ggc  gag gag acc atc      4530
Pro  Leu Arg Glu Leu Pro  Gly Trp Lys Gln Gly  Glu Glu Thr Ile          
1445                 1450                 1455                          

gag  cac gag gag ggc cgg  cac ttc aag gtc gtc  gcc gtc tcc gtg      4575
Glu  His Glu Glu Gly Arg  His Phe Lys Val Val  Ala Val Ser Val          
1460                 1465                 1470                          

cag  gcc ggg aac cgc gaa  gtg acc agc tgg acc  cag ccg ctg atc      4620
Gln  Ala Gly Asn Arg Glu  Val Thr Ser Trp Thr  Gln Pro Leu Ile          
1475                 1480                 1485                          

gaa  ccg gtc gga ctc ggc  gtc gcc gcc ttc ctg  acc cgc gac ttc      4665
Glu  Pro Val Gly Leu Gly  Val Ala Ala Phe Leu  Thr Arg Asp Phe          
1490                 1495                 1500                          

gac  ggc gtc ccg cac tac  ctg gtg cac gcc cgc  gtc gag ggc ggc      4710
Asp  Gly Val Pro His Tyr  Leu Val His Ala Arg  Val Glu Gly Gly          
1505                 1510                 1515                          

ttc  ctc gac acc gtg gaa  ctg gcc ccc acc gtc  cag tac acc ccg      4755
Phe  Leu Asp Thr Val Glu  Leu Ala Pro Thr Val  Gln Tyr Thr Pro          
1520                 1525                 1530                          

ggc  aac tac gcc cac ctg  ccg acc gac gag cgc  ccg ccc ttc ctc      4800
Gly  Asn Tyr Ala His Leu  Pro Thr Asp Glu Arg  Pro Pro Phe Leu          
1535                 1540                 1545                          

gac  ctc gtc ctc gac acc  gac ccc gcc cgc gtc  cgc tac gag gcc      4845
Asp  Leu Val Leu Asp Thr  Asp Pro Ala Arg Val  Arg Tyr Glu Ala          
1550                 1555                 1560                          

gtg  cac tcc gag gaa ggc  ggc cgc ttc ctc aac  gcc gag agc cgc      4890
Val  His Ser Glu Glu Gly  Gly Arg Phe Leu Asn  Ala Glu Ser Arg          
1565                 1570                 1575                          

tac  ctc ctg gtg gag gcc  gac gag acg cag gcc  ccg gcc gac ccg      4935
Tyr  Leu Leu Val Glu Ala  Asp Glu Thr Gln Ala  Pro Ala Asp Pro          
1580                 1585                 1590                          

ccg  ccc ggc tac gcc tgg  gcg acc gcc gca cag  ctc acc tcc ctc      4980
Pro  Pro Gly Tyr Ala Trp  Ala Thr Ala Ala Gln  Leu Thr Ser Leu          
1595                 1600                 1605                          

acc  cgg cac ggc cac tac  ctc aac gtc cag gcc  cgc acc ctg ctg      5025
Thr  Arg His Gly His Tyr  Leu Asn Val Gln Ala  Arg Thr Leu Leu          
1610                 1615                 1620                          

gcc  tgc gtc cac gcc ggg  gcg gtg cgg cct tga cgagcacccc            5068
Ala  Cys Val His Ala Gly  Ala Val Arg Pro                               
1625                 1630                                               

ggcgcatatg ggggaggtgc ggcc ttg  acg agc acc ccg gcg  ccc ctg cgg    5119
                           Leu  Thr Ser Thr Pro Ala  Pro Leu Arg        
                           1635                 1640                    

atc ggt  gtg ctc ggc tgc gcc  gac atc gcc gtc cgg  cgc atg atg      5164
Ile Gly  Val Leu Gly Cys Ala  Asp Ile Ala Val Arg  Arg Met Met          
    1645                 1650                 1655                      

ccc gcg  atg gcc gcg ctc ccc  ggg acc gag gtc acc  gcc gtc gcc      5209
Pro Ala  Met Ala Ala Leu Pro  Gly Thr Glu Val Thr  Ala Val Ala          
    1660                 1665                 1670                      

agc cgc  gac gcg gcg aag gcc  gcc gtg gcc gcc gcc  ccg tac ggc      5254
Ser Arg  Asp Ala Ala Lys Ala  Ala Val Ala Ala Ala  Pro Tyr Gly          
    1675                 1680                 1685                      

gcg gcg  gcc gtc gag ggc tac  cag gag ctg ctg cgc  cgc ccg gac      5299
Ala Ala  Ala Val Glu Gly Tyr  Gln Glu Leu Leu Arg  Arg Pro Asp          
    1690                 1695                 1700                      

gtc gac  gcc gtc tac gta ccg  ctg ccc gcc gcc ctg  cac gcc gag      5344
Val Asp  Ala Val Tyr Val Pro  Leu Pro Ala Ala Leu  His Ala Glu          
    1705                 1710                 1715                      

tgg acc  gag gcc gcc ctg cgg  gcc ggc aag cac gtc  ctg gcc gag      5389
Trp Thr  Glu Ala Ala Leu Arg  Ala Gly Lys His Val  Leu Ala Glu          
    1720                 1725                 1730                      

aag ccg  ctc acc acg gac ccg  gag agc acc gcc gcg  ctg ctc ggc      5434
Lys Pro  Leu Thr Thr Asp Pro  Glu Ser Thr Ala Ala  Leu Leu Gly          
    1735                 1740                 1745                      

ctg gcc  gcc gcg tcc ggg ctc  gcg ctg atg gag aac  gtc atg ttc      5479
Leu Ala  Ala Ala Ser Gly Leu  Ala Leu Met Glu Asn  Val Met Phe          
    1750                 1755                 1760                      

gtc cac  cac cgc ctc cac acc  gac gtc cgc aag ctc  gtc gcg gac      5524
Val His  His Arg Leu His Thr  Asp Val Arg Lys Leu  Val Ala Asp          
    1765                 1770                 1775                      

gga gcc  atc ggc gaa ctc cgc  gcc ctg cac gcc tcg  ttc ggc atc      5569
Gly Ala  Ile Gly Glu Leu Arg  Ala Leu His Ala Ser  Phe Gly Ile          
    1780                 1785                 1790                      

ccc cgg  ctg ccc gac acc gac  atc cgg cac gac ccc  ggg ctc ggc      5614
Pro Arg  Leu Pro Asp Thr Asp  Ile Arg His Asp Pro  Gly Leu Gly          
    1795                 1800                 1805                      

ggc ggc  gcc ctc ggc gac gtc  ggc gtc tac ccg ctg  cga gcc gcc      5659
Gly Gly  Ala Leu Gly Asp Val  Gly Val Tyr Pro Leu  Arg Ala Ala          
    1810                 1815                 1820                      

cag cac  ctg ctc ggc gac gaa  ctc gac gtc ctc ggc  gcg cac ctc      5704
Gln His  Leu Leu Gly Asp Glu  Leu Asp Val Leu Gly  Ala His Leu          
    1825                 1830                 1835                      

gtc cgg  ggg ccc ggc agc cgg  gtc gag acc gcc ggc  ggg gcg ctg      5749
Val Arg  Gly Pro Gly Ser Arg  Val Glu Thr Ala Gly  Gly Ala Leu          
    1840                 1845                 1850                      

ctc gcc  acc ccg gcg ggc gtc  acc gcg cac atc gcc  ttc ggc atg      5794
Leu Ala  Thr Pro Ala Gly Val  Thr Ala His Ile Ala  Phe Gly Met          
    1855                 1860                 1865                      

gac cac  ggc tac cgc tcg gcg  tac gag ctg tgg ggc  agc cag ggc      5839
Asp His  Gly Tyr Arg Ser Ala  Tyr Glu Leu Trp Gly  Ser Gln Gly          
    1870                 1875                 1880                      

cgg ctc  gtc gtc gag cgg gcc  tac acc ccg ccc gcc  gac cac cgc      5884
Arg Leu  Val Val Glu Arg Ala  Tyr Thr Pro Pro Ala  Asp His Arg          
    1885                 1890                 1895                      

ccg gtg  gtg cgc ctg gag acc  cgc acc ggc gtc gag  gag ctc gtc      5929
Pro Val  Val Arg Leu Glu Thr  Arg Thr Gly Val Glu  Glu Leu Val          
    1900                 1905                 1910                      

ctc gac  gcc gac gac cag gtc  cgc aac acg gtg gcc  gcc ttc gcc      5974
Leu Asp  Ala Asp Asp Gln Val  Arg Asn Thr Val Ala  Ala Phe Ala          
    1915                 1920                 1925                      

gcc ctc  gtg gcg cgc acc gga  gcc ggc cac ccc ggg  gac ggc ggc      6019
Ala Leu  Val Ala Arg Thr Gly  Ala Gly His Pro Gly  Asp Gly Gly          
    1930                 1935                 1940                      

gcg ccc  gac ccg gag gcc ccg  ctg cgc cag gcg cgg  ctg ctc gac      6064
Ala Pro  Asp Pro Glu Ala Pro  Leu Arg Gln Ala Arg  Leu Leu Asp          
    1945                 1950                 1955                      

gcc gtg  cgg cgc cgg gcc gcc  ctc gtc tga cccgcgcctc taga           6108
Ala Val  Arg Arg Arg Ala Ala  Leu Val                                   
    1960                 1965                                           


<210>  83
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  83

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  84
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  84

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  85
<211>  202
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  85

Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro 
1               5                   10                  15      


Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu 
            20                  25                  30          


Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr 
        35                  40                  45              


Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser 
    50                  55                  60                  


Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala 
65                  70                  75                  80  


Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly 
                85                  90                  95      


Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 
            100                 105                 110         


Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 
        115                 120                 125             


Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 
    130                 135                 140                 


Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 
145                 150                 155                 160 


Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 
                165                 170                 175     


Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 
            180                 185                 190         


Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 
        195                 200         


<210>  86
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  86

Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val 
1               5                   10                  15      


Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu 
            20                  25                  30          


Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr 
        35                  40                  45              


Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu 
    50                  55                  60                  


Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val 
65                  70                  75                  80  


Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr 
                85                  90                  95      


Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp 
            100                 105                 110         


Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu 
        115                 120                 125             


Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr 
    130                 135                 140                 


Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys 
145                 150                 155                 160 


Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu 
                165                 170                 175     


Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp 
            180                 185                 190         


Ser Thr Ala Arg Asp Lys Gly Ile Val Ser Ser Met Val Arg Arg Ala 
        195                 200                 205             


Val Ala Gly Glu Pro Ile Thr Met Trp His Asp Gly Thr Val Arg Arg 
    210                 215                 220                 


Asp Leu Leu Tyr Val Glu Asp Val Ala Arg Ala Phe Ala Ala Ala Leu 
225                 230                 235                 240 


Gly His Leu Asp Ala Leu Ala Gly Arg His Trp Val Leu Gly Ser Gly 
                245                 250                 255     


His Gly Ala Glu Leu Gly Pro Val Phe Thr Thr Val Ala Arg Met Val 
            260                 265                 270         


Ala Glu Arg Thr Gly Lys Pro Pro Val Ala Val Arg Ser Val Glu Pro 
        275                 280                 285             


Pro Ala His Ala Glu Ala Arg Asp Phe Ala Ser Val Thr Val Asp Pro 
    290                 295                 300                 


Arg Ala Phe His Glu Val Thr Gly Trp Arg Ala Glu Val Pro Leu Asp 
305                 310                 315                 320 


Glu Ala Leu Asp Arg Thr Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu 
                325                 330                 335     


His Phe Gly 
            


<210>  87
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  87

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  88
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  88

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  89
<211>  6002
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1967)..(2563)
<223>  epi gene from S. diversa


<220>
<221>  CDS
<222>  (2592)..(3509)
<223>  kre gene from S. spinosa


<220>
<221>  CDS
<222>  (3537)..(4952)
<223>  tdh gene from S. diversa


<220>
<221>  CDS
<222>  (4987)..(5988)
<223>  tkr gene from S. diversa


<400>  89
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgcggcaa ggagaagtga cgacgacc atg cag gtg acc ccc   1981
                                              Met Gln Val Thr Pro       
                                                      625               

ctg gcc atc gag ggc gcc ttc gcc ttc acg ccc ccc gtc ttc aag gac     2029
Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro Pro Val Phe Lys Asp         
        630                 635                 640                     

agc cgc ggc ctg ttc gcc tcc ccc tac cag ggg gac gtg ttc gcc ggg     2077
Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly Asp Val Phe Ala Gly         
    645                 650                 655                         

cag ctc ggc cgc ccg ctc ttc cag gtc gaa cag gtc agc cac aac ctg     2125
Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln Val Ser His Asn Leu         
660                 665                 670                 675         

tcc gcc agg ggc acc ctc cgc ggc gtc cac ttc acc gcg acc ccg ccg     2173
Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe Thr Ala Thr Pro Pro         
                680                 685                 690             

ggc atg gcg aag tac gtc tac tgc ccg tac ggc agg ctc cgg gac ttc     2221
Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly Arg Leu Arg Asp Phe         
            695                 700                 705                 

ctc atc gac ctc cgg gtc ggc tca ccg acc ttc ggg cag tgg gtg atg     2269
Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe Gly Gln Trp Val Met         
        710                 715                 720                     

aac gaa ctc gac gcg gag acc agc cgc gcc ctc tac gtc ccg gtc ggc     2317
Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu Tyr Val Pro Val Gly         
    725                 730                 735                         

gtc ggc cac gcg ttc gtc tcg ctc cag gac gac tcc atg tgc gtc tac     2365
Val Gly His Ala Phe Val Ser Leu Gln Asp Asp Ser Met Cys Val Tyr         
740                 745                 750                 755         

gtg atg tcg cag ggg tac gtc ccc gcc aac gaa ctg gcc ctg aac ccg     2413
Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu Leu Ala Leu Asn Pro         
                760                 765                 770             

ctc gac ccg gcg ctc gga ctc gac ctg ccg gac gac gtc gag ctg atc     2461
Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp Asp Val Glu Leu Ile         
            775                 780                 785                 

ctg tcc gac cgg gac aag atc gcc ccc acc ctc gcc gag gcc cgc gac     2509
Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu Ala Glu Ala Arg Asp         
        790                 795                 800                     

cgc ggc ctc ctg ccc gac ttc gac acc tgc cgc aag ctg gag gaa ctg     2557
Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg Lys Leu Glu Glu Leu         
    805                 810                 815                         

ctg tga ccgccaatgc atgatcggcg gtggctcg atg agt cgc ctc gcc gtg      2609
Leu                                    Met Ser Arg Leu Ala Val          
820                                                    825              

ctg gtg ccc ggc ggc cgc ggc cag ctg ggc tcg gag ctg gcc cgg atc     2657
Leu Val Pro Gly Gly Arg Gly Gln Leu Gly Ser Glu Leu Ala Arg Ile         
            830                 835                 840                 

ctc gcc gcg cgg acg ggg gcg ctg gtg cac cgg ccg ggt tcc ggg gaa     2705
Leu Ala Ala Arg Thr Gly Ala Leu Val His Arg Pro Gly Ser Gly Glu         
        845                 850                 855                     

ctg gac gtc acc gac gcc gag gag gtc gcc gac gcg ttg ggt tcc ttc     2753
Leu Asp Val Thr Asp Ala Glu Glu Val Ala Asp Ala Leu Gly Ser Phe         
    860                 865                 870                         

gcg gag acg gcg aag gac gcg gag ctg cga ccg gtg gtg atc aac gcc     2801
Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg Pro Val Val Ile Asn Ala         
875                 880                 885                 890         

gcg gcg tac acg gcg gtg gac gcg gcc gag tcc gac ccg gac cgc gcg     2849
Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu Ser Asp Pro Asp Arg Ala         
                895                 900                 905             

gcc cgg atc aac gcc gaa ggc gcg gcc tcg ctg gcg aaa gcg tgc cgg     2897
Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser Leu Ala Lys Ala Cys Arg         
            910                 915                 920                 

agc agc ggt ctg ccc ctg gtg cac gtg tcg acg gat tac gtg ttc ccc     2945
Ser Ser Gly Leu Pro Leu Val His Val Ser Thr Asp Tyr Val Phe Pro         
        925                 930                 935                     

ggt gat ggg gcc cgg ccg tac gag ccg acg gac ccg acc ggg ccg cga     2993
Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr Asp Pro Thr Gly Pro Arg         
    940                 945                 950                         

tcg gtc tac ggg cgc acc aag ctc gaa ggc gaa cgg gcc gtg ctg gag     3041
Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly Glu Arg Ala Val Leu Glu         
955                 960                 965                 970         

tcc ggc gcg cgg gcc tgg gtg gtg cgc acg gca tgg gtg tac ggc gcg     3089
Ser Gly Ala Arg Ala Trp Val Val Arg Thr Ala Trp Val Tyr Gly Ala         
                975                 980                 985             

agc ggc aag aac ttc ctg aaa acg atg atc cgc ctc tcg ggg  gag cgc    3137
Ser Gly Lys Asn Phe Leu Lys Thr Met Ile Arg Leu Ser Gly  Glu Arg        
            990                 995                 1000                

gac acg ctg  tcc gtt gtg gac gat  cag atc ggc tcg ccg  act tgg      3182
Asp Thr Leu  Ser Val Val Asp Asp  Gln Ile Gly Ser Pro  Thr Trp          
        1005                 1010                 1015                  

gcg gcg gac  ctg gcg agc ggc ctg  ctg gag ctg gcc gaa  cgg gtc      3227
Ala Ala Asp  Leu Ala Ser Gly Leu  Leu Glu Leu Ala Glu  Arg Val          
        1020                 1025                 1030                  

gcc gaa cgc  cgt gga ccg gag cag  aag gtg ctg cac tgc  acc aat      3272
Ala Glu Arg  Arg Gly Pro Glu Gln  Lys Val Leu His Cys  Thr Asn          
        1035                 1040                 1045                  

tcc ggc cag  gtg acc tgg tac gag  ttc gcg cgg gcg atc  ttc gcg      3317
Ser Gly Gln  Val Thr Trp Tyr Glu  Phe Ala Arg Ala Ile  Phe Ala          
        1050                 1055                 1060                  

gaa ttc ggc  ctg gac gag aac cgc  gtc cac ccg tgc acg  acg gcg      3362
Glu Phe Gly  Leu Asp Glu Asn Arg  Val His Pro Cys Thr  Thr Ala          
        1065                 1070                 1075                  

gac ttc ccc  ctc ccg gcg cac cgc  ccg gcc tac tcg gtc  ctg tcc      3407
Asp Phe Pro  Leu Pro Ala His Arg  Pro Ala Tyr Ser Val  Leu Ser          
        1080                 1085                 1090                  

gac gtg gcg  tgg cga gag gcg ggc  ctg acc ccg atg cgc  acc tgg      3452
Asp Val Ala  Trp Arg Glu Ala Gly  Leu Thr Pro Met Arg  Thr Trp          
        1095                 1100                 1105                  

cgg gaa gcc  ctg gcg gcg gcc ttc  gag aaa gac ggc gaa  acc ctc      3497
Arg Glu Ala  Leu Ala Ala Ala Phe  Glu Lys Asp Gly Glu  Thr Leu          
        1110                 1115                 1120                  

cga acc cgc  tga ccagtcacta gtggagggcc actcctg atg agc acc gcc      3548
Arg Thr Arg                                    Met Ser Thr Ala          
        1125                                                            

acc  acc acg ccc gcc ccc  gcc ctc acc gcc cgc  cgg ccc gcc ggg      3593
Thr  Thr Thr Pro Ala Pro  Ala Leu Thr Ala Arg  Arg Pro Ala Gly          
1130                 1135                 1140                          

ctc  gcc gag cgg atc gcc  cgc tcg gcc gcc acc  ggc cgc ggc gcc      3638
Leu  Ala Glu Arg Ile Ala  Arg Ser Ala Ala Thr  Gly Arg Gly Ala          
1145                 1150                 1155                          

cac  ctg gcc acc gag gac  ttc cac gac tgg ctc  gac ggc cgc cgc      3683
His  Leu Ala Thr Glu Asp  Phe His Asp Trp Leu  Asp Gly Arg Arg          
1160                 1165                 1170                          

cgc  gcc aac acc ttc cgc  gtc gac aag atc ccc  ttc gac gcg ctc      3728
Arg  Ala Asn Thr Phe Arg  Val Asp Lys Ile Pro  Phe Asp Ala Leu          
1175                 1180                 1185                          

gac  ggc tgg tcc ttc gac  gag gag gac ggc aac  ctc gtc cac cgc      3773
Asp  Gly Trp Ser Phe Asp  Glu Glu Asp Gly Asn  Leu Val His Arg          
1190                 1195                 1200                          

agc  ggc cgc ttc ttc acc  gtc gag ggc ctg cac  gtc gtc gag gag      3818
Ser  Gly Arg Phe Phe Thr  Val Glu Gly Leu His  Val Val Glu Glu          
1205                 1210                 1215                          

gac  gga ccc tac ggc gac  ggc ccg tac cgc tcc  tgg tac cag ccc      3863
Asp  Gly Pro Tyr Gly Asp  Gly Pro Tyr Arg Ser  Trp Tyr Gln Pro          
1220                 1225                 1230                          

gtc  atc aag cag ccc gag  gtc ggc atc ctc ggc  atc ctc gcc aag      3908
Val  Ile Lys Gln Pro Glu  Val Gly Ile Leu Gly  Ile Leu Ala Lys          
1235                 1240                 1245                          

gag  ttc gac ggc gtc ctg  cac ttc ctc atg cag  gcc aag atg gag      3953
Glu  Phe Asp Gly Val Leu  His Phe Leu Met Gln  Ala Lys Met Glu          
1250                 1255                 1260                          

ccc  ggc aac ccg aac ctg  ctc cag ctg tcg ccg  acc gtc cag gcc      3998
Pro  Gly Asn Pro Asn Leu  Leu Gln Leu Ser Pro  Thr Val Gln Ala          
1265                 1270                 1275                          

acc  cgc agc aac tac acc  aag gcg cac cgc ggc  ggc gac gtg aag      4043
Thr  Arg Ser Asn Tyr Thr  Lys Ala His Arg Gly  Gly Asp Val Lys          
1280                 1285                 1290                          

tac  atc gag tac ttc acc  ggc gcc gaa cac ggc  acc gtc atc gcc      4088
Tyr  Ile Glu Tyr Phe Thr  Gly Ala Glu His Gly  Thr Val Ile Ala          
1295                 1300                 1305                          

gac  tcc ctc cag tcc gag  cac ggc gcc tgg ttc  ttc cac aag tcc      4133
Asp  Ser Leu Gln Ser Glu  His Gly Ala Trp Phe  Phe His Lys Ser          
1310                 1315                 1320                          

aac  cgc aac atg atc gtc  gag gcc acc ggc gag  gtc ccg ctc ctc      4178
Asn  Arg Asn Met Ile Val  Glu Ala Thr Gly Glu  Val Pro Leu Leu          
1325                 1330                 1335                          

gac  gac ttc tgc tgg ctc  acc ctc ggc cag ctc  ggc gag ctc ctc      4223
Asp  Asp Phe Cys Trp Leu  Thr Leu Gly Gln Leu  Gly Glu Leu Leu          
1340                 1345                 1350                          

cac  cag gac aac gtc atc  aac atg gac gcc agg  acc gtc ctg tcc      4268
His  Gln Asp Asn Val Ile  Asn Met Asp Ala Arg  Thr Val Leu Ser          
1355                 1360                 1365                          

tgc  gtg ccg tac gag gac  gcc gac gcc ggg cgg  gcg ctg ctc tcc      4313
Cys  Val Pro Tyr Glu Asp  Ala Asp Ala Gly Arg  Ala Leu Leu Ser          
1370                 1375                 1380                          

gac  gtc cag ctg ctc tcc  tgg ttc acc ggc gag  cgc tcc cgc cac      4358
Asp  Val Gln Leu Leu Ser  Trp Phe Thr Gly Glu  Arg Ser Arg His          
1385                 1390                 1395                          

gac  gta cgg gcc cgg cgc  gtc ccg ctg cgc gag  ctg ccc ggc tgg      4403
Asp  Val Arg Ala Arg Arg  Val Pro Leu Arg Glu  Leu Pro Gly Trp          
1400                 1405                 1410                          

aag  cag ggc gag gag acc  atc gag cac gag gag  ggc cgg cac ttc      4448
Lys  Gln Gly Glu Glu Thr  Ile Glu His Glu Glu  Gly Arg His Phe          
1415                 1420                 1425                          

aag  gtc gtc gcc gtc tcc  gtg cag gcc ggg aac  cgc gaa gtg acc      4493
Lys  Val Val Ala Val Ser  Val Gln Ala Gly Asn  Arg Glu Val Thr          
1430                 1435                 1440                          

agc  tgg acc cag ccg ctg  atc gaa ccg gtc gga  ctc ggc gtc gcc      4538
Ser  Trp Thr Gln Pro Leu  Ile Glu Pro Val Gly  Leu Gly Val Ala          
1445                 1450                 1455                          

gcc  ttc ctg acc cgc gac  ttc gac ggc gtc ccg  cac tac ctg gtg      4583
Ala  Phe Leu Thr Arg Asp  Phe Asp Gly Val Pro  His Tyr Leu Val          
1460                 1465                 1470                          

cac  gcc cgc gtc gag ggc  ggc ttc ctc gac acc  gtg gaa ctg gcc      4628
His  Ala Arg Val Glu Gly  Gly Phe Leu Asp Thr  Val Glu Leu Ala          
1475                 1480                 1485                          

ccc  acc gtc cag tac acc  ccg ggc aac tac gcc  cac ctg ccg acc      4673
Pro  Thr Val Gln Tyr Thr  Pro Gly Asn Tyr Ala  His Leu Pro Thr          
1490                 1495                 1500                          

gac  gag cgc ccg ccc ttc  ctc gac ctc gtc ctc  gac acc gac ccc      4718
Asp  Glu Arg Pro Pro Phe  Leu Asp Leu Val Leu  Asp Thr Asp Pro          
1505                 1510                 1515                          

gcc  cgc gtc cgc tac gag  gcc gtg cac tcc gag  gaa ggc ggc cgc      4763
Ala  Arg Val Arg Tyr Glu  Ala Val His Ser Glu  Glu Gly Gly Arg          
1520                 1525                 1530                          

ttc  ctc aac gcc gag agc  cgc tac ctc ctg gtg  gag gcc gac gag      4808
Phe  Leu Asn Ala Glu Ser  Arg Tyr Leu Leu Val  Glu Ala Asp Glu          
1535                 1540                 1545                          

acg  cag gcc ccg gcc gac  ccg ccg ccc ggc tac  gcc tgg gcg acc      4853
Thr  Gln Ala Pro Ala Asp  Pro Pro Pro Gly Tyr  Ala Trp Ala Thr          
1550                 1555                 1560                          

gcc  gca cag ctc acc tcc  ctc acc cgg cac ggc  cac tac ctc aac      4898
Ala  Ala Gln Leu Thr Ser  Leu Thr Arg His Gly  His Tyr Leu Asn          
1565                 1570                 1575                          

gtc  cag gcc cgc acc ctg  ctg gcc tgc gtc cac  gcc ggg gcg gtg      4943
Val  Gln Ala Arg Thr Leu  Leu Ala Cys Val His  Ala Gly Ala Val          
1580                 1585                 1590                          

cgg  cct tga cgagcacccc ggcgcatatg ggggaggtgc ggcc ttg acg agc      4995
Arg  Pro                                           Leu Thr Ser          
1595                                                                    

acc  ccg gcg ccc ctg cgg  atc ggt gtg ctc ggc  tgc gcc gac atc      5040
Thr  Pro Ala Pro Leu Arg  Ile Gly Val Leu Gly  Cys Ala Asp Ile          
1600                 1605                 1610                          

gcc  gtc cgg cgc atg atg  ccc gcg atg gcc gcg  ctc ccc ggg acc      5085
Ala  Val Arg Arg Met Met  Pro Ala Met Ala Ala  Leu Pro Gly Thr          
1615                 1620                 1625                          

gag  gtc acc gcc gtc gcc  agc cgc gac gcg gcg  aag gcc gcc gtg      5130
Glu  Val Thr Ala Val Ala  Ser Arg Asp Ala Ala  Lys Ala Ala Val          
1630                 1635                 1640                          

gcc  gcc gcc ccg tac ggc  gcg gcg gcc gtc gag  ggc tac cag gag      5175
Ala  Ala Ala Pro Tyr Gly  Ala Ala Ala Val Glu  Gly Tyr Gln Glu          
1645                 1650                 1655                          

ctg  ctg cgc cgc ccg gac  gtc gac gcc gtc tac  gta ccg ctg ccc      5220
Leu  Leu Arg Arg Pro Asp  Val Asp Ala Val Tyr  Val Pro Leu Pro          
1660                 1665                 1670                          

gcc  gcc ctg cac gcc gag  tgg acc gag gcc gcc  ctg cgg gcc ggc      5265
Ala  Ala Leu His Ala Glu  Trp Thr Glu Ala Ala  Leu Arg Ala Gly          
1675                 1680                 1685                          

aag  cac gtc ctg gcc gag  aag ccg ctc acc acg  gac ccg gag agc      5310
Lys  His Val Leu Ala Glu  Lys Pro Leu Thr Thr  Asp Pro Glu Ser          
1690                 1695                 1700                          

acc  gcc gcg ctg ctc ggc  ctg gcc gcc gcg tcc  ggg ctc gcg ctg      5355
Thr  Ala Ala Leu Leu Gly  Leu Ala Ala Ala Ser  Gly Leu Ala Leu          
1705                 1710                 1715                          

atg  gag aac gtc atg ttc  gtc cac cac cgc ctc  cac acc gac gtc      5400
Met  Glu Asn Val Met Phe  Val His His Arg Leu  His Thr Asp Val          
1720                 1725                 1730                          

cgc  aag ctc gtc gcg gac  gga gcc atc ggc gaa  ctc cgc gcc ctg      5445
Arg  Lys Leu Val Ala Asp  Gly Ala Ile Gly Glu  Leu Arg Ala Leu          
1735                 1740                 1745                          

cac  gcc tcg ttc ggc atc  ccc cgg ctg ccc gac  acc gac atc cgg      5490
His  Ala Ser Phe Gly Ile  Pro Arg Leu Pro Asp  Thr Asp Ile Arg          
1750                 1755                 1760                          

cac  gac ccc ggg ctc ggc  ggc ggc gcc ctc ggc  gac gtc ggc gtc      5535
His  Asp Pro Gly Leu Gly  Gly Gly Ala Leu Gly  Asp Val Gly Val          
1765                 1770                 1775                          

tac  ccg ctg cga gcc gcc  cag cac ctg ctc ggc  gac gaa ctc gac      5580
Tyr  Pro Leu Arg Ala Ala  Gln His Leu Leu Gly  Asp Glu Leu Asp          
1780                 1785                 1790                          

gtc  ctc ggc gcg cac ctc  gtc cgg ggg ccc ggc  agc cgg gtc gag      5625
Val  Leu Gly Ala His Leu  Val Arg Gly Pro Gly  Ser Arg Val Glu          
1795                 1800                 1805                          

acc  gcc ggc ggg gcg ctg  ctc gcc acc ccg gcg  ggc gtc acc gcg      5670
Thr  Ala Gly Gly Ala Leu  Leu Ala Thr Pro Ala  Gly Val Thr Ala          
1810                 1815                 1820                          

cac  atc gcc ttc ggc atg  gac cac ggc tac cgc  tcg gcg tac gag      5715
His  Ile Ala Phe Gly Met  Asp His Gly Tyr Arg  Ser Ala Tyr Glu          
1825                 1830                 1835                          

ctg  tgg ggc agc cag ggc  cgg ctc gtc gtc gag  cgg gcc tac acc      5760
Leu  Trp Gly Ser Gln Gly  Arg Leu Val Val Glu  Arg Ala Tyr Thr          
1840                 1845                 1850                          

ccg  ccc gcc gac cac cgc  ccg gtg gtg cgc ctg  gag acc cgc acc      5805
Pro  Pro Ala Asp His Arg  Pro Val Val Arg Leu  Glu Thr Arg Thr          
1855                 1860                 1865                          

ggc  gtc gag gag ctc gtc  ctc gac gcc gac gac  cag gtc cgc aac      5850
Gly  Val Glu Glu Leu Val  Leu Asp Ala Asp Asp  Gln Val Arg Asn          
1870                 1875                 1880                          

acg  gtg gcc gcc ttc gcc  gcc ctc gtg gcg cgc  acc gga gcc ggc      5895
Thr  Val Ala Ala Phe Ala  Ala Leu Val Ala Arg  Thr Gly Ala Gly          
1885                 1890                 1895                          

cac  ccc ggg gac ggc ggc  gcg ccc gac ccg gag  gcc ccg ctg cgc      5940
His  Pro Gly Asp Gly Gly  Ala Pro Asp Pro Glu  Ala Pro Leu Arg          
1900                 1905                 1910                          

cag  gcg cgg ctg ctc gac  gcc gtg cgg cgc cgg  gcc gcc ctc gtc      5985
Gln  Ala Arg Leu Leu Asp  Ala Val Arg Arg Arg  Ala Ala Leu Val          
1915                 1920                 1925                          

tga cccgcgcctc taga                                                 6002


<210>  90
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  90

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  91
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  91

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  92
<211>  198
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  92

Met Gln Val Thr Pro Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro 
1               5                   10                  15      


Pro Val Phe Lys Asp Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly 
            20                  25                  30          


Asp Val Phe Ala Gly Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln 
        35                  40                  45              


Val Ser His Asn Leu Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe 
    50                  55                  60                  


Thr Ala Thr Pro Pro Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly 
65                  70                  75                  80  


Arg Leu Arg Asp Phe Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Trp Val Met Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu 
            100                 105                 110         


Tyr Val Pro Val Gly Val Gly His Ala Phe Val Ser Leu Gln Asp Asp 
        115                 120                 125             


Ser Met Cys Val Tyr Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu 
    130                 135                 140                 


Leu Ala Leu Asn Pro Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp 
145                 150                 155                 160 


Asp Val Glu Leu Ile Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu 
                165                 170                 175     


Ala Glu Ala Arg Asp Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg 
            180                 185                 190         


Lys Leu Glu Glu Leu Leu 
        195             


<210>  93
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  93

Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly 
1               5                   10                  15      


Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His 
            20                  25                  30          


Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala 
        35                  40                  45              


Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg 
    50                  55                  60                  


Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu 
65                  70                  75                  80  


Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser 
                85                  90                  95      


Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser 
            100                 105                 110         


Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr 
        115                 120                 125             


Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly 
    130                 135                 140                 


Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr 
145                 150                 155                 160 


Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile 
                165                 170                 175     


Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asp Gln Ile 
            180                 185                 190         


Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu 
        195                 200                 205             


Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gln Lys Val Leu His 
    210                 215                 220                 


Cys Thr Asn Ser Gly Gln Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile 
225                 230                 235                 240 


Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr 
                245                 250                 255     


Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser 
            260                 265                 270         


Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg 
        275                 280                 285             


Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr 
    290                 295                 300                 


Arg 
305 


<210>  94
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  94

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  95
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  95

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  96
<211>  6100
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1967)..(2563)
<223>  epi gene from S. diversa


<220>
<221>  CDS
<222>  (2591)..(3610)
<223>  kre gene from S. diversa


<220>
<221>  CDS
<222>  (3635)..(5050)
<223>  tdh gene from S. diversa


<220>
<221>  CDS
<222>  (5085)..(6086)
<223>  tkr gene from S. diversa


<400>  96
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgcggcaa ggagaagtga cgacgacc atg cag gtg acc ccc   1981
                                              Met Gln Val Thr Pro       
                                                      625               

ctg gcc atc gag ggc gcc ttc gcc ttc acg ccc ccc gtc ttc aag gac     2029
Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro Pro Val Phe Lys Asp         
        630                 635                 640                     

agc cgc ggc ctg ttc gcc tcc ccc tac cag ggg gac gtg ttc gcc ggg     2077
Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly Asp Val Phe Ala Gly         
    645                 650                 655                         

cag ctc ggc cgc ccg ctc ttc cag gtc gaa cag gtc agc cac aac ctg     2125
Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln Val Ser His Asn Leu         
660                 665                 670                 675         

tcc gcc agg ggc acc ctc cgc ggc gtc cac ttc acc gcg acc ccg ccg     2173
Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe Thr Ala Thr Pro Pro         
                680                 685                 690             

ggc atg gcg aag tac gtc tac tgc ccg tac ggc agg ctc cgg gac ttc     2221
Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly Arg Leu Arg Asp Phe         
            695                 700                 705                 

ctc atc gac ctc cgg gtc ggc tca ccg acc ttc ggg cag tgg gtg atg     2269
Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe Gly Gln Trp Val Met         
        710                 715                 720                     

aac gaa ctc gac gcg gag acc agc cgc gcc ctc tac gtc ccg gtc ggc     2317
Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu Tyr Val Pro Val Gly         
    725                 730                 735                         

gtc ggc cac gcg ttc gtc tcg ctc cag gac gac tcc atg tgc gtc tac     2365
Val Gly His Ala Phe Val Ser Leu Gln Asp Asp Ser Met Cys Val Tyr         
740                 745                 750                 755         

gtg atg tcg cag ggg tac gtc ccc gcc aac gaa ctg gcc ctg aac ccg     2413
Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu Leu Ala Leu Asn Pro         
                760                 765                 770             

ctc gac ccg gcg ctc gga ctc gac ctg ccg gac gac gtc gag ctg atc     2461
Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp Asp Val Glu Leu Ile         
            775                 780                 785                 

ctg tcc gac cgg gac aag atc gcc ccc acc ctc gcc gag gcc cgc gac     2509
Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu Ala Glu Ala Arg Asp         
        790                 795                 800                     

cgc ggc ctc ctg ccc gac ttc gac acc tgc cgc aag ctg gag gaa ctg     2557
Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg Lys Leu Glu Glu Leu         
    805                 810                 815                         

ctg tga ccgccaatgc atgctggagg aatcgct gtg acc gcc acc acc gga cag   2611
Leu                                   Val Thr Ala Thr Thr Gly Gln       
820                                                   825               

acc ggg gac acc cga ccc ctg gtg gtc gtc ctc ggc gcc gcc ggc ttc     2659
Thr Gly Asp Thr Arg Pro Leu Val Val Val Leu Gly Ala Ala Gly Phe         
        830                 835                 840                     

gtc ggc tcc gcc gtc ctg cgc gaa ctc gcc cgc cac gac ctg cgg gtg     2707
Val Gly Ser Ala Val Leu Arg Glu Leu Ala Arg His Asp Leu Arg Val         
    845                 850                 855                         

cgg gcc gtc tcc cgg cgc ccg gtg acc gtc ccg gcc ggc gcc cgc gcc     2755
Arg Ala Val Ser Arg Arg Pro Val Thr Val Pro Ala Gly Ala Arg Ala         
860                 865                 870                 875         

gag gtg gag acc cgc agc gtc gac ctc acc gtc ccc ggc gcg atg gcc     2803
Glu Val Glu Thr Arg Ser Val Asp Leu Thr Val Pro Gly Ala Met Ala         
                880                 885                 890             

ggg gcg atc gag ggc gcc gac gtg gtc gtc cac tcg atc gcc tac atc     2851
Gly Ala Ile Glu Gly Ala Asp Val Val Val His Ser Ile Ala Tyr Ile         
            895                 900                 905                 

gcg ggc tcc tcg acc tgg cgc atc acg gac ggc gac acc ggc gcc gag     2899
Ala Gly Ser Ser Thr Trp Arg Ile Thr Asp Gly Asp Thr Gly Ala Glu         
        910                 915                 920                     

cgg gtc aac gtg gga ctc gta cgg gac ctg gtc gag gcc gtg cgg gcg     2947
Arg Val Asn Val Gly Leu Val Arg Asp Leu Val Glu Ala Val Arg Ala         
    925                 930                 935                         

agc ggc cgc ccc gac acc gcc gtc ctg ttc acc ggc tcc gtc tcc gcc     2995
Ser Gly Arg Pro Asp Thr Ala Val Leu Phe Thr Gly Ser Val Ser Ala         
940                 945                 950                 955         

gcc gga ccc tcg gag cgg ggc gtc tac gac ggt acg gag ccg gac gag     3043
Ala Gly Pro Ser Glu Arg Gly Val Tyr Asp Gly Thr Glu Pro Asp Glu         
                960                 965                 970             

ccg cag ggc gag tac gac cgg cag aag ctg gcg gcc gag cgg gtg ctg     3091
Pro Gln Gly Glu Tyr Asp Arg Gln Lys Leu Ala Ala Glu Arg Val Leu         
            975                 980                 985                 

ctc gcg gcg agc gcc gag ggc gtg ctg cgc ggg atc tcg  ctc cgg ctc    3139
Leu Ala Ala Ser Ala Glu Gly Val Leu Arg Gly Ile Ser  Leu Arg Leu        
        990                 995                 1000                    

ccc acg  gtc ttc ggc tac ggc  ccc gac tcg acc gcg  cgg gac aag      3184
Pro Thr  Val Phe Gly Tyr Gly  Pro Asp Ser Thr Ala  Arg Asp Lys          
    1005                 1010                 1015                      

ggc atc  gtc tcc tcg atg gtc  cgc cgg gcg gtg gcg  ggc gag ccg      3229
Gly Ile  Val Ser Ser Met Val  Arg Arg Ala Val Ala  Gly Glu Pro          
    1020                 1025                 1030                      

atc acc  atg tgg cac gac ggc  acg gtc cgc cgc gac  ctg ctg tac      3274
Ile Thr  Met Trp His Asp Gly  Thr Val Arg Arg Asp  Leu Leu Tyr          
    1035                 1040                 1045                      

gtg gag  gac gtg gcg cgc gcc  ttc gcg gcg gcc ctc  ggc cac ctc      3319
Val Glu  Asp Val Ala Arg Ala  Phe Ala Ala Ala Leu  Gly His Leu          
    1050                 1055                 1060                      

gac gcg  ctc gcg gga cgg cac  tgg gtg ctc ggc agc  ggg cac ggc      3364
Asp Ala  Leu Ala Gly Arg His  Trp Val Leu Gly Ser  Gly His Gly          
    1065                 1070                 1075                      

gcc gag  ctc ggc ccg gtc ttc  acc acg gtc gcc cgg  atg gtg gcg      3409
Ala Glu  Leu Gly Pro Val Phe  Thr Thr Val Ala Arg  Met Val Ala          
    1080                 1085                 1090                      

gag cgg  acc ggc aag ccg ccg  gtg gcc gtg cgc tcg  gtg gag ccg      3454
Glu Arg  Thr Gly Lys Pro Pro  Val Ala Val Arg Ser  Val Glu Pro          
    1095                 1100                 1105                      

ccc gcg  cac gcc gag gcc cgg  gac ttc gcc agc gtc  acc gtc gac      3499
Pro Ala  His Ala Glu Ala Arg  Asp Phe Ala Ser Val  Thr Val Asp          
    1110                 1115                 1120                      

ccg cgc  gcc ttc cac gag gtc  acc ggc tgg cgg gcc  gag gtc ccg      3544
Pro Arg  Ala Phe His Glu Val  Thr Gly Trp Arg Ala  Glu Val Pro          
    1125                 1130                 1135                      

ctg gac  gag gcc ctg gac cgg  acg acg gcc ttc agc  gcg agc ggc      3589
Leu Asp  Glu Ala Leu Asp Arg  Thr Thr Ala Phe Ser  Ala Ser Gly          
    1140                 1145                 1150                      

gcg gag  gag cac ttc ggc tga cccactagtg gagggccact cctg atg  agc    3640
Ala Glu  Glu His Phe Gly                                Met  Ser        
    1155                                                1160            

acc gcc acc acc  acg ccc gcc ccc gcc  ctc acc gcc cgc cgg  ccc      3685
Thr Ala Thr Thr  Thr Pro Ala Pro Ala  Leu Thr Ala Arg Arg  Pro          
            1165                 1170                 1175              

gcc ggg ctc gcc  gag cgg atc gcc cgc  tcg gcc gcc acc ggc  cgc      3730
Ala Gly Leu Ala  Glu Arg Ile Ala Arg  Ser Ala Ala Thr Gly  Arg          
            1180                 1185                 1190              

ggc gcc cac ctg  gcc acc gag gac ttc  cac gac tgg ctc gac  ggc      3775
Gly Ala His Leu  Ala Thr Glu Asp Phe  His Asp Trp Leu Asp  Gly          
            1195                 1200                 1205              

cgc cgc cgc gcc  aac acc ttc cgc gtc  gac aag atc ccc ttc  gac      3820
Arg Arg Arg Ala  Asn Thr Phe Arg Val  Asp Lys Ile Pro Phe  Asp          
            1210                 1215                 1220              

gcg ctc gac ggc  tgg tcc ttc gac gag  gag gac ggc aac ctc  gtc      3865
Ala Leu Asp Gly  Trp Ser Phe Asp Glu  Glu Asp Gly Asn Leu  Val          
            1225                 1230                 1235              

cac cgc agc ggc  cgc ttc ttc acc gtc  gag ggc ctg cac gtc  gtc      3910
His Arg Ser Gly  Arg Phe Phe Thr Val  Glu Gly Leu His Val  Val          
            1240                 1245                 1250              

gag gag gac gga  ccc tac ggc gac ggc  ccg tac cgc tcc tgg  tac      3955
Glu Glu Asp Gly  Pro Tyr Gly Asp Gly  Pro Tyr Arg Ser Trp  Tyr          
            1255                 1260                 1265              

cag ccc gtc atc  aag cag ccc gag gtc  ggc atc ctc ggc atc  ctc      4000
Gln Pro Val Ile  Lys Gln Pro Glu Val  Gly Ile Leu Gly Ile  Leu          
            1270                 1275                 1280              

gcc aag gag ttc  gac ggc gtc ctg cac  ttc ctc atg cag gcc  aag      4045
Ala Lys Glu Phe  Asp Gly Val Leu His  Phe Leu Met Gln Ala  Lys          
            1285                 1290                 1295              

atg gag ccc ggc  aac ccg aac ctg ctc  cag ctg tcg ccg acc  gtc      4090
Met Glu Pro Gly  Asn Pro Asn Leu Leu  Gln Leu Ser Pro Thr  Val          
            1300                 1305                 1310              

cag gcc acc cgc  agc aac tac acc aag  gcg cac cgc ggc ggc  gac      4135
Gln Ala Thr Arg  Ser Asn Tyr Thr Lys  Ala His Arg Gly Gly  Asp          
            1315                 1320                 1325              

gtg aag tac atc  gag tac ttc acc ggc  gcc gaa cac ggc acc  gtc      4180
Val Lys Tyr Ile  Glu Tyr Phe Thr Gly  Ala Glu His Gly Thr  Val          
            1330                 1335                 1340              

atc gcc gac tcc  ctc cag tcc gag cac  ggc gcc tgg ttc ttc  cac      4225
Ile Ala Asp Ser  Leu Gln Ser Glu His  Gly Ala Trp Phe Phe  His          
            1345                 1350                 1355              

aag tcc aac cgc  aac atg atc gtc gag  gcc acc ggc gag gtc  ccg      4270
Lys Ser Asn Arg  Asn Met Ile Val Glu  Ala Thr Gly Glu Val  Pro          
            1360                 1365                 1370              

ctc ctc gac gac  ttc tgc tgg ctc acc  ctc ggc cag ctc ggc  gag      4315
Leu Leu Asp Asp  Phe Cys Trp Leu Thr  Leu Gly Gln Leu Gly  Glu          
            1375                 1380                 1385              

ctc ctc cac cag  gac aac gtc atc aac  atg gac gcc agg acc  gtc      4360
Leu Leu His Gln  Asp Asn Val Ile Asn  Met Asp Ala Arg Thr  Val          
            1390                 1395                 1400              

ctg tcc tgc gtg  ccg tac gag gac gcc  gac gcc ggg cgg gcg  ctg      4405
Leu Ser Cys Val  Pro Tyr Glu Asp Ala  Asp Ala Gly Arg Ala  Leu          
            1405                 1410                 1415              

ctc tcc gac gtc  cag ctg ctc tcc tgg  ttc acc ggc gag cgc  tcc      4450
Leu Ser Asp Val  Gln Leu Leu Ser Trp  Phe Thr Gly Glu Arg  Ser          
            1420                 1425                 1430              

cgc cac gac gta  cgg gcc cgg cgc gtc  ccg ctg cgc gag ctg  ccc      4495
Arg His Asp Val  Arg Ala Arg Arg Val  Pro Leu Arg Glu Leu  Pro          
            1435                 1440                 1445              

ggc tgg aag cag  ggc gag gag acc atc  gag cac gag gag ggc  cgg      4540
Gly Trp Lys Gln  Gly Glu Glu Thr Ile  Glu His Glu Glu Gly  Arg          
            1450                 1455                 1460              

cac ttc aag gtc  gtc gcc gtc tcc gtg  cag gcc ggg aac cgc  gaa      4585
His Phe Lys Val  Val Ala Val Ser Val  Gln Ala Gly Asn Arg  Glu          
            1465                 1470                 1475              

gtg acc agc tgg  acc cag ccg ctg atc  gaa ccg gtc gga ctc  ggc      4630
Val Thr Ser Trp  Thr Gln Pro Leu Ile  Glu Pro Val Gly Leu  Gly          
            1480                 1485                 1490              

gtc gcc gcc ttc  ctg acc cgc gac ttc  gac ggc gtc ccg cac  tac      4675
Val Ala Ala Phe  Leu Thr Arg Asp Phe  Asp Gly Val Pro His  Tyr          
            1495                 1500                 1505              

ctg gtg cac gcc  cgc gtc gag ggc ggc  ttc ctc gac acc gtg  gaa      4720
Leu Val His Ala  Arg Val Glu Gly Gly  Phe Leu Asp Thr Val  Glu          
            1510                 1515                 1520              

ctg gcc ccc acc  gtc cag tac acc ccg  ggc aac tac gcc cac  ctg      4765
Leu Ala Pro Thr  Val Gln Tyr Thr Pro  Gly Asn Tyr Ala His  Leu          
            1525                 1530                 1535              

ccg acc gac gag  cgc ccg ccc ttc ctc  gac ctc gtc ctc gac  acc      4810
Pro Thr Asp Glu  Arg Pro Pro Phe Leu  Asp Leu Val Leu Asp  Thr          
            1540                 1545                 1550              

gac ccc gcc cgc  gtc cgc tac gag gcc  gtg cac tcc gag gaa  ggc      4855
Asp Pro Ala Arg  Val Arg Tyr Glu Ala  Val His Ser Glu Glu  Gly          
            1555                 1560                 1565              

ggc cgc ttc ctc  aac gcc gag agc cgc  tac ctc ctg gtg gag  gcc      4900
Gly Arg Phe Leu  Asn Ala Glu Ser Arg  Tyr Leu Leu Val Glu  Ala          
            1570                 1575                 1580              

gac gag acg cag  gcc ccg gcc gac ccg  ccg ccc ggc tac gcc  tgg      4945
Asp Glu Thr Gln  Ala Pro Ala Asp Pro  Pro Pro Gly Tyr Ala  Trp          
            1585                 1590                 1595              

gcg acc gcc gca  cag ctc acc tcc ctc  acc cgg cac ggc cac  tac      4990
Ala Thr Ala Ala  Gln Leu Thr Ser Leu  Thr Arg His Gly His  Tyr          
            1600                 1605                 1610              

ctc aac gtc cag  gcc cgc acc ctg ctg  gcc tgc gtc cac gcc  ggg      5035
Leu Asn Val Gln  Ala Arg Thr Leu Leu  Ala Cys Val His Ala  Gly          
            1615                 1620                 1625              

gcg gtg cgg cct  tga cgagcacccc ggcgcatatg ggggaggtgc ggcc ttg      5087
Ala Val Arg Pro                                            Leu          
            1630                                                        

acg agc acc ccg  gcg ccc ctg cgg atc  ggt gtg ctc ggc tgc  gcc      5132
Thr Ser Thr Pro  Ala Pro Leu Arg Ile  Gly Val Leu Gly Cys  Ala          
            1635                 1640                 1645              

gac atc gcc gtc  cgg cgc atg atg ccc  gcg atg gcc gcg ctc  ccc      5177
Asp Ile Ala Val  Arg Arg Met Met Pro  Ala Met Ala Ala Leu  Pro          
            1650                 1655                 1660              

ggg acc gag gtc  acc gcc gtc gcc agc  cgc gac gcg gcg aag  gcc      5222
Gly Thr Glu Val  Thr Ala Val Ala Ser  Arg Asp Ala Ala Lys  Ala          
            1665                 1670                 1675              

gcc gtg gcc gcc  gcc ccg tac ggc gcg  gcg gcc gtc gag ggc  tac      5267
Ala Val Ala Ala  Ala Pro Tyr Gly Ala  Ala Ala Val Glu Gly  Tyr          
            1680                 1685                 1690              

cag gag ctg ctg  cgc cgc ccg gac gtc  gac gcc gtc tac gta  ccg      5312
Gln Glu Leu Leu  Arg Arg Pro Asp Val  Asp Ala Val Tyr Val  Pro          
            1695                 1700                 1705              

ctg ccc gcc gcc  ctg cac gcc gag tgg  acc gag gcc gcc ctg  cgg      5357
Leu Pro Ala Ala  Leu His Ala Glu Trp  Thr Glu Ala Ala Leu  Arg          
            1710                 1715                 1720              

gcc ggc aag cac  gtc ctg gcc gag aag  ccg ctc acc acg gac  ccg      5402
Ala Gly Lys His  Val Leu Ala Glu Lys  Pro Leu Thr Thr Asp  Pro          
            1725                 1730                 1735              

gag agc acc gcc  gcg ctg ctc ggc ctg  gcc gcc gcg tcc ggg  ctc      5447
Glu Ser Thr Ala  Ala Leu Leu Gly Leu  Ala Ala Ala Ser Gly  Leu          
            1740                 1745                 1750              

gcg ctg atg gag  aac gtc atg ttc gtc  cac cac cgc ctc cac  acc      5492
Ala Leu Met Glu  Asn Val Met Phe Val  His His Arg Leu His  Thr          
            1755                 1760                 1765              

gac gtc cgc aag  ctc gtc gcg gac gga  gcc atc ggc gaa ctc  cgc      5537
Asp Val Arg Lys  Leu Val Ala Asp Gly  Ala Ile Gly Glu Leu  Arg          
            1770                 1775                 1780              

gcc ctg cac gcc  tcg ttc ggc atc ccc  cgg ctg ccc gac acc  gac      5582
Ala Leu His Ala  Ser Phe Gly Ile Pro  Arg Leu Pro Asp Thr  Asp          
            1785                 1790                 1795              

atc cgg cac gac  ccc ggg ctc ggc ggc  ggc gcc ctc ggc gac  gtc      5627
Ile Arg His Asp  Pro Gly Leu Gly Gly  Gly Ala Leu Gly Asp  Val          
            1800                 1805                 1810              

ggc gtc tac ccg  ctg cga gcc gcc cag  cac ctg ctc ggc gac  gaa      5672
Gly Val Tyr Pro  Leu Arg Ala Ala Gln  His Leu Leu Gly Asp  Glu          
            1815                 1820                 1825              

ctc gac gtc ctc  ggc gcg cac ctc gtc  cgg ggg ccc ggc agc  cgg      5717
Leu Asp Val Leu  Gly Ala His Leu Val  Arg Gly Pro Gly Ser  Arg          
            1830                 1835                 1840              

gtc gag acc gcc  ggc ggg gcg ctg ctc  gcc acc ccg gcg ggc  gtc      5762
Val Glu Thr Ala  Gly Gly Ala Leu Leu  Ala Thr Pro Ala Gly  Val          
            1845                 1850                 1855              

acc gcg cac atc  gcc ttc ggc atg gac  cac ggc tac cgc tcg  gcg      5807
Thr Ala His Ile  Ala Phe Gly Met Asp  His Gly Tyr Arg Ser  Ala          
            1860                 1865                 1870              

tac gag ctg tgg  ggc agc cag ggc cgg  ctc gtc gtc gag cgg  gcc      5852
Tyr Glu Leu Trp  Gly Ser Gln Gly Arg  Leu Val Val Glu Arg  Ala          
            1875                 1880                 1885              

tac acc ccg ccc  gcc gac cac cgc ccg  gtg gtg cgc ctg gag  acc      5897
Tyr Thr Pro Pro  Ala Asp His Arg Pro  Val Val Arg Leu Glu  Thr          
            1890                 1895                 1900              

cgc acc ggc gtc  gag gag ctc gtc ctc  gac gcc gac gac cag  gtc      5942
Arg Thr Gly Val  Glu Glu Leu Val Leu  Asp Ala Asp Asp Gln  Val          
            1905                 1910                 1915              

cgc aac acg gtg  gcc gcc ttc gcc gcc  ctc gtg gcg cgc acc  gga      5987
Arg Asn Thr Val  Ala Ala Phe Ala Ala  Leu Val Ala Arg Thr  Gly          
            1920                 1925                 1930              

gcc ggc cac ccc  ggg gac ggc ggc gcg  ccc gac ccg gag gcc  ccg      6032
Ala Gly His Pro  Gly Asp Gly Gly Ala  Pro Asp Pro Glu Ala  Pro          
            1935                 1940                 1945              

ctg cgc cag gcg  cgg ctg ctc gac gcc  gtg cgg cgc cgg gcc  gcc      6077
Leu Arg Gln Ala  Arg Leu Leu Asp Ala  Val Arg Arg Arg Ala  Ala          
            1950                 1955                 1960              

ctc gtc tga cccgcgcctc taga                                         6100
Leu Val                                                                 
                                                                        


<210>  97
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  97

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  98
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  98

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  99
<211>  198
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  99

Met Gln Val Thr Pro Leu Ala Ile Glu Gly Ala Phe Ala Phe Thr Pro 
1               5                   10                  15      


Pro Val Phe Lys Asp Ser Arg Gly Leu Phe Ala Ser Pro Tyr Gln Gly 
            20                  25                  30          


Asp Val Phe Ala Gly Gln Leu Gly Arg Pro Leu Phe Gln Val Glu Gln 
        35                  40                  45              


Val Ser His Asn Leu Ser Ala Arg Gly Thr Leu Arg Gly Val His Phe 
    50                  55                  60                  


Thr Ala Thr Pro Pro Gly Met Ala Lys Tyr Val Tyr Cys Pro Tyr Gly 
65                  70                  75                  80  


Arg Leu Arg Asp Phe Leu Ile Asp Leu Arg Val Gly Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Trp Val Met Asn Glu Leu Asp Ala Glu Thr Ser Arg Ala Leu 
            100                 105                 110         


Tyr Val Pro Val Gly Val Gly His Ala Phe Val Ser Leu Gln Asp Asp 
        115                 120                 125             


Ser Met Cys Val Tyr Val Met Ser Gln Gly Tyr Val Pro Ala Asn Glu 
    130                 135                 140                 


Leu Ala Leu Asn Pro Leu Asp Pro Ala Leu Gly Leu Asp Leu Pro Asp 
145                 150                 155                 160 


Asp Val Glu Leu Ile Leu Ser Asp Arg Asp Lys Ile Ala Pro Thr Leu 
                165                 170                 175     


Ala Glu Ala Arg Asp Arg Gly Leu Leu Pro Asp Phe Asp Thr Cys Arg 
            180                 185                 190         


Lys Leu Glu Glu Leu Leu 
        195             


<210>  100
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  100

Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val 
1               5                   10                  15      


Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu 
            20                  25                  30          


Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr 
        35                  40                  45              


Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu 
    50                  55                  60                  


Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val 
65                  70                  75                  80  


Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr 
                85                  90                  95      


Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp 
            100                 105                 110         


Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu 
        115                 120                 125             


Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr 
    130                 135                 140                 


Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys 
145                 150                 155                 160 


Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu 
                165                 170                 175     


Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp 
            180                 185                 190         


Ser Thr Ala Arg Asp Lys Gly Ile Val Ser Ser Met Val Arg Arg Ala 
        195                 200                 205             


Val Ala Gly Glu Pro Ile Thr Met Trp His Asp Gly Thr Val Arg Arg 
    210                 215                 220                 


Asp Leu Leu Tyr Val Glu Asp Val Ala Arg Ala Phe Ala Ala Ala Leu 
225                 230                 235                 240 


Gly His Leu Asp Ala Leu Ala Gly Arg His Trp Val Leu Gly Ser Gly 
                245                 250                 255     


His Gly Ala Glu Leu Gly Pro Val Phe Thr Thr Val Ala Arg Met Val 
            260                 265                 270         


Ala Glu Arg Thr Gly Lys Pro Pro Val Ala Val Arg Ser Val Glu Pro 
        275                 280                 285             


Pro Ala His Ala Glu Ala Arg Asp Phe Ala Ser Val Thr Val Asp Pro 
    290                 295                 300                 


Arg Ala Phe His Glu Val Thr Gly Trp Arg Ala Glu Val Pro Leu Asp 
305                 310                 315                 320 


Glu Ala Leu Asp Arg Thr Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu 
                325                 330                 335     


His Phe Gly 
            


<210>  101
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  101

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  102
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  102

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  103
<211>  6104
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (79)..(948)
<223>  gtt gene from S. diversa


<220>
<221>  CDS
<222>  (1049)..(2017)
<223>  gdh gene from S. diversa


<220>
<221>  CDS
<222>  (2056)..(2664)
<223>  epi gene from S. spinosa


<220>
<221>  CDS
<222>  (2694)..(3611)
<223>  kre gene from S. spinosa


<220>
<221>  CDS
<222>  (3639)..(5054)
<223>  tdh gene from S. diversa


<220>
<221>  CDS
<222>  (5089)..(6090)
<223>  tkr gene from S. diversa


<400>  103
ggtctcaagc tttgaaccga ggctccttga acgccgcgcc gcacccggtg aggctgggaa     60

ccccaggagg agagaact gtg aaa ggc atc gtc ctg gcc gga ggc cac ggc      111
                    Val Lys Gly Ile Val Leu Ala Gly Gly His Gly         
                    1               5                   10              

acc cgg ctg cac ccg atc acc ctc ggc acg tcc aag cag atg ctg ccg      159
Thr Arg Leu His Pro Ile Thr Leu Gly Thr Ser Lys Gln Met Leu Pro         
            15                  20                  25                  

gtc tac gac aag ccg atg atc tac tac ccg ctc tcg gtg ctg atg ctc      207
Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu         
        30                  35                  40                      

gcc ggg atc cgg gac atc cag atc atc tcg tcc ccc gac gac atc gag      255
Ala Gly Ile Arg Asp Ile Gln Ile Ile Ser Ser Pro Asp Asp Ile Glu         
    45                  50                  55                          

aac ttc cgc cgg ctg ctc ggc gac ggc tcc ccg ctc ggc atc tcg ctc      303
Asn Phe Arg Arg Leu Leu Gly Asp Gly Ser Pro Leu Gly Ile Ser Leu         
60                  65                  70                  75          

agc tac gcc gtc cag gag cag ccc cgc ggc ctc gcc gag gcc ttc ctc      351
Ser Tyr Ala Val Gln Glu Gln Pro Arg Gly Leu Ala Glu Ala Phe Leu         
                80                  85                  90              

atc tcc gcc gac cac atc ggg gac gac tcc gtc gcc ctc gtc ctc ggc      399
Ile Ser Ala Asp His Ile Gly Asp Asp Ser Val Ala Leu Val Leu Gly         
            95                  100                 105                 

gac aac atc ttc cac ggc ccc ggc ttc gcc gga atc ctc cag gac aag      447
Asp Asn Ile Phe His Gly Pro Gly Phe Ala Gly Ile Leu Gln Asp Lys         
        110                 115                 120                     

gcc gtg gac gtg gac ggc tgc gtg ctc ttc ggc tac ccg gtc cgc gac      495
Ala Val Asp Val Asp Gly Cys Val Leu Phe Gly Tyr Pro Val Arg Asp         
    125                 130                 135                         

ccc gag cgc tac ggc gtc ggc gag gtc gac gcg gac ggc cgg ctg gtc      543
Pro Glu Arg Tyr Gly Val Gly Glu Val Asp Ala Asp Gly Arg Leu Val         
140                 145                 150                 155         

tcc ctg gag gag aag ccg gag cac ccg cgc tcc gac ctc gcc atc acc      591
Ser Leu Glu Glu Lys Pro Glu His Pro Arg Ser Asp Leu Ala Ile Thr         
                160                 165                 170             

ggc ctc tac ttc tac gac aac gac gtc atc gac atc gcc aag aac ctc      639
Gly Leu Tyr Phe Tyr Asp Asn Asp Val Ile Asp Ile Ala Lys Asn Leu         
            175                 180                 185                 

acg ccc tcg gcg cgc ggc gaa ctg gag atc acc gac gtc aac cgg atc      687
Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val Asn Arg Ile         
        190                 195                 200                     

tac ctg gag cgc ggc aag gcc gaa ctg gtg tcc ctg gga cgc ggg ttc      735
Tyr Leu Glu Arg Gly Lys Ala Glu Leu Val Ser Leu Gly Arg Gly Phe         
    205                 210                 215                         

gtc tgg ctc gac gcc gga acg cac gac gcg ctg acc gag gcc ggc cag      783
Val Trp Leu Asp Ala Gly Thr His Asp Ala Leu Thr Glu Ala Gly Gln         
220                 225                 230                 235         

tac gtg cag atc ctg gag cac cgc cag ggc gtc cgg ctc gcc tgc ctc      831
Tyr Val Gln Ile Leu Glu His Arg Gln Gly Val Arg Leu Ala Cys Leu         
                240                 245                 250             

gag gag atc gcc tgg cgc atg ggg ttc atc gac cgg gag gcc tgc ctg      879
Glu Glu Ile Ala Trp Arg Met Gly Phe Ile Asp Arg Glu Ala Cys Leu         
            255                 260                 265                 

cgg ctc ggc gag gag ctc tcg aag tcc ccg tac ggc cag tac gtc atg      927
Arg Leu Gly Glu Glu Leu Ser Lys Ser Pro Tyr Gly Gln Tyr Val Met         
        270                 275                 280                     

gag ata gcc cgg gcc ggc tga cccggccgcc cccaccgccc cgccacgccc         978
Glu Ile Ala Arg Ala Gly                                                 
    285                                                                 

ccgccccgcg gagagagaac catgcgataa gatctctggt ccagctcaac gcgctcctcg   1038

gagggacggc atg agg atc ctc gtc acc ggc ggt gcc ggc ttc atc ggc      1087
           Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly          
           290                 295                 300                  

tcc cac tac gtc cgc tcc ctc ctc gac ggg gcg tac ggc ggc gac ggc     1135
Ser His Tyr Val Arg Ser Leu Leu Asp Gly Ala Tyr Gly Gly Asp Gly         
        305                 310                 315                     

acc gac acc gtc acc gtc ctc gac aag ctg acc tac gcg ggc aac cgg     1183
Thr Asp Thr Val Thr Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Arg         
    320                 325                 330                         

gac aac ctg ccc gcc tcc cac gag cgg ctc acc ttc gtc cgc ggc gac     1231
Asp Asn Leu Pro Ala Ser His Glu Arg Leu Thr Phe Val Arg Gly Asp         
335                 340                 345                 350         

atc tgc gac ctg ccg ctg ctg ctc gac ctc ctc ccc ggg cac gac gcg     1279
Ile Cys Asp Leu Pro Leu Leu Leu Asp Leu Leu Pro Gly His Asp Ala         
                355                 360                 365             

gtc gtc cac ttc gcc gcc gag tcg cac gtc gac cgg tcc ctg gag tcg     1327
Val Val His Phe Ala Ala Glu Ser His Val Asp Arg Ser Leu Glu Ser         
            370                 375                 380                 

gcc gcc gag ttc gtc cgc acc aac gtc ctc ggc acc cag acc gtc ctg     1375
Ala Ala Glu Phe Val Arg Thr Asn Val Leu Gly Thr Gln Thr Val Leu         
        385                 390                 395                     

gag gcc gcg ctg cgc acc ggc gtc cag cgg ctc gtg cac gtc tcc acc     1423
Glu Ala Ala Leu Arg Thr Gly Val Gln Arg Leu Val His Val Ser Thr         
    400                 405                 410                         

gac gag gtg tac ggc acg atc gac gag ggc tcg tgg acc gag gac ttc     1471
Asp Glu Val Tyr Gly Thr Ile Asp Glu Gly Ser Trp Thr Glu Asp Phe         
415                 420                 425                 430         

ccg ctc ctg ccc aac tcc ccg tac gcc gcc tcc aag gcg agc tcg gac     1519
Pro Leu Leu Pro Asn Ser Pro Tyr Ala Ala Ser Lys Ala Ser Ser Asp         
                435                 440                 445             

ctg gtg gcc cgc tcc tac tgg cgc acc cac ggg ctc gac ctg tcg atc     1567
Leu Val Ala Arg Ser Tyr Trp Arg Thr His Gly Leu Asp Leu Ser Ile         
            450                 455                 460                 

acc cgc tgc tcc aac aac tac ggg ccg tac cag cac ccc gag aag ctc     1615
Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln His Pro Glu Lys Leu         
        465                 470                 475                     

atc ccg cgc ttc gtc acc aac ctc ctg gag ggc cac ccg gtg ccg gtc     1663
Ile Pro Arg Phe Val Thr Asn Leu Leu Glu Gly His Pro Val Pro Val         
    480                 485                 490                         

tac ggc gac ggg cgg aac gtc cgc gag tgg ctg cac gtc gac gac cac     1711
Tyr Gly Asp Gly Arg Asn Val Arg Glu Trp Leu His Val Asp Asp His         
495                 500                 505                 510         

tgc cgg gcg atc cac ctg gtg ctc acc acc ggc cgg gcg ggc gag acg     1759
Cys Arg Ala Ile His Leu Val Leu Thr Thr Gly Arg Ala Gly Glu Thr         
                515                 520                 525             

tac aac atc ggc agc ggg aac gag ctc acc aac ctc gac ctg acc gaa     1807
Tyr Asn Ile Gly Ser Gly Asn Glu Leu Thr Asn Leu Asp Leu Thr Glu         
            530                 535                 540                 

cgc atc ctg gac ctc tgc ggc gcc gac cgc tcg atg atc cgg tac gtc     1855
Arg Ile Leu Asp Leu Cys Gly Ala Asp Arg Ser Met Ile Arg Tyr Val         
        545                 550                 555                     

gag gac cgc aag gga cac gac ctg cgg tac tcg ctc tcc gac gcc aag     1903
Glu Asp Arg Lys Gly His Asp Leu Arg Tyr Ser Leu Ser Asp Ala Lys         
    560                 565                 570                         

atc cgc gaa gag ctg ggc tac acg ccc cgg acc tcc ttc gag gac ggc     1951
Ile Arg Glu Glu Leu Gly Tyr Thr Pro Arg Thr Ser Phe Glu Asp Gly         
575                 580                 585                 590         

ctg cgc cgg acc gtc gac tgg tac cgc gac aac ccc cag tgg tgg aag     1999
Leu Arg Arg Thr Val Asp Trp Tyr Arg Asp Asn Pro Gln Trp Trp Lys         
                595                 600                 605             

gcc ggc aag gag aag tga cgacgaccat gcacaattga cgtcataggc tttcggcc   2055
Ala Gly Lys Glu Lys                                                     
            610                                                         

gtg cag gta cgt cga ctt gac atc acg ggt gca tac gag ttc acc ccg     2103
Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro         
            615                 620                 625                 

aag gcc ttc ccc gac cac cgg ggc ctg ttc gtg gcc ccg ttc cag gag     2151
Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu         
        630                 635                 640                     

gcg gcg ttc atc gac gcc acg ggg cac ccg ctg cga gtc gcg cag acc     2199
Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr         
    645                 650                 655                         

aac cac agc gtc tcg gcg cgc aac gtc atc cgc ggc gtg cac ttc tcg     2247
Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser         
660                 665                 670                 675         

gac gtg ccg ccg ggc caa gcg aag tac gtg tac tgc ccg cag ggc gcg     2295
Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala         
                680                 685                 690             

ctg ctc gac gtg gtc atc gac atc cgg gtc ggt tcc ccg acc ttc ggc     2343
Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly         
            695                 700                 705                 

cgc tgg gag gcg gtc cgg ctc gac gac acc gag tac cgg gcc gtc tac     2391
Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr         
        710                 715                 720                     

cta gcc gaa gga ctc ggg cac gcg ttc gcc gcg ctg acc gac gac acc     2439
Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr         
    725                 730                 735                         

gtg atg acc tac ctc tgc tcg acg ccc tac acc ccg ggc gcc gag cac     2487
Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His         
740                 745                 750                 755         

ggc atc gac ccg ttc gac ccg gaa ctc gcg ttg ccg tgg tcc gac ctc     2535
Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu         
                760                 765                 770             

gac ggt gaa ccg gtc ctg tcc gaa aag gac cgg acc gcc ccg agc ctc     2583
Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu         
            775                 780                 785                 

gcg gaa gcc gcc gac aac ggc ctg ctt ccg gac tac gaa aca tgc ctc     2631
Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu         
        790                 795                 800                     

gcc cac tac gaa ggc ctg cgc agc ccc ggc tga acggtcaatg catgatcggc   2684
Ala His Tyr Glu Gly Leu Arg Ser Pro Gly                                 
    805                 810                                             

ggtggctcg atg agt cgc ctc gcc gtg ctg gtg ccc ggc ggc cgc ggc cag   2735
          Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln       
              815                 820                 825               

ctg ggc tcg gag ctg gcc cgg atc ctc gcc gcg cgg acg ggg gcg ctg     2783
Leu Gly Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu         
        830                 835                 840                     

gtg cac cgg ccg ggt tcc ggg gaa ctg gac gtc acc gac gcc gag gag     2831
Val His Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu         
    845                 850                 855                         

gtc gcc gac gcg ttg ggt tcc ttc gcg gag acg gcg aag gac gcg gag     2879
Val Ala Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu         
860                 865                 870                 875         

ctg cga ccg gtg gtg atc aac gcc gcg gcg tac acg gcg gtg gac gcg     2927
Leu Arg Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala         
                880                 885                 890             

gcc gag tcc gac ccg gac cgc gcg gcc cgg atc aac gcc gaa ggc gcg     2975
Ala Glu Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala         
            895                 900                 905                 

gcc tcg ctg gcg aaa gcg tgc cgg agc agc ggt ctg ccc ctg gtg cac     3023
Ala Ser Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His         
        910                 915                 920                     

gtg tcg acg gat tac gtg ttc ccc ggt gat ggg gcc cgg ccg tac gag     3071
Val Ser Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu         
    925                 930                 935                         

ccg acg gac ccg acc ggg ccg cga tcg gtc tac ggg cgc acc aag ctc     3119
Pro Thr Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu         
940                 945                 950                 955         

gaa ggc gaa cgg gcc gtg ctg gag tcc ggc gcg cgg gcc tgg gtg gtg     3167
Glu Gly Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val         
                960                 965                 970             

cgc acg gca tgg gtg tac ggc gcg agc ggc aag aac ttc ctg aaa acg     3215
Arg Thr Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr         
            975                 980                 985                 

atg atc cgc ctc tcg ggg gag cgc gac acg ctg tcc gtt  gtg gac gat    3263
Met Ile Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val  Val Asp Asp        
        990                 995                 1000                    

cag atc  ggc tcg ccg act tgg  gcg gcg gac ctg gcg  agc ggc ctg      3308
Gln Ile  Gly Ser Pro Thr Trp  Ala Ala Asp Leu Ala  Ser Gly Leu          
    1005                 1010                 1015                      

ctg gag  ctg gcc gaa cgg gtc  gcc gaa cgc cgt gga  ccg gag cag      3353
Leu Glu  Leu Ala Glu Arg Val  Ala Glu Arg Arg Gly  Pro Glu Gln          
    1020                 1025                 1030                      

aag gtg  ctg cac tgc acc aat  tcc ggc cag gtg acc  tgg tac gag      3398
Lys Val  Leu His Cys Thr Asn  Ser Gly Gln Val Thr  Trp Tyr Glu          
    1035                 1040                 1045                      

ttc gcg  cgg gcg atc ttc gcg  gaa ttc ggc ctg gac  gag aac cgc      3443
Phe Ala  Arg Ala Ile Phe Ala  Glu Phe Gly Leu Asp  Glu Asn Arg          
    1050                 1055                 1060                      

gtc cac  ccg tgc acg acg gcg  gac ttc ccc ctc ccg  gcg cac cgc      3488
Val His  Pro Cys Thr Thr Ala  Asp Phe Pro Leu Pro  Ala His Arg          
    1065                 1070                 1075                      

ccg gcc  tac tcg gtc ctg tcc  gac gtg gcg tgg cga  gag gcg ggc      3533
Pro Ala  Tyr Ser Val Leu Ser  Asp Val Ala Trp Arg  Glu Ala Gly          
    1080                 1085                 1090                      

ctg acc  ccg atg cgc acc tgg  cgg gaa gcc ctg gcg  gcg gcc ttc      3578
Leu Thr  Pro Met Arg Thr Trp  Arg Glu Ala Leu Ala  Ala Ala Phe          
    1095                 1100                 1105                      

gag aaa  gac ggc gaa acc ctc  cga acc cgc tga ccagtcacta            3621
Glu Lys  Asp Gly Glu Thr Leu  Arg Thr Arg                               
    1110                 1115                                           

gtggagggcc actcctg atg agc  acc gcc acc acc acg  ccc gcc ccc gcc    3671
                   Met Ser  Thr Ala Thr Thr Thr  Pro Ala Pro Ala        
                       1120                 1125                        

ctc  acc gcc cgc cgg ccc  gcc ggg ctc gcc gag  cgg atc gcc cgc      3716
Leu  Thr Ala Arg Arg Pro  Ala Gly Leu Ala Glu  Arg Ile Ala Arg          
1130                 1135                 1140                          

tcg  gcc gcc acc ggc cgc  ggc gcc cac ctg gcc  acc gag gac ttc      3761
Ser  Ala Ala Thr Gly Arg  Gly Ala His Leu Ala  Thr Glu Asp Phe          
1145                 1150                 1155                          

cac  gac tgg ctc gac ggc  cgc cgc cgc gcc aac  acc ttc cgc gtc      3806
His  Asp Trp Leu Asp Gly  Arg Arg Arg Ala Asn  Thr Phe Arg Val          
1160                 1165                 1170                          

gac  aag atc ccc ttc gac  gcg ctc gac ggc tgg  tcc ttc gac gag      3851
Asp  Lys Ile Pro Phe Asp  Ala Leu Asp Gly Trp  Ser Phe Asp Glu          
1175                 1180                 1185                          

gag  gac ggc aac ctc gtc  cac cgc agc ggc cgc  ttc ttc acc gtc      3896
Glu  Asp Gly Asn Leu Val  His Arg Ser Gly Arg  Phe Phe Thr Val          
1190                 1195                 1200                          

gag  ggc ctg cac gtc gtc  gag gag gac gga ccc  tac ggc gac ggc      3941
Glu  Gly Leu His Val Val  Glu Glu Asp Gly Pro  Tyr Gly Asp Gly          
1205                 1210                 1215                          

ccg  tac cgc tcc tgg tac  cag ccc gtc atc aag  cag ccc gag gtc      3986
Pro  Tyr Arg Ser Trp Tyr  Gln Pro Val Ile Lys  Gln Pro Glu Val          
1220                 1225                 1230                          

ggc  atc ctc ggc atc ctc  gcc aag gag ttc gac  ggc gtc ctg cac      4031
Gly  Ile Leu Gly Ile Leu  Ala Lys Glu Phe Asp  Gly Val Leu His          
1235                 1240                 1245                          

ttc  ctc atg cag gcc aag  atg gag ccc ggc aac  ccg aac ctg ctc      4076
Phe  Leu Met Gln Ala Lys  Met Glu Pro Gly Asn  Pro Asn Leu Leu          
1250                 1255                 1260                          

cag  ctg tcg ccg acc gtc  cag gcc acc cgc agc  aac tac acc aag      4121
Gln  Leu Ser Pro Thr Val  Gln Ala Thr Arg Ser  Asn Tyr Thr Lys          
1265                 1270                 1275                          

gcg  cac cgc ggc ggc gac  gtg aag tac atc gag  tac ttc acc ggc      4166
Ala  His Arg Gly Gly Asp  Val Lys Tyr Ile Glu  Tyr Phe Thr Gly          
1280                 1285                 1290                          

gcc  gaa cac ggc acc gtc  atc gcc gac tcc ctc  cag tcc gag cac      4211
Ala  Glu His Gly Thr Val  Ile Ala Asp Ser Leu  Gln Ser Glu His          
1295                 1300                 1305                          

ggc  gcc tgg ttc ttc cac  aag tcc aac cgc aac  atg atc gtc gag      4256
Gly  Ala Trp Phe Phe His  Lys Ser Asn Arg Asn  Met Ile Val Glu          
1310                 1315                 1320                          

gcc  acc ggc gag gtc ccg  ctc ctc gac gac ttc  tgc tgg ctc acc      4301
Ala  Thr Gly Glu Val Pro  Leu Leu Asp Asp Phe  Cys Trp Leu Thr          
1325                 1330                 1335                          

ctc  ggc cag ctc ggc gag  ctc ctc cac cag gac  aac gtc atc aac      4346
Leu  Gly Gln Leu Gly Glu  Leu Leu His Gln Asp  Asn Val Ile Asn          
1340                 1345                 1350                          

atg  gac gcc agg acc gtc  ctg tcc tgc gtg ccg  tac gag gac gcc      4391
Met  Asp Ala Arg Thr Val  Leu Ser Cys Val Pro  Tyr Glu Asp Ala          
1355                 1360                 1365                          

gac  gcc ggg cgg gcg ctg  ctc tcc gac gtc cag  ctg ctc tcc tgg      4436
Asp  Ala Gly Arg Ala Leu  Leu Ser Asp Val Gln  Leu Leu Ser Trp          
1370                 1375                 1380                          

ttc  acc ggc gag cgc tcc  cgc cac gac gta cgg  gcc cgg cgc gtc      4481
Phe  Thr Gly Glu Arg Ser  Arg His Asp Val Arg  Ala Arg Arg Val          
1385                 1390                 1395                          

ccg  ctg cgc gag ctg ccc  ggc tgg aag cag ggc  gag gag acc atc      4526
Pro  Leu Arg Glu Leu Pro  Gly Trp Lys Gln Gly  Glu Glu Thr Ile          
1400                 1405                 1410                          

gag  cac gag gag ggc cgg  cac ttc aag gtc gtc  gcc gtc tcc gtg      4571
Glu  His Glu Glu Gly Arg  His Phe Lys Val Val  Ala Val Ser Val          
1415                 1420                 1425                          

cag  gcc ggg aac cgc gaa  gtg acc agc tgg acc  cag ccg ctg atc      4616
Gln  Ala Gly Asn Arg Glu  Val Thr Ser Trp Thr  Gln Pro Leu Ile          
1430                 1435                 1440                          

gaa  ccg gtc gga ctc ggc  gtc gcc gcc ttc ctg  acc cgc gac ttc      4661
Glu  Pro Val Gly Leu Gly  Val Ala Ala Phe Leu  Thr Arg Asp Phe          
1445                 1450                 1455                          

gac  ggc gtc ccg cac tac  ctg gtg cac gcc cgc  gtc gag ggc ggc      4706
Asp  Gly Val Pro His Tyr  Leu Val His Ala Arg  Val Glu Gly Gly          
1460                 1465                 1470                          

ttc  ctc gac acc gtg gaa  ctg gcc ccc acc gtc  cag tac acc ccg      4751
Phe  Leu Asp Thr Val Glu  Leu Ala Pro Thr Val  Gln Tyr Thr Pro          
1475                 1480                 1485                          

ggc  aac tac gcc cac ctg  ccg acc gac gag cgc  ccg ccc ttc ctc      4796
Gly  Asn Tyr Ala His Leu  Pro Thr Asp Glu Arg  Pro Pro Phe Leu          
1490                 1495                 1500                          

gac  ctc gtc ctc gac acc  gac ccc gcc cgc gtc  cgc tac gag gcc      4841
Asp  Leu Val Leu Asp Thr  Asp Pro Ala Arg Val  Arg Tyr Glu Ala          
1505                 1510                 1515                          

gtg  cac tcc gag gaa ggc  ggc cgc ttc ctc aac  gcc gag agc cgc      4886
Val  His Ser Glu Glu Gly  Gly Arg Phe Leu Asn  Ala Glu Ser Arg          
1520                 1525                 1530                          

tac  ctc ctg gtg gag gcc  gac gag acg cag gcc  ccg gcc gac ccg      4931
Tyr  Leu Leu Val Glu Ala  Asp Glu Thr Gln Ala  Pro Ala Asp Pro          
1535                 1540                 1545                          

ccg  ccc ggc tac gcc tgg  gcg acc gcc gca cag  ctc acc tcc ctc      4976
Pro  Pro Gly Tyr Ala Trp  Ala Thr Ala Ala Gln  Leu Thr Ser Leu          
1550                 1555                 1560                          

acc  cgg cac ggc cac tac  ctc aac gtc cag gcc  cgc acc ctg ctg      5021
Thr  Arg His Gly His Tyr  Leu Asn Val Gln Ala  Arg Thr Leu Leu          
1565                 1570                 1575                          

gcc  tgc gtc cac gcc ggg  gcg gtg cgg cct tga cgagcacccc            5064
Ala  Cys Val His Ala Gly  Ala Val Arg Pro                               
1580                 1585                                               

ggcgcatatg ggggaggtgc ggcc ttg  acg agc acc ccg gcg  ccc ctg cgg    5115
                           Leu  Thr Ser Thr Pro Ala  Pro Leu Arg        
                           1590                 1595                    

atc ggt  gtg ctc ggc tgc gcc  gac atc gcc gtc cgg  cgc atg atg      5160
Ile Gly  Val Leu Gly Cys Ala  Asp Ile Ala Val Arg  Arg Met Met          
    1600                 1605                 1610                      

ccc gcg  atg gcc gcg ctc ccc  ggg acc gag gtc acc  gcc gtc gcc      5205
Pro Ala  Met Ala Ala Leu Pro  Gly Thr Glu Val Thr  Ala Val Ala          
    1615                 1620                 1625                      

agc cgc  gac gcg gcg aag gcc  gcc gtg gcc gcc gcc  ccg tac ggc      5250
Ser Arg  Asp Ala Ala Lys Ala  Ala Val Ala Ala Ala  Pro Tyr Gly          
    1630                 1635                 1640                      

gcg gcg  gcc gtc gag ggc tac  cag gag ctg ctg cgc  cgc ccg gac      5295
Ala Ala  Ala Val Glu Gly Tyr  Gln Glu Leu Leu Arg  Arg Pro Asp          
    1645                 1650                 1655                      

gtc gac  gcc gtc tac gta ccg  ctg ccc gcc gcc ctg  cac gcc gag      5340
Val Asp  Ala Val Tyr Val Pro  Leu Pro Ala Ala Leu  His Ala Glu          
    1660                 1665                 1670                      

tgg acc  gag gcc gcc ctg cgg  gcc ggc aag cac gtc  ctg gcc gag      5385
Trp Thr  Glu Ala Ala Leu Arg  Ala Gly Lys His Val  Leu Ala Glu          
    1675                 1680                 1685                      

aag ccg  ctc acc acg gac ccg  gag agc acc gcc gcg  ctg ctc ggc      5430
Lys Pro  Leu Thr Thr Asp Pro  Glu Ser Thr Ala Ala  Leu Leu Gly          
    1690                 1695                 1700                      

ctg gcc  gcc gcg tcc ggg ctc  gcg ctg atg gag aac  gtc atg ttc      5475
Leu Ala  Ala Ala Ser Gly Leu  Ala Leu Met Glu Asn  Val Met Phe          
    1705                 1710                 1715                      

gtc cac  cac cgc ctc cac acc  gac gtc cgc aag ctc  gtc gcg gac      5520
Val His  His Arg Leu His Thr  Asp Val Arg Lys Leu  Val Ala Asp          
    1720                 1725                 1730                      

gga gcc  atc ggc gaa ctc cgc  gcc ctg cac gcc tcg  ttc ggc atc      5565
Gly Ala  Ile Gly Glu Leu Arg  Ala Leu His Ala Ser  Phe Gly Ile          
    1735                 1740                 1745                      

ccc cgg  ctg ccc gac acc gac  atc cgg cac gac ccc  ggg ctc ggc      5610
Pro Arg  Leu Pro Asp Thr Asp  Ile Arg His Asp Pro  Gly Leu Gly          
    1750                 1755                 1760                      

ggc ggc  gcc ctc ggc gac gtc  ggc gtc tac ccg ctg  cga gcc gcc      5655
Gly Gly  Ala Leu Gly Asp Val  Gly Val Tyr Pro Leu  Arg Ala Ala          
    1765                 1770                 1775                      

cag cac  ctg ctc ggc gac gaa  ctc gac gtc ctc ggc  gcg cac ctc      5700
Gln His  Leu Leu Gly Asp Glu  Leu Asp Val Leu Gly  Ala His Leu          
    1780                 1785                 1790                      

gtc cgg  ggg ccc ggc agc cgg  gtc gag acc gcc ggc  ggg gcg ctg      5745
Val Arg  Gly Pro Gly Ser Arg  Val Glu Thr Ala Gly  Gly Ala Leu          
    1795                 1800                 1805                      

ctc gcc  acc ccg gcg ggc gtc  acc gcg cac atc gcc  ttc ggc atg      5790
Leu Ala  Thr Pro Ala Gly Val  Thr Ala His Ile Ala  Phe Gly Met          
    1810                 1815                 1820                      

gac cac  ggc tac cgc tcg gcg  tac gag ctg tgg ggc  agc cag ggc      5835
Asp His  Gly Tyr Arg Ser Ala  Tyr Glu Leu Trp Gly  Ser Gln Gly          
    1825                 1830                 1835                      

cgg ctc  gtc gtc gag cgg gcc  tac acc ccg ccc gcc  gac cac cgc      5880
Arg Leu  Val Val Glu Arg Ala  Tyr Thr Pro Pro Ala  Asp His Arg          
    1840                 1845                 1850                      

ccg gtg  gtg cgc ctg gag acc  cgc acc ggc gtc gag  gag ctc gtc      5925
Pro Val  Val Arg Leu Glu Thr  Arg Thr Gly Val Glu  Glu Leu Val          
    1855                 1860                 1865                      

ctc gac  gcc gac gac cag gtc  cgc aac acg gtg gcc  gcc ttc gcc      5970
Leu Asp  Ala Asp Asp Gln Val  Arg Asn Thr Val Ala  Ala Phe Ala          
    1870                 1875                 1880                      

gcc ctc  gtg gcg cgc acc gga  gcc ggc cac ccc ggg  gac ggc ggc      6015
Ala Leu  Val Ala Arg Thr Gly  Ala Gly His Pro Gly  Asp Gly Gly          
    1885                 1890                 1895                      

gcg ccc  gac ccg gag gcc ccg  ctg cgc cag gcg cgg  ctg ctc gac      6060
Ala Pro  Asp Pro Glu Ala Pro  Leu Arg Gln Ala Arg  Leu Leu Asp          
    1900                 1905                 1910                      

gcc gtg  cgg cgc cgg gcc gcc  ctc gtc tga cccgcgcctc taga           6104
Ala Val  Arg Arg Arg Ala Ala  Leu Val                                   
    1915                 1920                                           


<210>  104
<211>  289
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  104

Val Lys Gly Ile Val Leu Ala Gly Gly His Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Ile Thr Leu Gly Thr Ser Lys Gln Met Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Ile Gln Ile Ile Ser Ser Pro Asp Asp Ile Glu Asn Phe Arg Arg Leu 
    50                  55                  60                  


Leu Gly Asp Gly Ser Pro Leu Gly Ile Ser Leu Ser Tyr Ala Val Gln 
65                  70                  75                  80  


Glu Gln Pro Arg Gly Leu Ala Glu Ala Phe Leu Ile Ser Ala Asp His 
                85                  90                  95      


Ile Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe His 
            100                 105                 110         


Gly Pro Gly Phe Ala Gly Ile Leu Gln Asp Lys Ala Val Asp Val Asp 
        115                 120                 125             


Gly Cys Val Leu Phe Gly Tyr Pro Val Arg Asp Pro Glu Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Ala Asp Gly Arg Leu Val Ser Leu Glu Glu Lys 
145                 150                 155                 160 


Pro Glu His Pro Arg Ser Asp Leu Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Ile Asp Ile Ala Lys Asn Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Arg Ile Tyr Leu Glu Arg Gly 
        195                 200                 205             


Lys Ala Glu Leu Val Ser Leu Gly Arg Gly Phe Val Trp Leu Asp Ala 
    210                 215                 220                 


Gly Thr His Asp Ala Leu Thr Glu Ala Gly Gln Tyr Val Gln Ile Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Leu Ala Cys Leu Glu Glu Ile Ala Trp 
                245                 250                 255     


Arg Met Gly Phe Ile Asp Arg Glu Ala Cys Leu Arg Leu Gly Glu Glu 
            260                 265                 270         


Leu Ser Lys Ser Pro Tyr Gly Gln Tyr Val Met Glu Ile Ala Arg Ala 
        275                 280                 285             


Gly 
    


<210>  105
<211>  322
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  105

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Ser Leu Leu Asp Gly Ala Tyr Gly Gly Asp Gly Thr Asp Thr 
            20                  25                  30          


Val Thr Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Arg Asp Asn Leu 
        35                  40                  45              


Pro Ala Ser His Glu Arg Leu Thr Phe Val Arg Gly Asp Ile Cys Asp 
    50                  55                  60                  


Leu Pro Leu Leu Leu Asp Leu Leu Pro Gly His Asp Ala Val Val His 
65                  70                  75                  80  


Phe Ala Ala Glu Ser His Val Asp Arg Ser Leu Glu Ser Ala Ala Glu 
                85                  90                  95      


Phe Val Arg Thr Asn Val Leu Gly Thr Gln Thr Val Leu Glu Ala Ala 
            100                 105                 110         


Leu Arg Thr Gly Val Gln Arg Leu Val His Val Ser Thr Asp Glu Val 
        115                 120                 125             


Tyr Gly Thr Ile Asp Glu Gly Ser Trp Thr Glu Asp Phe Pro Leu Leu 
    130                 135                 140                 


Pro Asn Ser Pro Tyr Ala Ala Ser Lys Ala Ser Ser Asp Leu Val Ala 
145                 150                 155                 160 


Arg Ser Tyr Trp Arg Thr His Gly Leu Asp Leu Ser Ile Thr Arg Cys 
                165                 170                 175     


Ser Asn Asn Tyr Gly Pro Tyr Gln His Pro Glu Lys Leu Ile Pro Arg 
            180                 185                 190         


Phe Val Thr Asn Leu Leu Glu Gly His Pro Val Pro Val Tyr Gly Asp 
        195                 200                 205             


Gly Arg Asn Val Arg Glu Trp Leu His Val Asp Asp His Cys Arg Ala 
    210                 215                 220                 


Ile His Leu Val Leu Thr Thr Gly Arg Ala Gly Glu Thr Tyr Asn Ile 
225                 230                 235                 240 


Gly Ser Gly Asn Glu Leu Thr Asn Leu Asp Leu Thr Glu Arg Ile Leu 
                245                 250                 255     


Asp Leu Cys Gly Ala Asp Arg Ser Met Ile Arg Tyr Val Glu Asp Arg 
            260                 265                 270         


Lys Gly His Asp Leu Arg Tyr Ser Leu Ser Asp Ala Lys Ile Arg Glu 
        275                 280                 285             


Glu Leu Gly Tyr Thr Pro Arg Thr Ser Phe Glu Asp Gly Leu Arg Arg 
    290                 295                 300                 


Thr Val Asp Trp Tyr Arg Asp Asn Pro Gln Trp Trp Lys Ala Gly Lys 
305                 310                 315                 320 


Glu Lys 
        


<210>  106
<211>  202
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  106

Val Gln Val Arg Arg Leu Asp Ile Thr Gly Ala Tyr Glu Phe Thr Pro 
1               5                   10                  15      


Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gln Glu 
            20                  25                  30          


Ala Ala Phe Ile Asp Ala Thr Gly His Pro Leu Arg Val Ala Gln Thr 
        35                  40                  45              


Asn His Ser Val Ser Ala Arg Asn Val Ile Arg Gly Val His Phe Ser 
    50                  55                  60                  


Asp Val Pro Pro Gly Gln Ala Lys Tyr Val Tyr Cys Pro Gln Gly Ala 
65                  70                  75                  80  


Leu Leu Asp Val Val Ile Asp Ile Arg Val Gly Ser Pro Thr Phe Gly 
                85                  90                  95      


Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 
            100                 105                 110         


Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 
        115                 120                 125             


Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 
    130                 135                 140                 


Gly Ile Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 
145                 150                 155                 160 


Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 
                165                 170                 175     


Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 
            180                 185                 190         


Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 
        195                 200         


<210>  107
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  107

Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly 
1               5                   10                  15      


Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His 
            20                  25                  30          


Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala 
        35                  40                  45              


Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg 
    50                  55                  60                  


Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu 
65                  70                  75                  80  


Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser 
                85                  90                  95      


Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser 
            100                 105                 110         


Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr 
        115                 120                 125             


Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly 
    130                 135                 140                 


Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr 
145                 150                 155                 160 


Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile 
                165                 170                 175     


Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asp Gln Ile 
            180                 185                 190         


Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu 
        195                 200                 205             


Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gln Lys Val Leu His 
    210                 215                 220                 


Cys Thr Asn Ser Gly Gln Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile 
225                 230                 235                 240 


Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr 
                245                 250                 255     


Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser 
            260                 265                 270         


Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg 
        275                 280                 285             


Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr 
    290                 295                 300                 


Arg 
305 


<210>  108
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  108

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  109
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  109

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  110
<211>  7811
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (24)..(905)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (933)..(1922)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1964)..(3352)
<223>  spnQ gene from S. spinosa


<220>
<221>  CDS
<222>  (3390)..(4547)
<223>  spnR gene from S. spinosa


<220>
<221>  CDS
<222>  (4550)..(5299)
<223>  spnS gene from S. spinosa


<220>
<221>  CDS
<222>  (5346)..(6761)
<223>  tdh gene from S. diversa


<220>
<221>  CDS
<222>  (6796)..(7797)
<223>  tkr gene from S. diversa


<400>  110
aagcttccgc tggaggtatc cgg gtg aag ggg atc gtg ctg gcg ggt ggc aac     53
                          Val Lys Gly Ile Val Leu Ala Gly Gly Asn       
                          1               5                   10        

ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag cta ctt      101
Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln Leu Leu         
                15                  20                  25              

ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg ctg atg      149
Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val Leu Met         
            30                  35                  40                  

ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc gac atg      197
Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala Asp Met         
        45                  50                  55                      

ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc att cgg      245
Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg         
    60                  65                  70                          

atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag gcg ttc      293
Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe         
75                  80                  85                  90          

gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg gtg ctc      341
Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu Val Leu         
                95                  100                 105             

ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc cag cag      389
Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln         
            110                 115                 120                 

tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg gtc cgc      437
Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg         
        125                 130                 135                     

gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt cgg ctg      485
Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly Arg Leu         
    140                 145                 150                         

ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg gcc atc      533
Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met Ala Ile         
155                 160                 165                 170         

acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc aag ggg      581
Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala Lys Gly         
                175                 180                 185             

ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc aac ctg      629
Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val Asn Leu         
            190                 195                 200                 

gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc cgc ggg      677
Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly Arg Gly         
        205                 210                 215                     

ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag gcc tcg      725
Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu Ala Ser         
    220                 225                 230                         

cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc gcc tgc      773
Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile Ala Cys         
235                 240                 245                 250         

ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac gac tgt      821
Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys         
                255                 260                 265             

ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag tac gtc      869
Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val         
            270                 275                 280                 

atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga cccgagatcc           915
Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                             
        285                 290                                         

cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc ggt ttc       965
                   Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe          
                       295                 300                          

atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac ccc gca     1013
Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala         
305                 310                 315                 320         

ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac gcc ggc     1061
Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly         
                325                 330                 335             

aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg aag ttc     1109
Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe         
            340                 345                 350                 

gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg atg tcc     1157
Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser         
        355                 360                 365                     

ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc gac cgc     1205
Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val Asp Arg         
    370                 375                 380                         

tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc ggc acc     1253
Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr         
385                 390                 395                 400         

aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag ttc gtg     1301
Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val         
                405                 410                 415             

cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc tcg tgg     1349
His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp         
            420                 425                 430                 

ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg gcg aaa     1397
Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys         
        435                 440                 445                     

gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac gga ctg     1445
Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu         
    450                 455                 460                         

ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac cag ttc     1493
Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe         
465                 470                 475                 480         

ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac ggc agc     1541
Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser         
                485                 490                 495             

cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg ctg cac     1589
Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His         
            500                 505                 510                 

gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc ggg cgc     1637
Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg         
        515                 520                 525                     

gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc aac aac     1685
Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn         
    530                 535                 540                         

gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg tcg gtg     1733
Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val         
545                 550                 555                 560         

gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac tcg gtg     1781
Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val         
                565                 570                 575             

gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag gtc gac     1829
Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp         
            580                 585                 590                 

ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac aac cgg     1877
Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg         
        595                 600                 605                     

gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga tga         1922
Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg                 
    610                 615                 620                         

gtcgcctcca attgaaggcg cgaagactga tcgtcgcctg c atg cag agc cgg aaa   1978
                                              Met Gln Ser Arg Lys       
                                                      625               

acc aga gcg ctg ggg aaa ggg cgc gcc aga gtg act tcg tgt gac gac     2026
Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val Thr Ser Cys Asp Asp         
        630                 635                 640                     

act tgc gct acc gct act gag atg gtg ccg gat gcc aag gac cgg ata     2074
Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp Ala Lys Asp Arg Ile         
    645                 650                 655                         

ttg gca tcc gta cgc gat tac cac cgc gaa cag gaa tcc ccg acc ttc     2122
Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln Glu Ser Pro Thr Phe         
660                 665                 670                 675         

gtg gct gga tcg acg ccg atc cgg cca tcg ggc gcc gtg ctc gac gag     2170
Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly Ala Val Leu Asp Glu         
                680                 685                 690             

gac gac cgg gtg gca ctg gtg gaa gcc gcg ctg gag ctc cgg atc gcc     2218
Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu Glu Leu Arg Ile Ala         
            695                 700                 705                 

gcg ggc ggg aat gca cgg cga ttc gag agc gag ttc gcc cgc ttc ttc     2266
Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu Phe Ala Arg Phe Phe         
        710                 715                 720                     

ggc ctc cgc aag gct cat ctc gtc aac tcc ggt tcg tcg gcc aat ctc     2314
Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly Ser Ser Ala Asn Leu         
    725                 730                 735                         

ctg gca ctg agt tcg ctt acc tcc ccc aaa ctc ggc gag gca cga ctg     2362
Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu Gly Glu Ala Arg Leu         
740                 745                 750                 755         

cgg ccc ggc gac gaa gtg atc act gcg gcg gtc ggc ttc ccc acg acg     2410
Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val Gly Phe Pro Thr Thr         
                760                 765                 770             

atc aat ccg gcg gtc caa aac gga ctc gtc ccg gta ttc gtc gac gtg     2458
Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro Val Phe Val Asp Val         
            775                 780                 785                 

gaa ctg ggc acc tac aac gca acg cca gac cgc atc aag gcc gcc gtc     2506
Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg Ile Lys Ala Ala Val         
        790                 795                 800                     

acg gaa cgg acg cga gcc atc atg ctg gcg cac acc ctg ggc aac ccc     2554
Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His Thr Leu Gly Asn Pro         
    805                 810                 815                         

ttc gcc gct gac gaa atc gcg gag atc gca aaa gaa cac gag ctg ttc     2602
Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys Glu His Glu Leu Phe         
820                 825                 830                 835         

ctc gtc gaa gac aac tgt gat gcg gtg gga tcc acc tac cgg gga cgg     2650
Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser Thr Tyr Arg Gly Arg         
                840                 845                 850             

ctg acc gga acc ttc ggc gac ctg aca acg gtc agc ttc tat cct gcc     2698
Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val Ser Phe Tyr Pro Ala         
            855                 860                 865                 

cat cac atc acc agc ggc gag ggt ggc tgc gtg ttg acc ggc agc ctg     2746
His His Ile Thr Ser Gly Glu Gly Gly Cys Val Leu Thr Gly Ser Leu         
        870                 875                 880                     

gaa ttg gct cgc atc atc gag tcg ctg cgt gac tgg gga cgg gat tgc     2794
Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp Trp Gly Arg Asp Cys         
    885                 890                 895                         

tgg tgc gag ccc ggc gtg gac aac acc tgc cgc aag agg ttc gac tac     2842
Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg Lys Arg Phe Asp Tyr         
900                 905                 910                 915         

cac ctc ggt acc ctt cca ccg ggc tac gac cac aag tac acg ttc tcc     2890
His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His Lys Tyr Thr Phe Ser         
                920                 925                 930             

cac gtc ggt tac aac ctc aag acc acc gac ctg cag gcc gca ctt gcg     2938
His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu Gln Ala Ala Leu Ala         
            935                 940                 945                 

ctg agc cag ttg agc aag att tcc gca ttc ggg tcg gca cgc cgc cgt     2986
Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly Ser Ala Arg Arg Arg         
        950                 955                 960                     

aac tgg cga cgg ttg cgc gaa ggg ctg tcc ggg ttg ccg ggc ctg ctg     3034
Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly Leu Pro Gly Leu Leu         
    965                 970                 975                         

ctg ccg gta gcc aca ccg cac agc gac ccg agc tgg ttc ggg ttt gcg     3082
Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser Trp Phe Gly Phe Ala         
980                 985                 990                 995         

atc acc atc agt gcg  gac gcc ggg ttc acc  cgt gcc gcc ctg gtg       3127
Ile Thr Ile Ser Ala  Asp Ala Gly Phe Thr  Arg Ala Ala Leu Val           
                1000                 1005                 1010          

aac ttc ctg gaa tcc  cgc aac atc ggc acc  cga ctg ctg ttc ggc       3172
Asn Phe Leu Glu Ser  Arg Asn Ile Gly Thr  Arg Leu Leu Phe Gly           
                1015                 1020                 1025          

ggt aac atc acc cgg  cac ccg gcc ttc gag  cag gtg cgg tac cgg       3217
Gly Asn Ile Thr Arg  His Pro Ala Phe Glu  Gln Val Arg Tyr Arg           
                1030                 1035                 1040          

atc gcc gac gcg ctc  acc aac agc gac atc  gtc acc gac cga acc       3262
Ile Ala Asp Ala Leu  Thr Asn Ser Asp Ile  Val Thr Asp Arg Thr           
                1045                 1050                 1055          

ttc tgg gtc ggc gtc  tac cca ggc ata acg  gac caa atg atc gac       3307
Phe Trp Val Gly Val  Tyr Pro Gly Ile Thr  Asp Gln Met Ile Asp           
                1060                 1065                 1070          

tac gtc gtc gaa tca  atc gct gaa ttc gtg  gcc aag agt tcc tag       3352
Tyr Val Val Glu Ser  Ile Ala Glu Phe Val  Ala Lys Ser Ser               
                1075                 1080                               

catccagcat ggcggcatct cggaggattt cagcaac gtg  atc aac ctg cac       3404
                                         Val  Ile Asn Leu His           
                                         1085                           

cag  ccg atc ctc ggc acc  gaa gaa ctc gac gcg  atc gcg gag gtg      3449
Gln  Pro Ile Leu Gly Thr  Glu Glu Leu Asp Ala  Ile Ala Glu Val          
1090                 1095                 1100                          

ttc  gcc tcc aac tgg atc  ggg ctc ggg ccg cgc  acc cgg acg ttc      3494
Phe  Ala Ser Asn Trp Ile  Gly Leu Gly Pro Arg  Thr Arg Thr Phe          
1105                 1110                 1115                          

gag  gcc gaa ttc gcc cac  cac ctg gga gtg gat  ccc gaa cag gtc      3539
Glu  Ala Glu Phe Ala His  His Leu Gly Val Asp  Pro Glu Gln Val          
1120                 1125                 1130                          

gtg  ttc ctc aac tcg ggg  act gcc gcg ctg ttc  ctt acc gtg cag      3584
Val  Phe Leu Asn Ser Gly  Thr Ala Ala Leu Phe  Leu Thr Val Gln          
1135                 1140                 1145                          

gtg  ctc gac ctc ggc cca  ggc gac gac gtg gta  ctt cct tcg ata      3629
Val  Leu Asp Leu Gly Pro  Gly Asp Asp Val Val  Leu Pro Ser Ile          
1150                 1155                 1160                          

agc  ttc gtg gcg gcg gcc  aac gcc atc gca tcc  tcc ggt gcc cgc      3674
Ser  Phe Val Ala Ala Ala  Asn Ala Ile Ala Ser  Ser Gly Ala Arg          
1165                 1170                 1175                          

ccg  gtg ttc tgc gac gtc  gac ccc cgg acg ttg  aac ccc acg ctg      3719
Pro  Val Phe Cys Asp Val  Asp Pro Arg Thr Leu  Asn Pro Thr Leu          
1180                 1185                 1190                          

gat  gat gtg gcg agg gcc  atc acg ccg gcg acc  aag gcc gta ttg      3764
Asp  Asp Val Ala Arg Ala  Ile Thr Pro Ala Thr  Lys Ala Val Leu          
1195                 1200                 1205                          

ctg  ctc cac tat gga gga  tcg ccg gga gaa gtc  acc gcg atc gcc      3809
Leu  Leu His Tyr Gly Gly  Ser Pro Gly Glu Val  Thr Ala Ile Ala          
1210                 1215                 1220                          

gat  ttc tgc cgt gaa aag  ggc ctc atg ctc atc  gag gac tcc gcc      3854
Asp  Phe Cys Arg Glu Lys  Gly Leu Met Leu Ile  Glu Asp Ser Ala          
1225                 1230                 1235                          

tgc  gcg gtg gca tcg tcc  gtg cac ggc acc gct  tgc gga acc ttt      3899
Cys  Ala Val Ala Ser Ser  Val His Gly Thr Ala  Cys Gly Thr Phe          
1240                 1245                 1250                          

ggt  gac ctg gcc acg tgg  agt ttc gat gcg atg  aag atc ctg gtc      3944
Gly  Asp Leu Ala Thr Trp  Ser Phe Asp Ala Met  Lys Ile Leu Val          
1255                 1260                 1265                          

acc  ggg gat ggg ggc atg  ttc tac gcg gcg gat  ccg gag ctg gcg      3989
Thr  Gly Asp Gly Gly Met  Phe Tyr Ala Ala Asp  Pro Glu Leu Ala          
1270                 1275                 1280                          

cac  cgc gca aga cga ctc  gcc tac cac ggt ctt  gag cag atg agc      4034
His  Arg Ala Arg Arg Leu  Ala Tyr His Gly Leu  Glu Gln Met Ser          
1285                 1290                 1295                          

gga  ttc gat tcg gcc aag  tct tcc aac cgc tgg  tgg gat att cgc      4079
Gly  Phe Asp Ser Ala Lys  Ser Ser Asn Arg Trp  Trp Asp Ile Arg          
1300                 1305                 1310                          

gtc  gaa gac atc ggc cag  cgg ctg atc ggg aac  gac atg acg gca      4124
Val  Glu Asp Ile Gly Gln  Arg Leu Ile Gly Asn  Asp Met Thr Ala          
1315                 1320                 1325                          

gcg  ctt ggc agc gtg cag  ctg cgc aaa ctg cca  gaa ttc atc aac      4169
Ala  Leu Gly Ser Val Gln  Leu Arg Lys Leu Pro  Glu Phe Ile Asn          
1330                 1335                 1340                          

agg  cgt aga gaa atc gct  acg cag tac gac cgg  ttg ctt tcc gat      4214
Arg  Arg Arg Glu Ile Ala  Thr Gln Tyr Asp Arg  Leu Leu Ser Asp          
1345                 1350                 1355                          

gtg  ccg ggt gtc ctc cta  ccg ccg acg cta ccg  gat ggg cac gtc      4259
Val  Pro Gly Val Leu Leu  Pro Pro Thr Leu Pro  Asp Gly His Val          
1360                 1365                 1370                          

tcg  tca cac tac ttc tac  tgg gtc cag ctg gct  ccg gag atc cgc      4304
Ser  Ser His Tyr Phe Tyr  Trp Val Gln Leu Ala  Pro Glu Ile Arg          
1375                 1380                 1385                          

gac  cag gtg gcg cag caa  atg ctg gaa cgc ggc  atc tac acg agc      4349
Asp  Gln Val Ala Gln Gln  Met Leu Glu Arg Gly  Ile Tyr Thr Ser          
1390                 1395                 1400                          

tac  cgc tac ccg ccc ctg  cac aag gtc ccc atc  tac cgc gcg gac      4394
Tyr  Arg Tyr Pro Pro Leu  His Lys Val Pro Ile  Tyr Arg Ala Asp          
1405                 1410                 1415                          

tgc  aag ctg cct tct gcg  gag gac gcc tgc cgc  aga aca ctc ctg      4439
Cys  Lys Leu Pro Ser Ala  Glu Asp Ala Cys Arg  Arg Thr Leu Leu          
1420                 1425                 1430                          

cta  cca ctg cac cca agc  ctt gac gac gcc gag  gtg cgc acg gtg      4484
Leu  Pro Leu His Pro Ser  Leu Asp Asp Ala Glu  Val Arg Thr Val          
1435                 1440                 1445                          

gct  gac gag ttc cag aag  gcc gtc gaa cac cac  atc agc caa aga      4529
Ala  Asp Glu Phe Gln Lys  Ala Val Glu His His  Ile Ser Gln Arg          
1450                 1455                 1460                          

tca  cca ctc cga aag tga gg atg  tcg cgc gtg agc gac  aca ttc gca   4576
Ser  Pro Leu Arg Lys        Met  Ser Arg Val Ser Asp  Thr Phe Ala       
1465                        1470                 1475                   

gaa acc  tcc tcg gta tac agc  cca gat cat gcc gac  atc tac gac      4621
Glu Thr  Ser Ser Val Tyr Ser  Pro Asp His Ala Asp  Ile Tyr Asp          
    1480                 1485                 1490                      

gcg atc  cac tcc gcg cgt ggc  cgg gac tgg gca gcc  gag gcc ggg      4666
Ala Ile  His Ser Ala Arg Gly  Arg Asp Trp Ala Ala  Glu Ala Gly          
    1495                 1500                 1505                      

gaa gta  gtc cag ctc gta cgc  acc agg ctg ccc gaa  gca cag tcc      4711
Glu Val  Val Gln Leu Val Arg  Thr Arg Leu Pro Glu  Ala Gln Ser          
    1510                 1515                 1520                      

cta ctc  gac gtc gcc tgt ggg  acc ggg gcg cac cta  gag cga ttc      4756
Leu Leu  Asp Val Ala Cys Gly  Thr Gly Ala His Leu  Glu Arg Phe          
    1525                 1530                 1535                      

cgt gcc  gaa tac gcg aag gtc  gcg ggg ctt gaa ctg  tcc gat gcg      4801
Arg Ala  Glu Tyr Ala Lys Val  Ala Gly Leu Glu Leu  Ser Asp Ala          
    1540                 1545                 1550                      

atg cgg  gag atc gcg atc aga  cga gtc cct gag gta  ccg att cac      4846
Met Arg  Glu Ile Ala Ile Arg  Arg Val Pro Glu Val  Pro Ile His          
    1555                 1560                 1565                      

atc ggt  gac atc cgc gat ttc  gac ctc ggc gag cca  ttc gac gtc      4891
Ile Gly  Asp Ile Arg Asp Phe  Asp Leu Gly Glu Pro  Phe Asp Val          
    1570                 1575                 1580                      

atc acc  tgc ctg tgc ttt acc  gcg gct tac atg cgg  acc gtt gac      4936
Ile Thr  Cys Leu Cys Phe Thr  Ala Ala Tyr Met Arg  Thr Val Asp          
    1585                 1590                 1595                      

gac ctg  cga cgc gtg acg cgg  aac atg gcc cgg cac  ctg gcc cct      4981
Asp Leu  Arg Arg Val Thr Arg  Asn Met Ala Arg His  Leu Ala Pro          
    1600                 1605                 1610                      

ggt gga  gtc gcg gtc atc gaa  ccc tgg tgg ttt ccc  gac aag ttc      5026
Gly Gly  Val Ala Val Ile Glu  Pro Trp Trp Phe Pro  Asp Lys Phe          
    1615                 1620                 1625                      

atc gac  ggg ttc gtc acc gga  gcc gtc gcg cac cac  ggc gag cgg      5071
Ile Asp  Gly Phe Val Thr Gly  Ala Val Ala His His  Gly Glu Arg          
    1630                 1635                 1640                      

gtg atc  agc cgg cta tcg cac  tcg gtc ctg gag ggc  cgt acg agc      5116
Val Ile  Ser Arg Leu Ser His  Ser Val Leu Glu Gly  Arg Thr Ser          
    1645                 1650                 1655                      

cgg atg  acc gtc cgc tac aca  gtc gcc gaa ccc acc  ggg atc cgg      5161
Arg Met  Thr Val Arg Tyr Thr  Val Ala Glu Pro Thr  Gly Ile Arg          
    1660                 1665                 1670                      

gac ttc  aca gag ttc gaa atc  ctc tcg ctg ttc act  gag gac gag      5206
Asp Phe  Thr Glu Phe Glu Ile  Leu Ser Leu Phe Thr  Glu Asp Glu          
    1675                 1680                 1685                      

tac acc  gcc gcg ctc gaa gac  gca ggg atc cgc gcg  gaa tac ctt      5251
Tyr Thr  Ala Ala Leu Glu Asp  Ala Gly Ile Arg Ala  Glu Tyr Leu          
    1690                 1695                 1700                      

cct gga  gca ccg aac ggc cga  ggc ctg ttc gtc gga  atc cgc aac      5296
Pro Gly  Ala Pro Asn Gly Arg  Gly Leu Phe Val Gly  Ile Arg Asn          
    1705                 1710                 1715                      

tga gcccggaaca acgacgcaag acctgactag tggagggcca ctcctg atg agc      5351
                                                       Met Ser          
                                                           1720         

acc gcc acc acc acg  ccc gcc ccc gcc ctc  acc gcc cgc cgg ccc       5396
Thr Ala Thr Thr Thr  Pro Ala Pro Ala Leu  Thr Ala Arg Arg Pro           
                1725                 1730                 1735          

gcc ggg ctc gcc gag  cgg atc gcc cgc tcg  gcc gcc acc ggc cgc       5441
Ala Gly Leu Ala Glu  Arg Ile Ala Arg Ser  Ala Ala Thr Gly Arg           
                1740                 1745                 1750          

ggc gcc cac ctg gcc  acc gag gac ttc cac  gac tgg ctc gac ggc       5486
Gly Ala His Leu Ala  Thr Glu Asp Phe His  Asp Trp Leu Asp Gly           
                1755                 1760                 1765          

cgc cgc cgc gcc aac  acc ttc cgc gtc gac  aag atc ccc ttc gac       5531
Arg Arg Arg Ala Asn  Thr Phe Arg Val Asp  Lys Ile Pro Phe Asp           
                1770                 1775                 1780          

gcg ctc gac ggc tgg  tcc ttc gac gag gag  gac ggc aac ctc gtc       5576
Ala Leu Asp Gly Trp  Ser Phe Asp Glu Glu  Asp Gly Asn Leu Val           
                1785                 1790                 1795          

cac cgc agc ggc cgc  ttc ttc acc gtc gag  ggc ctg cac gtc gtc       5621
His Arg Ser Gly Arg  Phe Phe Thr Val Glu  Gly Leu His Val Val           
                1800                 1805                 1810          

gag gag gac gga ccc  tac ggc gac ggc ccg  tac cgc tcc tgg tac       5666
Glu Glu Asp Gly Pro  Tyr Gly Asp Gly Pro  Tyr Arg Ser Trp Tyr           
                1815                 1820                 1825          

cag ccc gtc atc aag  cag ccc gag gtc ggc  atc ctc ggc atc ctc       5711
Gln Pro Val Ile Lys  Gln Pro Glu Val Gly  Ile Leu Gly Ile Leu           
                1830                 1835                 1840          

gcc aag gag ttc gac  ggc gtc ctg cac ttc  ctc atg cag gcc aag       5756
Ala Lys Glu Phe Asp  Gly Val Leu His Phe  Leu Met Gln Ala Lys           
                1845                 1850                 1855          

atg gag ccc ggc aac  ccg aac ctg ctc cag  ctg tcg ccg acc gtc       5801
Met Glu Pro Gly Asn  Pro Asn Leu Leu Gln  Leu Ser Pro Thr Val           
                1860                 1865                 1870          

cag gcc acc cgc agc  aac tac acc aag gcg  cac cgc ggc ggc gac       5846
Gln Ala Thr Arg Ser  Asn Tyr Thr Lys Ala  His Arg Gly Gly Asp           
                1875                 1880                 1885          

gtg aag tac atc gag  tac ttc acc ggc gcc  gaa cac ggc acc gtc       5891
Val Lys Tyr Ile Glu  Tyr Phe Thr Gly Ala  Glu His Gly Thr Val           
                1890                 1895                 1900          

atc gcc gac tcc ctc  cag tcc gag cac ggc  gcc tgg ttc ttc cac       5936
Ile Ala Asp Ser Leu  Gln Ser Glu His Gly  Ala Trp Phe Phe His           
                1905                 1910                 1915          

aag tcc aac cgc aac  atg atc gtc gag gcc  acc ggc gag gtc ccg       5981
Lys Ser Asn Arg Asn  Met Ile Val Glu Ala  Thr Gly Glu Val Pro           
                1920                 1925                 1930          

ctc ctc gac gac ttc  tgc tgg ctc acc ctc  ggc cag ctc ggc gag       6026
Leu Leu Asp Asp Phe  Cys Trp Leu Thr Leu  Gly Gln Leu Gly Glu           
                1935                 1940                 1945          

ctc ctc cac cag gac  aac gtc atc aac atg  gac gcc agg acc gtc       6071
Leu Leu His Gln Asp  Asn Val Ile Asn Met  Asp Ala Arg Thr Val           
                1950                 1955                 1960          

ctg tcc tgc gtg ccg  tac gag gac gcc gac  gcc ggg cgg gcg ctg       6116
Leu Ser Cys Val Pro  Tyr Glu Asp Ala Asp  Ala Gly Arg Ala Leu           
                1965                 1970                 1975          

ctc tcc gac gtc cag  ctg ctc tcc tgg ttc  acc ggc gag cgc tcc       6161
Leu Ser Asp Val Gln  Leu Leu Ser Trp Phe  Thr Gly Glu Arg Ser           
                1980                 1985                 1990          

cgc cac gac gta cgg  gcc cgg cgc gtc ccg  ctg cgc gag ctg ccc       6206
Arg His Asp Val Arg  Ala Arg Arg Val Pro  Leu Arg Glu Leu Pro           
                1995                 2000                 2005          

ggc tgg aag cag ggc  gag gag acc atc gag  cac gag gag ggc cgg       6251
Gly Trp Lys Gln Gly  Glu Glu Thr Ile Glu  His Glu Glu Gly Arg           
                2010                 2015                 2020          

cac ttc aag gtc gtc  gcc gtc tcc gtg cag  gcc ggg aac cgc gaa       6296
His Phe Lys Val Val  Ala Val Ser Val Gln  Ala Gly Asn Arg Glu           
                2025                 2030                 2035          

gtg acc agc tgg acc  cag ccg ctg atc gaa  ccg gtc gga ctc ggc       6341
Val Thr Ser Trp Thr  Gln Pro Leu Ile Glu  Pro Val Gly Leu Gly           
                2040                 2045                 2050          

gtc gcc gcc ttc ctg  acc cgc gac ttc gac  ggc gtc ccg cac tac       6386
Val Ala Ala Phe Leu  Thr Arg Asp Phe Asp  Gly Val Pro His Tyr           
                2055                 2060                 2065          

ctg gtg cac gcc cgc  gtc gag ggc ggc ttc  ctc gac acc gtg gaa       6431
Leu Val His Ala Arg  Val Glu Gly Gly Phe  Leu Asp Thr Val Glu           
                2070                 2075                 2080          

ctg gcc ccc acc gtc  cag tac acc ccg ggc  aac tac gcc cac ctg       6476
Leu Ala Pro Thr Val  Gln Tyr Thr Pro Gly  Asn Tyr Ala His Leu           
                2085                 2090                 2095          

ccg acc gac gag cgc  ccg ccc ttc ctc gac  ctc gtc ctc gac acc       6521
Pro Thr Asp Glu Arg  Pro Pro Phe Leu Asp  Leu Val Leu Asp Thr           
                2100                 2105                 2110          

gac ccc gcc cgc gtc  cgc tac gag gcc gtg  cac tcc gag gaa ggc       6566
Asp Pro Ala Arg Val  Arg Tyr Glu Ala Val  His Ser Glu Glu Gly           
                2115                 2120                 2125          

ggc cgc ttc ctc aac  gcc gag agc cgc tac  ctc ctg gtg gag gcc       6611
Gly Arg Phe Leu Asn  Ala Glu Ser Arg Tyr  Leu Leu Val Glu Ala           
                2130                 2135                 2140          

gac gag acg cag gcc  ccg gcc gac ccg ccg  ccc ggc tac gcc tgg       6656
Asp Glu Thr Gln Ala  Pro Ala Asp Pro Pro  Pro Gly Tyr Ala Trp           
                2145                 2150                 2155          

gcg acc gcc gca cag  ctc acc tcc ctc acc  cgg cac ggc cac tac       6701
Ala Thr Ala Ala Gln  Leu Thr Ser Leu Thr  Arg His Gly His Tyr           
                2160                 2165                 2170          

ctc aac gtc cag gcc  cgc acc ctg ctg gcc  tgc gtc cac gcc ggg       6746
Leu Asn Val Gln Ala  Arg Thr Leu Leu Ala  Cys Val His Ala Gly           
                2175                 2180                 2185          

gcg gtg cgg cct tga cgagcacccc ggcgcatatg ggggaggtgc ggcc ttg       6798
Ala Val Arg Pro                                           Leu           
                                                          2190          

acg agc acc ccg gcg  ccc ctg cgg atc ggt  gtg ctc ggc tgc gcc       6843
Thr Ser Thr Pro Ala  Pro Leu Arg Ile Gly  Val Leu Gly Cys Ala           
                2195                 2200                 2205          

gac atc gcc gtc cgg  cgc atg atg ccc gcg  atg gcc gcg ctc ccc       6888
Asp Ile Ala Val Arg  Arg Met Met Pro Ala  Met Ala Ala Leu Pro           
                2210                 2215                 2220          

ggg acc gag gtc acc  gcc gtc gcc agc cgc  gac gcg gcg aag gcc       6933
Gly Thr Glu Val Thr  Ala Val Ala Ser Arg  Asp Ala Ala Lys Ala           
                2225                 2230                 2235          

gcc gtg gcc gcc gcc  ccg tac ggc gcg gcg  gcc gtc gag ggc tac       6978
Ala Val Ala Ala Ala  Pro Tyr Gly Ala Ala  Ala Val Glu Gly Tyr           
                2240                 2245                 2250          

cag gag ctg ctg cgc  cgc ccg gac gtc gac  gcc gtc tac gta ccg       7023
Gln Glu Leu Leu Arg  Arg Pro Asp Val Asp  Ala Val Tyr Val Pro           
                2255                 2260                 2265          

ctg ccc gcc gcc ctg  cac gcc gag tgg acc  gag gcc gcc ctg cgg       7068
Leu Pro Ala Ala Leu  His Ala Glu Trp Thr  Glu Ala Ala Leu Arg           
                2270                 2275                 2280          

gcc ggc aag cac gtc  ctg gcc gag aag ccg  ctc acc acg gac ccg       7113
Ala Gly Lys His Val  Leu Ala Glu Lys Pro  Leu Thr Thr Asp Pro           
                2285                 2290                 2295          

gag agc acc gcc gcg  ctg ctc ggc ctg gcc  gcc gcg tcc ggg ctc       7158
Glu Ser Thr Ala Ala  Leu Leu Gly Leu Ala  Ala Ala Ser Gly Leu           
                2300                 2305                 2310          

gcg ctg atg gag aac  gtc atg ttc gtc cac  cac cgc ctc cac acc       7203
Ala Leu Met Glu Asn  Val Met Phe Val His  His Arg Leu His Thr           
                2315                 2320                 2325          

gac gtc cgc aag ctc  gtc gcg gac gga gcc  atc ggc gaa ctc cgc       7248
Asp Val Arg Lys Leu  Val Ala Asp Gly Ala  Ile Gly Glu Leu Arg           
                2330                 2335                 2340          

gcc ctg cac gcc tcg  ttc ggc atc ccc cgg  ctg ccc gac acc gac       7293
Ala Leu His Ala Ser  Phe Gly Ile Pro Arg  Leu Pro Asp Thr Asp           
                2345                 2350                 2355          

atc cgg cac gac ccc  ggg ctc ggc ggc ggc  gcc ctc ggc gac gtc       7338
Ile Arg His Asp Pro  Gly Leu Gly Gly Gly  Ala Leu Gly Asp Val           
                2360                 2365                 2370          

ggc gtc tac ccg ctg  cga gcc gcc cag cac  ctg ctc ggc gac gaa       7383
Gly Val Tyr Pro Leu  Arg Ala Ala Gln His  Leu Leu Gly Asp Glu           
                2375                 2380                 2385          

ctc gac gtc ctc ggc  gcg cac ctc gtc cgg  ggg ccc ggc agc cgg       7428
Leu Asp Val Leu Gly  Ala His Leu Val Arg  Gly Pro Gly Ser Arg           
                2390                 2395                 2400          

gtc gag acc gcc ggc  ggg gcg ctg ctc gcc  acc ccg gcg ggc gtc       7473
Val Glu Thr Ala Gly  Gly Ala Leu Leu Ala  Thr Pro Ala Gly Val           
                2405                 2410                 2415          

acc gcg cac atc gcc  ttc ggc atg gac cac  ggc tac cgc tcg gcg       7518
Thr Ala His Ile Ala  Phe Gly Met Asp His  Gly Tyr Arg Ser Ala           
                2420                 2425                 2430          

tac gag ctg tgg ggc  agc cag ggc cgg ctc  gtc gtc gag cgg gcc       7563
Tyr Glu Leu Trp Gly  Ser Gln Gly Arg Leu  Val Val Glu Arg Ala           
                2435                 2440                 2445          

tac acc ccg ccc gcc  gac cac cgc ccg gtg  gtg cgc ctg gag acc       7608
Tyr Thr Pro Pro Ala  Asp His Arg Pro Val  Val Arg Leu Glu Thr           
                2450                 2455                 2460          

cgc acc ggc gtc gag  gag ctc gtc ctc gac  gcc gac gac cag gtc       7653
Arg Thr Gly Val Glu  Glu Leu Val Leu Asp  Ala Asp Asp Gln Val           
                2465                 2470                 2475          

cgc aac acg gtg gcc  gcc ttc gcc gcc ctc  gtg gcg cgc acc gga       7698
Arg Asn Thr Val Ala  Ala Phe Ala Ala Leu  Val Ala Arg Thr Gly           
                2480                 2485                 2490          

gcc ggc cac ccc ggg  gac ggc ggc gcg ccc  gac ccg gag gcc ccg       7743
Ala Gly His Pro Gly  Asp Gly Gly Ala Pro  Asp Pro Glu Ala Pro           
                2495                 2500                 2505          

ctg cgc cag gcg cgg  ctg ctc gac gcc gtg  cgg cgc cgg gcc gcc       7788
Leu Arg Gln Ala Arg  Leu Leu Asp Ala Val  Arg Arg Arg Ala Ala           
                2510                 2515                 2520          

ctc gtc tga cccgcgcctc taga                                         7811
Leu Val                                                                 
                                                                        


<210>  111
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  111

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  112
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  112

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  113
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  113

Met Gln Ser Arg Lys Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val 
1               5                   10                  15      


Thr Ser Cys Asp Asp Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp 
            20                  25                  30          


Ala Lys Asp Arg Ile Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln 
        35                  40                  45              


Glu Ser Pro Thr Phe Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly 
    50                  55                  60                  


Ala Val Leu Asp Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu 
65                  70                  75                  80  


Glu Leu Arg Ile Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu 
                85                  90                  95      


Phe Ala Arg Phe Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly 
            100                 105                 110         


Ser Ser Ala Asn Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu 
        115                 120                 125             


Gly Glu Ala Arg Leu Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val 
    130                 135                 140                 


Gly Phe Pro Thr Thr Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro 
145                 150                 155                 160 


Val Phe Val Asp Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg 
                165                 170                 175     


Ile Lys Ala Ala Val Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His 
            180                 185                 190         


Thr Leu Gly Asn Pro Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys 
        195                 200                 205             


Glu His Glu Leu Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser 
    210                 215                 220                 


Thr Tyr Arg Gly Arg Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val 
225                 230                 235                 240 


Ser Phe Tyr Pro Ala His His Ile Thr Ser Gly Glu Gly Gly Cys Val 
                245                 250                 255     


Leu Thr Gly Ser Leu Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp 
            260                 265                 270         


Trp Gly Arg Asp Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg 
        275                 280                 285             


Lys Arg Phe Asp Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His 
    290                 295                 300                 


Lys Tyr Thr Phe Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu 
305                 310                 315                 320 


Gln Ala Ala Leu Ala Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly 
                325                 330                 335     


Ser Ala Arg Arg Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly 
            340                 345                 350         


Leu Pro Gly Leu Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser 
        355                 360                 365             


Trp Phe Gly Phe Ala Ile Thr Ile Ser Ala Asp Ala Gly Phe Thr Arg 
    370                 375                 380                 


Ala Ala Leu Val Asn Phe Leu Glu Ser Arg Asn Ile Gly Thr Arg Leu 
385                 390                 395                 400 


Leu Phe Gly Gly Asn Ile Thr Arg His Pro Ala Phe Glu Gln Val Arg 
                405                 410                 415     


Tyr Arg Ile Ala Asp Ala Leu Thr Asn Ser Asp Ile Val Thr Asp Arg 
            420                 425                 430         


Thr Phe Trp Val Gly Val Tyr Pro Gly Ile Thr Asp Gln Met Ile Asp 
        435                 440                 445             


Tyr Val Val Glu Ser Ile Ala Glu Phe Val Ala Lys Ser Ser 
    450                 455                 460         


<210>  114
<211>  385
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  114

Val Ile Asn Leu His Gln Pro Ile Leu Gly Thr Glu Glu Leu Asp Ala 
1               5                   10                  15      


Ile Ala Glu Val Phe Ala Ser Asn Trp Ile Gly Leu Gly Pro Arg Thr 
            20                  25                  30          


Arg Thr Phe Glu Ala Glu Phe Ala His His Leu Gly Val Asp Pro Glu 
        35                  40                  45              


Gln Val Val Phe Leu Asn Ser Gly Thr Ala Ala Leu Phe Leu Thr Val 
    50                  55                  60                  


Gln Val Leu Asp Leu Gly Pro Gly Asp Asp Val Val Leu Pro Ser Ile 
65                  70                  75                  80  


Ser Phe Val Ala Ala Ala Asn Ala Ile Ala Ser Ser Gly Ala Arg Pro 
                85                  90                  95      


Val Phe Cys Asp Val Asp Pro Arg Thr Leu Asn Pro Thr Leu Asp Asp 
            100                 105                 110         


Val Ala Arg Ala Ile Thr Pro Ala Thr Lys Ala Val Leu Leu Leu His 
        115                 120                 125             


Tyr Gly Gly Ser Pro Gly Glu Val Thr Ala Ile Ala Asp Phe Cys Arg 
    130                 135                 140                 


Glu Lys Gly Leu Met Leu Ile Glu Asp Ser Ala Cys Ala Val Ala Ser 
145                 150                 155                 160 


Ser Val His Gly Thr Ala Cys Gly Thr Phe Gly Asp Leu Ala Thr Trp 
                165                 170                 175     


Ser Phe Asp Ala Met Lys Ile Leu Val Thr Gly Asp Gly Gly Met Phe 
            180                 185                 190         


Tyr Ala Ala Asp Pro Glu Leu Ala His Arg Ala Arg Arg Leu Ala Tyr 
        195                 200                 205             


His Gly Leu Glu Gln Met Ser Gly Phe Asp Ser Ala Lys Ser Ser Asn 
    210                 215                 220                 


Arg Trp Trp Asp Ile Arg Val Glu Asp Ile Gly Gln Arg Leu Ile Gly 
225                 230                 235                 240 


Asn Asp Met Thr Ala Ala Leu Gly Ser Val Gln Leu Arg Lys Leu Pro 
                245                 250                 255     


Glu Phe Ile Asn Arg Arg Arg Glu Ile Ala Thr Gln Tyr Asp Arg Leu 
            260                 265                 270         


Leu Ser Asp Val Pro Gly Val Leu Leu Pro Pro Thr Leu Pro Asp Gly 
        275                 280                 285             


His Val Ser Ser His Tyr Phe Tyr Trp Val Gln Leu Ala Pro Glu Ile 
    290                 295                 300                 


Arg Asp Gln Val Ala Gln Gln Met Leu Glu Arg Gly Ile Tyr Thr Ser 
305                 310                 315                 320 


Tyr Arg Tyr Pro Pro Leu His Lys Val Pro Ile Tyr Arg Ala Asp Cys 
                325                 330                 335     


Lys Leu Pro Ser Ala Glu Asp Ala Cys Arg Arg Thr Leu Leu Leu Pro 
            340                 345                 350         


Leu His Pro Ser Leu Asp Asp Ala Glu Val Arg Thr Val Ala Asp Glu 
        355                 360                 365             


Phe Gln Lys Ala Val Glu His His Ile Ser Gln Arg Ser Pro Leu Arg 
    370                 375                 380                 


Lys 
385 


<210>  115
<211>  249
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  115

Met Ser Arg Val Ser Asp Thr Phe Ala Glu Thr Ser Ser Val Tyr Ser 
1               5                   10                  15      


Pro Asp His Ala Asp Ile Tyr Asp Ala Ile His Ser Ala Arg Gly Arg 
            20                  25                  30          


Asp Trp Ala Ala Glu Ala Gly Glu Val Val Gln Leu Val Arg Thr Arg 
        35                  40                  45              


Leu Pro Glu Ala Gln Ser Leu Leu Asp Val Ala Cys Gly Thr Gly Ala 
    50                  55                  60                  


His Leu Glu Arg Phe Arg Ala Glu Tyr Ala Lys Val Ala Gly Leu Glu 
65                  70                  75                  80  


Leu Ser Asp Ala Met Arg Glu Ile Ala Ile Arg Arg Val Pro Glu Val 
                85                  90                  95      


Pro Ile His Ile Gly Asp Ile Arg Asp Phe Asp Leu Gly Glu Pro Phe 
            100                 105                 110         


Asp Val Ile Thr Cys Leu Cys Phe Thr Ala Ala Tyr Met Arg Thr Val 
        115                 120                 125             


Asp Asp Leu Arg Arg Val Thr Arg Asn Met Ala Arg His Leu Ala Pro 
    130                 135                 140                 


Gly Gly Val Ala Val Ile Glu Pro Trp Trp Phe Pro Asp Lys Phe Ile 
145                 150                 155                 160 


Asp Gly Phe Val Thr Gly Ala Val Ala His His Gly Glu Arg Val Ile 
                165                 170                 175     


Ser Arg Leu Ser His Ser Val Leu Glu Gly Arg Thr Ser Arg Met Thr 
            180                 185                 190         


Val Arg Tyr Thr Val Ala Glu Pro Thr Gly Ile Arg Asp Phe Thr Glu 
        195                 200                 205             


Phe Glu Ile Leu Ser Leu Phe Thr Glu Asp Glu Tyr Thr Ala Ala Leu 
    210                 215                 220                 


Glu Asp Ala Gly Ile Arg Ala Glu Tyr Leu Pro Gly Ala Pro Asn Gly 
225                 230                 235                 240 


Arg Gly Leu Phe Val Gly Ile Arg Asn 
                245                 


<210>  116
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  116

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  117
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  117

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  118
<211>  7065
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (24)..(905)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (933)..(1922)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1964)..(3352)
<223>  spnQ gene from S. spinosa


<220>
<221>  CDS
<222>  (3390)..(4547)
<223>  spnR gene from S. spinosa


<220>
<221>  CDS
<222>  (4600)..(6015)
<223>  tdh gene from S. diversa


<220>
<221>  CDS
<222>  (6050)..(7051)
<223>  tkr gene from S. diversa


<400>  118
aagcttccgc tggaggtatc cgg gtg aag ggg atc gtg ctg gcg ggt ggc aac     53
                          Val Lys Gly Ile Val Leu Ala Gly Gly Asn       
                          1               5                   10        

ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag cta ctt      101
Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln Leu Leu         
                15                  20                  25              

ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg ctg atg      149
Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val Leu Met         
            30                  35                  40                  

ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc gac atg      197
Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala Asp Met         
        45                  50                  55                      

ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc att cgg      245
Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg         
    60                  65                  70                          

atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag gcg ttc      293
Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe         
75                  80                  85                  90          

gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg gtg ctc      341
Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu Val Leu         
                95                  100                 105             

ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc cag cag      389
Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln         
            110                 115                 120                 

tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg gtc cgc      437
Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg         
        125                 130                 135                     

gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt cgg ctg      485
Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly Arg Leu         
    140                 145                 150                         

ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg gcc atc      533
Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met Ala Ile         
155                 160                 165                 170         

acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc aag ggg      581
Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala Lys Gly         
                175                 180                 185             

ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc aac ctg      629
Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val Asn Leu         
            190                 195                 200                 

gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc cgc ggg      677
Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly Arg Gly         
        205                 210                 215                     

ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag gcc tcg      725
Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu Ala Ser         
    220                 225                 230                         

cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc gcc tgc      773
Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile Ala Cys         
235                 240                 245                 250         

ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac gac tgt      821
Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys         
                255                 260                 265             

ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag tac gtc      869
Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val         
            270                 275                 280                 

atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga cccgagatcc           915
Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                             
        285                 290                                         

cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc ggt ttc       965
                   Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe          
                       295                 300                          

atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac ccc gca     1013
Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala         
305                 310                 315                 320         

ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac gcc ggc     1061
Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly         
                325                 330                 335             

aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg aag ttc     1109
Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe         
            340                 345                 350                 

gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg atg tcc     1157
Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser         
        355                 360                 365                     

ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc gac cgc     1205
Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val Asp Arg         
    370                 375                 380                         

tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc ggc acc     1253
Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr         
385                 390                 395                 400         

aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag ttc gtg     1301
Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val         
                405                 410                 415             

cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc tcg tgg     1349
His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp         
            420                 425                 430                 

ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg gcg aaa     1397
Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys         
        435                 440                 445                     

gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac gga ctg     1445
Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu         
    450                 455                 460                         

ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac cag ttc     1493
Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe         
465                 470                 475                 480         

ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac ggc agc     1541
Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser         
                485                 490                 495             

cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg ctg cac     1589
Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His         
            500                 505                 510                 

gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc ggg cgc     1637
Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg         
        515                 520                 525                     

gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc aac aac     1685
Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn         
    530                 535                 540                         

gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg tcg gtg     1733
Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val         
545                 550                 555                 560         

gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac tcg gtg     1781
Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val         
                565                 570                 575             

gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag gtc gac     1829
Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp         
            580                 585                 590                 

ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac aac cgg     1877
Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg         
        595                 600                 605                     

gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga tga         1922
Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg                 
    610                 615                 620                         

gtcgcctcca attgaaggcg cgaagactga tcgtcgcctg c atg cag agc cgg aaa   1978
                                              Met Gln Ser Arg Lys       
                                                      625               

acc aga gcg ctg ggg aaa ggg cgc gcc aga gtg act tcg tgt gac gac     2026
Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val Thr Ser Cys Asp Asp         
        630                 635                 640                     

act tgc gct acc gct act gag atg gtg ccg gat gcc aag gac cgg ata     2074
Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp Ala Lys Asp Arg Ile         
    645                 650                 655                         

ttg gca tcc gta cgc gat tac cac cgc gaa cag gaa tcc ccg acc ttc     2122
Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln Glu Ser Pro Thr Phe         
660                 665                 670                 675         

gtg gct gga tcg acg ccg atc cgg cca tcg ggc gcc gtg ctc gac gag     2170
Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly Ala Val Leu Asp Glu         
                680                 685                 690             

gac gac cgg gtg gca ctg gtg gaa gcc gcg ctg gag ctc cgg atc gcc     2218
Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu Glu Leu Arg Ile Ala         
            695                 700                 705                 

gcg ggc ggg aat gca cgg cga ttc gag agc gag ttc gcc cgc ttc ttc     2266
Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu Phe Ala Arg Phe Phe         
        710                 715                 720                     

ggc ctc cgc aag gct cat ctc gtc aac tcc ggt tcg tcg gcc aat ctc     2314
Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly Ser Ser Ala Asn Leu         
    725                 730                 735                         

ctg gca ctg agt tcg ctt acc tcc ccc aaa ctc ggc gag gca cga ctg     2362
Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu Gly Glu Ala Arg Leu         
740                 745                 750                 755         

cgg ccc ggc gac gaa gtg atc act gcg gcg gtc ggc ttc ccc acg acg     2410
Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val Gly Phe Pro Thr Thr         
                760                 765                 770             

atc aat ccg gcg gtc caa aac gga ctc gtc ccg gta ttc gtc gac gtg     2458
Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro Val Phe Val Asp Val         
            775                 780                 785                 

gaa ctg ggc acc tac aac gca acg cca gac cgc atc aag gcc gcc gtc     2506
Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg Ile Lys Ala Ala Val         
        790                 795                 800                     

acg gaa cgg acg cga gcc atc atg ctg gcg cac acc ctg ggc aac ccc     2554
Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His Thr Leu Gly Asn Pro         
    805                 810                 815                         

ttc gcc gct gac gaa atc gcg gag atc gca aaa gaa cac gag ctg ttc     2602
Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys Glu His Glu Leu Phe         
820                 825                 830                 835         

ctc gtc gaa gac aac tgt gat gcg gtg gga tcc acc tac cgg gga cgg     2650
Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser Thr Tyr Arg Gly Arg         
                840                 845                 850             

ctg acc gga acc ttc ggc gac ctg aca acg gtc agc ttc tat cct gcc     2698
Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val Ser Phe Tyr Pro Ala         
            855                 860                 865                 

cat cac atc acc agc ggc gag ggt ggc tgc gtg ttg acc ggc agc ctg     2746
His His Ile Thr Ser Gly Glu Gly Gly Cys Val Leu Thr Gly Ser Leu         
        870                 875                 880                     

gaa ttg gct cgc atc atc gag tcg ctg cgt gac tgg gga cgg gat tgc     2794
Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp Trp Gly Arg Asp Cys         
    885                 890                 895                         

tgg tgc gag ccc ggc gtg gac aac acc tgc cgc aag agg ttc gac tac     2842
Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg Lys Arg Phe Asp Tyr         
900                 905                 910                 915         

cac ctc ggt acc ctt cca ccg ggc tac gac cac aag tac acg ttc tcc     2890
His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His Lys Tyr Thr Phe Ser         
                920                 925                 930             

cac gtc ggt tac aac ctc aag acc acc gac ctg cag gcc gca ctt gcg     2938
His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu Gln Ala Ala Leu Ala         
            935                 940                 945                 

ctg agc cag ttg agc aag att tcc gca ttc ggg tcg gca cgc cgc cgt     2986
Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly Ser Ala Arg Arg Arg         
        950                 955                 960                     

aac tgg cga cgg ttg cgc gaa ggg ctg tcc ggg ttg ccg ggc ctg ctg     3034
Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly Leu Pro Gly Leu Leu         
    965                 970                 975                         

ctg ccg gta gcc aca ccg cac agc gac ccg agc tgg ttc ggg ttt gcg     3082
Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser Trp Phe Gly Phe Ala         
980                 985                 990                 995         

atc acc atc agt gcg  gac gcc ggg ttc acc  cgt gcc gcc ctg gtg       3127
Ile Thr Ile Ser Ala  Asp Ala Gly Phe Thr  Arg Ala Ala Leu Val           
                1000                 1005                 1010          

aac ttc ctg gaa tcc  cgc aac atc ggc acc  cga ctg ctg ttc ggc       3172
Asn Phe Leu Glu Ser  Arg Asn Ile Gly Thr  Arg Leu Leu Phe Gly           
                1015                 1020                 1025          

ggt aac atc acc cgg  cac ccg gcc ttc gag  cag gtg cgg tac cgg       3217
Gly Asn Ile Thr Arg  His Pro Ala Phe Glu  Gln Val Arg Tyr Arg           
                1030                 1035                 1040          

atc gcc gac gcg ctc  acc aac agc gac atc  gtc acc gac cga acc       3262
Ile Ala Asp Ala Leu  Thr Asn Ser Asp Ile  Val Thr Asp Arg Thr           
                1045                 1050                 1055          

ttc tgg gtc ggc gtc  tac cca ggc ata acg  gac caa atg atc gac       3307
Phe Trp Val Gly Val  Tyr Pro Gly Ile Thr  Asp Gln Met Ile Asp           
                1060                 1065                 1070          

tac gtc gtc gaa tca  atc gct gaa ttc gtg  gcc aag agt tcc tag       3352
Tyr Val Val Glu Ser  Ile Ala Glu Phe Val  Ala Lys Ser Ser               
                1075                 1080                               

catccagcat ggcggcatct cggaggattt cagcaac gtg  atc aac ctg cac       3404
                                         Val  Ile Asn Leu His           
                                         1085                           

cag  ccg atc ctc ggc acc  gaa gaa ctc gac gcg  atc gcg gag gtg      3449
Gln  Pro Ile Leu Gly Thr  Glu Glu Leu Asp Ala  Ile Ala Glu Val          
1090                 1095                 1100                          

ttc  gcc tcc aac tgg atc  ggg ctc ggg ccg cgc  acc cgg acg ttc      3494
Phe  Ala Ser Asn Trp Ile  Gly Leu Gly Pro Arg  Thr Arg Thr Phe          
1105                 1110                 1115                          

gag  gcc gaa ttc gcc cac  cac ctg gga gtg gat  ccc gaa cag gtc      3539
Glu  Ala Glu Phe Ala His  His Leu Gly Val Asp  Pro Glu Gln Val          
1120                 1125                 1130                          

gtg  ttc ctc aac tcg ggg  act gcc gcg ctg ttc  ctt acc gtg cag      3584
Val  Phe Leu Asn Ser Gly  Thr Ala Ala Leu Phe  Leu Thr Val Gln          
1135                 1140                 1145                          

gtg  ctc gac ctc ggc cca  ggc gac gac gtg gta  ctt cct tcg ata      3629
Val  Leu Asp Leu Gly Pro  Gly Asp Asp Val Val  Leu Pro Ser Ile          
1150                 1155                 1160                          

agc  ttc gtg gcg gcg gcc  aac gcc atc gca tcc  tcc ggt gcc cgc      3674
Ser  Phe Val Ala Ala Ala  Asn Ala Ile Ala Ser  Ser Gly Ala Arg          
1165                 1170                 1175                          

ccg  gtg ttc tgc gac gtc  gac ccc cgg acg ttg  aac ccc acg ctg      3719
Pro  Val Phe Cys Asp Val  Asp Pro Arg Thr Leu  Asn Pro Thr Leu          
1180                 1185                 1190                          

gat  gat gtg gcg agg gcc  atc acg ccg gcg acc  aag gcc gta ttg      3764
Asp  Asp Val Ala Arg Ala  Ile Thr Pro Ala Thr  Lys Ala Val Leu          
1195                 1200                 1205                          

ctg  ctc cac tat gga gga  tcg ccg gga gaa gtc  acc gcg atc gcc      3809
Leu  Leu His Tyr Gly Gly  Ser Pro Gly Glu Val  Thr Ala Ile Ala          
1210                 1215                 1220                          

gat  ttc tgc cgt gaa aag  ggc ctc atg ctc atc  gag gac tcc gcc      3854
Asp  Phe Cys Arg Glu Lys  Gly Leu Met Leu Ile  Glu Asp Ser Ala          
1225                 1230                 1235                          

tgc  gcg gtg gca tcg tcc  gtg cac ggc acc gct  tgc gga acc ttt      3899
Cys  Ala Val Ala Ser Ser  Val His Gly Thr Ala  Cys Gly Thr Phe          
1240                 1245                 1250                          

ggt  gac ctg gcc acg tgg  agt ttc gat gcg atg  aag atc ctg gtc      3944
Gly  Asp Leu Ala Thr Trp  Ser Phe Asp Ala Met  Lys Ile Leu Val          
1255                 1260                 1265                          

acc  ggg gat ggg ggc atg  ttc tac gcg gcg gat  ccg gag ctg gcg      3989
Thr  Gly Asp Gly Gly Met  Phe Tyr Ala Ala Asp  Pro Glu Leu Ala          
1270                 1275                 1280                          

cac  cgc gca aga cga ctc  gcc tac cac ggt ctt  gag cag atg agc      4034
His  Arg Ala Arg Arg Leu  Ala Tyr His Gly Leu  Glu Gln Met Ser          
1285                 1290                 1295                          

gga  ttc gat tcg gcc aag  tct tcc aac cgc tgg  tgg gat att cgc      4079
Gly  Phe Asp Ser Ala Lys  Ser Ser Asn Arg Trp  Trp Asp Ile Arg          
1300                 1305                 1310                          

gtc  gaa gac atc ggc cag  cgg ctg atc ggg aac  gac atg acg gca      4124
Val  Glu Asp Ile Gly Gln  Arg Leu Ile Gly Asn  Asp Met Thr Ala          
1315                 1320                 1325                          

gcg  ctt ggc agc gtg cag  ctg cgc aaa ctg cca  gaa ttc atc aac      4169
Ala  Leu Gly Ser Val Gln  Leu Arg Lys Leu Pro  Glu Phe Ile Asn          
1330                 1335                 1340                          

agg  cgt aga gaa atc gct  acg cag tac gac cgg  ttg ctt tcc gat      4214
Arg  Arg Arg Glu Ile Ala  Thr Gln Tyr Asp Arg  Leu Leu Ser Asp          
1345                 1350                 1355                          

gtg  ccg ggt gtc ctc cta  ccg ccg acg cta ccg  gat ggg cac gtc      4259
Val  Pro Gly Val Leu Leu  Pro Pro Thr Leu Pro  Asp Gly His Val          
1360                 1365                 1370                          

tcg  tca cac tac ttc tac  tgg gtc cag ctg gct  ccg gag atc cgc      4304
Ser  Ser His Tyr Phe Tyr  Trp Val Gln Leu Ala  Pro Glu Ile Arg          
1375                 1380                 1385                          

gac  cag gtg gcg cag caa  atg ctg gaa cgc ggc  atc tac acg agc      4349
Asp  Gln Val Ala Gln Gln  Met Leu Glu Arg Gly  Ile Tyr Thr Ser          
1390                 1395                 1400                          

tac  cgc tac ccg ccc ctg  cac aag gtc ccc atc  tac cgc gcg gac      4394
Tyr  Arg Tyr Pro Pro Leu  His Lys Val Pro Ile  Tyr Arg Ala Asp          
1405                 1410                 1415                          

tgc  aag ctg cct tct gcg  gag gac gcc tgc cgc  aga aca ctc ctg      4439
Cys  Lys Leu Pro Ser Ala  Glu Asp Ala Cys Arg  Arg Thr Leu Leu          
1420                 1425                 1430                          

cta  cca ctg cac cca agc  ctt gac gac gcc gag  gtg cgc acg gtg      4484
Leu  Pro Leu His Pro Ser  Leu Asp Asp Ala Glu  Val Arg Thr Val          
1435                 1440                 1445                          

gct  gac gag ttc cag aag  gcc gtc gaa cac cac  atc agc caa aga      4529
Ala  Asp Glu Phe Gln Lys  Ala Val Glu His His  Ile Ser Gln Arg          
1450                 1455                 1460                          

tca  cca ctc cga aag tga ggatgtcgcg cgtgagcgac acattcgcag           4577
Ser  Pro Leu Arg Lys                                                    
1465                                                                    

aactagtgga gggccactcc tg atg  agc acc gcc acc acc  acg ccc gcc      4626
                         Met  Ser Thr Ala Thr Thr  Thr Pro Ala          
                         1470                 1475                      

ccc gcc  ctc acc gcc cgc cgg  ccc gcc ggg ctc gcc  gag cgg atc      4671
Pro Ala  Leu Thr Ala Arg Arg  Pro Ala Gly Leu Ala  Glu Arg Ile          
    1480                 1485                 1490                      

gcc cgc  tcg gcc gcc acc ggc  cgc ggc gcc cac ctg  gcc acc gag      4716
Ala Arg  Ser Ala Ala Thr Gly  Arg Gly Ala His Leu  Ala Thr Glu          
    1495                 1500                 1505                      

gac ttc  cac gac tgg ctc gac  ggc cgc cgc cgc gcc  aac acc ttc      4761
Asp Phe  His Asp Trp Leu Asp  Gly Arg Arg Arg Ala  Asn Thr Phe          
    1510                 1515                 1520                      

cgc gtc  gac aag atc ccc ttc  gac gcg ctc gac ggc  tgg tcc ttc      4806
Arg Val  Asp Lys Ile Pro Phe  Asp Ala Leu Asp Gly  Trp Ser Phe          
    1525                 1530                 1535                      

gac gag  gag gac ggc aac ctc  gtc cac cgc agc ggc  cgc ttc ttc      4851
Asp Glu  Glu Asp Gly Asn Leu  Val His Arg Ser Gly  Arg Phe Phe          
    1540                 1545                 1550                      

acc gtc  gag ggc ctg cac gtc  gtc gag gag gac gga  ccc tac ggc      4896
Thr Val  Glu Gly Leu His Val  Val Glu Glu Asp Gly  Pro Tyr Gly          
    1555                 1560                 1565                      

gac ggc  ccg tac cgc tcc tgg  tac cag ccc gtc atc  aag cag ccc      4941
Asp Gly  Pro Tyr Arg Ser Trp  Tyr Gln Pro Val Ile  Lys Gln Pro          
    1570                 1575                 1580                      

gag gtc  ggc atc ctc ggc atc  ctc gcc aag gag ttc  gac ggc gtc      4986
Glu Val  Gly Ile Leu Gly Ile  Leu Ala Lys Glu Phe  Asp Gly Val          
    1585                 1590                 1595                      

ctg cac  ttc ctc atg cag gcc  aag atg gag ccc ggc  aac ccg aac      5031
Leu His  Phe Leu Met Gln Ala  Lys Met Glu Pro Gly  Asn Pro Asn          
    1600                 1605                 1610                      

ctg ctc  cag ctg tcg ccg acc  gtc cag gcc acc cgc  agc aac tac      5076
Leu Leu  Gln Leu Ser Pro Thr  Val Gln Ala Thr Arg  Ser Asn Tyr          
    1615                 1620                 1625                      

acc aag  gcg cac cgc ggc ggc  gac gtg aag tac atc  gag tac ttc      5121
Thr Lys  Ala His Arg Gly Gly  Asp Val Lys Tyr Ile  Glu Tyr Phe          
    1630                 1635                 1640                      

acc ggc  gcc gaa cac ggc acc  gtc atc gcc gac tcc  ctc cag tcc      5166
Thr Gly  Ala Glu His Gly Thr  Val Ile Ala Asp Ser  Leu Gln Ser          
    1645                 1650                 1655                      

gag cac  ggc gcc tgg ttc ttc  cac aag tcc aac cgc  aac atg atc      5211
Glu His  Gly Ala Trp Phe Phe  His Lys Ser Asn Arg  Asn Met Ile          
    1660                 1665                 1670                      

gtc gag  gcc acc ggc gag gtc  ccg ctc ctc gac gac  ttc tgc tgg      5256
Val Glu  Ala Thr Gly Glu Val  Pro Leu Leu Asp Asp  Phe Cys Trp          
    1675                 1680                 1685                      

ctc acc  ctc ggc cag ctc ggc  gag ctc ctc cac cag  gac aac gtc      5301
Leu Thr  Leu Gly Gln Leu Gly  Glu Leu Leu His Gln  Asp Asn Val          
    1690                 1695                 1700                      

atc aac  atg gac gcc agg acc  gtc ctg tcc tgc gtg  ccg tac gag      5346
Ile Asn  Met Asp Ala Arg Thr  Val Leu Ser Cys Val  Pro Tyr Glu          
    1705                 1710                 1715                      

gac gcc  gac gcc ggg cgg gcg  ctg ctc tcc gac gtc  cag ctg ctc      5391
Asp Ala  Asp Ala Gly Arg Ala  Leu Leu Ser Asp Val  Gln Leu Leu          
    1720                 1725                 1730                      

tcc tgg  ttc acc ggc gag cgc  tcc cgc cac gac gta  cgg gcc cgg      5436
Ser Trp  Phe Thr Gly Glu Arg  Ser Arg His Asp Val  Arg Ala Arg          
    1735                 1740                 1745                      

cgc gtc  ccg ctg cgc gag ctg  ccc ggc tgg aag cag  ggc gag gag      5481
Arg Val  Pro Leu Arg Glu Leu  Pro Gly Trp Lys Gln  Gly Glu Glu          
    1750                 1755                 1760                      

acc atc  gag cac gag gag ggc  cgg cac ttc aag gtc  gtc gcc gtc      5526
Thr Ile  Glu His Glu Glu Gly  Arg His Phe Lys Val  Val Ala Val          
    1765                 1770                 1775                      

tcc gtg  cag gcc ggg aac cgc  gaa gtg acc agc tgg  acc cag ccg      5571
Ser Val  Gln Ala Gly Asn Arg  Glu Val Thr Ser Trp  Thr Gln Pro          
    1780                 1785                 1790                      

ctg atc  gaa ccg gtc gga ctc  ggc gtc gcc gcc ttc  ctg acc cgc      5616
Leu Ile  Glu Pro Val Gly Leu  Gly Val Ala Ala Phe  Leu Thr Arg          
    1795                 1800                 1805                      

gac ttc  gac ggc gtc ccg cac  tac ctg gtg cac gcc  cgc gtc gag      5661
Asp Phe  Asp Gly Val Pro His  Tyr Leu Val His Ala  Arg Val Glu          
    1810                 1815                 1820                      

ggc ggc  ttc ctc gac acc gtg  gaa ctg gcc ccc acc  gtc cag tac      5706
Gly Gly  Phe Leu Asp Thr Val  Glu Leu Ala Pro Thr  Val Gln Tyr          
    1825                 1830                 1835                      

acc ccg  ggc aac tac gcc cac  ctg ccg acc gac gag  cgc ccg ccc      5751
Thr Pro  Gly Asn Tyr Ala His  Leu Pro Thr Asp Glu  Arg Pro Pro          
    1840                 1845                 1850                      

ttc ctc  gac ctc gtc ctc gac  acc gac ccc gcc cgc  gtc cgc tac      5796
Phe Leu  Asp Leu Val Leu Asp  Thr Asp Pro Ala Arg  Val Arg Tyr          
    1855                 1860                 1865                      

gag gcc  gtg cac tcc gag gaa  ggc ggc cgc ttc ctc  aac gcc gag      5841
Glu Ala  Val His Ser Glu Glu  Gly Gly Arg Phe Leu  Asn Ala Glu          
    1870                 1875                 1880                      

agc cgc  tac ctc ctg gtg gag  gcc gac gag acg cag  gcc ccg gcc      5886
Ser Arg  Tyr Leu Leu Val Glu  Ala Asp Glu Thr Gln  Ala Pro Ala          
    1885                 1890                 1895                      

gac ccg  ccg ccc ggc tac gcc  tgg gcg acc gcc gca  cag ctc acc      5931
Asp Pro  Pro Pro Gly Tyr Ala  Trp Ala Thr Ala Ala  Gln Leu Thr          
    1900                 1905                 1910                      

tcc ctc  acc cgg cac ggc cac  tac ctc aac gtc cag  gcc cgc acc      5976
Ser Leu  Thr Arg His Gly His  Tyr Leu Asn Val Gln  Ala Arg Thr          
    1915                 1920                 1925                      

ctg ctg  gcc tgc gtc cac gcc  ggg gcg gtg cgg cct  tga cgagcacccc   6025
Leu Leu  Ala Cys Val His Ala  Gly Ala Val Arg Pro                       
    1930                 1935                 1940                      

ggcgcatatg ggggaggtgc ggcc ttg acg agc acc ccg  gcg ccc ctg cgg     6076
                           Leu Thr Ser Thr Pro  Ala Pro Leu Arg         
                                           1945                         

atc  ggt gtg ctc ggc tgc  gcc gac atc gcc gtc  cgg cgc atg atg      6121
Ile  Gly Val Leu Gly Cys  Ala Asp Ile Ala Val  Arg Arg Met Met          
1950                 1955                 1960                          

ccc  gcg atg gcc gcg ctc  ccc ggg acc gag gtc  acc gcc gtc gcc      6166
Pro  Ala Met Ala Ala Leu  Pro Gly Thr Glu Val  Thr Ala Val Ala          
1965                 1970                 1975                          

agc  cgc gac gcg gcg aag  gcc gcc gtg gcc gcc  gcc ccg tac ggc      6211
Ser  Arg Asp Ala Ala Lys  Ala Ala Val Ala Ala  Ala Pro Tyr Gly          
1980                 1985                 1990                          

gcg  gcg gcc gtc gag ggc  tac cag gag ctg ctg  cgc cgc ccg gac      6256
Ala  Ala Ala Val Glu Gly  Tyr Gln Glu Leu Leu  Arg Arg Pro Asp          
1995                 2000                 2005                          

gtc  gac gcc gtc tac gta  ccg ctg ccc gcc gcc  ctg cac gcc gag      6301
Val  Asp Ala Val Tyr Val  Pro Leu Pro Ala Ala  Leu His Ala Glu          
2010                 2015                 2020                          

tgg  acc gag gcc gcc ctg  cgg gcc ggc aag cac  gtc ctg gcc gag      6346
Trp  Thr Glu Ala Ala Leu  Arg Ala Gly Lys His  Val Leu Ala Glu          
2025                 2030                 2035                          

aag  ccg ctc acc acg gac  ccg gag agc acc gcc  gcg ctg ctc ggc      6391
Lys  Pro Leu Thr Thr Asp  Pro Glu Ser Thr Ala  Ala Leu Leu Gly          
2040                 2045                 2050                          

ctg  gcc gcc gcg tcc ggg  ctc gcg ctg atg gag  aac gtc atg ttc      6436
Leu  Ala Ala Ala Ser Gly  Leu Ala Leu Met Glu  Asn Val Met Phe          
2055                 2060                 2065                          

gtc  cac cac cgc ctc cac  acc gac gtc cgc aag  ctc gtc gcg gac      6481
Val  His His Arg Leu His  Thr Asp Val Arg Lys  Leu Val Ala Asp          
2070                 2075                 2080                          

gga  gcc atc ggc gaa ctc  cgc gcc ctg cac gcc  tcg ttc ggc atc      6526
Gly  Ala Ile Gly Glu Leu  Arg Ala Leu His Ala  Ser Phe Gly Ile          
2085                 2090                 2095                          

ccc  cgg ctg ccc gac acc  gac atc cgg cac gac  ccc ggg ctc ggc      6571
Pro  Arg Leu Pro Asp Thr  Asp Ile Arg His Asp  Pro Gly Leu Gly          
2100                 2105                 2110                          

ggc  ggc gcc ctc ggc gac  gtc ggc gtc tac ccg  ctg cga gcc gcc      6616
Gly  Gly Ala Leu Gly Asp  Val Gly Val Tyr Pro  Leu Arg Ala Ala          
2115                 2120                 2125                          

cag  cac ctg ctc ggc gac  gaa ctc gac gtc ctc  ggc gcg cac ctc      6661
Gln  His Leu Leu Gly Asp  Glu Leu Asp Val Leu  Gly Ala His Leu          
2130                 2135                 2140                          

gtc  cgg ggg ccc ggc agc  cgg gtc gag acc gcc  ggc ggg gcg ctg      6706
Val  Arg Gly Pro Gly Ser  Arg Val Glu Thr Ala  Gly Gly Ala Leu          
2145                 2150                 2155                          

ctc  gcc acc ccg gcg ggc  gtc acc gcg cac atc  gcc ttc ggc atg      6751
Leu  Ala Thr Pro Ala Gly  Val Thr Ala His Ile  Ala Phe Gly Met          
2160                 2165                 2170                          

gac  cac ggc tac cgc tcg  gcg tac gag ctg tgg  ggc agc cag ggc      6796
Asp  His Gly Tyr Arg Ser  Ala Tyr Glu Leu Trp  Gly Ser Gln Gly          
2175                 2180                 2185                          

cgg  ctc gtc gtc gag cgg  gcc tac acc ccg ccc  gcc gac cac cgc      6841
Arg  Leu Val Val Glu Arg  Ala Tyr Thr Pro Pro  Ala Asp His Arg          
2190                 2195                 2200                          

ccg  gtg gtg cgc ctg gag  acc cgc acc ggc gtc  gag gag ctc gtc      6886
Pro  Val Val Arg Leu Glu  Thr Arg Thr Gly Val  Glu Glu Leu Val          
2205                 2210                 2215                          

ctc  gac gcc gac gac cag  gtc cgc aac acg gtg  gcc gcc ttc gcc      6931
Leu  Asp Ala Asp Asp Gln  Val Arg Asn Thr Val  Ala Ala Phe Ala          
2220                 2225                 2230                          

gcc  ctc gtg gcg cgc acc  gga gcc ggc cac ccc  ggg gac ggc ggc      6976
Ala  Leu Val Ala Arg Thr  Gly Ala Gly His Pro  Gly Asp Gly Gly          
2235                 2240                 2245                          

gcg  ccc gac ccg gag gcc  ccg ctg cgc cag gcg  cgg ctg ctc gac      7021
Ala  Pro Asp Pro Glu Ala  Pro Leu Arg Gln Ala  Arg Leu Leu Asp          
2250                 2255                 2260                          

gcc  gtg cgg cgc cgg gcc  gcc ctc gtc tga cccgcgcctc taga           7065
Ala  Val Arg Arg Arg Ala  Ala Leu Val                                   
2265                 2270                                               


<210>  119
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  119

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  120
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  120

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  121
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  121

Met Gln Ser Arg Lys Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val 
1               5                   10                  15      


Thr Ser Cys Asp Asp Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp 
            20                  25                  30          


Ala Lys Asp Arg Ile Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln 
        35                  40                  45              


Glu Ser Pro Thr Phe Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly 
    50                  55                  60                  


Ala Val Leu Asp Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu 
65                  70                  75                  80  


Glu Leu Arg Ile Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu 
                85                  90                  95      


Phe Ala Arg Phe Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly 
            100                 105                 110         


Ser Ser Ala Asn Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu 
        115                 120                 125             


Gly Glu Ala Arg Leu Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val 
    130                 135                 140                 


Gly Phe Pro Thr Thr Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro 
145                 150                 155                 160 


Val Phe Val Asp Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg 
                165                 170                 175     


Ile Lys Ala Ala Val Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His 
            180                 185                 190         


Thr Leu Gly Asn Pro Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys 
        195                 200                 205             


Glu His Glu Leu Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser 
    210                 215                 220                 


Thr Tyr Arg Gly Arg Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val 
225                 230                 235                 240 


Ser Phe Tyr Pro Ala His His Ile Thr Ser Gly Glu Gly Gly Cys Val 
                245                 250                 255     


Leu Thr Gly Ser Leu Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp 
            260                 265                 270         


Trp Gly Arg Asp Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg 
        275                 280                 285             


Lys Arg Phe Asp Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His 
    290                 295                 300                 


Lys Tyr Thr Phe Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu 
305                 310                 315                 320 


Gln Ala Ala Leu Ala Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly 
                325                 330                 335     


Ser Ala Arg Arg Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly 
            340                 345                 350         


Leu Pro Gly Leu Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser 
        355                 360                 365             


Trp Phe Gly Phe Ala Ile Thr Ile Ser Ala Asp Ala Gly Phe Thr Arg 
    370                 375                 380                 


Ala Ala Leu Val Asn Phe Leu Glu Ser Arg Asn Ile Gly Thr Arg Leu 
385                 390                 395                 400 


Leu Phe Gly Gly Asn Ile Thr Arg His Pro Ala Phe Glu Gln Val Arg 
                405                 410                 415     


Tyr Arg Ile Ala Asp Ala Leu Thr Asn Ser Asp Ile Val Thr Asp Arg 
            420                 425                 430         


Thr Phe Trp Val Gly Val Tyr Pro Gly Ile Thr Asp Gln Met Ile Asp 
        435                 440                 445             


Tyr Val Val Glu Ser Ile Ala Glu Phe Val Ala Lys Ser Ser 
    450                 455                 460         


<210>  122
<211>  385
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  122

Val Ile Asn Leu His Gln Pro Ile Leu Gly Thr Glu Glu Leu Asp Ala 
1               5                   10                  15      


Ile Ala Glu Val Phe Ala Ser Asn Trp Ile Gly Leu Gly Pro Arg Thr 
            20                  25                  30          


Arg Thr Phe Glu Ala Glu Phe Ala His His Leu Gly Val Asp Pro Glu 
        35                  40                  45              


Gln Val Val Phe Leu Asn Ser Gly Thr Ala Ala Leu Phe Leu Thr Val 
    50                  55                  60                  


Gln Val Leu Asp Leu Gly Pro Gly Asp Asp Val Val Leu Pro Ser Ile 
65                  70                  75                  80  


Ser Phe Val Ala Ala Ala Asn Ala Ile Ala Ser Ser Gly Ala Arg Pro 
                85                  90                  95      


Val Phe Cys Asp Val Asp Pro Arg Thr Leu Asn Pro Thr Leu Asp Asp 
            100                 105                 110         


Val Ala Arg Ala Ile Thr Pro Ala Thr Lys Ala Val Leu Leu Leu His 
        115                 120                 125             


Tyr Gly Gly Ser Pro Gly Glu Val Thr Ala Ile Ala Asp Phe Cys Arg 
    130                 135                 140                 


Glu Lys Gly Leu Met Leu Ile Glu Asp Ser Ala Cys Ala Val Ala Ser 
145                 150                 155                 160 


Ser Val His Gly Thr Ala Cys Gly Thr Phe Gly Asp Leu Ala Thr Trp 
                165                 170                 175     


Ser Phe Asp Ala Met Lys Ile Leu Val Thr Gly Asp Gly Gly Met Phe 
            180                 185                 190         


Tyr Ala Ala Asp Pro Glu Leu Ala His Arg Ala Arg Arg Leu Ala Tyr 
        195                 200                 205             


His Gly Leu Glu Gln Met Ser Gly Phe Asp Ser Ala Lys Ser Ser Asn 
    210                 215                 220                 


Arg Trp Trp Asp Ile Arg Val Glu Asp Ile Gly Gln Arg Leu Ile Gly 
225                 230                 235                 240 


Asn Asp Met Thr Ala Ala Leu Gly Ser Val Gln Leu Arg Lys Leu Pro 
                245                 250                 255     


Glu Phe Ile Asn Arg Arg Arg Glu Ile Ala Thr Gln Tyr Asp Arg Leu 
            260                 265                 270         


Leu Ser Asp Val Pro Gly Val Leu Leu Pro Pro Thr Leu Pro Asp Gly 
        275                 280                 285             


His Val Ser Ser His Tyr Phe Tyr Trp Val Gln Leu Ala Pro Glu Ile 
    290                 295                 300                 


Arg Asp Gln Val Ala Gln Gln Met Leu Glu Arg Gly Ile Tyr Thr Ser 
305                 310                 315                 320 


Tyr Arg Tyr Pro Pro Leu His Lys Val Pro Ile Tyr Arg Ala Asp Cys 
                325                 330                 335     


Lys Leu Pro Ser Ala Glu Asp Ala Cys Arg Arg Thr Leu Leu Leu Pro 
            340                 345                 350         


Leu His Pro Ser Leu Asp Asp Ala Glu Val Arg Thr Val Ala Asp Glu 
        355                 360                 365             


Phe Gln Lys Ala Val Glu His His Ile Ser Gln Arg Ser Pro Leu Arg 
    370                 375                 380                 


Lys 
385 


<210>  123
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  123

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  124
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  124

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  125
<211>  6825
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1970)..(3355)
<223>  spnQ gene from S. spinosa


<220>
<221>  CDS
<222>  (3415)..(4332)
<223>  kre gene from S. spinosa


<220>
<221>  CDS
<222>  (4360)..(5775)
<223>  tdh gene from S. diversa


<220>
<221>  CDS
<222>  (5810)..(6811)
<223>  tkr gene from S. diversa


<400>  125
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgaaggcg cgaagactga tcgtcgcctg c atg cag agc cgg   1981
                                                  Met Gln Ser Arg       
                                                          625           

aaa acc aga gcg ctg ggg aaa ggg cgc gcc aga gtg act tcg tgt gac     2029
Lys Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val Thr Ser Cys Asp         
            630                 635                 640                 

gac act tgc gct acc gct act gag atg gtg ccg gat gcc aag gac cgg     2077
Asp Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp Ala Lys Asp Arg         
        645                 650                 655                     

ata ttg gca tcc gta cgc gat tac cac cgc gaa cag gaa tcc ccg acc     2125
Ile Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln Glu Ser Pro Thr         
    660                 665                 670                         

ttc gtg gct gga tcg acg ccg atc cgg cca tcg ggc gcc gtg ctc gac     2173
Phe Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly Ala Val Leu Asp         
675                 680                 685                 690         

gag gac gac cgg gtg gca ctg gtg gaa gcc gcg ctg gag ctc cgg atc     2221
Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu Glu Leu Arg Ile         
                695                 700                 705             

gcc gcg ggc ggg aat gca cgg cga ttc gag agc gag ttc gcc cgc ttc     2269
Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu Phe Ala Arg Phe         
            710                 715                 720                 

ttc ggc ctc cgc aag gct cat ctc gtc aac tcc ggt tcg tcg gcc aat     2317
Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly Ser Ser Ala Asn         
        725                 730                 735                     

ctc ctg gca ctg agt tcg ctt acc tcc ccc aaa ctc ggc gag gca cga     2365
Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu Gly Glu Ala Arg         
    740                 745                 750                         

ctg cgg ccc ggc gac gaa gtg atc act gcg gcg gtc ggc ttc ccc acg     2413
Leu Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val Gly Phe Pro Thr         
755                 760                 765                 770         

acg atc aat ccg gcg gtc caa aac gga ctc gtc ccg gta ttc gtc gac     2461
Thr Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro Val Phe Val Asp         
                775                 780                 785             

gtg gaa ctg ggc acc tac aac gca acg cca gac cgc atc aag gcc gcc     2509
Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg Ile Lys Ala Ala         
            790                 795                 800                 

gtc acg gaa cgg acg cga gcc atc atg ctg gcg cac acc ctg ggc aac     2557
Val Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His Thr Leu Gly Asn         
        805                 810                 815                     

ccc ttc gcc gct gac gaa atc gcg gag atc gca aaa gaa cac gag ctg     2605
Pro Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys Glu His Glu Leu         
    820                 825                 830                         

ttc ctc gtc gaa gac aac tgt gat gcg gtg gga tcc acc tac cgg gga     2653
Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser Thr Tyr Arg Gly         
835                 840                 845                 850         

cgg ctg acc gga acc ttc ggc gac ctg aca acg gtc agc ttc tat cct     2701
Arg Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val Ser Phe Tyr Pro         
                855                 860                 865             

gcc cat cac atc acc agc ggc gag ggt ggc tgc gtg ttg acc ggc agc     2749
Ala His His Ile Thr Ser Gly Glu Gly Gly Cys Val Leu Thr Gly Ser         
            870                 875                 880                 

ctg gaa ttg gct cgc atc atc gag tcg ctg cgt gac tgg gga cgg gat     2797
Leu Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp Trp Gly Arg Asp         
        885                 890                 895                     

tgc tgg tgc gag ccc ggc gtg gac aac acc tgc cgc aag agg ttc gac     2845
Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg Lys Arg Phe Asp         
    900                 905                 910                         

tac cac ctc ggt acc ctt cca ccg ggc tac gac cac aag tac acg ttc     2893
Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His Lys Tyr Thr Phe         
915                 920                 925                 930         

tcc cac gtc ggt tac aac ctc aag acc acc gac ctg cag gcc gca ctt     2941
Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu Gln Ala Ala Leu         
                935                 940                 945             

gcg ctg agc cag ttg agc aag att tcc gca ttc ggg tcg gca cgc cgc     2989
Ala Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly Ser Ala Arg Arg         
            950                 955                 960                 

cgt aac tgg cga cgg ttg cgc gaa ggg ctg tcc ggg ttg ccg ggc ctg     3037
Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly Leu Pro Gly Leu         
        965                 970                 975                     

ctg ctg ccg gta gcc aca ccg cac agc gac ccg agc tgg ttc ggg ttt     3085
Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser Trp Phe Gly Phe         
    980                 985                 990                         

gcg atc acc atc agt gcg  gac gcc ggg ttc acc  cgt gcc gcc ctg       3130
Ala Ile Thr Ile Ser Ala  Asp Ala Gly Phe Thr  Arg Ala Ala Leu           
995                 1000                 1005                           

gtg  aac ttc ctg gaa tcc  cgc aac atc ggc acc  cga ctg ctg ttc      3175
Val  Asn Phe Leu Glu Ser  Arg Asn Ile Gly Thr  Arg Leu Leu Phe          
1010                 1015                 1020                          

ggc  ggt aac atc acc cgg  cac ccg gcc ttc gag  cag gtg cgg tac      3220
Gly  Gly Asn Ile Thr Arg  His Pro Ala Phe Glu  Gln Val Arg Tyr          
1025                 1030                 1035                          

cgg  atc gcc gac gcg ctc  acc aac agc gac atc  gtc acc gac cga      3265
Arg  Ile Ala Asp Ala Leu  Thr Asn Ser Asp Ile  Val Thr Asp Arg          
1040                 1045                 1050                          

acc  ttc tgg gtc ggc gtc  tac cca ggc ata acg  gac caa atg atc      3310
Thr  Phe Trp Val Gly Val  Tyr Pro Gly Ile Thr  Asp Gln Met Ile          
1055                 1060                 1065                          

gac  tac gtc gtc gaa tca  atc gct gaa ttc gtg  gcc aag agt tcc      3355
Asp  Tyr Val Val Glu Ser  Ile Ala Glu Phe Val  Ala Lys Ser Ser          
1070                 1075                 1080                          

tagcatccag catggcggca tctcggagga tactagtatg catgatcggc ggtggctcg    3414

atg  agt cgc ctc gcc gtg  ctg gtg ccc ggc ggc  cgc ggc cag ctg      3459
Met  Ser Arg Leu Ala Val  Leu Val Pro Gly Gly  Arg Gly Gln Leu          
1085                 1090                 1095                          

ggc  tcg gag ctg gcc cgg  atc ctc gcc gcg cgg  acg ggg gcg ctg      3504
Gly  Ser Glu Leu Ala Arg  Ile Leu Ala Ala Arg  Thr Gly Ala Leu          
1100                 1105                 1110                          

gtg  cac cgg ccg ggt tcc  ggg gaa ctg gac gtc  acc gac gcc gag      3549
Val  His Arg Pro Gly Ser  Gly Glu Leu Asp Val  Thr Asp Ala Glu          
1115                 1120                 1125                          

gag  gtc gcc gac gcg ttg  ggt tcc ttc gcg gag  acg gcg aag gac      3594
Glu  Val Ala Asp Ala Leu  Gly Ser Phe Ala Glu  Thr Ala Lys Asp          
1130                 1135                 1140                          

gcg  gag ctg cga ccg gtg  gtg atc aac gcc gcg  gcg tac acg gcg      3639
Ala  Glu Leu Arg Pro Val  Val Ile Asn Ala Ala  Ala Tyr Thr Ala          
1145                 1150                 1155                          

gtg  gac gcg gcc gag tcc  gac ccg gac cgc gcg  gcc cgg atc aac      3684
Val  Asp Ala Ala Glu Ser  Asp Pro Asp Arg Ala  Ala Arg Ile Asn          
1160                 1165                 1170                          

gcc  gaa ggc gcg gcc tcg  ctg gcg aaa gcg tgc  cgg agc agc ggt      3729
Ala  Glu Gly Ala Ala Ser  Leu Ala Lys Ala Cys  Arg Ser Ser Gly          
1175                 1180                 1185                          

ctg  ccc ctg gtg cac gtg  tcg acg gat tac gtg  ttc ccc ggt gat      3774
Leu  Pro Leu Val His Val  Ser Thr Asp Tyr Val  Phe Pro Gly Asp          
1190                 1195                 1200                          

ggg  gcc cgg ccg tac gag  ccg acg gac ccg acc  ggg ccg cga tcg      3819
Gly  Ala Arg Pro Tyr Glu  Pro Thr Asp Pro Thr  Gly Pro Arg Ser          
1205                 1210                 1215                          

gtc  tac ggg cgc acc aag  ctc gaa ggc gaa cgg  gcc gtg ctg gag      3864
Val  Tyr Gly Arg Thr Lys  Leu Glu Gly Glu Arg  Ala Val Leu Glu          
1220                 1225                 1230                          

tcc  ggc gcg cgg gcc tgg  gtg gtg cgc acg gca  tgg gtg tac ggc      3909
Ser  Gly Ala Arg Ala Trp  Val Val Arg Thr Ala  Trp Val Tyr Gly          
1235                 1240                 1245                          

gcg  agc ggc aag aac ttc  ctg aaa acg atg atc  cgc ctc tcg ggg      3954
Ala  Ser Gly Lys Asn Phe  Leu Lys Thr Met Ile  Arg Leu Ser Gly          
1250                 1255                 1260                          

gag  cgc gac acg ctg tcc  gtt gtg gac gat cag  atc ggc tcg ccg      3999
Glu  Arg Asp Thr Leu Ser  Val Val Asp Asp Gln  Ile Gly Ser Pro          
1265                 1270                 1275                          

act  tgg gcg gcg gac ctg  gcg agc ggc ctg ctg  gag ctg gcc gaa      4044
Thr  Trp Ala Ala Asp Leu  Ala Ser Gly Leu Leu  Glu Leu Ala Glu          
1280                 1285                 1290                          

cgg  gtc gcc gaa cgc cgt  gga ccg gag cag aag  gtg ctg cac tgc      4089
Arg  Val Ala Glu Arg Arg  Gly Pro Glu Gln Lys  Val Leu His Cys          
1295                 1300                 1305                          

acc  aat tcc ggc cag gtg  acc tgg tac gag ttc  gcg cgg gcg atc      4134
Thr  Asn Ser Gly Gln Val  Thr Trp Tyr Glu Phe  Ala Arg Ala Ile          
1310                 1315                 1320                          

ttc  gcg gaa ttc ggc ctg  gac gag aac cgc gtc  cac ccg tgc acg      4179
Phe  Ala Glu Phe Gly Leu  Asp Glu Asn Arg Val  His Pro Cys Thr          
1325                 1330                 1335                          

acg  gcg gac ttc ccc ctc  ccg gcg cac cgc ccg  gcc tac tcg gtc      4224
Thr  Ala Asp Phe Pro Leu  Pro Ala His Arg Pro  Ala Tyr Ser Val          
1340                 1345                 1350                          

ctg  tcc gac gtg gcg tgg  cga gag gcg ggc ctg  acc ccg atg cgc      4269
Leu  Ser Asp Val Ala Trp  Arg Glu Ala Gly Leu  Thr Pro Met Arg          
1355                 1360                 1365                          

acc  tgg cgg gaa gcc ctg  gcg gcg gcc ttc gag  aaa gac ggc gaa      4314
Thr  Trp Arg Glu Ala Leu  Ala Ala Ala Phe Glu  Lys Asp Gly Glu          
1370                 1375                 1380                          

acc  ctc cga acc cgc tga ccagtcacta gtggagggcc actcctg atg  agc     4365
Thr  Leu Arg Thr Arg                                   Met  Ser         
1385                                                   1390             

acc gcc acc acc  acg ccc gcc ccc gcc  ctc acc gcc cgc cgg  ccc      4410
Thr Ala Thr Thr  Thr Pro Ala Pro Ala  Leu Thr Ala Arg Arg  Pro          
            1395                 1400                 1405              

gcc ggg ctc gcc  gag cgg atc gcc cgc  tcg gcc gcc acc ggc  cgc      4455
Ala Gly Leu Ala  Glu Arg Ile Ala Arg  Ser Ala Ala Thr Gly  Arg          
            1410                 1415                 1420              

ggc gcc cac ctg  gcc acc gag gac ttc  cac gac tgg ctc gac  ggc      4500
Gly Ala His Leu  Ala Thr Glu Asp Phe  His Asp Trp Leu Asp  Gly          
            1425                 1430                 1435              

cgc cgc cgc gcc  aac acc ttc cgc gtc  gac aag atc ccc ttc  gac      4545
Arg Arg Arg Ala  Asn Thr Phe Arg Val  Asp Lys Ile Pro Phe  Asp          
            1440                 1445                 1450              

gcg ctc gac ggc  tgg tcc ttc gac gag  gag gac ggc aac ctc  gtc      4590
Ala Leu Asp Gly  Trp Ser Phe Asp Glu  Glu Asp Gly Asn Leu  Val          
            1455                 1460                 1465              

cac cgc agc ggc  cgc ttc ttc acc gtc  gag ggc ctg cac gtc  gtc      4635
His Arg Ser Gly  Arg Phe Phe Thr Val  Glu Gly Leu His Val  Val          
            1470                 1475                 1480              

gag gag gac gga  ccc tac ggc gac ggc  ccg tac cgc tcc tgg  tac      4680
Glu Glu Asp Gly  Pro Tyr Gly Asp Gly  Pro Tyr Arg Ser Trp  Tyr          
            1485                 1490                 1495              

cag ccc gtc atc  aag cag ccc gag gtc  ggc atc ctc ggc atc  ctc      4725
Gln Pro Val Ile  Lys Gln Pro Glu Val  Gly Ile Leu Gly Ile  Leu          
            1500                 1505                 1510              

gcc aag gag ttc  gac ggc gtc ctg cac  ttc ctc atg cag gcc  aag      4770
Ala Lys Glu Phe  Asp Gly Val Leu His  Phe Leu Met Gln Ala  Lys          
            1515                 1520                 1525              

atg gag ccc ggc  aac ccg aac ctg ctc  cag ctg tcg ccg acc  gtc      4815
Met Glu Pro Gly  Asn Pro Asn Leu Leu  Gln Leu Ser Pro Thr  Val          
            1530                 1535                 1540              

cag gcc acc cgc  agc aac tac acc aag  gcg cac cgc ggc ggc  gac      4860
Gln Ala Thr Arg  Ser Asn Tyr Thr Lys  Ala His Arg Gly Gly  Asp          
            1545                 1550                 1555              

gtg aag tac atc  gag tac ttc acc ggc  gcc gaa cac ggc acc  gtc      4905
Val Lys Tyr Ile  Glu Tyr Phe Thr Gly  Ala Glu His Gly Thr  Val          
            1560                 1565                 1570              

atc gcc gac tcc  ctc cag tcc gag cac  ggc gcc tgg ttc ttc  cac      4950
Ile Ala Asp Ser  Leu Gln Ser Glu His  Gly Ala Trp Phe Phe  His          
            1575                 1580                 1585              

aag tcc aac cgc  aac atg atc gtc gag  gcc acc ggc gag gtc  ccg      4995
Lys Ser Asn Arg  Asn Met Ile Val Glu  Ala Thr Gly Glu Val  Pro          
            1590                 1595                 1600              

ctc ctc gac gac  ttc tgc tgg ctc acc  ctc ggc cag ctc ggc  gag      5040
Leu Leu Asp Asp  Phe Cys Trp Leu Thr  Leu Gly Gln Leu Gly  Glu          
            1605                 1610                 1615              

ctc ctc cac cag  gac aac gtc atc aac  atg gac gcc agg acc  gtc      5085
Leu Leu His Gln  Asp Asn Val Ile Asn  Met Asp Ala Arg Thr  Val          
            1620                 1625                 1630              

ctg tcc tgc gtg  ccg tac gag gac gcc  gac gcc ggg cgg gcg  ctg      5130
Leu Ser Cys Val  Pro Tyr Glu Asp Ala  Asp Ala Gly Arg Ala  Leu          
            1635                 1640                 1645              

ctc tcc gac gtc  cag ctg ctc tcc tgg  ttc acc ggc gag cgc  tcc      5175
Leu Ser Asp Val  Gln Leu Leu Ser Trp  Phe Thr Gly Glu Arg  Ser          
            1650                 1655                 1660              

cgc cac gac gta  cgg gcc cgg cgc gtc  ccg ctg cgc gag ctg  ccc      5220
Arg His Asp Val  Arg Ala Arg Arg Val  Pro Leu Arg Glu Leu  Pro          
            1665                 1670                 1675              

ggc tgg aag cag  ggc gag gag acc atc  gag cac gag gag ggc  cgg      5265
Gly Trp Lys Gln  Gly Glu Glu Thr Ile  Glu His Glu Glu Gly  Arg          
            1680                 1685                 1690              

cac ttc aag gtc  gtc gcc gtc tcc gtg  cag gcc ggg aac cgc  gaa      5310
His Phe Lys Val  Val Ala Val Ser Val  Gln Ala Gly Asn Arg  Glu          
            1695                 1700                 1705              

gtg acc agc tgg  acc cag ccg ctg atc  gaa ccg gtc gga ctc  ggc      5355
Val Thr Ser Trp  Thr Gln Pro Leu Ile  Glu Pro Val Gly Leu  Gly          
            1710                 1715                 1720              

gtc gcc gcc ttc  ctg acc cgc gac ttc  gac ggc gtc ccg cac  tac      5400
Val Ala Ala Phe  Leu Thr Arg Asp Phe  Asp Gly Val Pro His  Tyr          
            1725                 1730                 1735              

ctg gtg cac gcc  cgc gtc gag ggc ggc  ttc ctc gac acc gtg  gaa      5445
Leu Val His Ala  Arg Val Glu Gly Gly  Phe Leu Asp Thr Val  Glu          
            1740                 1745                 1750              

ctg gcc ccc acc  gtc cag tac acc ccg  ggc aac tac gcc cac  ctg      5490
Leu Ala Pro Thr  Val Gln Tyr Thr Pro  Gly Asn Tyr Ala His  Leu          
            1755                 1760                 1765              

ccg acc gac gag  cgc ccg ccc ttc ctc  gac ctc gtc ctc gac  acc      5535
Pro Thr Asp Glu  Arg Pro Pro Phe Leu  Asp Leu Val Leu Asp  Thr          
            1770                 1775                 1780              

gac ccc gcc cgc  gtc cgc tac gag gcc  gtg cac tcc gag gaa  ggc      5580
Asp Pro Ala Arg  Val Arg Tyr Glu Ala  Val His Ser Glu Glu  Gly          
            1785                 1790                 1795              

ggc cgc ttc ctc  aac gcc gag agc cgc  tac ctc ctg gtg gag  gcc      5625
Gly Arg Phe Leu  Asn Ala Glu Ser Arg  Tyr Leu Leu Val Glu  Ala          
            1800                 1805                 1810              

gac gag acg cag  gcc ccg gcc gac ccg  ccg ccc ggc tac gcc  tgg      5670
Asp Glu Thr Gln  Ala Pro Ala Asp Pro  Pro Pro Gly Tyr Ala  Trp          
            1815                 1820                 1825              

gcg acc gcc gca  cag ctc acc tcc ctc  acc cgg cac ggc cac  tac      5715
Ala Thr Ala Ala  Gln Leu Thr Ser Leu  Thr Arg His Gly His  Tyr          
            1830                 1835                 1840              

ctc aac gtc cag  gcc cgc acc ctg ctg  gcc tgc gtc cac gcc  ggg      5760
Leu Asn Val Gln  Ala Arg Thr Leu Leu  Ala Cys Val His Ala  Gly          
            1845                 1850                 1855              

gcg gtg cgg cct  tga cgagcacccc ggcgcatatg ggggaggtgc ggcc ttg      5812
Ala Val Arg Pro                                            Leu          
            1860                                                        

acg agc acc ccg  gcg ccc ctg cgg atc  ggt gtg ctc ggc tgc  gcc      5857
Thr Ser Thr Pro  Ala Pro Leu Arg Ile  Gly Val Leu Gly Cys  Ala          
            1865                 1870                 1875              

gac atc gcc gtc  cgg cgc atg atg ccc  gcg atg gcc gcg ctc  ccc      5902
Asp Ile Ala Val  Arg Arg Met Met Pro  Ala Met Ala Ala Leu  Pro          
            1880                 1885                 1890              

ggg acc gag gtc  acc gcc gtc gcc agc  cgc gac gcg gcg aag  gcc      5947
Gly Thr Glu Val  Thr Ala Val Ala Ser  Arg Asp Ala Ala Lys  Ala          
            1895                 1900                 1905              

gcc gtg gcc gcc  gcc ccg tac ggc gcg  gcg gcc gtc gag ggc  tac      5992
Ala Val Ala Ala  Ala Pro Tyr Gly Ala  Ala Ala Val Glu Gly  Tyr          
            1910                 1915                 1920              

cag gag ctg ctg  cgc cgc ccg gac gtc  gac gcc gtc tac gta  ccg      6037
Gln Glu Leu Leu  Arg Arg Pro Asp Val  Asp Ala Val Tyr Val  Pro          
            1925                 1930                 1935              

ctg ccc gcc gcc  ctg cac gcc gag tgg  acc gag gcc gcc ctg  cgg      6082
Leu Pro Ala Ala  Leu His Ala Glu Trp  Thr Glu Ala Ala Leu  Arg          
            1940                 1945                 1950              

gcc ggc aag cac  gtc ctg gcc gag aag  ccg ctc acc acg gac  ccg      6127
Ala Gly Lys His  Val Leu Ala Glu Lys  Pro Leu Thr Thr Asp  Pro          
            1955                 1960                 1965              

gag agc acc gcc  gcg ctg ctc ggc ctg  gcc gcc gcg tcc ggg  ctc      6172
Glu Ser Thr Ala  Ala Leu Leu Gly Leu  Ala Ala Ala Ser Gly  Leu          
            1970                 1975                 1980              

gcg ctg atg gag  aac gtc atg ttc gtc  cac cac cgc ctc cac  acc      6217
Ala Leu Met Glu  Asn Val Met Phe Val  His His Arg Leu His  Thr          
            1985                 1990                 1995              

gac gtc cgc aag  ctc gtc gcg gac gga  gcc atc ggc gaa ctc  cgc      6262
Asp Val Arg Lys  Leu Val Ala Asp Gly  Ala Ile Gly Glu Leu  Arg          
            2000                 2005                 2010              

gcc ctg cac gcc  tcg ttc ggc atc ccc  cgg ctg ccc gac acc  gac      6307
Ala Leu His Ala  Ser Phe Gly Ile Pro  Arg Leu Pro Asp Thr  Asp          
            2015                 2020                 2025              

atc cgg cac gac  ccc ggg ctc ggc ggc  ggc gcc ctc ggc gac  gtc      6352
Ile Arg His Asp  Pro Gly Leu Gly Gly  Gly Ala Leu Gly Asp  Val          
            2030                 2035                 2040              

ggc gtc tac ccg  ctg cga gcc gcc cag  cac ctg ctc ggc gac  gaa      6397
Gly Val Tyr Pro  Leu Arg Ala Ala Gln  His Leu Leu Gly Asp  Glu          
            2045                 2050                 2055              

ctc gac gtc ctc  ggc gcg cac ctc gtc  cgg ggg ccc ggc agc  cgg      6442
Leu Asp Val Leu  Gly Ala His Leu Val  Arg Gly Pro Gly Ser  Arg          
            2060                 2065                 2070              

gtc gag acc gcc  ggc ggg gcg ctg ctc  gcc acc ccg gcg ggc  gtc      6487
Val Glu Thr Ala  Gly Gly Ala Leu Leu  Ala Thr Pro Ala Gly  Val          
            2075                 2080                 2085              

acc gcg cac atc  gcc ttc ggc atg gac  cac ggc tac cgc tcg  gcg      6532
Thr Ala His Ile  Ala Phe Gly Met Asp  His Gly Tyr Arg Ser  Ala          
            2090                 2095                 2100              

tac gag ctg tgg  ggc agc cag ggc cgg  ctc gtc gtc gag cgg  gcc      6577
Tyr Glu Leu Trp  Gly Ser Gln Gly Arg  Leu Val Val Glu Arg  Ala          
            2105                 2110                 2115              

tac acc ccg ccc  gcc gac cac cgc ccg  gtg gtg cgc ctg gag  acc      6622
Tyr Thr Pro Pro  Ala Asp His Arg Pro  Val Val Arg Leu Glu  Thr          
            2120                 2125                 2130              

cgc acc ggc gtc  gag gag ctc gtc ctc  gac gcc gac gac cag  gtc      6667
Arg Thr Gly Val  Glu Glu Leu Val Leu  Asp Ala Asp Asp Gln  Val          
            2135                 2140                 2145              

cgc aac acg gtg  gcc gcc ttc gcc gcc  ctc gtg gcg cgc acc  gga      6712
Arg Asn Thr Val  Ala Ala Phe Ala Ala  Leu Val Ala Arg Thr  Gly          
            2150                 2155                 2160              

gcc ggc cac ccc  ggg gac ggc ggc gcg  ccc gac ccg gag gcc  ccg      6757
Ala Gly His Pro  Gly Asp Gly Gly Ala  Pro Asp Pro Glu Ala  Pro          
            2165                 2170                 2175              

ctg cgc cag gcg  cgg ctg ctc gac gcc  gtg cgg cgc cgg gcc  gcc      6802
Leu Arg Gln Ala  Arg Leu Leu Asp Ala  Val Arg Arg Arg Ala  Ala          
            2180                 2185                 2190              

ctc gtc tga cccgcgcctc taga                                         6825
Leu Val                                                                 
                                                                        


<210>  126
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  126

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  127
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  127

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  128
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  128

Met Gln Ser Arg Lys Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val 
1               5                   10                  15      


Thr Ser Cys Asp Asp Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp 
            20                  25                  30          


Ala Lys Asp Arg Ile Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln 
        35                  40                  45              


Glu Ser Pro Thr Phe Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly 
    50                  55                  60                  


Ala Val Leu Asp Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu 
65                  70                  75                  80  


Glu Leu Arg Ile Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu 
                85                  90                  95      


Phe Ala Arg Phe Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly 
            100                 105                 110         


Ser Ser Ala Asn Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu 
        115                 120                 125             


Gly Glu Ala Arg Leu Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val 
    130                 135                 140                 


Gly Phe Pro Thr Thr Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro 
145                 150                 155                 160 


Val Phe Val Asp Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg 
                165                 170                 175     


Ile Lys Ala Ala Val Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His 
            180                 185                 190         


Thr Leu Gly Asn Pro Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys 
        195                 200                 205             


Glu His Glu Leu Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser 
    210                 215                 220                 


Thr Tyr Arg Gly Arg Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val 
225                 230                 235                 240 


Ser Phe Tyr Pro Ala His His Ile Thr Ser Gly Glu Gly Gly Cys Val 
                245                 250                 255     


Leu Thr Gly Ser Leu Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp 
            260                 265                 270         


Trp Gly Arg Asp Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg 
        275                 280                 285             


Lys Arg Phe Asp Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His 
    290                 295                 300                 


Lys Tyr Thr Phe Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu 
305                 310                 315                 320 


Gln Ala Ala Leu Ala Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly 
                325                 330                 335     


Ser Ala Arg Arg Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly 
            340                 345                 350         


Leu Pro Gly Leu Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser 
        355                 360                 365             


Trp Phe Gly Phe Ala Ile Thr Ile Ser Ala Asp Ala Gly Phe Thr Arg 
    370                 375                 380                 


Ala Ala Leu Val Asn Phe Leu Glu Ser Arg Asn Ile Gly Thr Arg Leu 
385                 390                 395                 400 


Leu Phe Gly Gly Asn Ile Thr Arg His Pro Ala Phe Glu Gln Val Arg 
                405                 410                 415     


Tyr Arg Ile Ala Asp Ala Leu Thr Asn Ser Asp Ile Val Thr Asp Arg 
            420                 425                 430         


Thr Phe Trp Val Gly Val Tyr Pro Gly Ile Thr Asp Gln Met Ile Asp 
        435                 440                 445             


Tyr Val Val Glu Ser Ile Ala Glu Phe Val Ala Lys Ser Ser 
    450                 455                 460         


<210>  129
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  129

Met Ser Arg Leu Ala Val Leu Val Pro Gly Gly Arg Gly Gln Leu Gly 
1               5                   10                  15      


Ser Glu Leu Ala Arg Ile Leu Ala Ala Arg Thr Gly Ala Leu Val His 
            20                  25                  30          


Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala 
        35                  40                  45              


Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu Arg 
    50                  55                  60                  


Pro Val Val Ile Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu 
65                  70                  75                  80  


Ser Asp Pro Asp Arg Ala Ala Arg Ile Asn Ala Glu Gly Ala Ala Ser 
                85                  90                  95      


Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser 
            100                 105                 110         


Thr Asp Tyr Val Phe Pro Gly Asp Gly Ala Arg Pro Tyr Glu Pro Thr 
        115                 120                 125             


Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly 
    130                 135                 140                 


Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr 
145                 150                 155                 160 


Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met Ile 
                165                 170                 175     


Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asp Gln Ile 
            180                 185                 190         


Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu 
        195                 200                 205             


Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gln Lys Val Leu His 
    210                 215                 220                 


Cys Thr Asn Ser Gly Gln Val Thr Trp Tyr Glu Phe Ala Arg Ala Ile 
225                 230                 235                 240 


Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr 
                245                 250                 255     


Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser 
            260                 265                 270         


Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg 
        275                 280                 285             


Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr 
    290                 295                 300                 


Arg 
305 


<210>  130
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  130

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  131
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  131

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  132
<211>  6923
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<220>
<221>  CDS
<222>  (30)..(911)
<223>  gtt gene from S. spinosa


<220>
<221>  CDS
<222>  (939)..(1928)
<223>  gdh gene from S. spinosa


<220>
<221>  CDS
<222>  (1970)..(3355)
<223>  spnQ gene from S. spinosa


<220>
<221>  CDS
<222>  (3414)..(4433)
<223>  kre gene from S. diversa


<220>
<221>  CDS
<222>  (4458)..(5873)
<223>  tdh gene from S. diversa


<220>
<221>  CDS
<222>  (5908)..(6909)
<223>  tkr gene from S. diversa


<400>  132
ggtctcaagc ttccgctgga ggtatccgg gtg aag ggg atc gtg ctg gcg ggt       53
                                Val Lys Gly Ile Val Leu Ala Gly         
                                1               5                       

ggc aac ggg acc cgg ctg cat ccg ctg acg cag gcc gtg tcc aaa cag      101
Gly Asn Gly Thr Arg Leu His Pro Leu Thr Gln Ala Val Ser Lys Gln         
    10                  15                  20                          

cta ctt ccg gtg tac gac aag ccg atg atc tac tac ccg ctg tcg gtg      149
Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr Tyr Pro Leu Ser Val         
25                  30                  35                  40          

ctg atg ctg gcc ggc atc cgg gac gtg ctg ctg atc tcg acc ccg gcc      197
Leu Met Leu Ala Gly Ile Arg Asp Val Leu Leu Ile Ser Thr Pro Ala         
                45                  50                  55              

gac atg ccg ttg ttc cag cgg ctg ctc ggg aac ggg tcg cag ttc ggc      245
Asp Met Pro Leu Phe Gln Arg Leu Leu Gly Asn Gly Ser Gln Phe Gly         
            60                  65                  70                  

att cgg atc gag tac gcc gag cag tcc cag ccc aac ggg cta gcc gag      293
Ile Arg Ile Glu Tyr Ala Glu Gln Ser Gln Pro Asn Gly Leu Ala Glu         
        75                  80                  85                      

gcg ttc gtg atc ggt gcc gac ttc gtc ggc gac gac tcg gtg gcg ttg      341
Ala Phe Val Ile Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala Leu         
    90                  95                  100                         

gtg ctc ggc gac aac atc ttt tac ggg cag ggc ttt tcc ggg atc ctc      389
Val Leu Gly Asp Asn Ile Phe Tyr Gly Gln Gly Phe Ser Gly Ile Leu         
105                 110                 115                 120         

cag cag tgc gtc cgg gag ctc gac ggc tgc acg ctg ttc ggc tac ccg      437
Gln Gln Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr Pro         
                125                 130                 135             

gtc cgc gac ccg cag cgc tac ggc gtc ggt gag gtg gac gac gac ggt      485
Val Arg Asp Pro Gln Arg Tyr Gly Val Gly Glu Val Asp Asp Asp Gly         
            140                 145                 150                 

cgg ctg ttg tcc atc gtg gag aag ccg gag cgg ccg aag tcc aac atg      533
Arg Leu Leu Ser Ile Val Glu Lys Pro Glu Arg Pro Lys Ser Asn Met         
        155                 160                 165                     

gcc atc acc ggc ctg tac ttc tac gac aac gac gtg gtg cgc atc gcc      581
Ala Ile Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg Ile Ala         
    170                 175                 180                         

aag ggg ctc acg ccg tcg gcc cgc ggc gag ctg gag atc acc gac gtc      629
Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val         
185                 190                 195                 200         

aac ctg gcc tac ctg cag gag ggc cgg gcg cac ctg acc aag ctc ggc      677
Asn Leu Ala Tyr Leu Gln Glu Gly Arg Ala His Leu Thr Lys Leu Gly         
                205                 210                 215             

cgc ggg ttc gcc tgg ctg gac acc ggg acc cac gac tcg cta gtg gag      725
Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val Glu         
            220                 225                 230                 

gcc tcg cag ttc gtg cag gtg ctg gag cac cgg cag ggc gtg cgg atc      773
Ala Ser Gln Phe Val Gln Val Leu Glu His Arg Gln Gly Val Arg Ile         
        235                 240                 245                     

gcc tgc ctg gag gag atc gcc ctg cgc atg ggc tac atc tcg gcc gac      821
Ala Cys Leu Glu Glu Ile Ala Leu Arg Met Gly Tyr Ile Ser Ala Asp         
    250                 255                 260                         

gac tgt ttc gcg ctg ggc gtg aag ctg gcc aag tcg ggc tac ggc gag      869
Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Gly Glu         
265                 270                 275                 280         

tac gtc atg gac gtc gcc cgc aac tcc ggc gcg cgg ggc tga              911
Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly                     
                285                 290                                 

cccgagatcc cggcgaggaa gggcgcg atg cgg att ctg gtc acc ggc gga gcc    965
                              Met Arg Ile Leu Val Thr Gly Gly Ala       
                                  295                 300               

ggt ttc atc ggc tcg cac tac gtt cgg cag ttg ctc ggt ggt gcg tac     1013
Gly Phe Ile Gly Ser His Tyr Val Arg Gln Leu Leu Gly Gly Ala Tyr         
        305                 310                 315                     

ccc gca ttc gcc gac gcc gac gtg gtc gtg ctc gac aag ctc acc tac     1061
Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu Thr Tyr         
    320                 325                 330                         

gcc ggc aac gag gcg aac ctg gcg ccg gtc gcg gac aac ccc cgg ctg     1109
Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg Leu         
335                 340                 345                 350         

aag ttc gtc tgc ggc gac atc tgc gac cgc gaa ctg gtt ggc ggc ctg     1157
Lys Phe Val Cys Gly Asp Ile Cys Asp Arg Glu Leu Val Gly Gly Leu         
                355                 360                 365             

atg tcc ggc gtg gac gtg gtg gtg cac ttc gcc gcc gaa acc cac gtc     1205
Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His Val         
            370                 375                 380                 

gac cgc tcg atc acc ggc tcg gac gcc ttc gtg atc acc aac gtg gtc     1253
Asp Arg Ser Ile Thr Gly Ser Asp Ala Phe Val Ile Thr Asn Val Val         
        385                 390                 395                     

ggc acc aac gtg ctg ctg cag gcc gcg ctc gac gcc gag atc ggc aag     1301
Gly Thr Asn Val Leu Leu Gln Ala Ala Leu Asp Ala Glu Ile Gly Lys         
    400                 405                 410                         

ttc gtg cac gtt tcc acc gac gag gtc tac ggc tcc atc gag gac ggc     1349
Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser Ile Glu Asp Gly         
415                 420                 425                 430         

tcg tgg ccc gaa gac cac gcg ctg gag ccg aat tcc ccg tac tcg gcg     1397
Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser Ala         
                435                 440                 445             

gcg aaa gcg ggc tcg gac ctg ctg gcc cgc gcc tac cac cgc acc cac     1445
Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr His         
            450                 455                 460                 

gga ctg ccg gtg tgc atc acc cgc tgc tcc aac aac tac ggg ccc tac     1493
Gly Leu Pro Val Cys Ile Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr         
        465                 470                 475                     

cag ttc ccg gag aag gtg ctg ccg ctg ttc atc acg aac ctg atg gac     1541
Gln Phe Pro Glu Lys Val Leu Pro Leu Phe Ile Thr Asn Leu Met Asp         
    480                 485                 490                         

ggc agc cag gtg ccg ctc tac ggc gac ggg ctc aac gtg cgg gac tgg     1589
Gly Ser Gln Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp Trp         
495                 500                 505                 510         

ctg cac gtc agc gac cac tgc cgg ggc atc cag ctg gtg gcc gac tcc     1637
Leu His Val Ser Asp His Cys Arg Gly Ile Gln Leu Val Ala Asp Ser         
                515                 520                 525             

ggg cgc gcg ggc gag atc tac aac atc ggc ggc ggc acc gag ctg acc     1685
Gly Arg Ala Gly Glu Ile Tyr Asn Ile Gly Gly Gly Thr Glu Leu Thr         
            530                 535                 540                 

aac aac gag ctg acc gag cgg ctg ctg gca gag ctg ggc ctc gac tgg     1733
Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp Trp         
        545                 550                 555                     

tcg gtg gtg cgg ccg gtc acc gac cgc aag ggc cac gac cgc cgc tac     1781
Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg Tyr         
    560                 565                 570                         

tcg gtg gac cac agc aag atc gtc gag gaa ctg ggg tac gcg ccg cag     1829
Ser Val Asp His Ser Lys Ile Val Glu Glu Leu Gly Tyr Ala Pro Gln         
575                 580                 585                 590         

gtc gac ttc gag acc ggg ctg cgc gag aca atc cgc tgg tac cag gac     1877
Val Asp Phe Glu Thr Gly Leu Arg Glu Thr Ile Arg Trp Tyr Gln Asp         
                595                 600                 605             

aac cgg gac tgg tgg gag ccg ctg aag gcc cga tcg gcg gtg gct cga     1925
Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala Arg         
            610                 615                 620                 

tga gtcgcctcca attgaaggcg cgaagactga tcgtcgcctg c atg cag agc cgg   1981
                                                  Met Gln Ser Arg       
                                                          625           

aaa acc aga gcg ctg ggg aaa ggg cgc gcc aga gtg act tcg tgt gac     2029
Lys Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val Thr Ser Cys Asp         
            630                 635                 640                 

gac act tgc gct acc gct act gag atg gtg ccg gat gcc aag gac cgg     2077
Asp Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp Ala Lys Asp Arg         
        645                 650                 655                     

ata ttg gca tcc gta cgc gat tac cac cgc gaa cag gaa tcc ccg acc     2125
Ile Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln Glu Ser Pro Thr         
    660                 665                 670                         

ttc gtg gct gga tcg acg ccg atc cgg cca tcg ggc gcc gtg ctc gac     2173
Phe Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly Ala Val Leu Asp         
675                 680                 685                 690         

gag gac gac cgg gtg gca ctg gtg gaa gcc gcg ctg gag ctc cgg atc     2221
Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu Glu Leu Arg Ile         
                695                 700                 705             

gcc gcg ggc ggg aat gca cgg cga ttc gag agc gag ttc gcc cgc ttc     2269
Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu Phe Ala Arg Phe         
            710                 715                 720                 

ttc ggc ctc cgc aag gct cat ctc gtc aac tcc ggt tcg tcg gcc aat     2317
Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly Ser Ser Ala Asn         
        725                 730                 735                     

ctc ctg gca ctg agt tcg ctt acc tcc ccc aaa ctc ggc gag gca cga     2365
Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu Gly Glu Ala Arg         
    740                 745                 750                         

ctg cgg ccc ggc gac gaa gtg atc act gcg gcg gtc ggc ttc ccc acg     2413
Leu Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val Gly Phe Pro Thr         
755                 760                 765                 770         

acg atc aat ccg gcg gtc caa aac gga ctc gtc ccg gta ttc gtc gac     2461
Thr Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro Val Phe Val Asp         
                775                 780                 785             

gtg gaa ctg ggc acc tac aac gca acg cca gac cgc atc aag gcc gcc     2509
Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg Ile Lys Ala Ala         
            790                 795                 800                 

gtc acg gaa cgg acg cga gcc atc atg ctg gcg cac acc ctg ggc aac     2557
Val Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His Thr Leu Gly Asn         
        805                 810                 815                     

ccc ttc gcc gct gac gaa atc gcg gag atc gca aaa gaa cac gag ctg     2605
Pro Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys Glu His Glu Leu         
    820                 825                 830                         

ttc ctc gtc gaa gac aac tgt gat gcg gtg gga tcc acc tac cgg gga     2653
Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser Thr Tyr Arg Gly         
835                 840                 845                 850         

cgg ctg acc gga acc ttc ggc gac ctg aca acg gtc agc ttc tat cct     2701
Arg Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val Ser Phe Tyr Pro         
                855                 860                 865             

gcc cat cac atc acc agc ggc gag ggt ggc tgc gtg ttg acc ggc agc     2749
Ala His His Ile Thr Ser Gly Glu Gly Gly Cys Val Leu Thr Gly Ser         
            870                 875                 880                 

ctg gaa ttg gct cgc atc atc gag tcg ctg cgt gac tgg gga cgg gat     2797
Leu Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp Trp Gly Arg Asp         
        885                 890                 895                     

tgc tgg tgc gag ccc ggc gtg gac aac acc tgc cgc aag agg ttc gac     2845
Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg Lys Arg Phe Asp         
    900                 905                 910                         

tac cac ctc ggt acc ctt cca ccg ggc tac gac cac aag tac acg ttc     2893
Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His Lys Tyr Thr Phe         
915                 920                 925                 930         

tcc cac gtc ggt tac aac ctc aag acc acc gac ctg cag gcc gca ctt     2941
Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu Gln Ala Ala Leu         
                935                 940                 945             

gcg ctg agc cag ttg agc aag att tcc gca ttc ggg tcg gca cgc cgc     2989
Ala Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly Ser Ala Arg Arg         
            950                 955                 960                 

cgt aac tgg cga cgg ttg cgc gaa ggg ctg tcc ggg ttg ccg ggc ctg     3037
Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly Leu Pro Gly Leu         
        965                 970                 975                     

ctg ctg ccg gta gcc aca ccg cac agc gac ccg agc tgg ttc ggg ttt     3085
Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser Trp Phe Gly Phe         
    980                 985                 990                         

gcg atc acc atc agt gcg  gac gcc ggg ttc acc  cgt gcc gcc ctg       3130
Ala Ile Thr Ile Ser Ala  Asp Ala Gly Phe Thr  Arg Ala Ala Leu           
995                 1000                 1005                           

gtg  aac ttc ctg gaa tcc  cgc aac atc ggc acc  cga ctg ctg ttc      3175
Val  Asn Phe Leu Glu Ser  Arg Asn Ile Gly Thr  Arg Leu Leu Phe          
1010                 1015                 1020                          

ggc  ggt aac atc acc cgg  cac ccg gcc ttc gag  cag gtg cgg tac      3220
Gly  Gly Asn Ile Thr Arg  His Pro Ala Phe Glu  Gln Val Arg Tyr          
1025                 1030                 1035                          

cgg  atc gcc gac gcg ctc  acc aac agc gac atc  gtc acc gac cga      3265
Arg  Ile Ala Asp Ala Leu  Thr Asn Ser Asp Ile  Val Thr Asp Arg          
1040                 1045                 1050                          

acc  ttc tgg gtc ggc gtc  tac cca ggc ata acg  gac caa atg atc      3310
Thr  Phe Trp Val Gly Val  Tyr Pro Gly Ile Thr  Asp Gln Met Ile          
1055                 1060                 1065                          

gac  tac gtc gtc gaa tca  atc gct gaa ttc gtg  gcc aag agt tcc      3355
Asp  Tyr Val Val Glu Ser  Ile Ala Glu Phe Val  Ala Lys Ser Ser          
1070                 1075                 1080                          

tagcatccag catggcggca tctcggagga tactagtatg catgctggag gaatcgct     3413

gtg  acc gcc acc acc gga  cag acc ggg gac acc  cga ccc ctg gtg      3458
Val  Thr Ala Thr Thr Gly  Gln Thr Gly Asp Thr  Arg Pro Leu Val          
1085                 1090                 1095                          

gtc  gtc ctc ggc gcc gcc  ggc ttc gtc ggc tcc  gcc gtc ctg cgc      3503
Val  Val Leu Gly Ala Ala  Gly Phe Val Gly Ser  Ala Val Leu Arg          
1100                 1105                 1110                          

gaa  ctc gcc cgc cac gac  ctg cgg gtg cgg gcc  gtc tcc cgg cgc      3548
Glu  Leu Ala Arg His Asp  Leu Arg Val Arg Ala  Val Ser Arg Arg          
1115                 1120                 1125                          

ccg  gtg acc gtc ccg gcc  ggc gcc cgc gcc gag  gtg gag acc cgc      3593
Pro  Val Thr Val Pro Ala  Gly Ala Arg Ala Glu  Val Glu Thr Arg          
1130                 1135                 1140                          

agc  gtc gac ctc acc gtc  ccc ggc gcg atg gcc  ggg gcg atc gag      3638
Ser  Val Asp Leu Thr Val  Pro Gly Ala Met Ala  Gly Ala Ile Glu          
1145                 1150                 1155                          

ggc  gcc gac gtg gtc gtc  cac tcg atc gcc tac  atc gcg ggc tcc      3683
Gly  Ala Asp Val Val Val  His Ser Ile Ala Tyr  Ile Ala Gly Ser          
1160                 1165                 1170                          

tcg  acc tgg cgc atc acg  gac ggc gac acc ggc  gcc gag cgg gtc      3728
Ser  Thr Trp Arg Ile Thr  Asp Gly Asp Thr Gly  Ala Glu Arg Val          
1175                 1180                 1185                          

aac  gtg gga ctc gta cgg  gac ctg gtc gag gcc  gtg cgg gcg agc      3773
Asn  Val Gly Leu Val Arg  Asp Leu Val Glu Ala  Val Arg Ala Ser          
1190                 1195                 1200                          

ggc  cgc ccc gac acc gcc  gtc ctg ttc acc ggc  tcc gtc tcc gcc      3818
Gly  Arg Pro Asp Thr Ala  Val Leu Phe Thr Gly  Ser Val Ser Ala          
1205                 1210                 1215                          

gcc  gga ccc tcg gag cgg  ggc gtc tac gac ggt  acg gag ccg gac      3863
Ala  Gly Pro Ser Glu Arg  Gly Val Tyr Asp Gly  Thr Glu Pro Asp          
1220                 1225                 1230                          

gag  ccg cag ggc gag tac  gac cgg cag aag ctg  gcg gcc gag cgg      3908
Glu  Pro Gln Gly Glu Tyr  Asp Arg Gln Lys Leu  Ala Ala Glu Arg          
1235                 1240                 1245                          

gtg  ctg ctc gcg gcg agc  gcc gag ggc gtg ctg  cgc ggg atc tcg      3953
Val  Leu Leu Ala Ala Ser  Ala Glu Gly Val Leu  Arg Gly Ile Ser          
1250                 1255                 1260                          

ctc  cgg ctc ccc acg gtc  ttc ggc tac ggc ccc  gac tcg acc gcg      3998
Leu  Arg Leu Pro Thr Val  Phe Gly Tyr Gly Pro  Asp Ser Thr Ala          
1265                 1270                 1275                          

cgg  gac aag ggc atc gtc  tcc tcg atg gtc cgc  cgg gcg gtg gcg      4043
Arg  Asp Lys Gly Ile Val  Ser Ser Met Val Arg  Arg Ala Val Ala          
1280                 1285                 1290                          

ggc  gag ccg atc acc atg  tgg cac gac ggc acg  gtc cgc cgc gac      4088
Gly  Glu Pro Ile Thr Met  Trp His Asp Gly Thr  Val Arg Arg Asp          
1295                 1300                 1305                          

ctg  ctg tac gtg gag gac  gtg gcg cgc gcc ttc  gcg gcg gcc ctc      4133
Leu  Leu Tyr Val Glu Asp  Val Ala Arg Ala Phe  Ala Ala Ala Leu          
1310                 1315                 1320                          

ggc  cac ctc gac gcg ctc  gcg gga cgg cac tgg  gtg ctc ggc agc      4178
Gly  His Leu Asp Ala Leu  Ala Gly Arg His Trp  Val Leu Gly Ser          
1325                 1330                 1335                          

ggg  cac ggc gcc gag ctc  ggc ccg gtc ttc acc  acg gtc gcc cgg      4223
Gly  His Gly Ala Glu Leu  Gly Pro Val Phe Thr  Thr Val Ala Arg          
1340                 1345                 1350                          

atg  gtg gcg gag cgg acc  ggc aag ccg ccg gtg  gcc gtg cgc tcg      4268
Met  Val Ala Glu Arg Thr  Gly Lys Pro Pro Val  Ala Val Arg Ser          
1355                 1360                 1365                          

gtg  gag ccg ccc gcg cac  gcc gag gcc cgg gac  ttc gcc agc gtc      4313
Val  Glu Pro Pro Ala His  Ala Glu Ala Arg Asp  Phe Ala Ser Val          
1370                 1375                 1380                          

acc  gtc gac ccg cgc gcc  ttc cac gag gtc acc  ggc tgg cgg gcc      4358
Thr  Val Asp Pro Arg Ala  Phe His Glu Val Thr  Gly Trp Arg Ala          
1385                 1390                 1395                          

gag  gtc ccg ctg gac gag  gcc ctg gac cgg acg  acg gcc ttc agc      4403
Glu  Val Pro Leu Asp Glu  Ala Leu Asp Arg Thr  Thr Ala Phe Ser          
1400                 1405                 1410                          

gcg  agc ggc gcg gag gag  cac ttc ggc tga cccactagtg gagggccact     4453
Ala  Ser Gly Ala Glu Glu  His Phe Gly                                   
1415                 1420                                               

cctg atg agc  acc gcc acc acc acg  ccc gcc ccc gcc ctc  acc gcc     4499
     Met Ser  Thr Ala Thr Thr Thr  Pro Ala Pro Ala Leu  Thr Ala         
         1425                 1430                 1435                 

cgc cgg ccc  gcc ggg ctc gcc gag  cgg atc gcc cgc tcg  gcc gcc      4544
Arg Arg Pro  Ala Gly Leu Ala Glu  Arg Ile Ala Arg Ser  Ala Ala          
        1440                 1445                 1450                  

acc ggc cgc  ggc gcc cac ctg gcc  acc gag gac ttc cac  gac tgg      4589
Thr Gly Arg  Gly Ala His Leu Ala  Thr Glu Asp Phe His  Asp Trp          
        1455                 1460                 1465                  

ctc gac ggc  cgc cgc cgc gcc aac  acc ttc cgc gtc gac  aag atc      4634
Leu Asp Gly  Arg Arg Arg Ala Asn  Thr Phe Arg Val Asp  Lys Ile          
        1470                 1475                 1480                  

ccc ttc gac  gcg ctc gac ggc tgg  tcc ttc gac gag gag  gac ggc      4679
Pro Phe Asp  Ala Leu Asp Gly Trp  Ser Phe Asp Glu Glu  Asp Gly          
        1485                 1490                 1495                  

aac ctc gtc  cac cgc agc ggc cgc  ttc ttc acc gtc gag  ggc ctg      4724
Asn Leu Val  His Arg Ser Gly Arg  Phe Phe Thr Val Glu  Gly Leu          
        1500                 1505                 1510                  

cac gtc gtc  gag gag gac gga ccc  tac ggc gac ggc ccg  tac cgc      4769
His Val Val  Glu Glu Asp Gly Pro  Tyr Gly Asp Gly Pro  Tyr Arg          
        1515                 1520                 1525                  

tcc tgg tac  cag ccc gtc atc aag  cag ccc gag gtc ggc  atc ctc      4814
Ser Trp Tyr  Gln Pro Val Ile Lys  Gln Pro Glu Val Gly  Ile Leu          
        1530                 1535                 1540                  

ggc atc ctc  gcc aag gag ttc gac  ggc gtc ctg cac ttc  ctc atg      4859
Gly Ile Leu  Ala Lys Glu Phe Asp  Gly Val Leu His Phe  Leu Met          
        1545                 1550                 1555                  

cag gcc aag  atg gag ccc ggc aac  ccg aac ctg ctc cag  ctg tcg      4904
Gln Ala Lys  Met Glu Pro Gly Asn  Pro Asn Leu Leu Gln  Leu Ser          
        1560                 1565                 1570                  

ccg acc gtc  cag gcc acc cgc agc  aac tac acc aag gcg  cac cgc      4949
Pro Thr Val  Gln Ala Thr Arg Ser  Asn Tyr Thr Lys Ala  His Arg          
        1575                 1580                 1585                  

ggc ggc gac  gtg aag tac atc gag  tac ttc acc ggc gcc  gaa cac      4994
Gly Gly Asp  Val Lys Tyr Ile Glu  Tyr Phe Thr Gly Ala  Glu His          
        1590                 1595                 1600                  

ggc acc gtc  atc gcc gac tcc ctc  cag tcc gag cac ggc  gcc tgg      5039
Gly Thr Val  Ile Ala Asp Ser Leu  Gln Ser Glu His Gly  Ala Trp          
        1605                 1610                 1615                  

ttc ttc cac  aag tcc aac cgc aac  atg atc gtc gag gcc  acc ggc      5084
Phe Phe His  Lys Ser Asn Arg Asn  Met Ile Val Glu Ala  Thr Gly          
        1620                 1625                 1630                  

gag gtc ccg  ctc ctc gac gac ttc  tgc tgg ctc acc ctc  ggc cag      5129
Glu Val Pro  Leu Leu Asp Asp Phe  Cys Trp Leu Thr Leu  Gly Gln          
        1635                 1640                 1645                  

ctc ggc gag  ctc ctc cac cag gac  aac gtc atc aac atg  gac gcc      5174
Leu Gly Glu  Leu Leu His Gln Asp  Asn Val Ile Asn Met  Asp Ala          
        1650                 1655                 1660                  

agg acc gtc  ctg tcc tgc gtg ccg  tac gag gac gcc gac  gcc ggg      5219
Arg Thr Val  Leu Ser Cys Val Pro  Tyr Glu Asp Ala Asp  Ala Gly          
        1665                 1670                 1675                  

cgg gcg ctg  ctc tcc gac gtc cag  ctg ctc tcc tgg ttc  acc ggc      5264
Arg Ala Leu  Leu Ser Asp Val Gln  Leu Leu Ser Trp Phe  Thr Gly          
        1680                 1685                 1690                  

gag cgc tcc  cgc cac gac gta cgg  gcc cgg cgc gtc ccg  ctg cgc      5309
Glu Arg Ser  Arg His Asp Val Arg  Ala Arg Arg Val Pro  Leu Arg          
        1695                 1700                 1705                  

gag ctg ccc  ggc tgg aag cag ggc  gag gag acc atc gag  cac gag      5354
Glu Leu Pro  Gly Trp Lys Gln Gly  Glu Glu Thr Ile Glu  His Glu          
        1710                 1715                 1720                  

gag ggc cgg  cac ttc aag gtc gtc  gcc gtc tcc gtg cag  gcc ggg      5399
Glu Gly Arg  His Phe Lys Val Val  Ala Val Ser Val Gln  Ala Gly          
        1725                 1730                 1735                  

aac cgc gaa  gtg acc agc tgg acc  cag ccg ctg atc gaa  ccg gtc      5444
Asn Arg Glu  Val Thr Ser Trp Thr  Gln Pro Leu Ile Glu  Pro Val          
        1740                 1745                 1750                  

gga ctc ggc  gtc gcc gcc ttc ctg  acc cgc gac ttc gac  ggc gtc      5489
Gly Leu Gly  Val Ala Ala Phe Leu  Thr Arg Asp Phe Asp  Gly Val          
        1755                 1760                 1765                  

ccg cac tac  ctg gtg cac gcc cgc  gtc gag ggc ggc ttc  ctc gac      5534
Pro His Tyr  Leu Val His Ala Arg  Val Glu Gly Gly Phe  Leu Asp          
        1770                 1775                 1780                  

acc gtg gaa  ctg gcc ccc acc gtc  cag tac acc ccg ggc  aac tac      5579
Thr Val Glu  Leu Ala Pro Thr Val  Gln Tyr Thr Pro Gly  Asn Tyr          
        1785                 1790                 1795                  

gcc cac ctg  ccg acc gac gag cgc  ccg ccc ttc ctc gac  ctc gtc      5624
Ala His Leu  Pro Thr Asp Glu Arg  Pro Pro Phe Leu Asp  Leu Val          
        1800                 1805                 1810                  

ctc gac acc  gac ccc gcc cgc gtc  cgc tac gag gcc gtg  cac tcc      5669
Leu Asp Thr  Asp Pro Ala Arg Val  Arg Tyr Glu Ala Val  His Ser          
        1815                 1820                 1825                  

gag gaa ggc  ggc cgc ttc ctc aac  gcc gag agc cgc tac  ctc ctg      5714
Glu Glu Gly  Gly Arg Phe Leu Asn  Ala Glu Ser Arg Tyr  Leu Leu          
        1830                 1835                 1840                  

gtg gag gcc  gac gag acg cag gcc  ccg gcc gac ccg ccg  ccc ggc      5759
Val Glu Ala  Asp Glu Thr Gln Ala  Pro Ala Asp Pro Pro  Pro Gly          
        1845                 1850                 1855                  

tac gcc tgg  gcg acc gcc gca cag  ctc acc tcc ctc acc  cgg cac      5804
Tyr Ala Trp  Ala Thr Ala Ala Gln  Leu Thr Ser Leu Thr  Arg His          
        1860                 1865                 1870                  

ggc cac tac  ctc aac gtc cag gcc  cgc acc ctg ctg gcc  tgc gtc      5849
Gly His Tyr  Leu Asn Val Gln Ala  Arg Thr Leu Leu Ala  Cys Val          
        1875                 1880                 1885                  

cac gcc ggg  gcg gtg cgg cct tga cgagcacccc ggcgcatatg ggggaggtgc   5903
His Ala Gly  Ala Val Arg Pro                                            
        1890                                                            

ggcc ttg  acg agc acc ccg gcg  ccc ctg cgg atc ggt  gtg ctc ggc     5949
     Leu  Thr Ser Thr Pro Ala  Pro Leu Arg Ile Gly  Val Leu Gly         
     1895                 1900                 1905                     

tgc gcc  gac atc gcc gtc cgg  cgc atg atg ccc gcg  atg gcc gcg      5994
Cys Ala  Asp Ile Ala Val Arg  Arg Met Met Pro Ala  Met Ala Ala          
    1910                 1915                 1920                      

ctc ccc  ggg acc gag gtc acc  gcc gtc gcc agc cgc  gac gcg gcg      6039
Leu Pro  Gly Thr Glu Val Thr  Ala Val Ala Ser Arg  Asp Ala Ala          
    1925                 1930                 1935                      

aag gcc  gcc gtg gcc gcc gcc  ccg tac ggc gcg gcg  gcc gtc gag      6084
Lys Ala  Ala Val Ala Ala Ala  Pro Tyr Gly Ala Ala  Ala Val Glu          
    1940                 1945                 1950                      

ggc tac  cag gag ctg ctg cgc  cgc ccg gac gtc gac  gcc gtc tac      6129
Gly Tyr  Gln Glu Leu Leu Arg  Arg Pro Asp Val Asp  Ala Val Tyr          
    1955                 1960                 1965                      

gta ccg  ctg ccc gcc gcc ctg  cac gcc gag tgg acc  gag gcc gcc      6174
Val Pro  Leu Pro Ala Ala Leu  His Ala Glu Trp Thr  Glu Ala Ala          
    1970                 1975                 1980                      

ctg cgg  gcc ggc aag cac gtc  ctg gcc gag aag ccg  ctc acc acg      6219
Leu Arg  Ala Gly Lys His Val  Leu Ala Glu Lys Pro  Leu Thr Thr          
    1985                 1990                 1995                      

gac ccg  gag agc acc gcc gcg  ctg ctc ggc ctg gcc  gcc gcg tcc      6264
Asp Pro  Glu Ser Thr Ala Ala  Leu Leu Gly Leu Ala  Ala Ala Ser          
    2000                 2005                 2010                      

ggg ctc  gcg ctg atg gag aac  gtc atg ttc gtc cac  cac cgc ctc      6309
Gly Leu  Ala Leu Met Glu Asn  Val Met Phe Val His  His Arg Leu          
    2015                 2020                 2025                      

cac acc  gac gtc cgc aag ctc  gtc gcg gac gga gcc  atc ggc gaa      6354
His Thr  Asp Val Arg Lys Leu  Val Ala Asp Gly Ala  Ile Gly Glu          
    2030                 2035                 2040                      

ctc cgc  gcc ctg cac gcc tcg  ttc ggc atc ccc cgg  ctg ccc gac      6399
Leu Arg  Ala Leu His Ala Ser  Phe Gly Ile Pro Arg  Leu Pro Asp          
    2045                 2050                 2055                      

acc gac  atc cgg cac gac ccc  ggg ctc ggc ggc ggc  gcc ctc ggc      6444
Thr Asp  Ile Arg His Asp Pro  Gly Leu Gly Gly Gly  Ala Leu Gly          
    2060                 2065                 2070                      

gac gtc  ggc gtc tac ccg ctg  cga gcc gcc cag cac  ctg ctc ggc      6489
Asp Val  Gly Val Tyr Pro Leu  Arg Ala Ala Gln His  Leu Leu Gly          
    2075                 2080                 2085                      

gac gaa  ctc gac gtc ctc ggc  gcg cac ctc gtc cgg  ggg ccc ggc      6534
Asp Glu  Leu Asp Val Leu Gly  Ala His Leu Val Arg  Gly Pro Gly          
    2090                 2095                 2100                      

agc cgg  gtc gag acc gcc ggc  ggg gcg ctg ctc gcc  acc ccg gcg      6579
Ser Arg  Val Glu Thr Ala Gly  Gly Ala Leu Leu Ala  Thr Pro Ala          
    2105                 2110                 2115                      

ggc gtc  acc gcg cac atc gcc  ttc ggc atg gac cac  ggc tac cgc      6624
Gly Val  Thr Ala His Ile Ala  Phe Gly Met Asp His  Gly Tyr Arg          
    2120                 2125                 2130                      

tcg gcg  tac gag ctg tgg ggc  agc cag ggc cgg ctc  gtc gtc gag      6669
Ser Ala  Tyr Glu Leu Trp Gly  Ser Gln Gly Arg Leu  Val Val Glu          
    2135                 2140                 2145                      

cgg gcc  tac acc ccg ccc gcc  gac cac cgc ccg gtg  gtg cgc ctg      6714
Arg Ala  Tyr Thr Pro Pro Ala  Asp His Arg Pro Val  Val Arg Leu          
    2150                 2155                 2160                      

gag acc  cgc acc ggc gtc gag  gag ctc gtc ctc gac  gcc gac gac      6759
Glu Thr  Arg Thr Gly Val Glu  Glu Leu Val Leu Asp  Ala Asp Asp          
    2165                 2170                 2175                      

cag gtc  cgc aac acg gtg gcc  gcc ttc gcc gcc ctc  gtg gcg cgc      6804
Gln Val  Arg Asn Thr Val Ala  Ala Phe Ala Ala Leu  Val Ala Arg          
    2180                 2185                 2190                      

acc gga  gcc ggc cac ccc ggg  gac ggc ggc gcg ccc  gac ccg gag      6849
Thr Gly  Ala Gly His Pro Gly  Asp Gly Gly Ala Pro  Asp Pro Glu          
    2195                 2200                 2205                      

gcc ccg  ctg cgc cag gcg cgg  ctg ctc gac gcc gtg  cgg cgc cgg      6894
Ala Pro  Leu Arg Gln Ala Arg  Leu Leu Asp Ala Val  Arg Arg Arg          
    2210                 2215                 2220                      

gcc gcc  ctc gtc tga cccgcgcctc taga                                6923
Ala Ala  Leu Val                                                        
    2225                                                                


<210>  133
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  133

Val Lys Gly Ile Val Leu Ala Gly Gly Asn Gly Thr Arg Leu His Pro 
1               5                   10                  15      


Leu Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Val Leu Leu Ile Ser Thr Pro Ala Asp Met Pro Leu Phe Gln Arg Leu 
    50                  55                  60                  


Leu Gly Asn Gly Ser Gln Phe Gly Ile Arg Ile Glu Tyr Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Pro Asn Gly Leu Ala Glu Ala Phe Val Ile Gly Ala Asp Phe 
                85                  90                  95      


Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn Ile Phe Tyr 
            100                 105                 110         


Gly Gln Gly Phe Ser Gly Ile Leu Gln Gln Cys Val Arg Glu Leu Asp 
        115                 120                 125             


Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gln Arg Tyr Gly 
    130                 135                 140                 


Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser Ile Val Glu Lys 
145                 150                 155                 160 


Pro Glu Arg Pro Lys Ser Asn Met Ala Ile Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Arg Ile Ala Lys Gly Leu Thr Pro Ser Ala Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Leu Ala Tyr Leu Gln Glu Gly 
        195                 200                 205             


Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Asp Ser Leu Val Glu Ala Ser Gln Phe Val Gln Val Leu 
225                 230                 235                 240 


Glu His Arg Gln Gly Val Arg Ile Ala Cys Leu Glu Glu Ile Ala Leu 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 
            260                 265                 270         


Leu Ala Lys Ser Gly Tyr Gly Glu Tyr Val Met Asp Val Ala Arg Asn 
        275                 280                 285             


Ser Gly Ala Arg Gly 
    290             


<210>  134
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  134

Met Arg Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Ser His Tyr 
1               5                   10                  15      


Val Arg Gln Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 
            20                  25                  30          


Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 
        35                  40                  45              


Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp Ile 
    50                  55                  60                  


Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 
65                  70                  75                  80  


Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser Ile Thr Gly Ser 
                85                  90                  95      


Asp Ala Phe Val Ile Thr Asn Val Val Gly Thr Asn Val Leu Leu Gln 
            100                 105                 110         


Ala Ala Leu Asp Ala Glu Ile Gly Lys Phe Val His Val Ser Thr Asp 
        115                 120                 125             


Glu Val Tyr Gly Ser Ile Glu Asp Gly Ser Trp Pro Glu Asp His Ala 
    130                 135                 140                 


Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Ile Thr 
                165                 170                 175     


Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Phe Pro Glu Lys Val Leu 
            180                 185                 190         


Pro Leu Phe Ile Thr Asn Leu Met Asp Gly Ser Gln Val Pro Leu Tyr 
        195                 200                 205             


Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 
    210                 215                 220                 


Arg Gly Ile Gln Leu Val Ala Asp Ser Gly Arg Ala Gly Glu Ile Tyr 
225                 230                 235                 240 


Asn Ile Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 
                245                 250                 255     


Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 
            260                 265                 270         


Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys Ile 
        275                 280                 285             


Val Glu Glu Leu Gly Tyr Ala Pro Gln Val Asp Phe Glu Thr Gly Leu 
    290                 295                 300                 


Arg Glu Thr Ile Arg Trp Tyr Gln Asp Asn Arg Asp Trp Trp Glu Pro 
305                 310                 315                 320 


Leu Lys Ala Arg Ser Ala Val Ala Arg 
                325                 


<210>  135
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  135

Met Gln Ser Arg Lys Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val 
1               5                   10                  15      


Thr Ser Cys Asp Asp Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp 
            20                  25                  30          


Ala Lys Asp Arg Ile Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gln 
        35                  40                  45              


Glu Ser Pro Thr Phe Val Ala Gly Ser Thr Pro Ile Arg Pro Ser Gly 
    50                  55                  60                  


Ala Val Leu Asp Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu 
65                  70                  75                  80  


Glu Leu Arg Ile Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu 
                85                  90                  95      


Phe Ala Arg Phe Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly 
            100                 105                 110         


Ser Ser Ala Asn Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu 
        115                 120                 125             


Gly Glu Ala Arg Leu Arg Pro Gly Asp Glu Val Ile Thr Ala Ala Val 
    130                 135                 140                 


Gly Phe Pro Thr Thr Ile Asn Pro Ala Val Gln Asn Gly Leu Val Pro 
145                 150                 155                 160 


Val Phe Val Asp Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg 
                165                 170                 175     


Ile Lys Ala Ala Val Thr Glu Arg Thr Arg Ala Ile Met Leu Ala His 
            180                 185                 190         


Thr Leu Gly Asn Pro Phe Ala Ala Asp Glu Ile Ala Glu Ile Ala Lys 
        195                 200                 205             


Glu His Glu Leu Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser 
    210                 215                 220                 


Thr Tyr Arg Gly Arg Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val 
225                 230                 235                 240 


Ser Phe Tyr Pro Ala His His Ile Thr Ser Gly Glu Gly Gly Cys Val 
                245                 250                 255     


Leu Thr Gly Ser Leu Glu Leu Ala Arg Ile Ile Glu Ser Leu Arg Asp 
            260                 265                 270         


Trp Gly Arg Asp Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg 
        275                 280                 285             


Lys Arg Phe Asp Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His 
    290                 295                 300                 


Lys Tyr Thr Phe Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu 
305                 310                 315                 320 


Gln Ala Ala Leu Ala Leu Ser Gln Leu Ser Lys Ile Ser Ala Phe Gly 
                325                 330                 335     


Ser Ala Arg Arg Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly 
            340                 345                 350         


Leu Pro Gly Leu Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser 
        355                 360                 365             


Trp Phe Gly Phe Ala Ile Thr Ile Ser Ala Asp Ala Gly Phe Thr Arg 
    370                 375                 380                 


Ala Ala Leu Val Asn Phe Leu Glu Ser Arg Asn Ile Gly Thr Arg Leu 
385                 390                 395                 400 


Leu Phe Gly Gly Asn Ile Thr Arg His Pro Ala Phe Glu Gln Val Arg 
                405                 410                 415     


Tyr Arg Ile Ala Asp Ala Leu Thr Asn Ser Asp Ile Val Thr Asp Arg 
            420                 425                 430         


Thr Phe Trp Val Gly Val Tyr Pro Gly Ile Thr Asp Gln Met Ile Asp 
        435                 440                 445             


Tyr Val Val Glu Ser Ile Ala Glu Phe Val Ala Lys Ser Ser 
    450                 455                 460         


<210>  136
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  136

Val Thr Ala Thr Thr Gly Gln Thr Gly Asp Thr Arg Pro Leu Val Val 
1               5                   10                  15      


Val Leu Gly Ala Ala Gly Phe Val Gly Ser Ala Val Leu Arg Glu Leu 
            20                  25                  30          


Ala Arg His Asp Leu Arg Val Arg Ala Val Ser Arg Arg Pro Val Thr 
        35                  40                  45              


Val Pro Ala Gly Ala Arg Ala Glu Val Glu Thr Arg Ser Val Asp Leu 
    50                  55                  60                  


Thr Val Pro Gly Ala Met Ala Gly Ala Ile Glu Gly Ala Asp Val Val 
65                  70                  75                  80  


Val His Ser Ile Ala Tyr Ile Ala Gly Ser Ser Thr Trp Arg Ile Thr 
                85                  90                  95      


Asp Gly Asp Thr Gly Ala Glu Arg Val Asn Val Gly Leu Val Arg Asp 
            100                 105                 110         


Leu Val Glu Ala Val Arg Ala Ser Gly Arg Pro Asp Thr Ala Val Leu 
        115                 120                 125             


Phe Thr Gly Ser Val Ser Ala Ala Gly Pro Ser Glu Arg Gly Val Tyr 
    130                 135                 140                 


Asp Gly Thr Glu Pro Asp Glu Pro Gln Gly Glu Tyr Asp Arg Gln Lys 
145                 150                 155                 160 


Leu Ala Ala Glu Arg Val Leu Leu Ala Ala Ser Ala Glu Gly Val Leu 
                165                 170                 175     


Arg Gly Ile Ser Leu Arg Leu Pro Thr Val Phe Gly Tyr Gly Pro Asp 
            180                 185                 190         


Ser Thr Ala Arg Asp Lys Gly Ile Val Ser Ser Met Val Arg Arg Ala 
        195                 200                 205             


Val Ala Gly Glu Pro Ile Thr Met Trp His Asp Gly Thr Val Arg Arg 
    210                 215                 220                 


Asp Leu Leu Tyr Val Glu Asp Val Ala Arg Ala Phe Ala Ala Ala Leu 
225                 230                 235                 240 


Gly His Leu Asp Ala Leu Ala Gly Arg His Trp Val Leu Gly Ser Gly 
                245                 250                 255     


His Gly Ala Glu Leu Gly Pro Val Phe Thr Thr Val Ala Arg Met Val 
            260                 265                 270         


Ala Glu Arg Thr Gly Lys Pro Pro Val Ala Val Arg Ser Val Glu Pro 
        275                 280                 285             


Pro Ala His Ala Glu Ala Arg Asp Phe Ala Ser Val Thr Val Asp Pro 
    290                 295                 300                 


Arg Ala Phe His Glu Val Thr Gly Trp Arg Ala Glu Val Pro Leu Asp 
305                 310                 315                 320 


Glu Ala Leu Asp Arg Thr Thr Ala Phe Ser Ala Ser Gly Ala Glu Glu 
                325                 330                 335     


His Phe Gly 
            


<210>  137
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  137

Met Ser Thr Ala Thr Thr Thr Pro Ala Pro Ala Leu Thr Ala Arg Arg 
1               5                   10                  15      


Pro Ala Gly Leu Ala Glu Arg Ile Ala Arg Ser Ala Ala Thr Gly Arg 
            20                  25                  30          


Gly Ala His Leu Ala Thr Glu Asp Phe His Asp Trp Leu Asp Gly Arg 
        35                  40                  45              


Arg Arg Ala Asn Thr Phe Arg Val Asp Lys Ile Pro Phe Asp Ala Leu 
    50                  55                  60                  


Asp Gly Trp Ser Phe Asp Glu Glu Asp Gly Asn Leu Val His Arg Ser 
65                  70                  75                  80  


Gly Arg Phe Phe Thr Val Glu Gly Leu His Val Val Glu Glu Asp Gly 
                85                  90                  95      


Pro Tyr Gly Asp Gly Pro Tyr Arg Ser Trp Tyr Gln Pro Val Ile Lys 
            100                 105                 110         


Gln Pro Glu Val Gly Ile Leu Gly Ile Leu Ala Lys Glu Phe Asp Gly 
        115                 120                 125             


Val Leu His Phe Leu Met Gln Ala Lys Met Glu Pro Gly Asn Pro Asn 
    130                 135                 140                 


Leu Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser Asn Tyr Thr 
145                 150                 155                 160 


Lys Ala His Arg Gly Gly Asp Val Lys Tyr Ile Glu Tyr Phe Thr Gly 
                165                 170                 175     


Ala Glu His Gly Thr Val Ile Ala Asp Ser Leu Gln Ser Glu His Gly 
            180                 185                 190         


Ala Trp Phe Phe His Lys Ser Asn Arg Asn Met Ile Val Glu Ala Thr 
        195                 200                 205             


Gly Glu Val Pro Leu Leu Asp Asp Phe Cys Trp Leu Thr Leu Gly Gln 
    210                 215                 220                 


Leu Gly Glu Leu Leu His Gln Asp Asn Val Ile Asn Met Asp Ala Arg 
225                 230                 235                 240 


Thr Val Leu Ser Cys Val Pro Tyr Glu Asp Ala Asp Ala Gly Arg Ala 
                245                 250                 255     


Leu Leu Ser Asp Val Gln Leu Leu Ser Trp Phe Thr Gly Glu Arg Ser 
            260                 265                 270         


Arg His Asp Val Arg Ala Arg Arg Val Pro Leu Arg Glu Leu Pro Gly 
        275                 280                 285             


Trp Lys Gln Gly Glu Glu Thr Ile Glu His Glu Glu Gly Arg His Phe 
    290                 295                 300                 


Lys Val Val Ala Val Ser Val Gln Ala Gly Asn Arg Glu Val Thr Ser 
305                 310                 315                 320 


Trp Thr Gln Pro Leu Ile Glu Pro Val Gly Leu Gly Val Ala Ala Phe 
                325                 330                 335     


Leu Thr Arg Asp Phe Asp Gly Val Pro His Tyr Leu Val His Ala Arg 
            340                 345                 350         


Val Glu Gly Gly Phe Leu Asp Thr Val Glu Leu Ala Pro Thr Val Gln 
        355                 360                 365             


Tyr Thr Pro Gly Asn Tyr Ala His Leu Pro Thr Asp Glu Arg Pro Pro 
    370                 375                 380                 


Phe Leu Asp Leu Val Leu Asp Thr Asp Pro Ala Arg Val Arg Tyr Glu 
385                 390                 395                 400 


Ala Val His Ser Glu Glu Gly Gly Arg Phe Leu Asn Ala Glu Ser Arg 
                405                 410                 415     


Tyr Leu Leu Val Glu Ala Asp Glu Thr Gln Ala Pro Ala Asp Pro Pro 
            420                 425                 430         


Pro Gly Tyr Ala Trp Ala Thr Ala Ala Gln Leu Thr Ser Leu Thr Arg 
        435                 440                 445             


His Gly His Tyr Leu Asn Val Gln Ala Arg Thr Leu Leu Ala Cys Val 
    450                 455                 460                 


His Ala Gly Ala Val Arg Pro 
465                 470     


<210>  138
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial pathway created with genes from S. spinosa and S. dive
       rsa

<400>  138

Leu Thr Ser Thr Pro Ala Pro Leu Arg Ile Gly Val Leu Gly Cys Ala 
1               5                   10                  15      


Asp Ile Ala Val Arg Arg Met Met Pro Ala Met Ala Ala Leu Pro Gly 
            20                  25                  30          


Thr Glu Val Thr Ala Val Ala Ser Arg Asp Ala Ala Lys Ala Ala Val 
        35                  40                  45              


Ala Ala Ala Pro Tyr Gly Ala Ala Ala Val Glu Gly Tyr Gln Glu Leu 
    50                  55                  60                  


Leu Arg Arg Pro Asp Val Asp Ala Val Tyr Val Pro Leu Pro Ala Ala 
65                  70                  75                  80  


Leu His Ala Glu Trp Thr Glu Ala Ala Leu Arg Ala Gly Lys His Val 
                85                  90                  95      


Leu Ala Glu Lys Pro Leu Thr Thr Asp Pro Glu Ser Thr Ala Ala Leu 
            100                 105                 110         


Leu Gly Leu Ala Ala Ala Ser Gly Leu Ala Leu Met Glu Asn Val Met 
        115                 120                 125             


Phe Val His His Arg Leu His Thr Asp Val Arg Lys Leu Val Ala Asp 
    130                 135                 140                 


Gly Ala Ile Gly Glu Leu Arg Ala Leu His Ala Ser Phe Gly Ile Pro 
145                 150                 155                 160 


Arg Leu Pro Asp Thr Asp Ile Arg His Asp Pro Gly Leu Gly Gly Gly 
                165                 170                 175     


Ala Leu Gly Asp Val Gly Val Tyr Pro Leu Arg Ala Ala Gln His Leu 
            180                 185                 190         


Leu Gly Asp Glu Leu Asp Val Leu Gly Ala His Leu Val Arg Gly Pro 
        195                 200                 205             


Gly Ser Arg Val Glu Thr Ala Gly Gly Ala Leu Leu Ala Thr Pro Ala 
    210                 215                 220                 


Gly Val Thr Ala His Ile Ala Phe Gly Met Asp His Gly Tyr Arg Ser 
225                 230                 235                 240 


Ala Tyr Glu Leu Trp Gly Ser Gln Gly Arg Leu Val Val Glu Arg Ala 
                245                 250                 255     


Tyr Thr Pro Pro Ala Asp His Arg Pro Val Val Arg Leu Glu Thr Arg 
            260                 265                 270         


Thr Gly Val Glu Glu Leu Val Leu Asp Ala Asp Asp Gln Val Arg Asn 
        275                 280                 285             


Thr Val Ala Ala Phe Ala Ala Leu Val Ala Arg Thr Gly Ala Gly His 
    290                 295                 300                 


Pro Gly Asp Gly Gly Ala Pro Asp Pro Glu Ala Pro Leu Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Leu Asp Ala Val Arg Arg Arg Ala Ala Leu Val 
                325                 330             


<210>  139
<211>  6013
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated vector

<220>
<221>  CDS
<222>  (2027)..(2803)
<223>  apramycin resistance gene


<220>
<221>  misc_feature
<222>  (4097)..(4135)
<223>  attP site


<220>
<221>  promoter
<222>  (503)..(548)
<223>  ermEp*


<220>
<221>  rep_origin
<222>  (3638)..(3749)
<223>  RP4 origin of single-stranded DNA transfer


<220>
<221>  -10_signal
<222>  (515)..(520)
<223>  

<220>
<221>  -35_signal
<222>  (535)..(540)
<223>  

<220>
<221>  variation
<222>  (806)..(807)
<223>  

<220>
<221>  CDS
<222>  (4152)..(5993)
<223>  integrase gene


<400>  139
atctacgtct gtcgagaagt ttctgatcga aaagttcgac agcgtctccg acctgatgca     60

gctctcgcag ggcgaagaat ctcgtgcttt cagcttcgat gtaggagggc gtggatatgt    120

cctgcgggta aatagctgcg ccgatggttt ctacaaagat cgttatgttg atcggcactt    180

tgcatcggcc gcgctcccga ttccggaagt gcttgacatt ggggaattta tgcggtgtga    240

aataccgcac agatgcgtaa ggagaaaata ccgcatcagg cgccattcgc cattcaggct    300

gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa    360

agggggatgt gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg    420

ttgtaaaacg acggccagtg ccaagcttgg gctgcaggtc gactctagag gatccgcggc    480

cgcgcgcgat atcgaattca agcttgagac ctagatccta ccaaccggca cgattgtcca    540

gcccacaaca gcatcgcggt gccacgtgtg gaccgcgtcg gtcagatcct ccccgcacct    600

ctcgccagcc gtcaagatcg accgcgtgca cctgcgatcg ccgatcaacc gcgactagca    660

tcgggcgcaa gccgccactc gaacggacac tcgcatggac gtccccttcc tggacctgca    720

agccgcgtac ctcgaactcc ggtccgacat cgaccaggcg tgccggcgcg tgctcgggtc    780

gggctggtac ccaattcgta atcatgtcat agctgtttcc tgtgtgaaat tgttatccgc    840

tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat    900

gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc    960

tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg   1020

ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag   1080

cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag   1140

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc   1200

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc   1260

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc   1320

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt   1380

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg   1440

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat   1500

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag   1560

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt   1620

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc   1680

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta   1740

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag   1800

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga   1860

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttggtt catgtgcagc   1920

tccatcagca aaaggggatg ataagtttat caccaccgac tatttgcaac agtgccgttg   1980

atcgtgctat gatcgactga tgtcatcagc ggtggagtgc aatgtc gtg caa tac      2035
                                                   Val Gln Tyr          
                                                   1                    

gaa tgg cga aaa gcc gag ctc atc ggt cag ctt ctc aac ctt ggg gtt     2083
Glu Trp Arg Lys Ala Glu Leu Ile Gly Gln Leu Leu Asn Leu Gly Val         
    5                   10                  15                          

acc ccc ggc ggt gtg ctg ctg gtc cac agc tcc ttc cgt agc gtc cgg     2131
Thr Pro Gly Gly Val Leu Leu Val His Ser Ser Phe Arg Ser Val Arg         
20                  25                  30                  35          

ccc ctc gaa gat ggg cca ctt gga ctg atc gag gcc ctg cgt gct gcg     2179
Pro Leu Glu Asp Gly Pro Leu Gly Leu Ile Glu Ala Leu Arg Ala Ala         
                40                  45                  50              

ctg ggt ccg gga ggg acg ctc gtc atg ccc tcg tgg tca ggt ctg gac     2227
Leu Gly Pro Gly Gly Thr Leu Val Met Pro Ser Trp Ser Gly Leu Asp         
            55                  60                  65                  

gac gag ccg ttc gat cct gcc acg tcg ccc gtt aca ccg gac ctt gga     2275
Asp Glu Pro Phe Asp Pro Ala Thr Ser Pro Val Thr Pro Asp Leu Gly         
        70                  75                  80                      

gtt gtc tct gac aca ttc tgg cgc ctg cca aat gta aag cgc agc gcc     2323
Val Val Ser Asp Thr Phe Trp Arg Leu Pro Asn Val Lys Arg Ser Ala         
    85                  90                  95                          

cat cca ttt gcc ttt gcg gca gcg ggg cca cag gca gag cag atc atc     2371
His Pro Phe Ala Phe Ala Ala Ala Gly Pro Gln Ala Glu Gln Ile Ile         
100                 105                 110                 115         

tct gat cca ttg ccc ctg cca cct cac tcg cct gca agc ccg gtc gcc     2419
Ser Asp Pro Leu Pro Leu Pro Pro His Ser Pro Ala Ser Pro Val Ala         
                120                 125                 130             

cgt gtc cat gaa ctc gat ggg cag gta ctt ctc ctc ggc gtg gga cac     2467
Arg Val His Glu Leu Asp Gly Gln Val Leu Leu Leu Gly Val Gly His         
            135                 140                 145                 

gat gcc aac acg acg ctg cat ctt gcc gag ttg atg gca aag gtt ccc     2515
Asp Ala Asn Thr Thr Leu His Leu Ala Glu Leu Met Ala Lys Val Pro         
        150                 155                 160                     

tat ggg gtg ccg aga cac tgc acc att ctt cag gat ggc aag ttg gta     2563
Tyr Gly Val Pro Arg His Cys Thr Ile Leu Gln Asp Gly Lys Leu Val         
    165                 170                 175                         

cgc gtc gat tat ctc gag aat gac cac tgc tgt gag cgc ttt gcc ttg     2611
Arg Val Asp Tyr Leu Glu Asn Asp His Cys Cys Glu Arg Phe Ala Leu         
180                 185                 190                 195         

gcg gac agg tgg ctc aag gag aag agc ctt cag aag gaa ggt cca gtc     2659
Ala Asp Arg Trp Leu Lys Glu Lys Ser Leu Gln Lys Glu Gly Pro Val         
                200                 205                 210             

ggt cat gcc ttt gct cgg ttg atc cgc tcc cgc gac att gtg gcg aca     2707
Gly His Ala Phe Ala Arg Leu Ile Arg Ser Arg Asp Ile Val Ala Thr         
            215                 220                 225                 

gcc ctg ggt caa ctg ggc cga gat ccg ttg atc ttc ctg cat ccg cca     2755
Ala Leu Gly Gln Leu Gly Arg Asp Pro Leu Ile Phe Leu His Pro Pro         
        230                 235                 240                     

gag gcg gga tgc gaa gaa tgc gat gcc gct cgc cag tcg att ggc tga     2803
Glu Ala Gly Cys Glu Glu Cys Asp Ala Ala Arg Gln Ser Ile Gly             
    245                 250                 255                         

gctcatgagc ggagaacgag atgacgttgg aggggcaagg tcgcgctgat tgctggggca   2863

acacgtggag cggatcgggg attgtctttc ttcagctcgc tgatgatatg ctgacgctca   2923

atgccgtttg gcctccgact aacgaaaatc ccgcatttgg acggctgatc cgattggcac   2983

ggcggacggc gaatggcgga gcagacgctc gtccgggggc aatgagatat gaaaaagcct   3043

gaactcaccg cgacgtatcg ggccctggcc agctagctag agtcgacctg caggtccccg   3103

gggatcggtc ttgccttgct cgtcggtgat gtacttcacc agctccgcga agtcgctctt   3163

cttgatggag cgcatgggga cgtgcttggc aatcacgcgc accccccggc cgttttagcg   3223

gctaaaaaag tcatggctct gccctcgggc ggaccacgcc catcatgacc ttgccaagct   3283

cgtcctgctt ctcttcgatc ttcgccagca gggcgaggat cgtggcatca ccgaaccgcg   3343

ccgtgcgcgg gtcgtcggtg agccagagtt tcagcaggcc gcccaggcgg cccaggtcgc   3403

cattgatgcg ggccagctcg cggacgtgct catagtccac gacgcccgtg attttgtagc   3463

cctggccgac ggccagcagg taggccgaca ggctcatgcc ggccgccgcc gccttttcct   3523

caatcgctct tcgttcgtct ggaaggcagt acaccttgat aggtgggctg cccttcctgg   3583

ttggcttggt ttcatcagcc atccgcttgc cctcatctgt tacgccggcg gtagccggcc   3643

agcctcgcag agcaggattc ccgttgagca ccgccaggtg cgaataaggg acagtgaaga   3703

aggaacaccc gctcgcgggt gggcctactt cacctatcct gcccggctga cgccgttgga   3763

tacaccaagg aaagtctaca cgaacccttt ggcaaaatcc tgtatatcgt gcgaaaaagg   3823

atggatatac cgaaaaaatc gctataatga ccccgaagca gggttatgca gcggaaaaga   3883

tccgtcgacc tgcaggcatg caagctctag cgattccaga cgtcccgaag gcgtggcgcg   3943

gcttccccgt gccggagcaa tcgccctggg tgggttacac gacgcccctc tatggcccgt   4003

actgacggac acaccgaagc cccggcggca accctcagcg gatgccccgg ggcttcacgt   4063

tttcccaggt cagaagcggt tttcgggagt agtgccccaa ctggggtaac ctttgagttc   4123

tctcagttgg gggcgtaggg tcgccgac atg aca caa ggg gtt gtg acc ggg      4175
                               Met Thr Gln Gly Val Val Thr Gly          
                                   260                 265              

gtg gac acg tac gcg ggt gct tac gac cgt cag tcg cgc gag cgc gaa     4223
Val Asp Thr Tyr Ala Gly Ala Tyr Asp Arg Gln Ser Arg Glu Arg Glu         
            270                 275                 280                 

aat tcg agc gca gca agc cca gcg aca cag cgt agc gcc aac gaa gac     4271
Asn Ser Ser Ala Ala Ser Pro Ala Thr Gln Arg Ser Ala Asn Glu Asp         
        285                 290                 295                     

aag gcg gcc gac ctt cag cgc gaa gtc gag cgc gac ggg ggc cgg ttc     4319
Lys Ala Ala Asp Leu Gln Arg Glu Val Glu Arg Asp Gly Gly Arg Phe         
    300                 305                 310                         

agg ttc gtc ggg cat ttc agc gaa gcg ccg ggc acg tcg gcg ttc ggg     4367
Arg Phe Val Gly His Phe Ser Glu Ala Pro Gly Thr Ser Ala Phe Gly         
315                 320                 325                 330         

acg gcg gag cgc ccg gag ttc gaa cgc atc ctg aac gaa tgc cgc gcc     4415
Thr Ala Glu Arg Pro Glu Phe Glu Arg Ile Leu Asn Glu Cys Arg Ala         
                335                 340                 345             

ggg cgg ctc aac atg atc att gtc tat gac gtg tcg cgc ttc tcg cgc     4463
Gly Arg Leu Asn Met Ile Ile Val Tyr Asp Val Ser Arg Phe Ser Arg         
            350                 355                 360                 

ctg aag gtc atg gac gcg att ccg att gtc tcg gaa ttg ctc gcc ctg     4511
Leu Lys Val Met Asp Ala Ile Pro Ile Val Ser Glu Leu Leu Ala Leu         
        365                 370                 375                     

ggc gtg acg att gtt tcc act cag gaa ggc gtc ttc cgg cag gga aac     4559
Gly Val Thr Ile Val Ser Thr Gln Glu Gly Val Phe Arg Gln Gly Asn         
    380                 385                 390                         

gtc atg gac ctg att cac ctg att atg cgg ctc gac gcg tcg cac aaa     4607
Val Met Asp Leu Ile His Leu Ile Met Arg Leu Asp Ala Ser His Lys         
395                 400                 405                 410         

gaa tct tcg ctg aag tcg gcg aag att ctc gac acg aag aac ctt cag     4655
Glu Ser Ser Leu Lys Ser Ala Lys Ile Leu Asp Thr Lys Asn Leu Gln         
                415                 420                 425             

cgc gaa ttg ggc ggg tac gtc ggc ggg aag gcg cct tac ggc ttc gag     4703
Arg Glu Leu Gly Gly Tyr Val Gly Gly Lys Ala Pro Tyr Gly Phe Glu         
            430                 435                 440                 

ctt gtt tcg gag acg aag gag atc acg cgc aac ggc cga atg gtc aat     4751
Leu Val Ser Glu Thr Lys Glu Ile Thr Arg Asn Gly Arg Met Val Asn         
        445                 450                 455                     

gtc gtc atc aac aag ctt gcg cac tcg acc act ccc ctt acc gga ccc     4799
Val Val Ile Asn Lys Leu Ala His Ser Thr Thr Pro Leu Thr Gly Pro         
    460                 465                 470                         

ttc gag ttc gag ccc gac gta atc cgg tgg tgg tgg cgt gag atc aag     4847
Phe Glu Phe Glu Pro Asp Val Ile Arg Trp Trp Trp Arg Glu Ile Lys         
475                 480                 485                 490         

acg cac aaa cac ctt ccc ttc aag ccg ggc agt caa gcc gcc att cac     4895
Thr His Lys His Leu Pro Phe Lys Pro Gly Ser Gln Ala Ala Ile His         
                495                 500                 505             

ccg ggc agc atc acg ggg ctt tgt aag cgc atg gac gct gac gcc gtg     4943
Pro Gly Ser Ile Thr Gly Leu Cys Lys Arg Met Asp Ala Asp Ala Val         
            510                 515                 520                 

ccg acc cgg ggc gag acg att ggg aag aag acc gct tca agc gcc tgg     4991
Pro Thr Arg Gly Glu Thr Ile Gly Lys Lys Thr Ala Ser Ser Ala Trp         
        525                 530                 535                     

gac ccg gca acc gtt atg cga atc ctt cgg gac ccg cgt att gcg ggc     5039
Asp Pro Ala Thr Val Met Arg Ile Leu Arg Asp Pro Arg Ile Ala Gly         
    540                 545                 550                         

ttc gcc gct gag gtg atc tac aag aag aag ccg gac ggc acg ccg acc     5087
Phe Ala Ala Glu Val Ile Tyr Lys Lys Lys Pro Asp Gly Thr Pro Thr         
555                 560                 565                 570         

acg aag att gag ggt tac cgc att cag cgc gac ccg atc acg ctc cgg     5135
Thr Lys Ile Glu Gly Tyr Arg Ile Gln Arg Asp Pro Ile Thr Leu Arg         
                575                 580                 585             

ccg gtc gag ctt gat tgc gga ccg atc atc gag ccc gct gag tgg tat     5183
Pro Val Glu Leu Asp Cys Gly Pro Ile Ile Glu Pro Ala Glu Trp Tyr         
            590                 595                 600                 

gag ctt cag gcg tgg ttg gac ggc agg ggg cgc ggc aag ggg ctt tcc     5231
Glu Leu Gln Ala Trp Leu Asp Gly Arg Gly Arg Gly Lys Gly Leu Ser         
        605                 610                 615                     

cgg ggg caa gcc att ctg tcc gcc atg gac aag ctg tac tgc gag tgt     5279
Arg Gly Gln Ala Ile Leu Ser Ala Met Asp Lys Leu Tyr Cys Glu Cys         
    620                 625                 630                         

ggc gcc gtc atg act tcg aag cgc ggg gaa gaa tcg atc aag gac tct     5327
Gly Ala Val Met Thr Ser Lys Arg Gly Glu Glu Ser Ile Lys Asp Ser         
635                 640                 645                 650         

tac cgc tgc cgt cgc cgg aag gtg gtc gac ccg tcc gca cct ggg cag     5375
Tyr Arg Cys Arg Arg Arg Lys Val Val Asp Pro Ser Ala Pro Gly Gln         
                655                 660                 665             

cac gaa ggc acg tgc aac gtc agc atg gcg gca ctc gac aag ttc gtt     5423
His Glu Gly Thr Cys Asn Val Ser Met Ala Ala Leu Asp Lys Phe Val         
            670                 675                 680                 

gcg gaa cgc atc ttc aac aag atc agg cac gcc gaa ggc gac gaa gag     5471
Ala Glu Arg Ile Phe Asn Lys Ile Arg His Ala Glu Gly Asp Glu Glu         
        685                 690                 695                     

acg ttg gcg ctt ctg tgg gaa gcc gcc cga cgc ttc ggc aag ctc act     5519
Thr Leu Ala Leu Leu Trp Glu Ala Ala Arg Arg Phe Gly Lys Leu Thr         
    700                 705                 710                         

gag gcg cct gag aag agc ggc gaa cgg gcg aac ctt gtt gcg gag cgc     5567
Glu Ala Pro Glu Lys Ser Gly Glu Arg Ala Asn Leu Val Ala Glu Arg         
715                 720                 725                 730         

gcc gac gcc ctg aac gcc ctt gaa gag ctg tac gaa gac cgc gcg gca     5615
Ala Asp Ala Leu Asn Ala Leu Glu Glu Leu Tyr Glu Asp Arg Ala Ala         
                735                 740                 745             

ggc gcg tac gac gga ccc gtt ggc agg aag cac ttc cgg aag caa cag     5663
Gly Ala Tyr Asp Gly Pro Val Gly Arg Lys His Phe Arg Lys Gln Gln         
            750                 755                 760                 

gca gcg ctg acg ctc cgg cag caa ggg gcg gaa gag cgg ctt gcc gaa     5711
Ala Ala Leu Thr Leu Arg Gln Gln Gly Ala Glu Glu Arg Leu Ala Glu         
        765                 770                 775                     

ctt gaa gcc gcc gaa gcc ccg aag ctt ccc ctt gac caa tgg ttc ccc     5759
Leu Glu Ala Ala Glu Ala Pro Lys Leu Pro Leu Asp Gln Trp Phe Pro         
    780                 785                 790                         

gaa gac gcc gac gct gac ccg acc ggc cct aag tcg tgg tgg ggg cgc     5807
Glu Asp Ala Asp Ala Asp Pro Thr Gly Pro Lys Ser Trp Trp Gly Arg         
795                 800                 805                 810         

gcg tca gta gac gac aag cgc gtg ttc gtc ggg ctc ttc gta gac aag     5855
Ala Ser Val Asp Asp Lys Arg Val Phe Val Gly Leu Phe Val Asp Lys         
                815                 820                 825             

atc gtt gtc acg aag tcg act acg ggc agg ggg cag gga acg ccc atc     5903
Ile Val Val Thr Lys Ser Thr Thr Gly Arg Gly Gln Gly Thr Pro Ile         
            830                 835                 840                 

gag aag cgc gct tcg atc acg tgg gcg aag ccg ccg acc gac gac gac     5951
Glu Lys Arg Ala Ser Ile Thr Trp Ala Lys Pro Pro Thr Asp Asp Asp         
        845                 850                 855                     

gaa gac gac gcc cag gac ggc acg gaa gac gta gcg gcg tag             5993
Glu Asp Asp Ala Gln Asp Gly Thr Glu Asp Val Ala Ala                     
    860                 865                 870                         

cgagacaccc gggaagcctg                                               6013


<210>  140
<211>  258
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated vector

<400>  140

Val Gln Tyr Glu Trp Arg Lys Ala Glu Leu Ile Gly Gln Leu Leu Asn 
1               5                   10                  15      


Leu Gly Val Thr Pro Gly Gly Val Leu Leu Val His Ser Ser Phe Arg 
            20                  25                  30          


Ser Val Arg Pro Leu Glu Asp Gly Pro Leu Gly Leu Ile Glu Ala Leu 
        35                  40                  45              


Arg Ala Ala Leu Gly Pro Gly Gly Thr Leu Val Met Pro Ser Trp Ser 
    50                  55                  60                  


Gly Leu Asp Asp Glu Pro Phe Asp Pro Ala Thr Ser Pro Val Thr Pro 
65                  70                  75                  80  


Asp Leu Gly Val Val Ser Asp Thr Phe Trp Arg Leu Pro Asn Val Lys 
                85                  90                  95      


Arg Ser Ala His Pro Phe Ala Phe Ala Ala Ala Gly Pro Gln Ala Glu 
            100                 105                 110         


Gln Ile Ile Ser Asp Pro Leu Pro Leu Pro Pro His Ser Pro Ala Ser 
        115                 120                 125             


Pro Val Ala Arg Val His Glu Leu Asp Gly Gln Val Leu Leu Leu Gly 
    130                 135                 140                 


Val Gly His Asp Ala Asn Thr Thr Leu His Leu Ala Glu Leu Met Ala 
145                 150                 155                 160 


Lys Val Pro Tyr Gly Val Pro Arg His Cys Thr Ile Leu Gln Asp Gly 
                165                 170                 175     


Lys Leu Val Arg Val Asp Tyr Leu Glu Asn Asp His Cys Cys Glu Arg 
            180                 185                 190         


Phe Ala Leu Ala Asp Arg Trp Leu Lys Glu Lys Ser Leu Gln Lys Glu 
        195                 200                 205             


Gly Pro Val Gly His Ala Phe Ala Arg Leu Ile Arg Ser Arg Asp Ile 
    210                 215                 220                 


Val Ala Thr Ala Leu Gly Gln Leu Gly Arg Asp Pro Leu Ile Phe Leu 
225                 230                 235                 240 


His Pro Pro Glu Ala Gly Cys Glu Glu Cys Asp Ala Ala Arg Gln Ser 
                245                 250                 255     


Ile Gly 
        


<210>  141
<211>  613
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated vector

<400>  141

Met Thr Gln Gly Val Val Thr Gly Val Asp Thr Tyr Ala Gly Ala Tyr 
1               5                   10                  15      


Asp Arg Gln Ser Arg Glu Arg Glu Asn Ser Ser Ala Ala Ser Pro Ala 
            20                  25                  30          


Thr Gln Arg Ser Ala Asn Glu Asp Lys Ala Ala Asp Leu Gln Arg Glu 
        35                  40                  45              


Val Glu Arg Asp Gly Gly Arg Phe Arg Phe Val Gly His Phe Ser Glu 
    50                  55                  60                  


Ala Pro Gly Thr Ser Ala Phe Gly Thr Ala Glu Arg Pro Glu Phe Glu 
65                  70                  75                  80  


Arg Ile Leu Asn Glu Cys Arg Ala Gly Arg Leu Asn Met Ile Ile Val 
                85                  90                  95      


Tyr Asp Val Ser Arg Phe Ser Arg Leu Lys Val Met Asp Ala Ile Pro 
            100                 105                 110         


Ile Val Ser Glu Leu Leu Ala Leu Gly Val Thr Ile Val Ser Thr Gln 
        115                 120                 125             


Glu Gly Val Phe Arg Gln Gly Asn Val Met Asp Leu Ile His Leu Ile 
    130                 135                 140                 


Met Arg Leu Asp Ala Ser His Lys Glu Ser Ser Leu Lys Ser Ala Lys 
145                 150                 155                 160 


Ile Leu Asp Thr Lys Asn Leu Gln Arg Glu Leu Gly Gly Tyr Val Gly 
                165                 170                 175     


Gly Lys Ala Pro Tyr Gly Phe Glu Leu Val Ser Glu Thr Lys Glu Ile 
            180                 185                 190         


Thr Arg Asn Gly Arg Met Val Asn Val Val Ile Asn Lys Leu Ala His 
        195                 200                 205             


Ser Thr Thr Pro Leu Thr Gly Pro Phe Glu Phe Glu Pro Asp Val Ile 
    210                 215                 220                 


Arg Trp Trp Trp Arg Glu Ile Lys Thr His Lys His Leu Pro Phe Lys 
225                 230                 235                 240 


Pro Gly Ser Gln Ala Ala Ile His Pro Gly Ser Ile Thr Gly Leu Cys 
                245                 250                 255     


Lys Arg Met Asp Ala Asp Ala Val Pro Thr Arg Gly Glu Thr Ile Gly 
            260                 265                 270         


Lys Lys Thr Ala Ser Ser Ala Trp Asp Pro Ala Thr Val Met Arg Ile 
        275                 280                 285             


Leu Arg Asp Pro Arg Ile Ala Gly Phe Ala Ala Glu Val Ile Tyr Lys 
    290                 295                 300                 


Lys Lys Pro Asp Gly Thr Pro Thr Thr Lys Ile Glu Gly Tyr Arg Ile 
305                 310                 315                 320 


Gln Arg Asp Pro Ile Thr Leu Arg Pro Val Glu Leu Asp Cys Gly Pro 
                325                 330                 335     


Ile Ile Glu Pro Ala Glu Trp Tyr Glu Leu Gln Ala Trp Leu Asp Gly 
            340                 345                 350         


Arg Gly Arg Gly Lys Gly Leu Ser Arg Gly Gln Ala Ile Leu Ser Ala 
        355                 360                 365             


Met Asp Lys Leu Tyr Cys Glu Cys Gly Ala Val Met Thr Ser Lys Arg 
    370                 375                 380                 


Gly Glu Glu Ser Ile Lys Asp Ser Tyr Arg Cys Arg Arg Arg Lys Val 
385                 390                 395                 400 


Val Asp Pro Ser Ala Pro Gly Gln His Glu Gly Thr Cys Asn Val Ser 
                405                 410                 415     


Met Ala Ala Leu Asp Lys Phe Val Ala Glu Arg Ile Phe Asn Lys Ile 
            420                 425                 430         


Arg His Ala Glu Gly Asp Glu Glu Thr Leu Ala Leu Leu Trp Glu Ala 
        435                 440                 445             


Ala Arg Arg Phe Gly Lys Leu Thr Glu Ala Pro Glu Lys Ser Gly Glu 
    450                 455                 460                 


Arg Ala Asn Leu Val Ala Glu Arg Ala Asp Ala Leu Asn Ala Leu Glu 
465                 470                 475                 480 


Glu Leu Tyr Glu Asp Arg Ala Ala Gly Ala Tyr Asp Gly Pro Val Gly 
                485                 490                 495     


Arg Lys His Phe Arg Lys Gln Gln Ala Ala Leu Thr Leu Arg Gln Gln 
            500                 505                 510         


Gly Ala Glu Glu Arg Leu Ala Glu Leu Glu Ala Ala Glu Ala Pro Lys 
        515                 520                 525             


Leu Pro Leu Asp Gln Trp Phe Pro Glu Asp Ala Asp Ala Asp Pro Thr 
    530                 535                 540                 


Gly Pro Lys Ser Trp Trp Gly Arg Ala Ser Val Asp Asp Lys Arg Val 
545                 550                 555                 560 


Phe Val Gly Leu Phe Val Asp Lys Ile Val Val Thr Lys Ser Thr Thr 
                565                 570                 575     


Gly Arg Gly Gln Gly Thr Pro Ile Glu Lys Arg Ala Ser Ile Thr Trp 
            580                 585                 590         


Ala Lys Pro Pro Thr Asp Asp Asp Glu Asp Asp Ala Gln Asp Gly Thr 
        595                 600                 605             


Glu Asp Val Ala Ala 
    610             


<210>  142
<211>  8215
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated vector construction containing spnP gene

<220>
<221>  CDS
<222>  (418)..(1227)
<223>  tsr gene


<220>
<221>  misc_difference
<222>  (4206)..(5525)
<223>  spnP gene from S. spinosa (complementary)


<220>
<221>  CDS
<222>  (2282)..(3142)
<223>  bla gene


<220>
<221>  CDS
<222>  (6020)..(7390)
<223>  rep-pIJ101


<220>
<221>  promoter
<222>  (5583)..(5852)
<223>  ermEp*


<220>
<221>  rep_origin
<222>  (3168)..(3910)
<223>  ColE1-ori


<220>
<221>  rep_origin
<222>  (7412)..(8172)
<223>  ori-pIJ101


<220>
<221>  terminator
<222>  (1282)..(1620)
<223>  fd-terminator


<220>
<221>  misc
<222>  (1282)..(1620)
<223>  fd-terminator


<400>  142
gccccgcggg ggttggtcgg gtcaggcgcc gaaccggcgg gcggcggcgg cgaccaggcc     60

gtcggcggcg gccatggcgc ggtcgcggtc ggtggtgagg gcggtgcggt cggcggcggc    120

ccagtcctgc tctcacgcaa cgtctacgtg gacgctcagg gcgacacgat cgaggtcggg    180

gagtccgtcg ctccggcggg ccgctggcgc gtccaccggg actgatcaag gcgaatactt    240

catatgcggg gatcgaccgc gcgggtcccg gacggggaag agcggggagc tttgccagag    300

agcgacgact tccccttgcg ttggtgattg ccggtcaggg cagccatccg ccatcgtcgc    360

gtagggtgtc acaccccagg aatcgcgtca ctgaacacag cagccggtag gacgacc       417

atg act gag ttg gac acc atc gca aat ccg tcc gat ccc gcg gtg cag      465
Met Thr Glu Leu Asp Thr Ile Ala Asn Pro Ser Asp Pro Ala Val Gln         
1               5                   10                  15              

cgg atc atc gat gtc acc aag ccg tcg cga tcc aac ata aag aca acg      513
Arg Ile Ile Asp Val Thr Lys Pro Ser Arg Ser Asn Ile Lys Thr Thr         
            20                  25                  30                  

ttg atc gag gac gtc gag ccc ctc atg cac agc atc gcg gcc ggg gtg      561
Leu Ile Glu Asp Val Glu Pro Leu Met His Ser Ile Ala Ala Gly Val         
        35                  40                  45                      

gag ttc atc gag gtc tac ggc agc gac agc agt cct ttt cca tct gag      609
Glu Phe Ile Glu Val Tyr Gly Ser Asp Ser Ser Pro Phe Pro Ser Glu         
    50                  55                  60                          

ttg ctg gat ctg tgc ggg cgg cag aac ata ccg gtc cgc ctc atc gac      657
Leu Leu Asp Leu Cys Gly Arg Gln Asn Ile Pro Val Arg Leu Ile Asp         
65                  70                  75                  80          

tcc tcg atc gtc aac cag ttg ttc aag ggg gag cgg aag gcc aag aca      705
Ser Ser Ile Val Asn Gln Leu Phe Lys Gly Glu Arg Lys Ala Lys Thr         
                85                  90                  95              

ttc ggc atc gcc cgc gtc cct cgc ccg gcc agg ttc ggc gat atc gcg      753
Phe Gly Ile Ala Arg Val Pro Arg Pro Ala Arg Phe Gly Asp Ile Ala         
            100                 105                 110                 

agc cgg cgt ggg gac gtc gtc gtt ctc gac ggg gtg aag atc gtc ggg      801
Ser Arg Arg Gly Asp Val Val Val Leu Asp Gly Val Lys Ile Val Gly         
        115                 120                 125                     

aac atc ggc gcg ata gta cgc acg tcg ctc gcg ctc gga gcg tcg ggg      849
Asn Ile Gly Ala Ile Val Arg Thr Ser Leu Ala Leu Gly Ala Ser Gly         
    130                 135                 140                         

atc atc ctg gtc gac agt gac atc acc agc atc gcg gac cgg cgt ctc      897
Ile Ile Leu Val Asp Ser Asp Ile Thr Ser Ile Ala Asp Arg Arg Leu         
145                 150                 155                 160         

caa agg gcc agc cga ggt tac gtc ttc tcc ctt ccc gtc gtt ctc tcc      945
Gln Arg Ala Ser Arg Gly Tyr Val Phe Ser Leu Pro Val Val Leu Ser         
                165                 170                 175             

ggt cgc gag gag gcc atc gcc ttc att cgg gac agc ggt atg cag ctg      993
Gly Arg Glu Glu Ala Ile Ala Phe Ile Arg Asp Ser Gly Met Gln Leu         
            180                 185                 190                 

atg acg ctc aag gcg gat ggc gac att tcc gtg aag gaa ctc ggg gac     1041
Met Thr Leu Lys Ala Asp Gly Asp Ile Ser Val Lys Glu Leu Gly Asp         
        195                 200                 205                     

aat ccg gat cgg ctg gcc ttg ctg ttc ggc agc gaa aag ggt ggg cct     1089
Asn Pro Asp Arg Leu Ala Leu Leu Phe Gly Ser Glu Lys Gly Gly Pro         
    210                 215                 220                         

tcc gac ctg ttc gag gag gcg tct tcc gcc tcg gtt tcc atc ccc atg     1137
Ser Asp Leu Phe Glu Glu Ala Ser Ser Ala Ser Val Ser Ile Pro Met         
225                 230                 235                 240         

atg agc cag acc gag tct ctc aac gtt tcc gtt tcc ctc gga atc gcg     1185
Met Ser Gln Thr Glu Ser Leu Asn Val Ser Val Ser Leu Gly Ile Ala         
                245                 250                 255             

ctg cac gag agg atc gac agg aat ctc gcg gcc aac cga taa             1227
Leu His Glu Arg Ile Asp Arg Asn Leu Ala Ala Asn Arg                     
            260                 265                                     

gcgcctctgt tcctcggacg ctcggttcct cgacctcgat tcgtcagtga tgatcccgca   1287

aaagcggcct ttgactccct gcaagcctca gcgaccgaat atatcggtta tgcgtgggcg   1347

atggttgttg tcattgtcgg cgcaactatc ggtatcaagc tgtttaagaa attcacctcg   1407

aaagcaagct gataaaccga tacaattaaa ggctcctttt ggagcctttt tttttggaga   1467

ttttcaacgt gaaaaaatta ttattcgcaa ttcctttagt tgttcctttc tattctcact   1527

ccgctgaaac tgttgaaagt tgtttagcaa aacctcatac agaaaattca tttactaacg   1587

tctggaaaga cgacaaaact ttagatccgg ccaagctctg gcgtaatagc gaagaggccc   1647

gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggaaa ttgtaagcgt   1707

taatattttg ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata   1767

ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt   1827

tgttccagtt tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg   1887

aaaaaccgtc tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt   1947

ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc   2007

ttgacgggga aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg   2067

cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct   2127

taatgcgccg ctacagggcg cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc   2187

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg   2247

ataaatgctt caataatatt gaaaaaggaa gagt atg agt att caa cat ttc cgt   2302
                                      Met Ser Ile Gln His Phe Arg       
                                      270                 275           

gtc gcc ctt att ccc ttt ttt gcg gca ttt tgc ctt cct gtt ttt gct     2350
Val Ala Leu Ile Pro Phe Phe Ala Ala Phe Cys Leu Pro Val Phe Ala         
            280                 285                 290                 

cac cca gaa acg ctg gtg aaa gta aaa gat gct gaa gat cag ttg ggt     2398
His Pro Glu Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly         
        295                 300                 305                     

gca cga gtg ggt tac atc gaa ctg gat ctc aac agc ggt aag atc ctt     2446
Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu         
    310                 315                 320                         

gag agt ttt cgc ccc gaa gaa cgt ttt cca atg atg agc act ttt aaa     2494
Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro Met Met Ser Thr Phe Lys         
325                 330                 335                 340         

gtt ctg cta tgt ggc gcg gta tta tcc cgt att gac gcc ggg caa gag     2542
Val Leu Leu Cys Gly Ala Val Leu Ser Arg Ile Asp Ala Gly Gln Glu         
                345                 350                 355             

caa ctc ggt cgc cgc ata cac tat tct cag aat gac ttg gtt gag tac     2590
Gln Leu Gly Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr         
            360                 365                 370                 

tca cca gtc aca gaa aag cat ctt acg gat ggc atg aca gta aga gaa     2638
Ser Pro Val Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu         
        375                 380                 385                     

tta tgc agt gct gcc ata acc atg agt gat aac act gcg gcc aac tta     2686
Leu Cys Ser Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu         
    390                 395                 400                         

ctt ctg aca acg atc gga gga ccg aag gag cta acc gct ttt ttg cac     2734
Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His         
405                 410                 415                 420         

aac atg ggg gat cat gta act cgc ctt gat cgt tgg gaa ccg gag ctg     2782
Asn Met Gly Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu         
                425                 430                 435             

aat gaa gcc ata cca aac gac gag cgt gac acc acg atg cct gta gca     2830
Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Val Ala         
            440                 445                 450                 

atg gca aca acg ttg cgc aaa cta tta act ggc gaa cta ctt act cta     2878
Met Ala Thr Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu         
        455                 460                 465                     

gct tcc cgg caa caa tta ata gac tgg atg gag gcg gat aaa gtt gca     2926
Ala Ser Arg Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala         
    470                 475                 480                         

gga cca ctt ctg cgc tcg gcc ctt ccg gct ggc tgg ttt att gct gat     2974
Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp         
485                 490                 495                 500         

aaa tct gga gcc ggt gag cgt ggg tct cgc ggt atc att gca gca ctg     3022
Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu         
                505                 510                 515             

ggg cca gat ggt aag ccc tcc cgt atc gta gtt atc tac acg acg ggg     3070
Gly Pro Asp Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly         
            520                 525                 530                 

agt cag gca act atg gat gaa cga aat aga cag atc gct gag ata ggt     3118
Ser Gln Ala Thr Met Asp Glu Arg Asn Arg Gln Ile Ala Glu Ile Gly         
        535                 540                 545                     

gcc tca ctg att aag cat tgg taa ctgtcagacc aagtttactc atatatactt    3172
Ala Ser Leu Ile Lys His Trp                                             
    550                 555                                             

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat   3232

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta   3292

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa   3352

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt   3412

tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag   3472

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta   3532

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca   3592

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag   3652

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa   3712

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga   3772

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc   3832

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc   3892

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt   3952

gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt   4012

gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag   4072

gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa   4132

tgcagagctt ctagatgcat gctcgagcgg ccgccagtgt gatggatatc tgcagaattc   4192

ggccagatct tgctcacgga tggccatcag actgcccagt gcggcggttc tcacgttcgg   4252

caactagctt ttccagacgt ggaacgatgt cgtgcgggct gggactttcc tcgatttcac   4312

ggcggatcag cgccgcgttg gcagcgaacg acggctcgtc gagcaggcgg gccagctgac   4372

ctcgcacgtc gtcttcggta aacgtcgcgg ggtcgaggac cagaccggct ccccgatcgg   4432

ctaggagctc cgccctacga gattcgtccc agaaggtccc agggagaatc aactgcggta   4492

cgccgttgac cgtggcggtt tcctgcgtcg tcgtcgagcc atgatggatg atcactgaac   4552

acgactccag cagttcgttg agcggtacgt attcgtggac ccggacgttc gagggcaact   4612

cccccatctc ccgtacttcg tcgtcagaca aggtggcgat cacctcgacg tcgagcctgg   4672

ccgcgccgcg caacaacctt tccaccattg cttgttcctg gtcactttgc tccccgtact   4732

gttcggtcac cctgctcagc cgccgcttgg tcagcccgcg cgtgatgcag acgcgcggct   4792

tcgtcggtcg ttcgcgcaac cactccggca acaccgccgg accgttgtac ggcacgaaac   4852

gcatcgagat gtagtccaag tccacaggca ggcgcatcca ggatggaatc ggatctatgg   4912

tcgcttggcc cgtcacgatc tcttcatcga acgtggctcc gaacttggcg agcttcgctc   4972

ccagccacgt cccgagcggg tcgacgcgct gctcaggcgg cttcgattcc tggtattcga   5032

ggaaaccgga ccgcagccac cccgacacat cgagggcgac gagcatccgc acgtgtcgtg   5092

cgccgagcgc tcgcgccaca actggccccg aacacaccat agcgtcccac acaacgagat   5152

caggctgcca tttctcggcg aaccccatga gatcgtccag cgatcggtca tccacaaggt   5212

ggagttgctc cacggcgtcc gtgtctctgc cggagttgat tgacagcagc tcgtcgaaga   5272

gttccggatg ccgccccttc tcgtcgaacg agaccccgct gccgagaacg agttcgttct   5332

tggccgccaa ggagatgagg tcgagctcgt cgccgacggg aaccgcggtg agtcctgctc   5392

cggtgaccat cgacaccata ttcgggcaga tggcgacacg gacctcgtgc cccgcggcac   5452

gcaacgccca cgccaacggc accaggttga agaagtgcga actcgccggc agcggggtga   5512

acaggacacg catgaactct ccgatcgcaa ttgaacaccg aattcgatat caagcttatc   5572

gataccgtcg atcctaccaa ccggcacgat tgtgcccaca acagcatcgc ggtgccacgt   5632

gtggaccgcg tcggtcagat cctccccgca cctctcgcca gccgtcaaga tcgaccgcgt   5692

gcacctgcga tcgccgatca accgcgacta gcatcgggcg caagccgcca ctcgaacgga   5752

cactcgcatg gacgtcccct tcctggacct gcaagccgcg tacctcgaac tccggtccga   5812

catcgaccag gcgtgccggc gcgtgctcgg gtcgggctgg acctcgaggg ggggcccggt   5872

accgcctgca cgaagtgccg gcggggccga ccccgggcga gtaatcccag gattactccc   5932

gcggcttcga ccccggccgc cgtcgccgcg tacgtcaccg acccccgccg tacgtcaccg   5992

ggatgacgta cggcgggggg gagcgag tta gtg cga agt ggg ccc act tgc gag   6046
                              Leu Val Arg Ser Gly Pro Thr Cys Glu       
                                              560                       

ccg ggc gat gtg ccg ggc ggc ccg ctc ctg gcg gtc gtc ggc gtc gtc     6094
Pro Gly Asp Val Pro Gly Gly Pro Leu Leu Ala Val Val Gly Val Val         
565                 570                 575                 580         

gtc ctg gtc gtc gtc ctg ctc tcg ccg tcg gcg tgc agt tgc ttc ctc     6142
Val Leu Val Val Val Leu Leu Ser Pro Ser Ala Cys Ser Cys Phe Leu         
                585                 590                 595             

gcg gcg ctg ggc gag ggc ggc gag cat gtc ggc gta cgc ctc ggc cac     6190
Ala Ala Leu Gly Glu Gly Gly Glu His Val Gly Val Arg Leu Gly His         
            600                 605                 610                 

ctc ccc cgc cgt gag cac cac cac tgt gtc ggc cgc gtc ggc cag cgc     6238
Leu Pro Arg Arg Glu His His His Cys Val Gly Arg Val Gly Gln Arg         
        615                 620                 625                     

cag gac ctc ccg cac ccg ttc gcc cac ggc cgc cga atc ctc gtt gcc     6286
Gln Asp Leu Pro His Pro Phe Ala His Gly Arg Arg Ile Leu Val Ala         
    630                 635                 640                         

gtc ctt gcc ttc ggc ggc ccg ggt cgc ctc gag gtc gag ggc gcg gcg     6334
Val Leu Ala Phe Gly Gly Pro Gly Arg Leu Glu Val Glu Gly Ala Ala         
645                 650                 655                 660         

ggt gac cgc gtg cca tcc gtc ctc ggt cac ggc gac ccc ggc ccg cag     6382
Gly Asp Arg Val Pro Ser Val Leu Gly His Gly Asp Pro Gly Pro Gln         
                665                 670                 675             

ctc ccc gcc gtc ggc gtc ggc cgc cag gag cag atc gag gtc gtc ggc     6430
Leu Pro Ala Val Gly Val Gly Arg Gln Glu Gln Ile Glu Val Val Gly         
            680                 685                 690                 

ctc ggt gtc gcc gcc gtc gag ccc gag cat ctg ccg cag gta gcg ggt     6478
Leu Gly Val Ala Ala Val Glu Pro Glu His Leu Pro Gln Val Ala Gly         
        695                 700                 705                     

cca ttc gat ggc ccg gcg tcc ccg ggt tgc ccg ctc gta ctc gtg cca     6526
Pro Phe Asp Gly Pro Ala Ser Pro Gly Cys Pro Leu Val Leu Val Pro         
    710                 715                 720                         

gcg cga gag gtt cca ctc cag cga gcc gac ccc ggc ggc gtc gtc ctc     6574
Ala Arg Glu Val Pro Leu Gln Arg Ala Asp Pro Gly Gly Val Val Leu         
725                 730                 735                 740         

ggt cat gcc gcc ggt cag gtc ccc gat ccg tcc gag gag ttc gaa cgg     6622
Gly His Ala Ala Gly Gln Val Pro Asp Pro Ser Glu Glu Phe Glu Arg         
                745                 750                 755             

ggc gac gtt ccc gcc ggt cgc cgt ctt gag gtc ggc gcg ggc gag ttc     6670
Gly Asp Val Pro Ala Gly Arg Arg Leu Glu Val Gly Ala Gly Glu Phe         
            760                 765                 770                 

gag ggc ggg cgc ctt ccc gtc ctg ggt ctt ggc gat gta ctc ggc gag     6718
Glu Gly Gly Arg Leu Pro Val Leu Gly Leu Gly Asp Val Leu Gly Glu         
        775                 780                 785                     

gtc gtt ggc gtc gcg ctc ggt ctc cag ccg ctt gaa gtc gac gcc gtg     6766
Val Val Gly Val Ala Leu Gly Leu Gln Pro Leu Glu Val Asp Ala Val         
    790                 795                 800                         

ccg gtc gtc ggg cgt gaa ggc ggg gtt gac ctt gcg cag ggc ggc ggt     6814
Pro Val Val Gly Arg Glu Gly Gly Val Asp Leu Ala Gln Gly Gly Gly         
805                 810                 815                 820         

cca cac gga ccg cca gtg ccc ctg cca ctc gtc gag cgc ggc gcc ggt     6862
Pro His Gly Pro Pro Val Pro Leu Pro Leu Val Glu Arg Gly Ala Gly         
                825                 830                 835             

cgg ctc gaa ggt ggc gac gat ctg ctt cgc gga ccg ctc ccc ctc ggt     6910
Arg Leu Glu Gly Gly Asp Asp Leu Leu Arg Gly Pro Leu Pro Leu Gly         
            840                 845                 850                 

ccg gcc gcc gac cag gac gat cgc gtg gat gtg cgg gtg cca gcc gtt     6958
Pro Ala Ala Asp Gln Asp Asp Arg Val Asp Val Arg Val Pro Ala Val         
        855                 860                 865                     

gat ctg ccc cac ggt gac ttc ggt cgc gcg gat cat gcc gac gta ccc     7006
Asp Leu Pro His Gly Asp Phe Gly Arg Ala Asp His Ala Asp Val Pro         
    870                 875                 880                         

gat ccg gtc tcg gat gcc ctc gcg gtc ggc ggc ccg gtg ccc gtc ctt     7054
Asp Pro Val Ser Asp Ala Leu Ala Val Gly Gly Pro Val Pro Val Leu         
885                 890                 895                 900         

ggc ccg gcg tcc ggc cca cgt gcc gcc cgt gat cag tcg ctg gta ggc     7102
Gly Pro Ala Ser Gly Pro Arg Ala Ala Arg Asp Gln Ser Leu Val Gly         
                905                 910                 915             

gcc cgg ccg ccg ggg gct gtc cgg cgt ctt ccg ggt gcc ctg gag ggc     7150
Ala Arg Pro Pro Gly Ala Val Arg Arg Leu Pro Gly Ala Leu Glu Gly         
            920                 925                 930                 

gtc cat gag gtc cgc gag ccg gtc cgt gtg ccc atg gcg ggc cgt gaa     7198
Val His Glu Val Arg Glu Pro Val Arg Val Pro Met Ala Gly Arg Glu         
        935                 940                 945                     

ggt gac cag gta ggc ggt ccc ccc gcg ctt gat cca ctc gac cac ggc     7246
Gly Asp Gln Val Gly Gly Pro Pro Ala Leu Asp Pro Leu Asp His Gly         
    950                 955                 960                         

ggc ggt gat ctc ctc ggc ccg ctt gtg ccg gat cgt ggc ggc gca gac     7294
Gly Gly Asp Leu Leu Gly Pro Leu Val Pro Asp Arg Gly Gly Ala Asp         
965                 970                 975                 980         

cgg gca gag cca gat ccg ccc gca ccg cat cag gcc cag gac cac gga     7342
Arg Ala Glu Pro Asp Pro Pro Ala Pro His Gln Ala Gln Asp His Gly         
                985                 990                 995             

cgt tcc ggc cgc  cgt ctg ggc gac gat  tac gcc gga ggc agg  gtc      7387
Arg Ser Gly Arg  Arg Leu Gly Asp Asp  Tyr Ala Gly Gly Arg  Val          
            1000                 1005                 1010              

cat cagggcgcgg ccgcagccct tgcacgcggc gtccccgctg atccgccaca          7440
His                                                                     
                                                                        

gcgtccggcg gcggctgtac cgggcggctt tccgcagtcg ggcagcgtcg ctccgcgacg   7500

tgcttcctac ttccgagagg ctgtcgcctc tcgggctctc cccatccacc ccgtccggag   7560

aaaccgcagg tcggaggggt gcgggaaact ctgttgtttc tttcccaagg tgttcgcttt   7620

tgcctcgggc ggcatctcgc gtcacacgcg cgatcgcccg cttcgctgcc atccggcagc   7680

ggtctgagca gtagatacgc ggccgtttgc ccggtgtgtg ggcaattgcg gtcccgcagt   7740

ggcagcgggg cccggcgggc cgatctggca atgcctcggc atcgctccgt actctgggca   7800

cgagcaacgt tcctgtctcg cccggctaag gggcgcgagt ctgggagcgg acgggtcgga   7860

ggtgcgaagt ccggcccgtt gctctttggt ctggtgggaa tcctggcacc aatcgggcca   7920

gaggttccct ccgccactcc cgacgcccct tggggctggt gtgacttgga gggccgaaga   7980

gagccccgcc ggtgatccgg cggggctttg acgtgcggtc agtgcgtgtg tcggcgagcg   8040

atggccacga ggccctggaa gccgagcggt ccggcgaagt cggcccagtc gcaaccgggc   8100

tcagcgcagt gggcggacca gccaccgccg ttggggtcct ggaccaggtt cacggtcccc   8160

tcggtcaggc gtccgtcgaa gtcggtcatg gtcggtctcc tggtgggtgg gggcg        8215


<210>  143
<211>  269
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated vector construction containing spnP gene

<400>  143

Met Thr Glu Leu Asp Thr Ile Ala Asn Pro Ser Asp Pro Ala Val Gln 
1               5                   10                  15      


Arg Ile Ile Asp Val Thr Lys Pro Ser Arg Ser Asn Ile Lys Thr Thr 
            20                  25                  30          


Leu Ile Glu Asp Val Glu Pro Leu Met His Ser Ile Ala Ala Gly Val 
        35                  40                  45              


Glu Phe Ile Glu Val Tyr Gly Ser Asp Ser Ser Pro Phe Pro Ser Glu 
    50                  55                  60                  


Leu Leu Asp Leu Cys Gly Arg Gln Asn Ile Pro Val Arg Leu Ile Asp 
65                  70                  75                  80  


Ser Ser Ile Val Asn Gln Leu Phe Lys Gly Glu Arg Lys Ala Lys Thr 
                85                  90                  95      


Phe Gly Ile Ala Arg Val Pro Arg Pro Ala Arg Phe Gly Asp Ile Ala 
            100                 105                 110         


Ser Arg Arg Gly Asp Val Val Val Leu Asp Gly Val Lys Ile Val Gly 
        115                 120                 125             


Asn Ile Gly Ala Ile Val Arg Thr Ser Leu Ala Leu Gly Ala Ser Gly 
    130                 135                 140                 


Ile Ile Leu Val Asp Ser Asp Ile Thr Ser Ile Ala Asp Arg Arg Leu 
145                 150                 155                 160 


Gln Arg Ala Ser Arg Gly Tyr Val Phe Ser Leu Pro Val Val Leu Ser 
                165                 170                 175     


Gly Arg Glu Glu Ala Ile Ala Phe Ile Arg Asp Ser Gly Met Gln Leu 
            180                 185                 190         


Met Thr Leu Lys Ala Asp Gly Asp Ile Ser Val Lys Glu Leu Gly Asp 
        195                 200                 205             


Asn Pro Asp Arg Leu Ala Leu Leu Phe Gly Ser Glu Lys Gly Gly Pro 
    210                 215                 220                 


Ser Asp Leu Phe Glu Glu Ala Ser Ser Ala Ser Val Ser Ile Pro Met 
225                 230                 235                 240 


Met Ser Gln Thr Glu Ser Leu Asn Val Ser Val Ser Leu Gly Ile Ala 
                245                 250                 255     


Leu His Glu Arg Ile Asp Arg Asn Leu Ala Ala Asn Arg 
            260                 265                 


<210>  144
<211>  286
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated vector construction containing spnP gene

<400>  144

Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 
1               5                   10                  15      


Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 
            20                  25                  30          


Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 
        35                  40                  45              


Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 
    50                  55                  60                  


Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser 
65                  70                  75                  80  


Arg Ile Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr Ser 
                85                  90                  95      


Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr 
            100                 105                 110         


Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser 
        115                 120                 125             


Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys 
    130                 135                 140                 


Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu 
145                 150                 155                 160 


Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg 
                165                 170                 175     


Asp Thr Thr Met Pro Val Ala Met Ala Thr Thr Leu Arg Lys Leu Leu 
            180                 185                 190         


Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp 
        195                 200                 205             


Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro 
    210                 215                 220                 


Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser 
225                 230                 235                 240 


Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile 
                245                 250                 255     


Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn 
            260                 265                 270         


Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 
        275                 280                 285     


<210>  145
<211>  457
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated vector construction containing spnP gene

<400>  145

Leu Val Arg Ser Gly Pro Thr Cys Glu Pro Gly Asp Val Pro Gly Gly 
1               5                   10                  15      


Pro Leu Leu Ala Val Val Gly Val Val Val Leu Val Val Val Leu Leu 
            20                  25                  30          


Ser Pro Ser Ala Cys Ser Cys Phe Leu Ala Ala Leu Gly Glu Gly Gly 
        35                  40                  45              


Glu His Val Gly Val Arg Leu Gly His Leu Pro Arg Arg Glu His His 
    50                  55                  60                  


His Cys Val Gly Arg Val Gly Gln Arg Gln Asp Leu Pro His Pro Phe 
65                  70                  75                  80  


Ala His Gly Arg Arg Ile Leu Val Ala Val Leu Ala Phe Gly Gly Pro 
                85                  90                  95      


Gly Arg Leu Glu Val Glu Gly Ala Ala Gly Asp Arg Val Pro Ser Val 
            100                 105                 110         


Leu Gly His Gly Asp Pro Gly Pro Gln Leu Pro Ala Val Gly Val Gly 
        115                 120                 125             


Arg Gln Glu Gln Ile Glu Val Val Gly Leu Gly Val Ala Ala Val Glu 
    130                 135                 140                 


Pro Glu His Leu Pro Gln Val Ala Gly Pro Phe Asp Gly Pro Ala Ser 
145                 150                 155                 160 


Pro Gly Cys Pro Leu Val Leu Val Pro Ala Arg Glu Val Pro Leu Gln 
                165                 170                 175     


Arg Ala Asp Pro Gly Gly Val Val Leu Gly His Ala Ala Gly Gln Val 
            180                 185                 190         


Pro Asp Pro Ser Glu Glu Phe Glu Arg Gly Asp Val Pro Ala Gly Arg 
        195                 200                 205             


Arg Leu Glu Val Gly Ala Gly Glu Phe Glu Gly Gly Arg Leu Pro Val 
    210                 215                 220                 


Leu Gly Leu Gly Asp Val Leu Gly Glu Val Val Gly Val Ala Leu Gly 
225                 230                 235                 240 


Leu Gln Pro Leu Glu Val Asp Ala Val Pro Val Val Gly Arg Glu Gly 
                245                 250                 255     


Gly Val Asp Leu Ala Gln Gly Gly Gly Pro His Gly Pro Pro Val Pro 
            260                 265                 270         


Leu Pro Leu Val Glu Arg Gly Ala Gly Arg Leu Glu Gly Gly Asp Asp 
        275                 280                 285             


Leu Leu Arg Gly Pro Leu Pro Leu Gly Pro Ala Ala Asp Gln Asp Asp 
    290                 295                 300                 


Arg Val Asp Val Arg Val Pro Ala Val Asp Leu Pro His Gly Asp Phe 
305                 310                 315                 320 


Gly Arg Ala Asp His Ala Asp Val Pro Asp Pro Val Ser Asp Ala Leu 
                325                 330                 335     


Ala Val Gly Gly Pro Val Pro Val Leu Gly Pro Ala Ser Gly Pro Arg 
            340                 345                 350         


Ala Ala Arg Asp Gln Ser Leu Val Gly Ala Arg Pro Pro Gly Ala Val 
        355                 360                 365             


Arg Arg Leu Pro Gly Ala Leu Glu Gly Val His Glu Val Arg Glu Pro 
    370                 375                 380                 


Val Arg Val Pro Met Ala Gly Arg Glu Gly Asp Gln Val Gly Gly Pro 
385                 390                 395                 400 


Pro Ala Leu Asp Pro Leu Asp His Gly Gly Gly Asp Leu Leu Gly Pro 
                405                 410                 415     


Leu Val Pro Asp Arg Gly Gly Ala Asp Arg Ala Glu Pro Asp Pro Pro 
            420                 425                 430         


Ala Pro His Gln Ala Gln Asp His Gly Arg Ser Gly Arg Arg Leu Gly 
        435                 440                 445             


Asp Asp Tyr Ala Gly Gly Arg Val His 
    450                 455         


<210>  146
<211>  8065
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated vector construction containing spnG gene

<220>
<221>  CDS
<222>  (418)..(1227)
<223>  tsr gene


<220>
<221>  CDS
<222>  (5870)..(7240)
<223>  rep-pIJ101


<220>
<221>  CDS
<222>  (2282)..(3142)
<223>  bla gene


<220>
<221>  misc_difference
<222>  (4205)..(5377)
<223>  spnG gene from S. spinosa (complementary)


<220>
<221>  promoter
<222>  (5433)..(5702)
<223>  ermEp*


<220>
<221>  rep_origin
<222>  (3168)..(3910)
<223>  ColE1-ori


<220>
<221>  rep_origin
<222>  (7262)..(8022)
<223>  ori-pIJ101


<220>
<221>  terminator
<222>  (1282)..(1620)
<223>  fd-terminator


<400>  146
gccccgcggg ggttggtcgg gtcaggcgcc gaaccggcgg gcggcggcgg cgaccaggcc     60

gtcggcggcg gccatggcgc ggtcgcggtc ggtggtgagg gcggtgcggt cggcggcggc    120

ccagtcctgc tctcacgcaa cgtctacgtg gacgctcagg gcgacacgat cgaggtcggg    180

gagtccgtcg ctccggcggg ccgctggcgc gtccaccggg actgatcaag gcgaatactt    240

catatgcggg gatcgaccgc gcgggtcccg gacggggaag agcggggagc tttgccagag    300

agcgacgact tccccttgcg ttggtgattg ccggtcaggg cagccatccg ccatcgtcgc    360

gtagggtgtc acaccccagg aatcgcgtca ctgaacacag cagccggtag gacgacc       417

atg act gag ttg gac acc atc gca aat ccg tcc gat ccc gcg gtg cag      465
Met Thr Glu Leu Asp Thr Ile Ala Asn Pro Ser Asp Pro Ala Val Gln         
1               5                   10                  15              

cgg atc atc gat gtc acc aag ccg tcg cga tcc aac ata aag aca acg      513
Arg Ile Ile Asp Val Thr Lys Pro Ser Arg Ser Asn Ile Lys Thr Thr         
            20                  25                  30                  

ttg atc gag gac gtc gag ccc ctc atg cac agc atc gcg gcc ggg gtg      561
Leu Ile Glu Asp Val Glu Pro Leu Met His Ser Ile Ala Ala Gly Val         
        35                  40                  45                      

gag ttc atc gag gtc tac ggc agc gac agc agt cct ttt cca tct gag      609
Glu Phe Ile Glu Val Tyr Gly Ser Asp Ser Ser Pro Phe Pro Ser Glu         
    50                  55                  60                          

ttg ctg gat ctg tgc ggg cgg cag aac ata ccg gtc cgc ctc atc gac      657
Leu Leu Asp Leu Cys Gly Arg Gln Asn Ile Pro Val Arg Leu Ile Asp         
65                  70                  75                  80          

tcc tcg atc gtc aac cag ttg ttc aag ggg gag cgg aag gcc aag aca      705
Ser Ser Ile Val Asn Gln Leu Phe Lys Gly Glu Arg Lys Ala Lys Thr         
                85                  90                  95              

ttc ggc atc gcc cgc gtc cct cgc ccg gcc agg ttc ggc gat atc gcg      753
Phe Gly Ile Ala Arg Val Pro Arg Pro Ala Arg Phe Gly Asp Ile Ala         
            100                 105                 110                 

agc cgg cgt ggg gac gtc gtc gtt ctc gac ggg gtg aag atc gtc ggg      801
Ser Arg Arg Gly Asp Val Val Val Leu Asp Gly Val Lys Ile Val Gly         
        115                 120                 125                     

aac atc ggc gcg ata gta cgc acg tcg ctc gcg ctc gga gcg tcg ggg      849
Asn Ile Gly Ala Ile Val Arg Thr Ser Leu Ala Leu Gly Ala Ser Gly         
    130                 135                 140                         

atc atc ctg gtc gac agt gac atc acc agc atc gcg gac cgg cgt ctc      897
Ile Ile Leu Val Asp Ser Asp Ile Thr Ser Ile Ala Asp Arg Arg Leu         
145                 150                 155                 160         

caa agg gcc agc cga ggt tac gtc ttc tcc ctt ccc gtc gtt ctc tcc      945
Gln Arg Ala Ser Arg Gly Tyr Val Phe Ser Leu Pro Val Val Leu Ser         
                165                 170                 175             

ggt cgc gag gag gcc atc gcc ttc att cgg gac agc ggt atg cag ctg      993
Gly Arg Glu Glu Ala Ile Ala Phe Ile Arg Asp Ser Gly Met Gln Leu         
            180                 185                 190                 

atg acg ctc aag gcg gat ggc gac att tcc gtg aag gaa ctc ggg gac     1041
Met Thr Leu Lys Ala Asp Gly Asp Ile Ser Val Lys Glu Leu Gly Asp         
        195                 200                 205                     

aat ccg gat cgg ctg gcc ttg ctg ttc ggc agc gaa aag ggt ggg cct     1089
Asn Pro Asp Arg Leu Ala Leu Leu Phe Gly Ser Glu Lys Gly Gly Pro         
    210                 215                 220                         

tcc gac ctg ttc gag gag gcg tct tcc gcc tcg gtt tcc atc ccc atg     1137
Ser Asp Leu Phe Glu Glu Ala Ser Ser Ala Ser Val Ser Ile Pro Met         
225                 230                 235                 240         

atg agc cag acc gag tct ctc aac gtt tcc gtt tcc ctc gga atc gcg     1185
Met Ser Gln Thr Glu Ser Leu Asn Val Ser Val Ser Leu Gly Ile Ala         
                245                 250                 255             

ctg cac gag agg atc gac agg aat ctc gcg gcc aac cga taa             1227
Leu His Glu Arg Ile Asp Arg Asn Leu Ala Ala Asn Arg                     
            260                 265                                     

gcgcctctgt tcctcggacg ctcggttcct cgacctcgat tcgtcagtga tgatcccgca   1287

aaagcggcct ttgactccct gcaagcctca gcgaccgaat atatcggtta tgcgtgggcg   1347

atggttgttg tcattgtcgg cgcaactatc ggtatcaagc tgtttaagaa attcacctcg   1407

aaagcaagct gataaaccga tacaattaaa ggctcctttt ggagcctttt tttttggaga   1467

ttttcaacgt gaaaaaatta ttattcgcaa ttcctttagt tgttcctttc tattctcact   1527

ccgctgaaac tgttgaaagt tgtttagcaa aacctcatac agaaaattca tttactaacg   1587

tctggaaaga cgacaaaact ttagatccgg ccaagctctg gcgtaatagc gaagaggccc   1647

gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggaaa ttgtaagcgt   1707

taatattttg ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata   1767

ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt   1827

tgttccagtt tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg   1887

aaaaaccgtc tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt   1947

ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc   2007

ttgacgggga aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg   2067

cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct   2127

taatgcgccg ctacagggcg cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc   2187

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg   2247

ataaatgctt caataatatt gaaaaaggaa gagt atg agt att caa cat ttc cgt   2302
                                      Met Ser Ile Gln His Phe Arg       
                                      270                 275           

gtc gcc ctt att ccc ttt ttt gcg gca ttt tgc ctt cct gtt ttt gct     2350
Val Ala Leu Ile Pro Phe Phe Ala Ala Phe Cys Leu Pro Val Phe Ala         
            280                 285                 290                 

cac cca gaa acg ctg gtg aaa gta aaa gat gct gaa gat cag ttg ggt     2398
His Pro Glu Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly         
        295                 300                 305                     

gca cga gtg ggt tac atc gaa ctg gat ctc aac agc ggt aag atc ctt     2446
Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu         
    310                 315                 320                         

gag agt ttt cgc ccc gaa gaa cgt ttt cca atg atg agc act ttt aaa     2494
Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro Met Met Ser Thr Phe Lys         
325                 330                 335                 340         

gtt ctg cta tgt ggc gcg gta tta tcc cgt att gac gcc ggg caa gag     2542
Val Leu Leu Cys Gly Ala Val Leu Ser Arg Ile Asp Ala Gly Gln Glu         
                345                 350                 355             

caa ctc ggt cgc cgc ata cac tat tct cag aat gac ttg gtt gag tac     2590
Gln Leu Gly Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr         
            360                 365                 370                 

tca cca gtc aca gaa aag cat ctt acg gat ggc atg aca gta aga gaa     2638
Ser Pro Val Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu         
        375                 380                 385                     

tta tgc agt gct gcc ata acc atg agt gat aac act gcg gcc aac tta     2686
Leu Cys Ser Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu         
    390                 395                 400                         

ctt ctg aca acg atc gga gga ccg aag gag cta acc gct ttt ttg cac     2734
Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His         
405                 410                 415                 420         

aac atg ggg gat cat gta act cgc ctt gat cgt tgg gaa ccg gag ctg     2782
Asn Met Gly Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu         
                425                 430                 435             

aat gaa gcc ata cca aac gac gag cgt gac acc acg atg cct gta gca     2830
Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Val Ala         
            440                 445                 450                 

atg gca aca acg ttg cgc aaa cta tta act ggc gaa cta ctt act cta     2878
Met Ala Thr Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu         
        455                 460                 465                     

gct tcc cgg caa caa tta ata gac tgg atg gag gcg gat aaa gtt gca     2926
Ala Ser Arg Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala         
    470                 475                 480                         

gga cca ctt ctg cgc tcg gcc ctt ccg gct ggc tgg ttt att gct gat     2974
Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp         
485                 490                 495                 500         

aaa tct gga gcc ggt gag cgt ggg tct cgc ggt atc att gca gca ctg     3022
Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu         
                505                 510                 515             

ggg cca gat ggt aag ccc tcc cgt atc gta gtt atc tac acg acg ggg     3070
Gly Pro Asp Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly         
            520                 525                 530                 

agt cag gca act atg gat gaa cga aat aga cag atc gct gag ata ggt     3118
Ser Gln Ala Thr Met Asp Glu Arg Asn Arg Gln Ile Ala Glu Ile Gly         
        535                 540                 545                     

gcc tca ctg att aag cat tgg taa ctgtcagacc aagtttactc atatatactt    3172
Ala Ser Leu Ile Lys His Trp                                             
    550                 555                                             

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat   3232

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta   3292

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa   3352

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt   3412

tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag   3472

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta   3532

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca   3592

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag   3652

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa   3712

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga   3772

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc   3832

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc   3892

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt   3952

gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt   4012

gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag   4072

gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa   4132

tgcagagctt ctagatgcat gctcgagcgg ccgccagtgt gatggatatc tgcagaattc   4192

gtgactagat cttcaggcac ggatggccgc agtgttctcc agtgtccgca ccagcgcggc   4252

gggatggggc atggccgtga tctcgtcgct gagtttgatt gccgcagaag cgaagccggt   4312

gtcgccgagc accgttgcga ttgagtcggt gaactgttcg tggtcggact gggcctgctc   4372

atccggcaag cagatgcccg ccccggcagc ggcgaggttg cgcgcgtagt cgaactggtc   4432

gaagtactgg ggaagcacga gttgcgggat gccgagtcgg gtcgcggtga atgccgttcc   4492

cgagccgccc gcgcagatga ccagctcgca ggtacgcagg aacaggttga gcgggaccga   4552

ttcggcgatc cgggcgttgt cgggtaggtc ggtgagaagt gcccggtgct cggggggaac   4612

ggcgatcacg gcctcgacgc cgggcaactc ggtggcagcc gctactgcgc gcagcagcgg   4672

agccggcccg gtggcgttca gcaccatgcg gcccatgcag atgcagaccc gccgtgctga   4732

ggtgcgcgcc gcgccccatg ccgggaatgc gccgcttccg ttgtacggca cgtactggac   4792

cggtgcgcct tgcggcgcgt cgcttgcttg caggctcggc ggacagggat cgaggatgag   4852

ctcgggagtg ggcaggccgg tcagtccgtg gtgccggcac accgggtcaa gcaactcgtg   4912

ggctcgatcg ctgaaggggc ctgcggtggg gtcgactccc cagcggtgca gcacgaccgg   4972

caggtcgagc aatccgccga gcacccggcc gatcagcgcg cagacgtcga ccaacagcac   5032

tgacggtcgc caggcctcgg ccagtcgaag gtattcgggg agctgatcga gcgagctttg   5092

cgcgacattg gacgcggtct gctcccacag ttgccggcct gcctcggtgt cgcgctgacc   5152

gaacgccgga ttgggaaagc gcagctgcgt ggttccaccc gtatcgccgg tcctgtcgtt   5212

cccgcggatc ccggccgtgg tgagacctgc accatgcgcg gtcgcctgca gctctggtgg   5272

tgcggcgatc aggacctcgt gcccggatgc ttgcagcgcc cagcacagcg gcaccattgc   5332

catgagatgc gtcggatagg gcaagggaac gacgagtacg cgcatacttc ggaccccagt   5392

caattgcccg aattcgatat caagcttatc gataccgtcg atcctaccaa ccggcacgat   5452

tgtgcccaca acagcatcgc ggtgccacgt gtggaccgcg tcggtcagat cctccccgca   5512

cctctcgcca gccgtcaaga tcgaccgcgt gcacctgcga tcgccgatca accgcgacta   5572

gcatcgggcg caagccgcca ctcgaacgga cactcgcatg gacgtcccct tcctggacct   5632

gcaagccgcg tacctcgaac tccggtccga catcgaccag gcgtgccggc gcgtgctcgg   5692

gtcgggctgg acctcgaggg ggggcccggt accgcctgca cgaagtgccg gcggggccga   5752

ccccgggcga gtaatcccag gattactccc gcggcttcga ccccggccgc cgtcgccgcg   5812

tacgtcaccg acccccgccg tacgtcaccg ggatgacgta cggcgggggg gagcgag      5869

tta gtg cga agt ggg ccc act tgc gag ccg ggc gat gtg ccg ggc ggc     5917
Leu Val Arg Ser Gly Pro Thr Cys Glu Pro Gly Asp Val Pro Gly Gly         
                560                 565                 570             

ccg ctc ctg gcg gtc gtc ggc gtc gtc gtc ctg gtc gtc gtc ctg ctc     5965
Pro Leu Leu Ala Val Val Gly Val Val Val Leu Val Val Val Leu Leu         
            575                 580                 585                 

tcg ccg tcg gcg tgc agt tgc ttc ctc gcg gcg ctg ggc gag ggc ggc     6013
Ser Pro Ser Ala Cys Ser Cys Phe Leu Ala Ala Leu Gly Glu Gly Gly         
        590                 595                 600                     

gag cat gtc ggc gta cgc ctc ggc cac ctc ccc cgc cgt gag cac cac     6061
Glu His Val Gly Val Arg Leu Gly His Leu Pro Arg Arg Glu His His         
    605                 610                 615                         

cac tgt gtc ggc cgc gtc ggc cag cgc cag gac ctc ccg cac ccg ttc     6109
His Cys Val Gly Arg Val Gly Gln Arg Gln Asp Leu Pro His Pro Phe         
620                 625                 630                 635         

gcc cac ggc cgc cga atc ctc gtt gcc gtc ctt gcc ttc ggc ggc ccg     6157
Ala His Gly Arg Arg Ile Leu Val Ala Val Leu Ala Phe Gly Gly Pro         
                640                 645                 650             

ggt cgc ctc gag gtc gag ggc gcg gcg ggt gac cgc gtg cca tcc gtc     6205
Gly Arg Leu Glu Val Glu Gly Ala Ala Gly Asp Arg Val Pro Ser Val         
            655                 660                 665                 

ctc ggt cac ggc gac ccc ggc ccg cag ctc ccc gcc gtc ggc gtc ggc     6253
Leu Gly His Gly Asp Pro Gly Pro Gln Leu Pro Ala Val Gly Val Gly         
        670                 675                 680                     

cgc cag gag cag atc gag gtc gtc ggc ctc ggt gtc gcc gcc gtc gag     6301
Arg Gln Glu Gln Ile Glu Val Val Gly Leu Gly Val Ala Ala Val Glu         
    685                 690                 695                         

ccc gag cat ctg ccg cag gta gcg ggt cca ttc gat ggc ccg gcg tcc     6349
Pro Glu His Leu Pro Gln Val Ala Gly Pro Phe Asp Gly Pro Ala Ser         
700                 705                 710                 715         

ccg ggt tgc ccg ctc gta ctc gtg cca gcg cga gag gtt cca ctc cag     6397
Pro Gly Cys Pro Leu Val Leu Val Pro Ala Arg Glu Val Pro Leu Gln         
                720                 725                 730             

cga gcc gac ccc ggc ggc gtc gtc ctc ggt cat gcc gcc ggt cag gtc     6445
Arg Ala Asp Pro Gly Gly Val Val Leu Gly His Ala Ala Gly Gln Val         
            735                 740                 745                 

ccc gat ccg tcc gag gag ttc gaa cgg ggc gac gtt ccc gcc ggt cgc     6493
Pro Asp Pro Ser Glu Glu Phe Glu Arg Gly Asp Val Pro Ala Gly Arg         
        750                 755                 760                     

cgt ctt gag gtc ggc gcg ggc gag ttc gag ggc ggg cgc ctt ccc gtc     6541
Arg Leu Glu Val Gly Ala Gly Glu Phe Glu Gly Gly Arg Leu Pro Val         
    765                 770                 775                         

ctg ggt ctt ggc gat gta ctc ggc gag gtc gtt ggc gtc gcg ctc ggt     6589
Leu Gly Leu Gly Asp Val Leu Gly Glu Val Val Gly Val Ala Leu Gly         
780                 785                 790                 795         

ctc cag ccg ctt gaa gtc gac gcc gtg ccg gtc gtc ggg cgt gaa ggc     6637
Leu Gln Pro Leu Glu Val Asp Ala Val Pro Val Val Gly Arg Glu Gly         
                800                 805                 810             

ggg gtt gac ctt gcg cag ggc ggc ggt cca cac gga ccg cca gtg ccc     6685
Gly Val Asp Leu Ala Gln Gly Gly Gly Pro His Gly Pro Pro Val Pro         
            815                 820                 825                 

ctg cca ctc gtc gag cgc ggc gcc ggt cgg ctc gaa ggt ggc gac gat     6733
Leu Pro Leu Val Glu Arg Gly Ala Gly Arg Leu Glu Gly Gly Asp Asp         
        830                 835                 840                     

ctg ctt cgc gga ccg ctc ccc ctc ggt ccg gcc gcc gac cag gac gat     6781
Leu Leu Arg Gly Pro Leu Pro Leu Gly Pro Ala Ala Asp Gln Asp Asp         
    845                 850                 855                         

cgc gtg gat gtg cgg gtg cca gcc gtt gat ctg ccc cac ggt gac ttc     6829
Arg Val Asp Val Arg Val Pro Ala Val Asp Leu Pro His Gly Asp Phe         
860                 865                 870                 875         

ggt cgc gcg gat cat gcc gac gta ccc gat ccg gtc tcg gat gcc ctc     6877
Gly Arg Ala Asp His Ala Asp Val Pro Asp Pro Val Ser Asp Ala Leu         
                880                 885                 890             

gcg gtc ggc ggc ccg gtg ccc gtc ctt ggc ccg gcg tcc ggc cca cgt     6925
Ala Val Gly Gly Pro Val Pro Val Leu Gly Pro Ala Ser Gly Pro Arg         
            895                 900                 905                 

gcc gcc cgt gat cag tcg ctg gta ggc gcc cgg ccg ccg ggg gct gtc     6973
Ala Ala Arg Asp Gln Ser Leu Val Gly Ala Arg Pro Pro Gly Ala Val         
        910                 915                 920                     

cgg cgt ctt ccg ggt gcc ctg gag ggc gtc cat gag gtc cgc gag ccg     7021
Arg Arg Leu Pro Gly Ala Leu Glu Gly Val His Glu Val Arg Glu Pro         
    925                 930                 935                         

gtc cgt gtg ccc atg gcg ggc cgt gaa ggt gac cag gta ggc ggt ccc     7069
Val Arg Val Pro Met Ala Gly Arg Glu Gly Asp Gln Val Gly Gly Pro         
940                 945                 950                 955         

ccc gcg ctt gat cca ctc gac cac ggc ggc ggt gat ctc ctc ggc ccg     7117
Pro Ala Leu Asp Pro Leu Asp His Gly Gly Gly Asp Leu Leu Gly Pro         
                960                 965                 970             

ctt gtg ccg gat cgt ggc ggc gca gac cgg gca gag cca gat ccg ccc     7165
Leu Val Pro Asp Arg Gly Gly Ala Asp Arg Ala Glu Pro Asp Pro Pro         
            975                 980                 985                 

gca ccg cat cag gcc cag gac cac gga cgt tcc ggc cgc  cgt ctg ggc    7213
Ala Pro His Gln Ala Gln Asp His Gly Arg Ser Gly Arg  Arg Leu Gly        
        990                 995                 1000                    

gac gat  tac gcc gga ggc agg  gtc cat cagggcgcgg ccgcagccct         7260
Asp Asp  Tyr Ala Gly Gly Arg  Val His                                   
    1005                 1010                                           

tgcacgcggc gtccccgctg atccgccaca gcgtccggcg gcggctgtac cgggcggctt   7320

tccgcagtcg ggcagcgtcg ctccgcgacg tgcttcctac ttccgagagg ctgtcgcctc   7380

tcgggctctc cccatccacc ccgtccggag aaaccgcagg tcggaggggt gcgggaaact   7440

ctgttgtttc tttcccaagg tgttcgcttt tgcctcgggc ggcatctcgc gtcacacgcg   7500

cgatcgcccg cttcgctgcc atccggcagc ggtctgagca gtagatacgc ggccgtttgc   7560

ccggtgtgtg ggcaattgcg gtcccgcagt ggcagcgggg cccggcgggc cgatctggca   7620

atgcctcggc atcgctccgt actctgggca cgagcaacgt tcctgtctcg cccggctaag   7680

gggcgcgagt ctgggagcgg acgggtcgga ggtgcgaagt ccggcccgtt gctctttggt   7740

ctggtgggaa tcctggcacc aatcgggcca gaggttccct ccgccactcc cgacgcccct   7800

tggggctggt gtgacttgga gggccgaaga gagccccgcc ggtgatccgg cggggctttg   7860

acgtgcggtc agtgcgtgtg tcggcgagcg atggccacga ggccctggaa gccgagcggt   7920

ccggcgaagt cggcccagtc gcaaccgggc tcagcgcagt gggcggacca gccaccgccg   7980

ttggggtcct ggaccaggtt cacggtcccc tcggtcaggc gtccgtcgaa gtcggtcatg   8040

gtcggtctcc tggtgggtgg gggcg                                         8065


<210>  147
<211>  269
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated vector construction containing spnG gene

<400>  147

Met Thr Glu Leu Asp Thr Ile Ala Asn Pro Ser Asp Pro Ala Val Gln 
1               5                   10                  15      


Arg Ile Ile Asp Val Thr Lys Pro Ser Arg Ser Asn Ile Lys Thr Thr 
            20                  25                  30          


Leu Ile Glu Asp Val Glu Pro Leu Met His Ser Ile Ala Ala Gly Val 
        35                  40                  45              


Glu Phe Ile Glu Val Tyr Gly Ser Asp Ser Ser Pro Phe Pro Ser Glu 
    50                  55                  60                  


Leu Leu Asp Leu Cys Gly Arg Gln Asn Ile Pro Val Arg Leu Ile Asp 
65                  70                  75                  80  


Ser Ser Ile Val Asn Gln Leu Phe Lys Gly Glu Arg Lys Ala Lys Thr 
                85                  90                  95      


Phe Gly Ile Ala Arg Val Pro Arg Pro Ala Arg Phe Gly Asp Ile Ala 
            100                 105                 110         


Ser Arg Arg Gly Asp Val Val Val Leu Asp Gly Val Lys Ile Val Gly 
        115                 120                 125             


Asn Ile Gly Ala Ile Val Arg Thr Ser Leu Ala Leu Gly Ala Ser Gly 
    130                 135                 140                 


Ile Ile Leu Val Asp Ser Asp Ile Thr Ser Ile Ala Asp Arg Arg Leu 
145                 150                 155                 160 


Gln Arg Ala Ser Arg Gly Tyr Val Phe Ser Leu Pro Val Val Leu Ser 
                165                 170                 175     


Gly Arg Glu Glu Ala Ile Ala Phe Ile Arg Asp Ser Gly Met Gln Leu 
            180                 185                 190         


Met Thr Leu Lys Ala Asp Gly Asp Ile Ser Val Lys Glu Leu Gly Asp 
        195                 200                 205             


Asn Pro Asp Arg Leu Ala Leu Leu Phe Gly Ser Glu Lys Gly Gly Pro 
    210                 215                 220                 


Ser Asp Leu Phe Glu Glu Ala Ser Ser Ala Ser Val Ser Ile Pro Met 
225                 230                 235                 240 


Met Ser Gln Thr Glu Ser Leu Asn Val Ser Val Ser Leu Gly Ile Ala 
                245                 250                 255     


Leu His Glu Arg Ile Asp Arg Asn Leu Ala Ala Asn Arg 
            260                 265                 


<210>  148
<211>  286
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated vector construction containing spnG gene

<400>  148

Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 
1               5                   10                  15      


Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 
            20                  25                  30          


Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 
        35                  40                  45              


Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 
    50                  55                  60                  


Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser 
65                  70                  75                  80  


Arg Ile Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr Ser 
                85                  90                  95      


Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr 
            100                 105                 110         


Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser 
        115                 120                 125             


Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys 
    130                 135                 140                 


Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu 
145                 150                 155                 160 


Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg 
                165                 170                 175     


Asp Thr Thr Met Pro Val Ala Met Ala Thr Thr Leu Arg Lys Leu Leu 
            180                 185                 190         


Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp 
        195                 200                 205             


Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro 
    210                 215                 220                 


Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser 
225                 230                 235                 240 


Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile 
                245                 250                 255     


Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn 
            260                 265                 270         


Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 
        275                 280                 285     


<210>  149
<211>  457
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated vector construction containing spnG gene

<400>  149

Leu Val Arg Ser Gly Pro Thr Cys Glu Pro Gly Asp Val Pro Gly Gly 
1               5                   10                  15      


Pro Leu Leu Ala Val Val Gly Val Val Val Leu Val Val Val Leu Leu 
            20                  25                  30          


Ser Pro Ser Ala Cys Ser Cys Phe Leu Ala Ala Leu Gly Glu Gly Gly 
        35                  40                  45              


Glu His Val Gly Val Arg Leu Gly His Leu Pro Arg Arg Glu His His 
    50                  55                  60                  


His Cys Val Gly Arg Val Gly Gln Arg Gln Asp Leu Pro His Pro Phe 
65                  70                  75                  80  


Ala His Gly Arg Arg Ile Leu Val Ala Val Leu Ala Phe Gly Gly Pro 
                85                  90                  95      


Gly Arg Leu Glu Val Glu Gly Ala Ala Gly Asp Arg Val Pro Ser Val 
            100                 105                 110         


Leu Gly His Gly Asp Pro Gly Pro Gln Leu Pro Ala Val Gly Val Gly 
        115                 120                 125             


Arg Gln Glu Gln Ile Glu Val Val Gly Leu Gly Val Ala Ala Val Glu 
    130                 135                 140                 


Pro Glu His Leu Pro Gln Val Ala Gly Pro Phe Asp Gly Pro Ala Ser 
145                 150                 155                 160 


Pro Gly Cys Pro Leu Val Leu Val Pro Ala Arg Glu Val Pro Leu Gln 
                165                 170                 175     


Arg Ala Asp Pro Gly Gly Val Val Leu Gly His Ala Ala Gly Gln Val 
            180                 185                 190         


Pro Asp Pro Ser Glu Glu Phe Glu Arg Gly Asp Val Pro Ala Gly Arg 
        195                 200                 205             


Arg Leu Glu Val Gly Ala Gly Glu Phe Glu Gly Gly Arg Leu Pro Val 
    210                 215                 220                 


Leu Gly Leu Gly Asp Val Leu Gly Glu Val Val Gly Val Ala Leu Gly 
225                 230                 235                 240 


Leu Gln Pro Leu Glu Val Asp Ala Val Pro Val Val Gly Arg Glu Gly 
                245                 250                 255     


Gly Val Asp Leu Ala Gln Gly Gly Gly Pro His Gly Pro Pro Val Pro 
            260                 265                 270         


Leu Pro Leu Val Glu Arg Gly Ala Gly Arg Leu Glu Gly Gly Asp Asp 
        275                 280                 285             


Leu Leu Arg Gly Pro Leu Pro Leu Gly Pro Ala Ala Asp Gln Asp Asp 
    290                 295                 300                 


Arg Val Asp Val Arg Val Pro Ala Val Asp Leu Pro His Gly Asp Phe 
305                 310                 315                 320 


Gly Arg Ala Asp His Ala Asp Val Pro Asp Pro Val Ser Asp Ala Leu 
                325                 330                 335     


Ala Val Gly Gly Pro Val Pro Val Leu Gly Pro Ala Ser Gly Pro Arg 
            340                 345                 350         


Ala Ala Arg Asp Gln Ser Leu Val Gly Ala Arg Pro Pro Gly Ala Val 
        355                 360                 365             


Arg Arg Leu Pro Gly Ala Leu Glu Gly Val His Glu Val Arg Glu Pro 
    370                 375                 380                 


Val Arg Val Pro Met Ala Gly Arg Glu Gly Asp Gln Val Gly Gly Pro 
385                 390                 395                 400 


Pro Ala Leu Asp Pro Leu Asp His Gly Gly Gly Asp Leu Leu Gly Pro 
                405                 410                 415     


Leu Val Pro Asp Arg Gly Gly Ala Asp Arg Ala Glu Pro Asp Pro Pro 
            420                 425                 430         


Ala Pro His Gln Ala Gln Asp His Gly Arg Ser Gly Arg Arg Leu Gly 
        435                 440                 445             


Asp Asp Tyr Ala Gly Gly Arg Val His 
    450                 455         







